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Feuer G, Stewart SA, Baird SM, Lee F, Feuer R, Chen IS. Potential role of natural killer cells in controlling tumorigenesis by human T-cell leukemia viruses. J Virol. 1995 Feb;69(2):1328-33. doi: 10.1128/JVI.69.2.1328-1333.1995. PubMed PMID: 7815516; PubMed Central PMCID: PMC188715.
Planelles V, Haislip A, Withers-Ward ES, Stewart SA, Xie Y, Shah NP, Chen IS. A new reporter system for detection of retroviral infection. Gene Ther. 1995 Aug;2(6):369-76. PubMed PMID: 7584111.
Stewart SA, Feuer G, Jewett A, Lee FV, Bonavida B, Chen IS. HTLV-1 gene expression in adult T-cell leukemia cells elicits an NK cell response in vitro and correlates with cell rejection in SCID mice. Virology. 1996 Dec 15;226(2):167-75. doi: 10.1006/viro.1996.0643. PubMed PMID: 8955035.
Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS. Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard. J Virol. 1997 May;71(5):3961-71. doi: 10.1128/JVI.71.5.3961-3971.1997. PubMed PMID: 9094673; PubMed Central PMCID: PMC191548.
Stewart SA, Poon B, Jowett JB, Chen IS. Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrest. J Virol. 1997 Jul;71(7):5579-92. doi: 10.1128/JVI.71.7.5579-5592.1997. PubMed PMID: 9188632; PubMed Central PMCID: PMC191800.
Withers-Ward ES, Jowett JB, Stewart SA, Xie YM, Garfinkel A, Shibagaki Y, Chow SA, Shah N, Hanaoka F, Sawitz DG, Armstrong RW, Souza LM, Chen IS. Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair. J Virol. 1997 Dec;71(12):9732-42. doi: 10.1128/JVI.71.12.9732-9742.1997. PubMed PMID: 9371639; PubMed Central PMCID: PMC230283.
Poon B, Grovit-Ferbas K, Stewart SA, Chen IS. Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents. Science. 1998 Jul 10;281(5374):266-9. doi: 10.1126/science.281.5374.266. PubMed PMID: 9657723.
Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, Beijersbergen RL, Knoll JH, Meyerson M, Weinberg RA. Inhibition of telomerase limits the growth of human cancer cells. Nat Med. 1999 Oct;5(10):1164-70. doi: 10.1038/13495. PubMed PMID: 10502820.
Stewart SA, Poon B, Jowett JB, Xie Y, Chen IS. Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12039-43. doi: 10.1073/pnas.96.21.12039. PubMed PMID: 10518572; PubMed Central PMCID: PMC18408.
Stewart SA, Poon B, Song JY, Chen IS. Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation. J Virol. 2000 Apr;74(7):3105-11. doi: 10.1128/jvi.74.7.3105-3111.2000. PubMed PMID: 10708425; PubMed Central PMCID: PMC111809.
Stewart SA, Weinberg RA. Telomerase and human tumorigenesis. Semin Cancer Biol. 2000 Dec;10(6):399-406. doi: 10.1006/scbi.2000.0339. Review. PubMed PMID: 11170862.
Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L. The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase. EMBO J. 2001 Feb 15;20(4):905-13. doi: 10.1093/emboj/20.4.905. PubMed PMID: 11179234; PubMed Central PMCID: PMC145415.
Stewart SA, Weinberg RA. Senescence: does it all happen at the ends?. Oncogene. 2002 Jan 21;21(4):627-30. doi: 10.1038/sj.onc.1205062. Review. PubMed PMID: 11850788.
Stewart SA, Hahn WC. Prospects for anti-neoplastic therapies based on telomere biology. Curr Cancer Drug Targets. 2002 Mar;2(1):1-17. doi: 10.2174/1568009023334015. Review. PubMed PMID: 12188917.
Lundberg AS, Randell SH, Stewart SA, Elenbaas B, Hartwell KA, Brooks MW, Fleming MD, Olsen JC, Miller SW, Weinberg RA, Hahn WC. Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene. 2002 Jul 4;21(29):4577-86. doi: 10.1038/sj.onc.1205550. PubMed PMID: 12085236.
Stewart SA, Hahn WC, O'Connor BF, Banner EN, Lundberg AS, Modha P, Mizuno H, Brooks MW, Fleming M, Zimonjic DB, Popescu NC, Weinberg RA. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12606-11. doi: 10.1073/pnas.182407599. Epub 2002 Aug 22. PubMed PMID: 12193655; PubMed Central PMCID: PMC130507.
Stewart SA. Multiple levels of telomerase regulation. Mol Interv. 2002 Dec;2(8):481-3. doi: 10.1124/mi.2.8.481. PubMed PMID: 14993399.
Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA. 2003 Apr;9(4):493-501. doi: 10.1261/rna.2192803. PubMed PMID: 12649500; PubMed Central PMCID: PMC1370415.
Stewart SA, Ben-Porath I, Carey VJ, O'Connor BF, Hahn WC, Weinberg RA. Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet. 2003 Apr;33(4):492-6. doi: 10.1038/ng1127. Epub 2003 Mar 24. PubMed PMID: 12652299.
Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC. Telomerase maintains telomere structure in normal human cells. Cell. 2003 Jul 25;114(2):241-53. doi: 10.1016/s0092-8674(03)00550-6. PubMed PMID: 12887925.
Stewart SA. Telomere maintenance and tumorigenesis: an "ALT"ernative road. Curr Mol Med. 2005 Mar;5(2):253-7. doi: 10.2174/1566524053586653. Review. PubMed PMID: 15974880.
Stewart SA, Weinberg RA. Telomeres: cancer to human aging. Annu Rev Cell Dev Biol. 2006;22:531-57. doi: 10.1146/annurev.cellbio.22.010305.104518. Review. PubMed PMID: 16824017.
Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 2006 Mar 24;124(6):1283-98. doi: 10.1016/j.cell.2006.01.040. PubMed PMID: 16564017.
Nittis T, Guittat L, Stewart SA. Alternative lengthening of telomeres (ALT) and chromatin: is there a connection?. Biochimie. 2008 Jan;90(1):5-12. doi: 10.1016/j.biochi.2007.08.009. Epub 2007 Sep 2. Review. PubMed PMID: 17935854.
Pazolli E, Stewart SA. Senescence: the good the bad and the dysfunctional. Curr Opin Genet Dev. 2008 Feb;18(1):42-7. doi: 10.1016/j.gde.2007.12.002. Epub 2008 Feb 8. Review. PubMed PMID: 18262406.
Saharia A, Guittat L, Crocker S, Lim A, Steffen M, Kulkarni S, Stewart SA. Flap endonuclease 1 contributes to telomere stability. Curr Biol. 2008 Apr 8;18(7):496-500. doi: 10.1016/j.cub.2008.02.071. PubMed PMID: 18394896; PubMed Central PMCID: PMC2367431.
Nyström AM, Xu Z, Xu J, Taylor S, Nittis T, Stewart SA, Leonard J, Wooley KL. SCKs as nanoparticle carriers of doxorubicin: investigation of core composition on the loading, release and cytotoxicity profiles. Chem Commun (Camb). 2008 Aug 14;(30):3579-81. doi: 10.1039/b805428b. Epub 2008 Jun 10. PubMed PMID: 18654719; PubMed Central PMCID: PMC2828943.
Pazolli E, Luo X, Brehm S, Carbery K, Chung JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res. 2009 Feb 1;69(3):1230-9. doi: 10.1158/0008-5472.CAN-08-2970. Epub 2009 Jan 20. PubMed PMID: 19155301; PubMed Central PMCID: PMC2633422.
Saharia A, Stewart SA. FEN1 contributes to telomere stability in ALT-positive tumor cells. Oncogene. 2009 Feb 26;28(8):1162-7. doi: 10.1038/onc.2008.458. Epub 2009 Jan 12. PubMed PMID: 19137021.
Duxin JP, Dao B, Martinsson P, Rajala N, Guittat L, Campbell JL, Spelbrink JN, Stewart SA. Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Mol Cell Biol. 2009 Aug;29(15):4274-82. doi: 10.1128/MCB.01834-08. Epub 2009 Jun 1. PubMed PMID: 19487465; PubMed Central PMCID: PMC2715806.
Nittis T, Guittat L, LeDuc RD, Dao B, Duxin JP, Rohrs H, Townsend RR, Stewart SA. Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MS. Mol Cell Proteomics. 2010 Jun;9(6):1144-56. doi: 10.1074/mcp.M900490-MCP200. Epub 2010 Jan 22. PubMed PMID: 20097687; PubMed Central PMCID: PMC2877976.
Saharia A, Teasley DC, Duxin JP, Dao B, Chiappinelli KB, Stewart SA. FEN1 ensures telomere stability by facilitating replication fork re-initiation. J Biol Chem. 2010 Aug 27;285(35):27057-27066. doi: 10.1074/jbc.M110.112276. Epub 2010 Jun 15. PubMed PMID: 20551483; PubMed Central PMCID: PMC2930705.
Stewart SA, Bertuch AA. The role of telomeres and telomerase in cancer research. Cancer Res. 2010 Oct 1;70(19):7365-71. doi: 10.1158/0008-5472.CAN-10-1373. Epub 2010 Sep 14. PubMed PMID: 20841475; PubMed Central PMCID: PMC2948573.
Luo X, Ruhland MK, Pazolli E, Lind AC, Stewart SA. Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway. Mol Cancer Res. 2011 Aug;9(8):1018-29. doi: 10.1158/1541-7786.MCR-10-0472. Epub 2011 Jun 14. PubMed PMID: 21673011; PubMed Central PMCID: PMC3685505.
Pazolli E, Alspach E, Milczarek A, Prior J, Piwnica-Worms D, Stewart SA. Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res. 2012 May 1;72(9):2251-61. doi: 10.1158/0008-5472.CAN-11-3386. Epub 2012 Mar 15. PubMed PMID: 22422937; PubMed Central PMCID: PMC3605047.
Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ Jr, Stewart SA. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem. 2012 Jun 22;287(26):21980-91. doi: 10.1074/jbc.M112.359018. Epub 2012 May 7. PubMed PMID: 22570476; PubMed Central PMCID: PMC3381158.
Lee S, Stewart S, Nagtegaal I, Luo J, Wu Y, Colditz G, Medina D, Allred DC. Differentially expressed genes regulating the progression of ductal carcinoma in situ to invasive breast cancer. Cancer Res. 2012 Sep 1;72(17):4574-86. doi: 10.1158/0008-5472.CAN-12-0636. Epub 2012 Jul 2. PubMed PMID: 22751464; PubMed Central PMCID: PMC3899801.
Karanja KK, Cox SW, Duxin JP, Stewart SA, Campbell JL. DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network. Cell Cycle. 2012 Nov 1;11(21):3983-96. doi: 10.4161/cc.22215. Epub 2012 Sep 17. PubMed PMID: 22987153; PubMed Central PMCID: PMC3507494.
Alspach E, Fu Y, Stewart SA. Senescence and the pro-tumorigenic stroma. Crit Rev Oncog. 2013;18(6):549-58. doi: 10.1615/critrevoncog.2014010630. Review. PubMed PMID: 24579734; PubMed Central PMCID: PMC3951899.
Saheb-Al-Zamani M, Yan Y, Farber SJ, Hunter DA, Newton P, Wood MD, Stewart SA, Johnson PJ, Mackinnon SE. Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence. Exp Neurol. 2013 Sep;247:165-77. doi: 10.1016/j.expneurol.2013.04.011. Epub 2013 May 3. PubMed PMID: 23644284; PubMed Central PMCID: PMC3863361.
Alspach E, Flanagan KC, Luo X, Ruhland MK, Huang H, Pazolli E, Donlin MJ, Marsh T, Piwnica-Worms D, Monahan J, Novack DV, McAllister SS, Stewart SA. p38MAPK plays a crucial role in stromal-mediated tumorigenesis. Cancer Discov. 2014 Jun;4(6):716-29. doi: 10.1158/2159-8290.CD-13-0743. Epub 2014 Mar 26. PubMed PMID: 24670723; PubMed Central PMCID: PMC4049323.
Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A. DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol. 2015 Mar 2;208(5):545-62. doi: 10.1083/jcb.201406100. PubMed PMID: 25733713; PubMed Central PMCID: PMC4347643.
Alspach E, Stewart SA. RNA-binding Protein Immunoprecipitation (RIP) to Examine AUF1 Binding to Senescence-Associated Secretory Phenotype (SASP) Factor mRNA. Bio Protoc. 2015 May 20;5(10). doi: 10.21769/bioprotoc.1481. PubMed PMID: 27453911; PubMed Central PMCID: PMC4957555.
Teasley DC, Parajuli S, Nguyen M, Moore HR, Alspach E, Lock YJ, Honaker Y, Saharia A, Piwnica-Worms H, Stewart SA. Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem. 2015 Jun 12;290(24):15133-45. doi: 10.1074/jbc.M115.647388. Epub 2015 Apr 28. PubMed PMID: 25922071; PubMed Central PMCID: PMC4463456.
Ruhland MK, Coussens LM, Stewart SA. Senescence and cancer: An evolving inflammatory paradox. Biochim Biophys Acta. 2016 Jan;1865(1):14-22. doi: 10.1016/j.bbcan.2015.10.001. Epub 2015 Oct 8. Review. PubMed PMID: 26453912; PubMed Central PMCID: PMC4733607.
Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA. Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development. Cell Rep. 2016 Jan 5;14(1):82-92. doi: 10.1016/j.celrep.2015.12.016. Epub 2015 Dec 24. PubMed PMID: 26725121; PubMed Central PMCID: PMC4706805.
D'Amico L, Mahajan S, Capietto AH, Yang Z, Zamani A, Ricci B, Bumpass DB, Meyer M, Su X, Wang-Gillam A, Weilbaecher K, Stewart SA, DeNardo DG, Faccio R. Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer. J Exp Med. 2016 May 2;213(5):827-40. doi: 10.1084/jem.20150950. Epub 2016 Apr 4. PubMed PMID: 27045006; PubMed Central PMCID: PMC4854727.
Marsh T, Wong I, Sceneay J, Barakat A, Qin Y, Sjödin A, Alspach E, Nilsson B, Stewart SA, McAllister SS. Hematopoietic Age at Onset of Triple-Negative Breast Cancer Dictates Disease Aggressiveness and Progression. Cancer Res. 2016 May 15;76(10):2932-43. doi: 10.1158/0008-5472.CAN-15-3332. Epub 2016 Apr 7. PubMed PMID: 27197230; PubMed Central PMCID: PMC8504438.
Ruhland MK, Loza AJ, Capietto AH, Luo X, Knolhoff BL, Flanagan KC, Belt BA, Alspach E, Leahy K, Luo J, Schaffer A, Edwards JR, Longmore G, Faccio R, DeNardo DG, Stewart SA. Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nat Commun. 2016 Jun 8;7:11762. doi: 10.1038/ncomms11762. PubMed PMID: 27272654; PubMed Central PMCID: PMC4899869.
Poppler LH, Ee X, Schellhardt L, Hoben GM, Pan D, Hunter DA, Yan Y, Moore AM, Snyder-Warwick AK, Stewart SA, Mackinnon SE, Wood MD. Axonal Growth Arrests After an Increased Accumulation of Schwann Cells Expressing Senescence Markers and Stromal Cells in Acellular Nerve Allografts. Tissue Eng Part A. 2016 Jul;22(13-14):949-61. doi: 10.1089/ten.TEA.2016.0003. Epub 2016 Jul 7. PubMed PMID: 27297909; PubMed Central PMCID: PMC4948214.
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