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Van Skike CE, Galvan V. mTOR in cerebrovascular disease. Aging (Albany NY). 2019 Mar 13;11(5):1331-1332. doi: 10.18632/aging.101869. PubMed PMID: 30867339; PubMed Central PMCID: PMC6428111.
Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):290-298. doi: 10.1093/gerona/gly127. PubMed PMID: 29893815; PubMed Central PMCID: PMC6376091.
Kaeberlein M, Galvan V. Rapamycin and Alzheimer's disease: Time for a clinical trial?. Sci Transl Med. 2019 Jan 23;11(476). doi: 10.1126/scitranslmed.aar4289. Review. PubMed PMID: 30674654; PubMed Central PMCID: PMC6762017.
Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N. NFκB Regulates Muscle Development and Mitochondrial Function. J Gerontol A Biol Sci Med Sci. 2018 Nov 13;. doi: 10.1093/gerona/gly262. [Epub ahead of print] PubMed PMID: 30423026.
Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Mechanisms of Vascular Aging. Circ Res. 2018 Sep 14;123(7):849-867. doi: 10.1161/CIRCRESAHA.118.311378. Review. PubMed PMID: 30355080; PubMed Central PMCID: PMC6248882.
Nie J, Sun C, Chang Z, Musi N, Shi Y. SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells. Endocrinology. 2018 Aug 1;159(8):3036-3047. doi: 10.1210/en.2017-03243. PubMed PMID: 29873699; PubMed Central PMCID: PMC6693047.
Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS. Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PubMed PMID: 29717417; PubMed Central PMCID: PMC5964063.
Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H693-H703. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22. PubMed PMID: 29351469; PubMed Central PMCID: PMC5966773.
Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL. Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 2018 Feb 22;172(5):952-965.e18. doi: 10.1016/j.cell.2018.02.019. PubMed PMID: 29474921; PubMed Central PMCID: PMC5886375.
Van Skike CE, Galvan V. A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology. 2018;64(3):205-211. doi: 10.1159/000485381. Epub 2018 Jan 11. Review. PubMed PMID: 29320772; PubMed Central PMCID: PMC5876078.
Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V. mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment. J Cereb Blood Flow Metab. 2018 Jan;38(1):58-74. doi: 10.1177/0271678X17705973. Epub 2017 May 17. PubMed PMID: 28511572; PubMed Central PMCID: PMC5757441.
Marinesco S, Ungvari Z, Galvan V. Age-related impairment of metabovascular coupling during cortical spreading depolarizations. Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1209-H1212. doi: 10.1152/ajpheart.00514.2017. Epub 2017 Aug 25. PubMed PMID: 28842440; PubMed Central PMCID: PMC5814652.
Csiszar A, Tarantini S, Fülöp GA, Kiss T, Valcarcel-Ares MN, Galvan V, Ungvari Z, Yabluchanskiy A. Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease. Geroscience. 2017 Aug;39(4):359-372. doi: 10.1007/s11357-017-9991-9. Epub 2017 Aug 29. PubMed PMID: 28853030; PubMed Central PMCID: PMC5636770.
Tarantini S, Fulop GA, Kiss T, Farkas E, Zölei-Szénási D, Galvan V, Toth P, Csiszar A, Ungvari Z, Yabluchanskiy A. Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging. Geroscience. 2017 Aug;39(4):465-473. doi: 10.1007/s11357-017-9980-z. Epub 2017 Jun 3. PubMed PMID: 28578467; PubMed Central PMCID: PMC5636768.
Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R. Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies. Aging Dis. 2017 May;8(3):257-266. doi: 10.14336/AD.2017.0112. eCollection 2017 May. PubMed PMID: 28580182; PubMed Central PMCID: PMC5440106.
Lin AL, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, Galvan V, Richardson A. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab. 2017 Jan;37(1):217-226. doi: 10.1177/0271678X15621575. Epub 2015 Dec 31. PubMed PMID: 26721390; PubMed Central PMCID: PMC5167110.
Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. Polyphosphate: A Conserved Modifier of Amyloidogenic Processes. Mol Cell. 2016 Sep 1;63(5):768-80. doi: 10.1016/j.molcel.2016.07.016. Epub 2016 Aug 25. PubMed PMID: 27570072; PubMed Central PMCID: PMC5234082.
Galvan V, Hart MJ. Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease. Biochim Biophys Acta. 2016 May;1862(5):992-1007. doi: 10.1016/j.bbadis.2015.11.010. Epub 2015 Nov 27. Review. PubMed PMID: 26639036; PubMed Central PMCID: PMC6762019.
Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 Mar 8;52(1):223-42. doi: 10.3233/JAD-151046. PubMed PMID: 27060954; NIHMSID:NIHMS1028066.
Pomilio C, Pavia P, Gorojod RM, Vinuesa A, Alaimo A, Galvan V, Kotler ML, Beauquis J, Saravia F. Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization. Hippocampus. 2016 Feb;26(2):194-210. doi: 10.1002/hipo.22503. Epub 2015 Sep 4. PubMed PMID: 26235241; PubMed Central PMCID: PMC5467976.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. PubMed PMID: 26315673; PubMed Central PMCID: PMC4693453.
Richardson A, Galvan V, Lin AL, Oddo S. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Exp Gerontol. 2015 Aug;68:51-8. doi: 10.1016/j.exger.2014.12.002. Epub 2014 Dec 3. Review. PubMed PMID: 25481271; PubMed Central PMCID: PMC6417920.
Galvan V, Jahrling JB. TOR-dependent cerebrovascular aging in Alzheimer’s disease. Current trends in neurology. 2014 December; 8:31.
Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Front Mol Neurosci. 2014;7:83. doi: 10.3389/fnmol.2014.00083. eCollection 2014. PubMed PMID: 25414638; PubMed Central PMCID: PMC4220119.
Beauquis J, Vinuesa A, Pomilio C, Pavía P, Galván V, Saravia F. Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease. Hippocampus. 2014 Mar;24(3):257-69. doi: 10.1002/hipo.22219. Epub 2013 Nov 12. PubMed PMID: 24132937.
Sun YX, Ji X, Mao X, Xie L, Jia J, Galvan V, Greenberg DA, Jin K. Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease. J Alzheimers Dis. 2014;38(2):437-44. doi: 10.3233/JAD-131124. PubMed PMID: 23979023.
Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. doi: 10.1038/jcbfm.2013.116. Epub 2013 Jul 10. PubMed PMID: 23838831; PubMed Central PMCID: PMC3790931.
Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26. PubMed PMID: 23801246; PubMed Central PMCID: PMC3764385.
Pierce A, Podlutskaya N, Halloran JJ, Hussong SA, Lin PY, Burbank R, Hart MJ, Galvan V. Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease. J Neurochem. 2013 Mar;124(6):880-93. doi: 10.1111/jnc.12080. Epub 2012 Dec 26. PubMed PMID: 23121022; PubMed Central PMCID: PMC6762020.
Beauquis J, Pavía P, Pomilio C, Vinuesa A, Podlutskaya N, Galvan V, Saravia F. Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease. Exp Neurol. 2013 Jan;239:28-37. doi: 10.1016/j.expneurol.2012.09.009. Epub 2012 Sep 28. PubMed PMID: 23022919; NIHMSID:NIHMS1028074.
Sultana R, Robinson RA, Lange MB, Fiorini A, Galvan V, Fombonne J, Baker A, Gorostiza O, Zhang J, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?. Antioxid Redox Signal. 2012 Dec 1;17(11):1507-14. doi: 10.1089/ars.2011.4470. Epub 2012 Jun 6. PubMed PMID: 22500616; PubMed Central PMCID: PMC3448937.
Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience. 2012 Oct 25;223:102-13. doi: 10.1016/j.neuroscience.2012.06.054. Epub 2012 Jun 28. PubMed PMID: 22750207; PubMed Central PMCID: PMC3454865.
Hart MJ, Glicksman M, Liu M, Sharma MK, Cuny G, Galvan V. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Anal Biochem. 2012 Feb 15;421(2):467-76. doi: 10.1016/j.ab.2011.11.020. Epub 2011 Dec 1. PubMed PMID: 22178911.
Vogt DL, Thomas D, Galvan V, Bredesen DE, Lamb BT, Pimplikar SW. Abnormal neuronal networks and seizure susceptibility in mice overexpressing the APP intracellular domain. Neurobiol Aging. 2011 Sep;32(9):1725-9. doi: 10.1016/j.neurobiolaging.2009.09.002. Epub 2009 Oct 13. PubMed PMID: 19828212; PubMed Central PMCID: PMC2889215.
Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Neuroscience. 2011 Mar 17;177:207-22. doi: 10.1016/j.neuroscience.2011.01.005. Epub 2011 Jan 9. PubMed PMID: 21223993; PubMed Central PMCID: PMC3058851.
Zhang J, Rao RV, Spilman P, Mangada J, Xie L, Vitelli C, Gorostiza OF, Madden DT, Zeng X, Jin K, Hart MJ, Bredesen DE, Galvan V. Endogenously EGFP-Labeled Mouse Embryonic Stem Cells. Aging Dis. 2011 Feb;2(1):18-29. PubMed PMID: 21874159; PubMed Central PMCID: PMC3160738.
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010 Apr 1;5(4):e9979. doi: 10.1371/journal.pone.0009979. PubMed PMID: 20376313; PubMed Central PMCID: PMC2848616.
Jin K, Mao X, Xie L, Galvan V, Lai B, Wang Y, Gorostiza O, Wang X, Greenberg DA. Transplantation of human neural precursor cells in Matrigel scaffolding improves outcome from focal cerebral ischemia after delayed postischemic treatment in rats. J Cereb Blood Flow Metab. 2010 Mar;30(3):534-44. doi: 10.1038/jcbfm.2009.219. Epub 2009 Oct 14. PubMed PMID: 19826433; PubMed Central PMCID: PMC2831107.
Zhang J, Gorostiza OF, Tang H, Bredesen DE, Galvan V. Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav Brain Res. 2010 Jan 20;206(2):202-7. doi: 10.1016/j.bbr.2009.09.013. Epub 2009 Sep 12. PubMed PMID: 19751769; PubMed Central PMCID: PMC2783897.
Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R, Bredesen DE. In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. Free Radic Biol Med. 2010 Jan 1;48(1):136-44. doi: 10.1016/j.freeradbiomed.2009.10.035. Epub 2009 Oct 23. PubMed PMID: 19854267; PubMed Central PMCID: PMC2818480.
Bredesen DE, John V, Galvan V. Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis. 2010;22(1):57-63. doi: 10.3233/JAD-2010-100537. Review. PubMed PMID: 20847422; PubMed Central PMCID: PMC3968071.
Lourenço FC, Galvan V, Fombonne J, Corset V, Llambi F, Müller U, Bredesen DE, Mehlen P. Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production. Cell Death Differ. 2009 May;16(5):655-63. doi: 10.1038/cdd.2008.191. Epub 2009 Jan 16. PubMed PMID: 19148186; PubMed Central PMCID: PMC2757418.
Tang H, Wang Y, Xie L, Mao X, Won SJ, Galvan V, Jin K. Effect of neural precursor proliferation level on neurogenesis in rat brain during aging and after focal ischemia. Neurobiol Aging. 2009 Feb;30(2):299-308. doi: 10.1016/j.neurobiolaging.2007.06.004. Epub 2007 Jul 17. PubMed PMID: 17644223; PubMed Central PMCID: PMC2634816.
Kumasaka DK, Galvan V, Head E, Rohn TT. Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease. Int J Physiol Pathophysiol Pharmacol. 2009 Jan 12;1(1):48-56. PubMed PMID: 20411026; PubMed Central PMCID: PMC2856934.
Galvan V, Zhang J, Gorostiza OF, Banwait S, Huang W, Ataie M, Tang H, Bredesen DE. Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664. Behav Brain Res. 2008 Aug 22;191(2):246-55. doi: 10.1016/j.bbr.2008.03.035. Epub 2008 Apr 8. PubMed PMID: 18485495; PubMed Central PMCID: PMC2757410.
Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb;13(1):1-16. doi: 10.3233/jad-2008-13101. PubMed PMID: 18334752; PubMed Central PMCID: PMC2818039.
Nguyen TV, Galvan V, Huang W, Banwait S, Tang H, Zhang J, Bredesen DE. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem. 2008 Feb;104(4):1065-80. doi: 10.1111/j.1471-4159.2007.05031.x. Epub 2007 Nov 6. PubMed PMID: 17986220; PubMed Central PMCID: PMC2553705.
Galvan V, Bredesen DE. Neurogenesis in the adult brain: implications for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2007 Oct;6(5):303-10. doi: 10.2174/187152707783220938. Review. PubMed PMID: 18045158.
Galvan V, Banwait S, Spilman P, Gorostiza OF, Peel A, Ataie M, Crippen D, Huang W, Sidhu G, Ichijo H, Bredesen DE. Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex. Neurobiol Dis. 2007 Oct;28(1):65-75. doi: 10.1016/j.nbd.2007.06.017. Epub 2007 Jul 3. PubMed PMID: 17719230; PubMed Central PMCID: PMC2084074.
Jin K, Galvan V. Endogenous neural stem cells in the adult brain. J Neuroimmune Pharmacol. 2007 Sep;2(3):236-42. doi: 10.1007/s11481-007-9076-0. Epub 2007 May 18. Review. PubMed PMID: 18040856.
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