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Chucair-Elliott AJ, Pham K, Cleuren ACA, Schafer CM, Griffin CT, Ocanas SR, Freeman WM, Elliott MH. Comparative analysis of In vivo endothelial cell translatomes across central nervous system vascular beds. Exp Eye Res. 2024 Nov;248:110101. doi: 10.1016/j.exer.2024.110101. Epub 2024 Sep 18. PubMed PMID: 39303842; PubMed Central PMCID: PMC11532013.
Pomilio C, Presa J, Oses C, Vinuesa A, Bentivegna M, Gregosa A, Riudavets M, Sevlever G, Galvan V, Levi V, Beauquis J, Saravia F. Loss of Direct Vascular Contact to Astrocytes in the Hippocampus as an Initial Event in Alzheimer's Disease. Evidence from Patients, In Vivo and In Vitro Experimental Models. Mol Neurobiol. 2024 Aug;61(8):5142-5160. doi: 10.1007/s12035-023-03897-5. Epub 2024 Jan 3. PubMed PMID: 38172288; NIHMSID:NIHMS2004577.
Owens CD, Pinto CB, Mukli P, Gulej R, Velez FS, Detwiler S, Olay L, Hoffmeister JR, Szarvas Z, Muranyi M, Peterfi A, Pinaffi-Langley ACDC, Adams C, Sharps J, Kaposzta Z, Prodan CI, Kirkpatrick AC, Tarantini S, Csiszar A, Ungvari Z, Olson AL, Li G, Balasubramanian P, Galvan V, Bauer A, Smith ZA, Dasari TW, Whitehead S, Medapti MR, Elahi FM, Thanou A, Yabluchanskiy A. Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment. Alzheimers Dement. 2024 Aug;20(8):5590-5606. doi: 10.1002/alz.14072. Epub 2024 Jul 3. PubMed PMID: 38958537; PubMed Central PMCID: PMC11350141.
Quarleri J, Delpino MV, Galvan V. Anticipating the future of the COVID-19 pandemic: insights into the emergence of SARS-CoV-2 variant JN.1 and its projected impact on older adults. Geroscience. 2024 Jun;46(3):2879-2883. doi: 10.1007/s11357-024-01066-7. Epub 2024 Jan 10. PubMed PMID: 38198026; PubMed Central PMCID: PMC11009205.
Rose HM, Ferrán B, Ranjit R, Masingale AM, Owen DB, Hussong S, Kinter MT, Galvan V, Logan S, Díaz-García CM. Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning. J Neurochem. 2024 May;168(5):592-607. doi: 10.1111/jnc.15901. Epub 2023 Jul 6. PubMed PMID: 37415312; PubMed Central PMCID: PMC10770303.
Owens CD, Bonin Pinto C, Detwiler S, Olay L, Pinaffi-Langley ACDC, Mukli P, Peterfi A, Szarvas Z, James JA, Galvan V, Tarantini S, Csiszar A, Ungvari Z, Kirkpatrick AC, Prodan CI, Yabluchanskiy A. Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19. Brain Commun. 2024;6(2):fcae080. doi: 10.1093/braincomms/fcae080. eCollection 2024. Review. PubMed PMID: 38495306; PubMed Central PMCID: PMC10943572.
Owens CD, Bonin Pinto C, Mukli P, Szarvas Z, Peterfi A, Detwiler S, Olay L, Olson AL, Li G, Galvan V, Kirkpatrick AC, Balasubramanian P, Tarantini S, Csiszar A, Ungvari Z, Prodan CI, Yabluchanskiy A. Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study. PLoS One. 2023;18(8):e0289508. doi: 10.1371/journal.pone.0289508. eCollection 2023. PubMed PMID: 37535668; PubMed Central PMCID: PMC10399897.
Riordan R, Rong W, Yu Z, Ross G, Valerio J, Dimas-Muñoz J, Heredia V, Magnusson K, Galvan V, Perez VI. Effect of Nrf2 loss on senescence and cognition of tau-based P301S mice. Geroscience. 2023 Jun;45(3):1451-1469. doi: 10.1007/s11357-023-00760-2. Epub 2023 Mar 28. PubMed PMID: 36976489; PubMed Central PMCID: PMC10400516.
Van Skike CE, DeRosa N, Galvan V, Hussong SA. Rapamycin restores peripheral blood flow in aged mice and in mouse models of atherosclerosis and Alzheimer's disease. Geroscience. 2023 Jun;45(3):1987-1996. doi: 10.1007/s11357-023-00786-6. Epub 2023 Apr 13. PubMed PMID: 37052770; PubMed Central PMCID: PMC10400743.
Hussong SA, Banh AQ, Van Skike CE, Dorigatti AO, Hernandez SF, Hart MJ, Ferran B, Makhlouf H, Gaczynska M, Osmulski PA, McAllen SA, Dineley KT, Ungvari Z, Perez VI, Kayed R, Galvan V. Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy. Nat Commun. 2023 Apr 25;14(1):2367. doi: 10.1038/s41467-023-37840-y. PubMed PMID: 37185259; PubMed Central PMCID: PMC10126555.
Quarleri J, Galvan V, Delpino MV. Henipaviruses: an expanding global public health concern?. Geroscience. 2022 Oct;44(5):2447-2459. doi: 10.1007/s11357-022-00670-9. Epub 2022 Oct 11. Review. PubMed PMID: 36219280; PubMed Central PMCID: PMC9550596.
Quarleri J, Delpino MV, Galvan V. Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries. Geroscience. 2022 Aug;44(4):2095-2103. doi: 10.1007/s11357-022-00611-6. Epub 2022 Jun 20. PubMed PMID: 35726117; PubMed Central PMCID: PMC9208705.
Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models. Sci Adv. 2022 Jun 10;8(23):eabk2252. doi: 10.1126/sciadv.abk2252. Epub 2022 Jun 8. PubMed PMID: 35675410; PubMed Central PMCID: PMC9177073.
Dorigatti AO, Riordan R, Yu Z, Ross G, Wang R, Reynolds-Lallement N, Magnusson K, Galvan V, Perez VI. Brain cellular senescence in mouse models of Alzheimer's disease. Geroscience. 2022 Apr;44(2):1157-1168. doi: 10.1007/s11357-022-00531-5. Epub 2022 Mar 6. PubMed PMID: 35249206; PubMed Central PMCID: PMC9135905.
Galvan V, Quarleri J. Editorial: Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans. Geroscience. 2022 Feb;44(1):57-61. doi: 10.1007/s11357-021-00501-3. Epub 2021 Dec 21. PubMed PMID: 34935099; PubMed Central PMCID: PMC8691152.
Quarleri J, Galvan V, Delpino MV. Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load. Geroscience. 2022 Feb;44(1):53-56. doi: 10.1007/s11357-021-00500-4. Epub 2021 Dec 18. PubMed PMID: 34921354; PubMed Central PMCID: PMC8683309.
Salmon AB, Nelson JF, Gelfond JAL, Javors M, Ginsburg B, Lopez-Cruzan M, Galvan V, Fernandez E, Musi N, Ikeno Y, Hubbard G, Lechleiter J, Hornsby PJ, Strong R. San Antonio Nathan Shock Center: your one-stop shop for aging research. Geroscience. 2021 Oct;43(5):2105-2118. doi: 10.1007/s11357-021-00417-y. Epub 2021 Jul 9. PubMed PMID: 34240333; PubMed Central PMCID: PMC8599539.
Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Van Skike CE, Galvan V, Dupree JL, Han X. Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment. Mol Neurodegener. 2021 Sep 15;16(1):64. doi: 10.1186/s13024-021-00488-7. PubMed PMID: 34526055; PubMed Central PMCID: PMC8442347.
Van Skike CE, Hussong SA, Hernandez SF, Banh AQ, DeRosa N, Galvan V. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. J Neurosci. 2021 May 12;41(19):4305-4320. doi: 10.1523/JNEUROSCI.2144-20.2021. Epub 2021 Apr 22. PubMed PMID: 33888602; PubMed Central PMCID: PMC8143195.
Wen B, Li E, Ustiyan V, Wang G, Guo M, Na CL, Kalin GT, Galvan V, Xu Y, Weaver TE, Kalin TV, Whitsett JA, Kalinichenko VV. In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. Am J Respir Crit Care Med. 2021 Feb 15;203(4):471-483. doi: 10.1164/rccm.201909-1836OC. PubMed PMID: 32877203; PubMed Central PMCID: PMC7885842.
Dorigatti AO, Hussong SA, Hernandez SF, Sills AM, Salmon AB, Galvan V. Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging. Geroscience. 2021 Feb;43(1):115-124. doi: 10.1007/s11357-020-00284-z. Epub 2020 Oct 15. PubMed PMID: 33063253; PubMed Central PMCID: PMC8050148.
Nyúl-Tóth Á, Tarantini S, Kiss T, Toth P, Galvan V, Tarantini A, Yabluchanskiy A, Csiszar A, Ungvari Z. Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease. Geroscience. 2020 Dec;42(6):1685-1698. doi: 10.1007/s11357-020-00256-3. Epub 2020 Aug 25. PubMed PMID: 32844283; PubMed Central PMCID: PMC7732885.
Galvan V, Quarleri J. An evaluation of the SARS-CoV-2 epidemic 16 days after the end of social confinement in Hungary. Geroscience. 2020 Oct;42(5):1221-1223. doi: 10.1007/s11357-020-00237-6. Epub 2020 Jul 31. PubMed PMID: 32737759; PubMed Central PMCID: PMC7394474.
Van Skike CE, Galvan V. Cerebrovascular dysfunction links aging to neurological disease. Aging (Albany NY). 2020 Jul 29;12(14):13847-13848. doi: 10.18632/aging.103854. Epub 2020 Jul 29. PubMed PMID: 32756010; PubMed Central PMCID: PMC7425428.
Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V. mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6. PubMed PMID: 31693798; PubMed Central PMCID: PMC6974719.
Van Skike CE, Galvan V. mTOR in cerebrovascular disease. Aging (Albany NY). 2019 Mar 13;11(5):1331-1332. doi: 10.18632/aging.101869. PubMed PMID: 30867339; PubMed Central PMCID: PMC6428111.
Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):290-298. doi: 10.1093/gerona/gly127. PubMed PMID: 29893815; PubMed Central PMCID: PMC6376091.
Kaeberlein M, Galvan V. Rapamycin and Alzheimer's disease: Time for a clinical trial?. Sci Transl Med. 2019 Jan 23;11(476). doi: 10.1126/scitranslmed.aar4289. Review. PubMed PMID: 30674654; PubMed Central PMCID: PMC6762017.
Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Mechanisms of Vascular Aging. Circ Res. 2018 Sep 14;123(7):849-867. doi: 10.1161/CIRCRESAHA.118.311378. Review. PubMed PMID: 30355080; PubMed Central PMCID: PMC6248882.
Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS. Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PubMed PMID: 29717417; PubMed Central PMCID: PMC5964063.
Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H693-H703. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22. PubMed PMID: 29351469; PubMed Central PMCID: PMC5966773.
Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL. Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 2018 Feb 22;172(5):952-965.e18. doi: 10.1016/j.cell.2018.02.019. PubMed PMID: 29474921; PubMed Central PMCID: PMC5886375.
Van Skike CE, Galvan V. A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology. 2018;64(3):205-211. doi: 10.1159/000485381. Epub 2018 Jan 11. Review. PubMed PMID: 29320772; PubMed Central PMCID: PMC5876078.
Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V. mTOR drives cerebral blood flow and memory deficits in LDLR(-/-) mice modeling atherosclerosis and vascular cognitive impairment. J Cereb Blood Flow Metab. 2018 Jan;38(1):58-74. doi: 10.1177/0271678X17705973. Epub 2017 May 17. PubMed PMID: 28511572; PubMed Central PMCID: PMC5757441.
Marinesco S, Ungvari Z, Galvan V. Age-related impairment of metabovascular coupling during cortical spreading depolarizations. Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1209-H1212. doi: 10.1152/ajpheart.00514.2017. Epub 2017 Aug 25. PubMed PMID: 28842440; PubMed Central PMCID: PMC5814652.
Csiszar A, Tarantini S, Fülöp GA, Kiss T, Valcarcel-Ares MN, Galvan V, Ungvari Z, Yabluchanskiy A. Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease. Geroscience. 2017 Aug;39(4):359-372. doi: 10.1007/s11357-017-9991-9. Epub 2017 Aug 29. PubMed PMID: 28853030; PubMed Central PMCID: PMC5636770.
Tarantini S, Fulop GA, Kiss T, Farkas E, Zölei-Szénási D, Galvan V, Toth P, Csiszar A, Ungvari Z, Yabluchanskiy A. Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging. Geroscience. 2017 Aug;39(4):465-473. doi: 10.1007/s11357-017-9980-z. Epub 2017 Jun 3. PubMed PMID: 28578467; PubMed Central PMCID: PMC5636768.
Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R. Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies. Aging Dis. 2017 May;8(3):257-266. doi: 10.14336/AD.2017.0112. eCollection 2017 May. PubMed PMID: 28580182; PubMed Central PMCID: PMC5440106.
Lin AL, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, Galvan V, Richardson A. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab. 2017 Jan;37(1):217-226. doi: 10.1177/0271678X15621575. Epub 2015 Dec 31. PubMed PMID: 26721390; PubMed Central PMCID: PMC5167110.
Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. Polyphosphate: A Conserved Modifier of Amyloidogenic Processes. Mol Cell. 2016 Sep 1;63(5):768-80. doi: 10.1016/j.molcel.2016.07.016. Epub 2016 Aug 25. PubMed PMID: 27570072; PubMed Central PMCID: PMC5234082.
Galvan V, Hart MJ. Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease. Biochim Biophys Acta. 2016 May;1862(5):992-1007. doi: 10.1016/j.bbadis.2015.11.010. Epub 2015 Nov 27. Review. PubMed PMID: 26639036; PubMed Central PMCID: PMC6762019.
Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 Mar 8;52(1):223-42. doi: 10.3233/JAD-151046. PubMed PMID: 27060954; NIHMSID:NIHMS1028066.
Pomilio C, Pavia P, Gorojod RM, Vinuesa A, Alaimo A, Galvan V, Kotler ML, Beauquis J, Saravia F. Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization. Hippocampus. 2016 Feb;26(2):194-210. doi: 10.1002/hipo.22503. Epub 2015 Sep 4. PubMed PMID: 26235241; PubMed Central PMCID: PMC5467976.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. PubMed PMID: 26315673; PubMed Central PMCID: PMC4693453.
Richardson A, Galvan V, Lin AL, Oddo S. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Exp Gerontol. 2015 Aug;68:51-8. doi: 10.1016/j.exger.2014.12.002. Epub 2014 Dec 3. Review. PubMed PMID: 25481271; PubMed Central PMCID: PMC6417920.
Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Front Mol Neurosci. 2014;7:83. doi: 10.3389/fnmol.2014.00083. eCollection 2014. PubMed PMID: 25414638; PubMed Central PMCID: PMC4220119.
Beauquis J, Vinuesa A, Pomilio C, Pavía P, Galván V, Saravia F. Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease. Hippocampus. 2014 Mar;24(3):257-69. doi: 10.1002/hipo.22219. Epub 2013 Nov 12. PubMed PMID: 24132937; NIHMSID:NIHMS1028070.
Sun YX, Ji X, Mao X, Xie L, Jia J, Galvan V, Greenberg DA, Jin K. Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease. J Alzheimers Dis. 2014;38(2):437-44. doi: 10.3233/JAD-131124. PubMed PMID: 23979023.
Jahrling JB, Galvan V. TOR-dependent cerebrovascular aging in Alzheimer's disease. Curr Trends Neurol. 2014;8:31-38. PubMed PMID: 34924724; PubMed Central PMCID: PMC8676146.
Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. doi: 10.1038/jcbfm.2013.116. Epub 2013 Jul 10. PubMed PMID: 23838831; PubMed Central PMCID: PMC3790931.
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