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Riordan R, Rong W, Yu Z, Ross G, Valerio J, Dimas-Muñoz J, Heredia V, Magnusson K, Galvan V, Perez VI. Effect of Nrf2 loss on senescence and cognition of tau-based P301S mice. Geroscience. 2023 Mar 28;. doi: 10.1007/s11357-023-00760-2. [Epub ahead of print] PubMed PMID: 36976489.
Kellogg CM, Pham K, Machalinski AH, Porter HL, Blankenship HE, Stout MB, Rice HC, Sharpe AL, Beckstead MJ, Chucair-Elliott AJ, Ocañas SR, Freeman WM. Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans. bioRxiv. 2023 Mar 10;. doi: 10.1101/2023.03.07.531435. PubMed PMID: 36945372; PubMed Central PMCID: PMC10028873.
Ding Y, Chen J, Li S, Wren JD, Bajpai AK, Wang J, Tanaka T, Rice HC, Hays FA, Lu L, Zhang XA. EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy. Oncogene. 2023 Mar;42(12):861-868. doi: 10.1038/s41388-023-02623-8. Epub 2023 Feb 14. Review. PubMed PMID: 36788350.
Roopnarinesingh XR, Porter H, Giles C, Brown C, Georgescu C, Wren J. Multi-tissue DNA methylation microarray signature is predictive of gene function. Epigenetics. 2022 Nov;17(11):1404-1418. doi: 10.1080/15592294.2022.2036411. Epub 2022 Feb 13. PubMed PMID: 35152835; PubMed Central PMCID: PMC9586602.
Quarleri J, Galvan V, Delpino MV. Henipaviruses: an expanding global public health concern?. Geroscience. 2022 Oct;44(5):2447-2459. doi: 10.1007/s11357-022-00670-9. Epub 2022 Oct 11. Review. PubMed PMID: 36219280; PubMed Central PMCID: PMC9550596.
Coit P, Roopnarinesingh X, Ortiz-Fernández L, McKinnon-Maksimowicz K, Lewis EE, Merrill JT, McCune WJ, Wren JD, Sawalha AH. Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature. Ann Rheum Dis. 2022 Oct;81(10):1428-1437. doi: 10.1136/annrheumdis-2022-222656. Epub 2022 Jun 16. PubMed PMID: 35710306.
Quarleri J, Delpino MV, Galvan V. Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries. Geroscience. 2022 Aug;44(4):2095-2103. doi: 10.1007/s11357-022-00611-6. Epub 2022 Jun 20. PubMed PMID: 35726117; PubMed Central PMCID: PMC9208705.
Chocron ES, Munkácsy E, Kim HS, Karpowicz P, Jiang N, Van Skike CE, DeRosa N, Banh AQ, Palavicini JP, Wityk P, Kalinowski L, Galvan V, Osmulski PA, Jankowska E, Gaczynska M, Pickering AM. Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models. Sci Adv. 2022 Jun 10;8(23):eabk2252. doi: 10.1126/sciadv.abk2252. Epub 2022 Jun 8. PubMed PMID: 35675410; PubMed Central PMCID: PMC9177073.
Allani SK, Rayala R, Rivera O, Prentice HM, Chen X, Ramírez-Alcántara V, Canzoneri J, Menzie-Suderam J, Huang X, Georgescu C, Wren JD, Piazza GA, Weissbach H. A novel sulindac derivative protects against oxidative damage by a cyclooxygenase-independent mechanism. J Pharmacol Exp Ther. 2022 Jun 9;. doi: 10.1124/jpet.122.001086. [Epub ahead of print] PubMed PMID: 35680377; PubMed Central PMCID: PMC9341458.
Dorigatti AO, Riordan R, Yu Z, Ross G, Wang R, Reynolds-Lallement N, Magnusson K, Galvan V, Perez VI. Brain cellular senescence in mouse models of Alzheimer's disease. Geroscience. 2022 Apr;44(2):1157-1168. doi: 10.1007/s11357-022-00531-5. Epub 2022 Mar 6. PubMed PMID: 35249206; PubMed Central PMCID: PMC9135905.
Dorigatti AO, Hussong SA, Hernandez SF, Sills AM, Salmon AB, Galvan V. Correction to: Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging. Geroscience. 2022 Apr;44(2):1171. doi: 10.1007/s11357-022-00524-4. PubMed PMID: 35107706; PubMed Central PMCID: PMC9135920.
Garcia MG, Deng Y, Murray C, Reyes RM, Padron A, Bai H, Kancharla A, Gupta H, Shen-Orr S, Curiel TJ. Immune checkpoint expression and relationships to anti-PD-L1 immune checkpoint blockade cancer immunotherapy efficacy in aged versus young mice. Aging Cancer. 2022 Mar;3(1):68-83. doi: 10.1002/aac2.12045. Epub 2022 Feb 25. PubMed PMID: 36876140; PubMed Central PMCID: PMC9980712.
Galvan V, Quarleri J. Editorial: Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans. Geroscience. 2022 Feb;44(1):57-61. doi: 10.1007/s11357-021-00501-3. Epub 2021 Dec 21. PubMed PMID: 34935099; PubMed Central PMCID: PMC8691152.
Quarleri J, Galvan V, Delpino MV. Omicron variant of the SARS-CoV-2: a quest to define the consequences of its high mutational load. Geroscience. 2022 Feb;44(1):53-56. doi: 10.1007/s11357-021-00500-4. Epub 2021 Dec 18. PubMed PMID: 34921354; PubMed Central PMCID: PMC8683309.
Qiu S, Palavicini JP, Wang J, Gonzalez NS, He S, Dustin E, Zou C, Ding L, Bhattacharjee A, Van Skike CE, Galvan V, Dupree JL, Han X. Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment. Mol Neurodegener. 2021 Sep 15;16(1):64. doi: 10.1186/s13024-021-00488-7. PubMed PMID: 34526055; PubMed Central PMCID: PMC8442347.
Brown AD, Greenman S, Claybon AB, Bishop AJR. BRCA2 Promotes Spontaneous Homologous Recombination In Vivo. Cancers (Basel). 2021 Jul 21;13(15). doi: 10.3390/cancers13153663. PubMed PMID: 34359565; PubMed Central PMCID: PMC8345144.
Van Skike CE, Hussong SA, Hernandez SF, Banh AQ, DeRosa N, Galvan V. mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. J Neurosci. 2021 May 12;41(19):4305-4320. doi: 10.1523/JNEUROSCI.2144-20.2021. Epub 2021 Apr 22. PubMed PMID: 33888602; PubMed Central PMCID: PMC8143195.
Wen B, Li E, Ustiyan V, Wang G, Guo M, Na CL, Kalin GT, Galvan V, Xu Y, Weaver TE, Kalin TV, Whitsett JA, Kalinichenko VV. In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation. Am J Respir Crit Care Med. 2021 Feb 15;203(4):471-483. doi: 10.1164/rccm.201909-1836OC. PubMed PMID: 32877203; PubMed Central PMCID: PMC7885842.
Dorigatti AO, Hussong SA, Hernandez SF, Sills AM, Salmon AB, Galvan V. Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging. Geroscience. 2021 Feb;43(1):115-124. doi: 10.1007/s11357-020-00284-z. Epub 2020 Oct 15. PubMed PMID: 33063253; PubMed Central PMCID: PMC8050148.
Deng Y, Reyes RM, Zhang C, Conejo-Garcia J, Curiel TJ. Targeting Ovarian Cancer with IL-2 Cytokine/Antibody Complexes: A Summary and Recent Advances. J Cell Immunol. 2021;3(6):387-396. doi: 10.33696/immunology.3.122. PubMed PMID: 36968176; PubMed Central PMCID: PMC10035448.
Nyúl-Tóth Á, Tarantini S, Kiss T, Toth P, Galvan V, Tarantini A, Yabluchanskiy A, Csiszar A, Ungvari Z. Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease. Geroscience. 2020 Dec;42(6):1685-1698. doi: 10.1007/s11357-020-00256-3. Epub 2020 Aug 25. PubMed PMID: 32844283; PubMed Central PMCID: PMC7732885.
Galvan V, Quarleri J. An evaluation of the SARS-CoV-2 epidemic 16 days after the end of social confinement in Hungary. Geroscience. 2020 Oct;42(5):1221-1223. doi: 10.1007/s11357-020-00237-6. Epub 2020 Jul 31. PubMed PMID: 32737759; PubMed Central PMCID: PMC7394474.
Van Skike CE, Galvan V. Cerebrovascular dysfunction links aging to neurological disease. Aging (Albany NY). 2020 Jul 29;12(14):13847-13848. doi: 10.18632/aging.103854. Epub 2020 Jul 29. PubMed PMID: 32756010; PubMed Central PMCID: PMC7425428.
Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V. mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6. PubMed PMID: 31693798; PubMed Central PMCID: PMC6974719.
Van Skike CE, Galvan V. mTOR in cerebrovascular disease. Aging (Albany NY). 2019 Mar 13;11(5):1331-1332. doi: 10.18632/aging.101869. PubMed PMID: 30867339; PubMed Central PMCID: PMC6428111.
Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):290-298. doi: 10.1093/gerona/gly127. PubMed PMID: 29893815; PubMed Central PMCID: PMC6376091.
Kaeberlein M, Galvan V. Rapamycin and Alzheimer's disease: Time for a clinical trial?. Sci Transl Med. 2019 Jan 23;11(476). doi: 10.1126/scitranslmed.aar4289. Review. PubMed PMID: 30674654; PubMed Central PMCID: PMC6762017.
Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A. Mechanisms of Vascular Aging. Circ Res. 2018 Sep 14;123(7):849-867. doi: 10.1161/CIRCRESAHA.118.311378. Review. PubMed PMID: 30355080; PubMed Central PMCID: PMC6248882.
Lee HJ, Feliers D, Barnes JL, Oh S, Choudhury GG, Diaz V, Galvan V, Strong R, Nelson J, Salmon A, Kevil CG, Kasinath BS. Hydrogen sulfide ameliorates aging-associated changes in the kidney. Geroscience. 2018 Apr;40(2):163-176. doi: 10.1007/s11357-018-0018-y. Epub 2018 May 1. PubMed PMID: 29717417; PubMed Central PMCID: PMC5964063.
Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H693-H703. doi: 10.1152/ajpheart.00570.2017. Epub 2017 Dec 22. PubMed PMID: 29351469; PubMed Central PMCID: PMC5966773.
Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL. Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 2018 Feb 22;172(5):952-965.e18. doi: 10.1016/j.cell.2018.02.019. PubMed PMID: 29474921; PubMed Central PMCID: PMC5886375.
Van Skike CE, Galvan V. A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology. 2018;64(3):205-211. doi: 10.1159/000485381. Epub 2018 Jan 11. Review. PubMed PMID: 29320772; PubMed Central PMCID: PMC5876078.
Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V. mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment. J Cereb Blood Flow Metab. 2018 Jan;38(1):58-74. doi: 10.1177/0271678X17705973. Epub 2017 May 17. PubMed PMID: 28511572; PubMed Central PMCID: PMC5757441.
Marinesco S, Ungvari Z, Galvan V. Age-related impairment of metabovascular coupling during cortical spreading depolarizations. Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1209-H1212. doi: 10.1152/ajpheart.00514.2017. Epub 2017 Aug 25. PubMed PMID: 28842440; PubMed Central PMCID: PMC5814652.
Csiszar A, Tarantini S, Fülöp GA, Kiss T, Valcarcel-Ares MN, Galvan V, Ungvari Z, Yabluchanskiy A. Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease. Geroscience. 2017 Aug;39(4):359-372. doi: 10.1007/s11357-017-9991-9. Epub 2017 Aug 29. PubMed PMID: 28853030; PubMed Central PMCID: PMC5636770.
Tarantini S, Fulop GA, Kiss T, Farkas E, Zölei-Szénási D, Galvan V, Toth P, Csiszar A, Ungvari Z, Yabluchanskiy A. Demonstration of impaired neurovascular coupling responses in TG2576 mouse model of Alzheimer's disease using functional laser speckle contrast imaging. Geroscience. 2017 Aug;39(4):465-473. doi: 10.1007/s11357-017-9980-z. Epub 2017 Jun 3. PubMed PMID: 28578467; PubMed Central PMCID: PMC5636768.
Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R. Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies. Aging Dis. 2017 May;8(3):257-266. doi: 10.14336/AD.2017.0112. eCollection 2017 May. PubMed PMID: 28580182; PubMed Central PMCID: PMC5440106.
Lin AL, Jahrling JB, Zhang W, DeRosa N, Bakshi V, Romero P, Galvan V, Richardson A. Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease. J Cereb Blood Flow Metab. 2017 Jan;37(1):217-226. doi: 10.1177/0271678X15621575. Epub 2015 Dec 31. PubMed PMID: 26721390; PubMed Central PMCID: PMC5167110.
Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. Polyphosphate: A Conserved Modifier of Amyloidogenic Processes. Mol Cell. 2016 Sep 1;63(5):768-80. doi: 10.1016/j.molcel.2016.07.016. Epub 2016 Aug 25. PubMed PMID: 27570072; PubMed Central PMCID: PMC5234082.
Galvan V, Hart MJ. Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease. Biochim Biophys Acta. 2016 May;1862(5):992-1007. doi: 10.1016/j.bbadis.2015.11.010. Epub 2015 Nov 27. Review. PubMed PMID: 26639036; PubMed Central PMCID: PMC6762019.
Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. Netrin-1 Interrupts Amyloid-β Amplification, Increases sAβPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 Mar 8;52(1):223-42. doi: 10.3233/JAD-151046. PubMed PMID: 27060954; NIHMSID:NIHMS1028066.
Pomilio C, Pavia P, Gorojod RM, Vinuesa A, Alaimo A, Galvan V, Kotler ML, Beauquis J, Saravia F. Glial alterations from early to late stages in a model of Alzheimer's disease: Evidence of autophagy involvement in Aβ internalization. Hippocampus. 2016 Feb;26(2):194-210. doi: 10.1002/hipo.22503. Epub 2015 Sep 4. PubMed PMID: 26235241; PubMed Central PMCID: PMC5467976.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. PubMed PMID: 26315673; PubMed Central PMCID: PMC4693453.
Richardson A, Galvan V, Lin AL, Oddo S. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Exp Gerontol. 2015 Aug;68:51-8. doi: 10.1016/j.exger.2014.12.002. Epub 2014 Dec 3. Review. PubMed PMID: 25481271; PubMed Central PMCID: PMC6417920.
Rodriguez KA, Dodds SG, Strong R, Galvan V, Sharp ZD, Buffenstein R. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Front Mol Neurosci. 2014;7:83. doi: 10.3389/fnmol.2014.00083. eCollection 2014. PubMed PMID: 25414638; PubMed Central PMCID: PMC4220119.
Beauquis J, Vinuesa A, Pomilio C, Pavía P, Galván V, Saravia F. Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease. Hippocampus. 2014 Mar;24(3):257-69. doi: 10.1002/hipo.22219. Epub 2013 Nov 12. PubMed PMID: 24132937; NIHMSID:NIHMS1028070.
Sun YX, Ji X, Mao X, Xie L, Jia J, Galvan V, Greenberg DA, Jin K. Differential activation of mTOR complex 1 signaling in human brain with mild to severe Alzheimer's disease. J Alzheimers Dis. 2014;38(2):437-44. doi: 10.3233/JAD-131124. PubMed PMID: 23979023.
Jahrling JB, Galvan V. TOR-dependent cerebrovascular aging in Alzheimer's disease. Curr Trends Neurol. 2014;8:31-38. PubMed PMID: 34924724; PubMed Central PMCID: PMC8676146.
Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. doi: 10.1038/jcbfm.2013.116. Epub 2013 Jul 10. PubMed PMID: 23838831; PubMed Central PMCID: PMC3790931.
Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26. PubMed PMID: 23801246; PubMed Central PMCID: PMC3764385.
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