My Bibliography

select

Kisling SG, Atri P, Shah A, Cox JL, Sharma S, Smith LM, Ghersi D, Batra SK. A Novel HOXA10-Associated 5-Gene-Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2023 Sep 15;29(18):3759-3770. doi: 10.1158/1078-0432.CCR-23-0825. PubMed PMID: 37432996; PubMed Central PMCID: PMC10529249.

select

Shah A, Chaudhary S, Lakshmanan I, Aithal A, Kisling SG, Sorrell C, Marimuthu S, Gautam SK, Rauth S, Kshirsagar P, Cox JL, Natarajan G, Bhatia R, Mallya K, Rachagani S, Nasser MW, Ganti AK, Salgia R, Kumar S, Jain M, Ponnusamy MP, Batra SK. Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies. NPJ Precis Oncol. 2023 Aug 11;7(1):74. doi: 10.1038/s41698-023-00423-7. PubMed PMID: 37567918; PubMed Central PMCID: PMC10421872.

select

Prajapati DR, Molczyk C, Purohit A, Saxena S, Sturgeon R, Dave BJ, Kumar S, Batra SK, Singh RK. Small molecule antagonist of CXCR2 and CXCR1 inhibits tumor growth, angiogenesis, and metastasis in pancreatic cancer. Cancer Lett. 2023 Jun 1;563:216185. doi: 10.1016/j.canlet.2023.216185. Epub 2023 Apr 14. PubMed PMID: 37062329; PubMed Central PMCID: PMC10218365.

select

Ogunleye AO, Nimmakayala RK, Batra SK, Ponnusamy MP. Metabolic Rewiring and Stemness: A Critical Attribute of Pancreatic Cancer Progression. Stem Cells. 2023 May 15;41(5):417-430. doi: 10.1093/stmcls/sxad017. Review. PubMed PMID: 36869789; PubMed Central PMCID: PMC10183971.

select

Kehrberg RJ, Bhyravbhatla N, Batra SK, Kumar S. Epigenetic regulation of cancer-associated fibroblast heterogeneity. Biochim Biophys Acta Rev Cancer. 2023 May;1878(3):188901. doi: 10.1016/j.bbcan.2023.188901. Epub 2023 Apr 28. Review. PubMed PMID: 37120098; PubMed Central PMCID: PMC10375465.

select

Bhatia R, Siddiqui JA, Ganguly K, Thompson CM, Cannon A, Aithal A, Perumal N, Maurya SK, Li X, Cox JL, Gurumurthy CB, Rachagani S, Jain M, Nasser MW, Batra SK, Kumar S. Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis. Oncogene. 2023 Mar;42(10):759-770. doi: 10.1038/s41388-022-02587-1. Epub 2023 Jan 9. PubMed PMID: 36624189; PubMed Central PMCID: PMC10198580.

select

Rauth S, Ganguly K, Atri P, Parte S, Nimmakayala RK, Varadharaj V, Nallasamy P, Vengoji R, Ogunleye AO, Lakshmanan I, Chirravuri R, Bessho M, Cox JL, Foster JM, Talmon GA, Bessho T, Ganti AK, Batra SK, Ponnusamy MP. Elevated PAF1-RAD52 axis confers chemoresistance to human cancers. Cell Rep. 2023 Feb 28;42(2):112043. doi: 10.1016/j.celrep.2023.112043. Epub 2023 Jan 28. PubMed PMID: 36709426; PubMed Central PMCID: PMC10374878.

select

Molczyk C, Singh RK. CXCR1: A Cancer Stem Cell Marker and Therapeutic Target in Solid Tumors. Biomedicines. 2023 Feb 16;11(2). doi: 10.3390/biomedicines11020576. Review. PubMed PMID: 36831112; PubMed Central PMCID: PMC9953306.

select

Chirravuri-Venkata R, Dam V, Nimmakayala RK, Alsafwani ZW, Bhyravbhatla N, Lakshmanan I, Ponnusamy MP, Kumar S, Jain M, Ghersi D, Batra SK. MUC16 and TP53 family co-regulate tumor-stromal heterogeneity in pancreatic adenocarcinoma. Front Oncol. 2023;13:1073820. doi: 10.3389/fonc.2023.1073820. eCollection 2023. PubMed PMID: 36816942; PubMed Central PMCID: PMC9936860.

select

Raut P, Nimmakayala RK, Batra SK, Ponnusamy MP. Clinical and Molecular Attributes and Evaluation of Pancreatic Cystic Neoplasm. Biochim Biophys Acta Rev Cancer. 2023 Jan;1878(1):188851. doi: 10.1016/j.bbcan.2022.188851. Epub 2022 Dec 16. Review. PubMed PMID: 36535512; PubMed Central PMCID: PMC9898173.

select

Zhang C, Atri P, Nallasamy P, Parte S, Rauth S, Nimmakayala RK, Marimuthu S, Chirravuri-Venkata R, Bhatia R, Halder S, Shah A, Cox JL, Smith L, Kumar S, Foster JM, Kukreja RC, Seshacharyulu P, Ponnusamy MP, Batra SK. Small molecule inhibitor against onco-mucins disrupts Src/FosL1 axis to enhance gemcitabine efficacy in pancreatic ductal adenocarcinoma. Cancer Lett. 2022 Dec 28;551:215922. doi: 10.1016/j.canlet.2022.215922. Epub 2022 Sep 19. PubMed PMID: 36285687; PubMed Central PMCID: PMC10124158.

select

Nallasamy P, Nimmakayala RK, Parte S, Are AC, Batra SK, Ponnusamy MP. Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis. Mol Cancer. 2022 Dec 22;21(1):225. doi: 10.1186/s12943-022-01682-x. Review. PubMed PMID: 36550571; PubMed Central PMCID: PMC9773588.

select

Bhatia R, Bhyravbhatla N, Kisling A, Li X, Batra SK, Kumar S. Cytokines chattering in pancreatic ductal adenocarcinoma tumor microenvironment. Semin Cancer Biol. 2022 Nov;86(Pt 2):499-510. doi: 10.1016/j.semcancer.2022.03.021. Epub 2022 Mar 26. Review. PubMed PMID: 35346801; PubMed Central PMCID: PMC9510605.

select

Ganguly K, Shah A, Atri P, Rauth S, Ponnusamy MP, Kumar S, Batra SK. Chemokine-mucinome interplay in shaping the heterogeneous tumor microenvironment of pancreatic cancer. Semin Cancer Biol. 2022 Nov;86(Pt 2):511-520. doi: 10.1016/j.semcancer.2022.03.022. Epub 2022 Mar 26. Review. PubMed PMID: 35346803; PubMed Central PMCID: PMC9793394.

select

Lakshmanan I, Marimuthu S, Chaudhary S, Seshacharyulu P, Rachagani S, Muniyan S, Chirravuri-Venkata R, Atri P, Rauth S, Nimmakayala RK, Siddiqui JA, Gautam SK, Shah A, Natarajan G, Parte S, Bhyravbhatla N, Mallya K, Haridas D, Talmon GA, Smith LM, Kumar S, Ganti AK, Jain M, Ponnusamy MP, Batra SK. Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma. Oncogene. 2022 Nov;41(48):5147-5159. doi: 10.1038/s41388-022-02493-6. Epub 2022 Oct 21. PubMed PMID: 36271032; PubMed Central PMCID: PMC9841597.

select

Bhatia R, Thompson CM, Clement EJ, Ganguly K, Cox JL, Rauth S, Siddiqui JA, Mashiana SS, Jain M, Wyatt TA, Mashiana HS, Singh S, Woods NT, Kharbanda KK, Batra SK, Kumar S. Malondialdehyde-Acetaldehyde Extracellular Matrix Protein Adducts Attenuate Unfolded Protein Response During Alcohol and Smoking-Induced Pancreatitis. Gastroenterology. 2022 Oct;163(4):1064-1078.e10. doi: 10.1053/j.gastro.2022.06.071. Epub 2022 Jul 3. PubMed PMID: 35788346; PubMed Central PMCID: PMC9796922.

select

Marimuthu S, Lakshmanan I, Muniyan S, Gautam SK, Nimmakayala RK, Rauth S, Atri P, Shah A, Bhyravbhatla N, Mallya K, Grandgenett PM, Hollingsworth MA, Datta K, Jain M, Ponnusamy MP, Batra SK. MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion. Mol Cancer Res. 2022 Aug 5;20(8):1208-1221. doi: 10.1158/1541-7786.MCR-21-0888. PubMed PMID: 35533267; PubMed Central PMCID: PMC9635595.

select

Muniyan S, Pothuraju R, Seshacharyulu P, Batra SK. Macrophage inhibitory cytokine-1 in cancer: Beyond the cellular phenotype. Cancer Lett. 2022 Jun 28;536:215664. doi: 10.1016/j.canlet.2022.215664. Epub 2022 Mar 26. Review. PubMed PMID: 35351601; PubMed Central PMCID: PMC9088220.

select

Marimuthu S, Batra SK, Ponnusamy MP. Pan-cancer analysis of altered glycosyltransferases confers poor clinical outcomes. Clin Transl Discov. 2022 Jun;2(2). doi: 10.1002/ctd2.100. Epub 2022 Jun 26. PubMed PMID: 35875597; PubMed Central PMCID: PMC9302706.

select

Saxena S, Molczyk C, Purohit A, Ehrhorn E, Goel P, Prajapati DR, Atri P, Kaur S, Grandgenett PM, Hollingsworth MA, Batra SK, Singh RK. Differential expression profile of CXC-receptor-2 ligands as potential biomarkers in pancreatic ductal adenocarcinoma. Am J Cancer Res. 2022;12(1):68-90. eCollection 2022. PubMed PMID: 35141005; PubMed Central PMCID: PMC8822283.

select

Ye Z, Abdelmoaty MM, Curran SM, Dyavar SR, Kumar D, Alnouti Y, Coulter DW, Podany AT, Singh RK, Vetro JA. Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC. Noncoding RNA. 2022 Jan 13;8(1). doi: 10.3390/ncrna8010008. PubMed PMID: 35076584; PubMed Central PMCID: PMC8788547.

select

Cannon A, Thompson CM, Bhatia R, Kandy RRK, Solheim JC, Batra SK, Kumar S. Contribution of CXCR3-mediated signaling in the metastatic cascade of solid malignancies. Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188628. doi: 10.1016/j.bbcan.2021.188628. Epub 2021 Sep 22. Review. PubMed PMID: 34560199; PubMed Central PMCID: PMC8595872.

select

Gunda V, Chhonker YS, Natesh NS, Raut P, Muniyan S, Wyatt TA, Murry DJ, Batra SK, Rachagani S. Nuclear factor kappa-B contributes to cigarette smoke tolerance in pancreatic ductal adenocarcinoma through cysteine metabolism. Biomed Pharmacother. 2021 Dec;144:112312. doi: 10.1016/j.biopha.2021.112312. Epub 2021 Oct 19. PubMed PMID: 34678726; PubMed Central PMCID: PMC8599650.

select

Nallasamy P, Nimmakayala RK, Karmakar S, Leon F, Seshacharyulu P, Lakshmanan I, Rachagani S, Mallya K, Zhang C, Ly QP, Myers MS, Josh L, Grabow CE, Gautam SK, Kumar S, Lele SM, Jain M, Batra SK, Ponnusamy MP. Pancreatic Tumor Microenvironment Factor Promotes Cancer Stemness via SPP1-CD44 Axis. Gastroenterology. 2021 Dec;161(6):1998-2013.e7. doi: 10.1053/j.gastro.2021.08.023. Epub 2021 Aug 19. PubMed PMID: 34418441; PubMed Central PMCID: PMC10069715.

select

Rauth S, Karmakar S, Shah A, Seshacharyulu P, Nimmakayala RK, Ganguly K, Bhatia R, Muniyan S, Kumar S, Dutta S, Lin C, Datta K, Batra SK, Ponnusamy MP. SUMO Modification of PAF1/PD2 Enables PML Interaction and Promotes Radiation Resistance in Pancreatic Ductal Adenocarcinoma. Mol Cell Biol. 2021 Nov 22;41(12):e0013521. doi: 10.1128/MCB.00135-21. Epub 2021 Sep 27. PubMed PMID: 34570619; PubMed Central PMCID: PMC8608017.

select

Vengoji R, Atri P, Macha MA, Seshacharyulu P, Perumal N, Mallya K, Liu Y, Smith LM, Rachagani S, Mahapatra S, Ponnusamy MP, Jain M, Batra SK, Shonka N. Differential gene expression-based connectivity mapping identified novel drug candidate and improved Temozolomide efficacy for Glioblastoma. J Exp Clin Cancer Res. 2021 Oct 25;40(1):335. doi: 10.1186/s13046-021-02135-x. PubMed PMID: 34696786; PubMed Central PMCID: PMC8543939.

select

Kisling SG, Natarajan G, Pothuraju R, Shah A, Batra SK, Kaur S. Implications of prognosis-associated genes in pancreatic tumor metastasis: lessons from global studies in bioinformatics. Cancer Metastasis Rev. 2021 Sep;40(3):721-738. doi: 10.1007/s10555-021-09991-1. Epub 2021 Sep 30. Review. PubMed PMID: 34591244; PubMed Central PMCID: PMC8556170.

select

Cannon A, Thompson CM, Bhatia R, Armstrong KA, Solheim JC, Kumar S, Batra SK. Molecular mechanisms of pancreatic myofibroblast activation in chronic pancreatitis and pancreatic ductal adenocarcinoma. J Gastroenterol. 2021 Aug;56(8):689-703. doi: 10.1007/s00535-021-01800-4. Epub 2021 Jul 19. Review. PubMed PMID: 34279724; PubMed Central PMCID: PMC9052363.

select

Kaushal JB, Bhatia R, Kanchan RK, Raut P, Mallapragada S, Ly QP, Batra SK, Rachagani S. Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β. Cancers (Basel). 2021 Jun 22;13(13). doi: 10.3390/cancers13133105. PubMed PMID: 34206370; PubMed Central PMCID: PMC8269055.

select

Saxena S, Singh RK. Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity. Cancer Metastasis Rev. 2021 Jun;40(2):447-476. doi: 10.1007/s10555-021-09970-6. Epub 2021 May 6. Review. PubMed PMID: 33959849; PubMed Central PMCID: PMC9863248.

select

Marimuthu S, Rauth S, Ganguly K, Zhang C, Lakshmanan I, Batra SK, Ponnusamy MP. Mucins reprogram stemness, metabolism and promote chemoresistance during cancer progression. Cancer Metastasis Rev. 2021 Jun;40(2):575-588. doi: 10.1007/s10555-021-09959-1. Epub 2021 Apr 4. Review. PubMed PMID: 33813658; PubMed Central PMCID: PMC9635594.

select

Hang Y, Tang S, Tang W, Větvička D, Zhang C, Xie Y, Yu F, Yu A, Sil D, Li J, Singh RK, Oupický D. Polycation fluorination improves intraperitoneal siRNA delivery in metastatic pancreatic cancer. J Control Release. 2021 May 10;333:139-150. doi: 10.1016/j.jconrel.2021.03.028. Epub 2021 Mar 25. PubMed PMID: 33774121; PubMed Central PMCID: PMC8122076.

select

Purohit A, Saxena S, Varney M, Prajapati DR, Kozel JA, Lazenby A, Singh RK. Host Cxcr2-Dependent Regulation of Pancreatic Cancer Growth, Angiogenesis, and Metastasis. Am J Pathol. 2021 Apr;191(4):759-771. doi: 10.1016/j.ajpath.2021.01.002. Epub 2021 Jan 14. PubMed PMID: 33453178; PubMed Central PMCID: PMC8027924.

select

Ye Z, Abdelmoaty MM, Ambardekar VV, Curran SM, Dyavar SR, Arnold LL, Cohen SM, Kumar D, Alnouti Y, Coulter DW, Singh RK, Vetro JA. Preliminary preclinical study of Chol-DsiRNA polyplexes formed with PLL[30]-PEG[5K] for the RNAi-based therapy of breast cancer. Nanomedicine. 2021 Apr;33:102363. doi: 10.1016/j.nano.2021.102363. Epub 2021 Feb 3. PubMed PMID: 33545405; PubMed Central PMCID: PMC8184584.

select

Rauth S, Karmakar S, Batra SK, Ponnusamy MP. Recent advances in organoid development and applications in disease modeling. Biochim Biophys Acta Rev Cancer. 2021 Apr;1875(2):188527. doi: 10.1016/j.bbcan.2021.188527. Epub 2021 Feb 26. Review. PubMed PMID: 33640383; PubMed Central PMCID: PMC8068668.

select

Kaushik G, Seshacharyulu P, Rauth S, Nallasamy P, Rachagani S, Nimmakayala RK, Vengoji R, Mallya K, Chirravuri-Venkata R, Singh AB, Foster JM, Ly QP, Smith LM, Lele SM, Malafa MP, Jain M, Ponnusamy MP, Batra SK. Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis. Oncogene. 2021 Jan;40(4):848-862. doi: 10.1038/s41388-020-01564-w. Epub 2020 Dec 7. PubMed PMID: 33288882; PubMed Central PMCID: PMC7848971.

select

Nimmakayala RK, Leon F, Rachagani S, Rauth S, Nallasamy P, Marimuthu S, Shailendra GK, Chhonker YS, Chugh S, Chirravuri R, Gupta R, Mallya K, Prajapati DR, Lele SM, C Caffrey T, L Grem J, Grandgenett PM, Hollingsworth MA, Murry DJ, Batra SK, Ponnusamy MP. Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma. Oncogene. 2021 Jan;40(1):215-231. doi: 10.1038/s41388-020-01518-2. Epub 2020 Oct 27. PubMed PMID: 33110235; PubMed Central PMCID: PMC10041665.

select

Cannon A, Thompson CM, Maurer HC, Atri P, Bhatia R, West S, Ghersi D, Olive KP, Kumar S, Batra SK. CXCR3 and Cognate Ligands are Associated with Immune Cell Alteration and Aggressiveness of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2020 Nov 15;26(22):6051-6063. doi: 10.1158/1078-0432.CCR-20-1359. Epub 2020 Sep 1. PubMed PMID: 32873571; PubMed Central PMCID: PMC8261859.

select

Bhatia R, Muniyan S, Thompson CM, Kaur S, Jain M, Singh RK, Dhaliwal A, Cox JL, Akira S, Singh S, Batra SK, Kumar S. Neutrophil Gelatinase-Associated Lipocalin Protects Acinar Cells From Cerulein-Induced Damage During Acute Pancreatitis. Pancreas. 2020 Nov/Dec;49(10):1297-1306. doi: 10.1097/MPA.0000000000001690. PubMed PMID: 33122517; PubMed Central PMCID: PMC8056863.

select

Wu L, Saxena S, Goel P, Prajapati DR, Wang C, Singh RK. Breast Cancer Cell-Neutrophil Interactions Enhance Neutrophil Survival and Pro-Tumorigenic Activities. Cancers (Basel). 2020 Oct 8;12(10). doi: 10.3390/cancers12102884. PubMed PMID: 33049964; PubMed Central PMCID: PMC7599756.

select

Ganguly K, Rauth S, Marimuthu S, Kumar S, Batra SK. Unraveling mucin domains in cancer and metastasis: when protectors become predators. Cancer Metastasis Rev. 2020 Sep;39(3):647-659. doi: 10.1007/s10555-020-09896-5. Review. PubMed PMID: 32488403; PubMed Central PMCID: PMC7487023.

select

Awaji M, Saxena S, Wu L, Prajapati DR, Purohit A, Varney ML, Kumar S, Rachagani S, Ly QP, Jain M, Batra SK, Singh RK. CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma. FASEB J. 2020 Jul;34(7):9405-9418. doi: 10.1096/fj.201902990R. Epub 2020 May 26. PubMed PMID: 32453916; PubMed Central PMCID: PMC7501205.

select

Gupta R, Leon F, Rauth S, Batra SK, Ponnusamy MP. A Systematic Review on the Implications of O-linked Glycan Branching and Truncating Enzymes on Cancer Progression and Metastasis. Cells. 2020 Feb 14;9(2). doi: 10.3390/cells9020446. PubMed PMID: 32075174; PubMed Central PMCID: PMC7072808.

select

Xie Y, Hang Y, Wang Y, Sleightholm R, Prajapati DR, Bader J, Yu A, Tang W, Jaramillo L, Li J, Singh RK, Oupický D. Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy. ACS Nano. 2020 Jan 28;14(1):255-271. doi: 10.1021/acsnano.9b03978. Epub 2020 Jan 13. PubMed PMID: 31927946; PubMed Central PMCID: PMC7041410.

select

Wu L, Awaji M, Saxena S, Varney ML, Sharma B, Singh RK. IL-17-CXC Chemokine Receptor 2 Axis Facilitates Breast Cancer Progression by Up-Regulating Neutrophil Recruitment. Am J Pathol. 2020 Jan;190(1):222-233. doi: 10.1016/j.ajpath.2019.09.016. Epub 2019 Oct 22. PubMed PMID: 31654638; PubMed Central PMCID: PMC6943375.

select

Wu L, Saxena S, Singh RK. Neutrophils in the Tumor Microenvironment. Adv Exp Med Biol. 2020;1224:1-20. doi: 10.1007/978-3-030-35723-8_1. Review. PubMed PMID: 32036601; PubMed Central PMCID: PMC7325741.

select

Liu T, Romanova S, Wang S, Hyun MA, Zhang C, Cohen SM, Singh RK, Bronich TK. Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis. Mol Pharm. 2019 Jul 1;16(7):2872-2883. doi: 10.1021/acs.molpharmaceut.8b01343. Epub 2019 Jun 14. PubMed PMID: 31150251; PubMed Central PMCID: PMC6632075.

select

Awaji M, Futakuchi M, Heavican T, Iqbal J, Singh RK. Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8. Cancer Microenviron. 2019 Apr;12(1):37-46. doi: 10.1007/s12307-019-00223-3. Epub 2019 Apr 26. PubMed PMID: 31025289; PubMed Central PMCID: PMC6529493.

select

Wu L, Saxena S, Awaji M, Singh RK. Tumor-Associated Neutrophils in Cancer: Going Pro. Cancers (Basel). 2019 Apr 19;11(4). doi: 10.3390/cancers11040564. Review. PubMed PMID: 31010242; PubMed Central PMCID: PMC6520693.

select

Sharma B, Nannuru KC, Saxena S, Varney ML, Singh RK. CXCR2: A Novel Mediator of Mammary Tumor Bone Metastasis. Int J Mol Sci. 2019 Mar 12;20(5). doi: 10.3390/ijms20051237. PubMed PMID: 30871004; PubMed Central PMCID: PMC6429058.