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  1. Bai L, Li H. Cryo-EM is uncovering the mechanism of eukaryotic protein N-glycosylation. FEBS J. 2019 May;286(9):1638-1644. doi: 10.1111/febs.14705. Epub 2018 Dec 3. Review. PubMed PMID: 30450807; PubMed Central PMCID: PMC6504584.
  2. Li H, O'Donnell ME. Mathematical description of eukaryotic chromosome replication. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4776-4778. doi: 10.1073/pnas.1900968116. Epub 2019 Feb 19. PubMed PMID: 30782813; PubMed Central PMCID: PMC6421408.
  3. Merriman C, Li H, Li H, Fu D. Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8. J Biol Chem. 2018 Oct 19;293(42):16206-16216. doi: 10.1074/jbc.RA118.005136. Epub 2018 Sep 4. PubMed PMID: 30181214; PubMed Central PMCID: PMC6200924.
  4. Yu H, Lupoli TJ, Kovach A, Meng X, Zhao G, Nathan CF, Li H. ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9560-E9569. doi: 10.1073/pnas.1810648115. Epub 2018 Sep 26. PubMed PMID: 30257943; PubMed Central PMCID: PMC6187150.
  5. Du M, Yuan Z, Yu H, Henderson N, Sarowar S, Zhao G, Werneburg GT, Thanassi DG, Li H. Handover mechanism of the growing pilus by the bacterial outer-membrane usher FimD. Nature. 2018 Oct;562(7727):444-447. doi: 10.1038/s41586-018-0587-z. Epub 2018 Oct 3. PubMed PMID: 30283140; PubMed Central PMCID: PMC6309448.
  6. Yan S, Elmes MW, Tong S, Hu K, Awwa M, Teng GYH, Jing Y, Freitag M, Gan Q, Clement T, Wei L, Sweeney JM, Joseph OM, Che J, Carbonetti GS, Wang L, Bogdan DM, Falcone J, Smietalo N, Zhou Y, Ralph B, Hsu HC, Li H, Rizzo RC, Deutsch DG, Kaczocha M, Ojima I. SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins. Eur J Med Chem. 2018 Jun 25;154:233-252. doi: 10.1016/j.ejmech.2018.04.050. Epub 2018 May 26. PubMed PMID: 29803996; PubMed Central PMCID: PMC5999033.
  7. Samanovic MI, Hsu HC, Jones MB, Jones V, McNeil MR, Becker SH, Jordan AT, Strnad M, Xu C, Jackson M, Li H, Darwin KH. Cytokinin Signaling in Mycobacterium tuberculosis. MBio. 2018 Jun 19;9(3). doi: 10.1128/mBio.00989-18. PubMed PMID: 29921668; PubMed Central PMCID: PMC6016246.
  8. Yu H, Wu CH, Schut GJ, Haja DK, Zhao G, Peters JW, Adams MWW, Li H. Structure of an Ancient Respiratory System. Cell. 2018 Jun 14;173(7):1636-1649.e16. doi: 10.1016/j.cell.2018.03.071. Epub 2018 May 10. PubMed PMID: 29754813; PubMed Central PMCID: PMC6003862.
  9. Hu K, Jastrab JB, Zhang S, Kovach A, Zhao G, Darwin KH, Li H. Proteasome substrate capture and gate opening by the accessory factor PafE from Mycobacterium tuberculosis. J Biol Chem. 2018 Mar 30;293(13):4713-4723. doi: 10.1074/jbc.RA117.001471. Epub 2018 Feb 5. PubMed PMID: 29414791; PubMed Central PMCID: PMC5880150.
  10. Bai L, Wang T, Zhao G, Kovach A, Li H. The atomic structure of a eukaryotic oligosaccharyltransferase complex. Nature. 2018 Mar 15;555(7696):328-333. doi: 10.1038/nature25755. Epub 2018 Jan 22. PubMed PMID: 29466327; PubMed Central PMCID: PMC6112861.
  11. Li H, O'Donnell ME. The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism. Bioessays. 2018 Mar;40(3). doi: 10.1002/bies.201700208. Epub 2018 Feb 6. Review. PubMed PMID: 29405332; PubMed Central PMCID: PMC5873959.
  12. O'Donnell ME, Li H. The ring-shaped hexameric helicases that function at DNA replication forks. Nat Struct Mol Biol. 2018 Feb;25(2):122-130. doi: 10.1038/s41594-018-0024-x. Epub 2018 Jan 29. Review. PubMed PMID: 29379175; PubMed Central PMCID: PMC5876725.
  13. Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G. Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nat Commun. 2017 Nov 22;8(1):1692. doi: 10.1038/s41467-017-01760-5. PubMed PMID: 29167449; PubMed Central PMCID: PMC5700161.
  14. Noguchi Y, Yuan Z, Bai L, Schneider S, Zhao G, Stillman B, Speck C, Li H. Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9529-E9538. doi: 10.1073/pnas.1712537114. Epub 2017 Oct 25. PubMed PMID: 29078375; PubMed Central PMCID: PMC5692578.
  15. Burgie ES, Bussell AN, Lye SH, Wang T, Hu W, McLoughlin KE, Weber EL, Li H, Vierstra RD. Photosensing and Thermosensing by Phytochrome B Require Both Proximal and Distal Allosteric Features within the Dimeric Photoreceptor. Sci Rep. 2017 Oct 20;7(1):13648. doi: 10.1038/s41598-017-14037-0. PubMed PMID: 29057954; PubMed Central PMCID: PMC5651913.
  16. Takeuchi H, Yu H, Hao H, Takeuchi M, Ito A, Li H, Haltiwanger RS. O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking. J Biol Chem. 2017 Sep 22;292(38):15964-15973. doi: 10.1074/jbc.M117.800102. Epub 2017 Jul 20. PubMed PMID: 28729422; PubMed Central PMCID: PMC5612125.
  17. Elkayam E, Faehnle CR, Morales M, Sun J, Li H, Joshua-Tor L. Multivalent Recruitment of Human Argonaute by GW182. Mol Cell. 2017 Aug 17;67(4):646-658.e3. doi: 10.1016/j.molcel.2017.07.007. Epub 2017 Aug 3. PubMed PMID: 28781232; PubMed Central PMCID: PMC5915679.
  18. Vaccaro BJ, Clarkson SM, Holden JF, Lee DW, Wu CH, Poole Ii FL, Cotelesage JJH, Hackett MJ, Mohebbi S, Sun J, Li H, Johnson MK, George GN, Adams MWW. Biological iron-sulfur storage in a thioferrate-protein nanoparticle. Nat Commun. 2017 Jul 20;8:16110. doi: 10.1038/ncomms16110. PubMed PMID: 28726794; PubMed Central PMCID: PMC5524996.
  19. Hsu HC, Tong S, Zhou Y, Elmes MW, Yan S, Kaczocha M, Deutsch DG, Rizzo RC, Ojima I, Li H. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites. Biochemistry. 2017 Jul 11;56(27):3454-3462. doi: 10.1021/acs.biochem.7b00194. Epub 2017 Jun 28. PubMed PMID: 28632393; PubMed Central PMCID: PMC5884075.
  20. Wu Y, Hu K, Li D, Bai L, Yang S, Jastrab JB, Xiao S, Hu Y, Zhang S, Darwin KH, Wang T, Li H. Mycobacterium tuberculosis proteasomal ATPase Mpa has a ╬▓-grasp domain that hinders docking with the proteasome core protease. Mol Microbiol. 2017 Jul;105(2):227-241. doi: 10.1111/mmi.13695. Epub 2017 May 3. PubMed PMID: 28419599; PubMed Central PMCID: PMC5575984.
  21. Bai L, Jastrab JB, Isasa M, Hu K, Yu H, Gygi SP, Darwin KH, Li H. Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2). J Bacteriol. 2017 May 1;199(9). doi: 10.1128/JB.00846-16. Print 2017 May 1. PubMed PMID: 28193903; PubMed Central PMCID: PMC5388811.
  22. Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H. Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nat Struct Mol Biol. 2017 Mar;24(3):316-324. doi: 10.1038/nsmb.3372. Epub 2017 Feb 13. PubMed PMID: 28191893; PubMed Central PMCID: PMC5503505.
  23. Zhang S, Burns-Huang KE, Janssen GV, Li H, Ovaa H, Hedstrom L, Darwin KH. Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates. MBio. 2017 Feb 21;8(1). doi: 10.1128/mBio.00122-17. PubMed PMID: 28223451; PubMed Central PMCID: PMC5358908.
  24. Georgescu R, Yuan Z, Bai L, de Luna Almeida Santos R, Sun J, Zhang D, Yurieva O, Li H, O'Donnell ME. Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E697-E706. doi: 10.1073/pnas.1620500114. Epub 2017 Jan 17. PubMed PMID: 28096349; PubMed Central PMCID: PMC5293012.
  25. Tocilj A, On KF, Yuan Z, Sun J, Elkayam E, Li H, Stillman B, Joshua-Tor L. Structure of the active form of human origin recognition complex and its ATPase motor module. Elife. 2017 Jan 23;6. doi: 10.7554/eLife.20818. PubMed PMID: 28112645; PubMed Central PMCID: PMC5291709.
  26. Hsu HC, Singh PK, Fan H, Wang R, Sukenick G, Nathan C, Lin G, Li H. Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry. 2017 Jan 10;56(1):324-333. doi: 10.1021/acs.biochem.6b01107. Epub 2016 Dec 27. PubMed PMID: 27976853; PubMed Central PMCID: PMC5745808.
  27. Peng X, Studholme K, Kanjiya MP, Luk J, Bogdan D, Elmes MW, Carbonetti G, Tong S, Gary Teng YH, Rizzo RC, Li H, Deutsch DG, Ojima I, Rebecchi MJ, Puopolo M, Kaczocha M. Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Mol Pain. 2017 Jan;13:1744806917697007. doi: 10.1177/1744806917697007. PubMed PMID: 28326944; PubMed Central PMCID: PMC5407663.
  28. Sun J, Yuan Z, Bai L, Li H. Cryo-EM of dynamic protein complexes in eukaryotic DNA replication. Protein Sci. 2017 Jan;26(1):40-51. doi: 10.1002/pro.3033. Epub 2016 Sep 14. Review. PubMed PMID: 27589669; PubMed Central PMCID: PMC5192969.
  29. Bai L, Yuan Z, Sun J, Georgescu R, O'Donnell ME, Li H. Architecture of the Saccharomyces cerevisiae Replisome. Adv Exp Med Biol. 2017;1042:207-228. doi: 10.1007/978-981-10-6955-0_10. Review. PubMed PMID: 29357060; PubMed Central PMCID: PMC5800748.
  30. Sarowar S, Hu OJ, Werneburg GT, Thanassi DG, Li H. The Escherichia coli P and Type 1 Pilus Assembly Chaperones PapD and FimC Are Monomeric in Solution. J Bacteriol. 2016 Sep 1;198(17):2360-9. doi: 10.1128/JB.00366-16. Print 2016 Sep 1. PubMed PMID: 27353649; PubMed Central PMCID: PMC4984555.
  31. Yu H, Takeuchi H, Takeuchi M, Liu Q, Kantharia J, Haltiwanger RS, Li H. Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat Chem Biol. 2016 Sep;12(9):735-40. doi: 10.1038/nchembio.2135. Epub 2016 Jul 18. PubMed PMID: 27428513; PubMed Central PMCID: PMC4990500.
  32. Tian Y, Zhang Y, Wang T, Xin HL, Li H, Gang O. Lattice engineering through nanoparticle-DNA frameworks. Nat Mater. 2016 Jun;15(6):654-61. doi: 10.1038/nmat4571. Epub 2016 Feb 22. PubMed PMID: 26901516; PubMed Central PMCID: PMC5282967.
  33. Sun J, Yuan Z, Georgescu R, Li H, O'Donnell M. The eukaryotic CMG helicase pumpjack and integration into the replisome. Nucleus. 2016 Apr 25;7(2):146-54. doi: 10.1080/19491034.2016.1174800. Review. PubMed PMID: 27310307; PubMed Central PMCID: PMC4916876.
  34. Bai L, Hu K, Wang T, Jastrab JB, Darwin KH, Li H. Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E1983-92. doi: 10.1073/pnas.1512094113. Epub 2016 Mar 21. PubMed PMID: 27001842; PubMed Central PMCID: PMC4833279.
  35. O'Donnell M, Li H. The Eukaryotic Replisome Goes Under the Microscope. Curr Biol. 2016 Mar 21;26(6):R247-56. doi: 10.1016/j.cub.2016.02.034. Review. PubMed PMID: 27003891; PubMed Central PMCID: PMC4859309.
  36. Yuan Z, Bai L, Sun J, Georgescu R, Liu J, O'Donnell ME, Li H. Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nat Struct Mol Biol. 2016 Mar;23(3):217-24. doi: 10.1038/nsmb.3170. Epub 2016 Feb 8. PubMed PMID: 26854665; PubMed Central PMCID: PMC4812828.
  37. Liu W, Tagawa M, Xin HL, Wang T, Emamy H, Li H, Yager KG, Starr FW, Tkachenko AV, Gang O. Diamond family of nanoparticle superlattices. Science. 2016 Feb 5;351(6273):582-6. doi: 10.1126/science.aad2080. PubMed PMID: 26912698; PubMed Central PMCID: PMC5275765.
  38. Eswaramoorthy S, Sun J, Li H, Singh BR, Swaminathan S. Molecular Assembly of Clostridium botulinum progenitor M complex of type E. Sci Rep. 2015 Dec 7;5:17795. doi: 10.1038/srep17795. PubMed PMID: 26639353; PubMed Central PMCID: PMC4671068.
  39. Sun J, Shi Y, Georgescu RE, Yuan Z, Chait BT, Li H, O'Donnell ME. The architecture of a eukaryotic replisome. Nat Struct Mol Biol. 2015 Dec;22(12):976-82. doi: 10.1038/nsmb.3113. Epub 2015 Nov 2. PubMed PMID: 26524492; PubMed Central PMCID: PMC4849863.
  40. Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H. Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nat Chem Biol. 2015 Nov;11(11):847-54. doi: 10.1038/nchembio.1927. Epub 2015 Sep 28. PubMed PMID: 26414444; PubMed Central PMCID: PMC4618232.
  41. Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, Weinreich M. Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication. Elife. 2015 Aug 25;4. doi: 10.7554/eLife.05795. PubMed PMID: 26305410; PubMed Central PMCID: PMC4547096.
  42. Werneburg GT, Henderson NS, Portnoy EB, Sarowar S, Hultgren SJ, Li H, Thanassi DG. The pilus usher controls protein interactions via domain masking and is functional as an oligomer. Nat Struct Mol Biol. 2015 Jul;22(7):540-6. doi: 10.1038/nsmb.3044. Epub 2015 Jun 8. PubMed PMID: 26052892; PubMed Central PMCID: PMC4496297.
  43. Tian Y, Wang T, Liu W, Xin HL, Li H, Ke Y, Shih WM, Gang O. Prescribed nanoparticle cluster architectures and low-dimensional arrays built using octahedral DNA origami frames. Nat Nanotechnol. 2015 Jul;10(7):637-44. doi: 10.1038/nnano.2015.105. Epub 2015 May 25. PubMed PMID: 26005999; PubMed Central PMCID: PMC5282466.
  44. Lin Q, Wang T, Li H, London E. Decreasing Transmembrane Segment Length Greatly Decreases Perfringolysin O Pore Size. J Membr Biol. 2015 Jun;248(3):517-27. doi: 10.1007/s00232-015-9798-5. Epub 2015 Apr 8. PubMed PMID: 25850715.
  45. Jastrab JB, Wang T, Murphy JP, Bai L, Hu K, Merkx R, Huang J, Chatterjee C, Ovaa H, Gygi SP, Li H, Darwin KH. An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1763-72. doi: 10.1073/pnas.1423319112. Epub 2015 Mar 23. PubMed PMID: 25831519; PubMed Central PMCID: PMC4394314.
  46. Sun J, Fernandez-Cid A, Riera A, Tognetti S, Yuan Z, Stillman B, Speck C, Li H. Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function. Genes Dev. 2014 Oct 15;28(20):2291-303. doi: 10.1101/gad.242313.114. PubMed PMID: 25319829; PubMed Central PMCID: PMC4201289.
  47. Burgie ES, Wang T, Bussell AN, Walker JM, Li H, Vierstra RD. Crystallographic and electron microscopic analyses of a bacterial phytochrome reveal local and global rearrangements during photoconversion. J Biol Chem. 2014 Aug 29;289(35):24573-87. doi: 10.1074/jbc.M114.571661. Epub 2014 Jul 8. PubMed PMID: 25006244; PubMed Central PMCID: PMC4148881.
  48. Samel SA, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C. A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA. Genes Dev. 2014 Aug 1;28(15):1653-66. doi: 10.1101/gad.242404.114. PubMed PMID: 25085418; PubMed Central PMCID: PMC4117941.
  49. Sanson B, Wang T, Sun J, Wang L, Kaczocha M, Ojima I, Deutsch D, Li H. Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):290-8. doi: 10.1107/S1399004713026795. Epub 2014 Jan 29. PubMed PMID: 24531463; PubMed Central PMCID: PMC3940194.
  50. Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF. Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4790-7. doi: 10.1073/pnas.1320118110. Epub 2013 Nov 18. PubMed PMID: 24248369; PubMed Central PMCID: PMC3856836.