My Bibliography

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Pahan K, Khan M, Smith BT, Singh I. Ketoconazole and other imidazole derivatives are potent inhibitors of peroxisomal phytanic acid alpha-oxidation. FEBS Lett. 1995 Dec 18;377(2):213-6. doi: 10.1016/0014-5793(95)01341-5. PubMed PMID: 8543053.

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Pahan K, Khan M, Singh I. Phytanic acid oxidation: normal activation and transport yet defective alpha-hydroxylation of phytanic acid in peroxisomes from Refsum disease and rhizomelic chondrodysplasia punctata. J Lipid Res. 1996 May;37(5):1137-43. PubMed PMID: 8725164.

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Pahan K, Sheikh FG, Khan M, Namboodiri AM, Singh I. Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem. 1998 Jan 30;273(5):2591-600. doi: 10.1074/jbc.273.5.2591. PubMed PMID: 9446561.

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Sheikh FG, Pahan K, Khan M, Barbosa E, Singh I. Abnormality in catalase import into peroxisomes leads to severe neurological disorder. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2961-6. doi: 10.1073/pnas.95.6.2961. PubMed PMID: 9501198; PubMed Central PMCID: PMC19677.

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Singh I, Pahan K, Khan M. Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy. FEBS Lett. 1998 Apr 24;426(3):342-6. doi: 10.1016/s0014-5793(98)00370-6. PubMed PMID: 9600263.

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Pahan K, Khan M, Singh I. Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP. J Lipid Res. 1998 May;39(5):1091-100. PubMed PMID: 9610777.

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Chahal A, Khan M, Pai SG, Barbosa E, Singh I. Restoration of phytanic acid oxidation in Refsum disease fibroblasts from patients with mutations in the phytanoyl-CoA hydroxylase gene. FEBS Lett. 1998 Jun 5;429(1):119-22. doi: 10.1016/s0014-5793(98)00575-4. PubMed PMID: 9657395.

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Khan M, Pahan K, Singh AK, Singh I. Cytokine-induced accumulation of very long-chain fatty acids in rat C6 glial cells: implication for X-adrenoleukodystrophy. J Neurochem. 1998 Jul;71(1):78-87. doi: 10.1046/j.1471-4159.1998.71010078.x. PubMed PMID: 9648853.

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Singh I, Pahan K, Khan M, Singh AK. Cytokine-mediated induction of ceramide production is redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases. J Biol Chem. 1998 Aug 7;273(32):20354-62. doi: 10.1074/jbc.273.32.20354. PubMed PMID: 9685387.

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Singh I, Khan M, Key L, Pai S. Lovastatin for X-linked adrenoleukodystrophy. N Engl J Med. 1998 Sep 3;339(10):702-3. doi: 10.1056/NEJM199809033391012. PubMed PMID: 9729143.

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Sandhir R, Khan M, Chahal A, Singh I. Localization of nervonic acid beta-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy. J Lipid Res. 1998 Nov;39(11):2161-71. PubMed PMID: 9799802.

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Contreras MA, Khan M, Smith BT, Cimini AM, Gilg AG, Orak J, Singh I, Singh AK. Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators. Hepatology. 2000 Feb;31(2):446-55. doi: 10.1002/hep.510310226. PubMed PMID: 10655269.

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Pai GS, Khan M, Barbosa E, Key LL, Craver JR, Curé JK, Betros R, Singh I. Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. Mol Genet Metab. 2000 Apr;69(4):312-22. doi: 10.1006/mgme.2000.2977. PubMed PMID: 10870849.

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Pahan K, Khan M, Singh I. Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase. J Neurochem. 2000 Aug;75(2):576-82. doi: 10.1046/j.1471-4159.2000.0750576.x. PubMed PMID: 10899932.

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Sandhir R, Khan M, Singh I. Identification of the pathway of alpha-oxidation of cerebronic acid in peroxisomes. Lipids. 2000 Oct;35(10):1127-33. doi: 10.1007/s11745-000-0628-5. PubMed PMID: 11104019.

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Khan M, Contreras M, Singh I. Endotoxin-induced alterations of lipid and fatty acid compositions in rat liver peroxisomes. J Endotoxin Res. 2000;6(1):41-50. doi: 10.1177/09680519000060010601. PubMed PMID: 11061031.

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Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK. N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res. 2003 May 2;971(1):1-8. doi: 10.1016/s0006-8993(03)02244-3. PubMed PMID: 12691831.

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Paintlia AS, Gilg AG, Khan M, Singh AK, Barbosa E, Singh I. Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: implications for potential therapies. Neurobiol Dis. 2003 Dec;14(3):425-39. doi: 10.1016/j.nbd.2003.08.013. PubMed PMID: 14678759.

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Won JS, Im YB, Khan M, Singh AK, Singh I. The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase. J Neurochem. 2004 Feb;88(3):583-93. doi: 10.1046/j.1471-4159.2003.02165.x. PubMed PMID: 14720208.

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Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK. Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res. 2004 May 15;76(4):519-27. doi: 10.1002/jnr.20087. PubMed PMID: 15114624.

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Pannu R, Won JS, Khan M, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases. J Neurosci. 2004 Jun 30;24(26):5942-54. doi: 10.1523/JNEUROSCI.1271-04.2004. PubMed PMID: 15229242; PubMed Central PMCID: PMC6729229.

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Ayasolla K, Khan M, Singh AK, Singh I. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med. 2004 Aug 1;37(3):325-38. doi: 10.1016/j.freeradbiomed.2004.04.007. PubMed PMID: 15223066.

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Singh I, Paintlia AS, Khan M, Stanislaus R, Paintlia MK, Haq E, Singh AK, Contreras MA. Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment. Brain Res. 2004 Oct 1;1022(1-2):1-11. doi: 10.1016/j.brainres.2004.06.059. PubMed PMID: 15353207.

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Kawada Y, Khan M, Sharma AK, Ratnayake DB, Dobashi K, Asayama K, Moser HW, Contreras MA, Singh I. Inhibition of peroxisomal functions due to oxidative imbalance induced by mistargeting of catalase to cytoplasm is restored by vitamin E treatment in skin fibroblasts from Zellweger syndrome-like patients. Mol Genet Metab. 2004 Dec;83(4):297-305. doi: 10.1016/j.ymgme.2004.07.012. PubMed PMID: 15589116.

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Khan M, Sekhon B, Giri S, Jatana M, Gilg AG, Ayasolla K, Elango C, Singh AK, Singh I. S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke. J Cereb Blood Flow Metab. 2005 Feb;25(2):177-92. doi: 10.1038/sj.jcbfm.9600012. PubMed PMID: 15647746.

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Khan M, Haq E, Giri S, Singh I, Singh AK. Peroxisomal participation in psychosine-mediated toxicity: implications for Krabbe's disease. J Neurosci Res. 2005 Jun 15;80(6):845-54. doi: 10.1002/jnr.20529. PubMed PMID: 15898099.

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Won JS, Im YB, Khan M, Singh AK, Singh I. Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells. Glia. 2005 Jul;51(1):13-21. doi: 10.1002/glia.20178. PubMed PMID: 15779087.

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Paintlia AS, Paintlia MK, Khan M, Vollmer T, Singh AK, Singh I. HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis. FASEB J. 2005 Sep;19(11):1407-21. doi: 10.1096/fj.05-3861com. PubMed PMID: 16126908.

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Khan M, Jatana M, Elango C, Paintlia AS, Singh AK, Singh I. Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke. Nitric Oxide. 2006 Sep;15(2):114-24. doi: 10.1016/j.niox.2006.01.008. Epub 2006 Mar 9. PubMed PMID: 16524750.

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Giri S, Khan M, Rattan R, Singh I, Singh AK. Krabbe disease: psychosine-mediated activation of phospholipase A2 in oligodendrocyte cell death. J Lipid Res. 2006 Jul;47(7):1478-92. doi: 10.1194/jlr.M600084-JLR200. Epub 2006 Apr 27. PubMed PMID: 16645197.

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Jatana M, Giri S, Ansari MA, Elango C, Singh AK, Singh I, Khan M. Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. J Neuroinflammation. 2006 May 11;3:12. doi: 10.1186/1742-2094-3-12. PubMed PMID: 16689995; PubMed Central PMCID: PMC1526713.

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Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, Key L, Singh AK, Singh I. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab (Lond). 2006 Aug 10;3:31. doi: 10.1186/1743-7075-3-31. PubMed PMID: 16901342; PubMed Central PMCID: PMC1564022.

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Khan M, Elango C, Ansari MA, Singh I, Singh AK. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem. 2007 Jul;102(2):365-77. doi: 10.1111/j.1471-4159.2007.04526.x. Epub 2007 Apr 16. PubMed PMID: 17437550.

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Paintlia MK, Paintlia AS, Khan M, Singh I, Singh AK. Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures. J Neurochem. 2008 May;105(3):956-70. doi: 10.1111/j.1471-4159.2007.05199.x. Epub 2008 Jan 12. PubMed PMID: 18205750; PubMed Central PMCID: PMC2659629.

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Giri S, Khan M, Nath N, Singh I, Singh AK. The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease. J Neurochem. 2008 Jun;105(5):1820-33. doi: 10.1111/j.1471-4159.2008.05279.x. Epub 2008 Feb 4. PubMed PMID: 18248608; PubMed Central PMCID: PMC2673995.

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Won JS, Im YB, Khan M, Contreras M, Singh AK, Singh I. Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts. J Neurochem. 2008 May;105(4):1536-49. doi: 10.1111/j.1471-4159.2008.05283.x. Epub 2008 Feb 5. PubMed PMID: 18266936; PubMed Central PMCID: PMC2707757.

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Khan M, Singh J, Singh I. Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin. J Neurochem. 2008 Aug;106(4):1766-79. doi: 10.1111/j.1471-4159.2008.05513.x. Epub 2008 Jun 7. PubMed PMID: 18540993; PubMed Central PMCID: PMC2575097.

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Singh J, Khan M, Singh I. Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy. J Lipid Res. 2009 Jan;50(1):135-47. doi: 10.1194/jlr.M800321-JLR200. Epub 2008 Aug 21. PubMed PMID: 18723473; PubMed Central PMCID: PMC2602866.

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Nath N, Khan M, Rattan R, Mangalam A, Makkar RS, de Meester C, Bertrand L, Singh I, Chen Y, Viollet B, Giri S. Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochem Biophys Res Commun. 2009 Aug 14;386(1):16-20. doi: 10.1016/j.bbrc.2009.05.106. Epub 2009 May 30. PubMed PMID: 19486896; PubMed Central PMCID: PMC2976596.

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Nath N, Khan M, Paintlia MK, Singh I, Hoda MN, Giri S. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J Immunol. 2009 Jun 15;182(12):8005-14. doi: 10.4049/jimmunol.0803563. PubMed PMID: 19494326; PubMed Central PMCID: PMC2965405.

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Hoda MN, Singh I, Singh AK, Khan M. Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat. J Neuroinflammation. 2009 Aug 13;6:21. doi: 10.1186/1742-2094-6-21. PubMed PMID: 19678934; PubMed Central PMCID: PMC2739168.

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Khan M, Im YB, Shunmugavel A, Gilg AG, Dhindsa RK, Singh AK, Singh I. Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. J Neuroinflammation. 2009 Nov 4;6:32. doi: 10.1186/1742-2094-6-32. PubMed PMID: 19889224; PubMed Central PMCID: PMC2777134.

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Khan M, Singh J, Gilg AG, Uto T, Singh I. Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy. J Lipid Res. 2010 Jul;51(7):1685-95. doi: 10.1194/jlr.M002329. Epub 2010 Feb 20. PubMed PMID: 20173212; PubMed Central PMCID: PMC2882744.

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Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, Khan M, Huang J, Guo D, Yu S, Sarkar J, Singh I, Rao MS, Wanders RJ, Reddy JK, Cherkaoui-Malki M. Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab Invest. 2010 May;90(5):696-708. doi: 10.1038/labinvest.2010.46. Epub 2010 Mar 1. PubMed PMID: 20195242; NIHMSID:NIHMS693271.

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Shunmugavel A, Khan M, Te Chou PC, Dhindsa RK, Martin MM, Copay AG, Subach BR, Schuler TC, Bilgen M, Orak JK, Singh I. Simvastatin protects bladder and renal functions following spinal cord injury in rats. J Inflamm (Lond). 2010 Apr 19;7:17. doi: 10.1186/1476-9255-7-17. PubMed PMID: 20403180; PubMed Central PMCID: PMC2873501.

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Chou PC, Shunmugavel A, El Sayed H, Desouki MM, Nguyen SA, Khan M, Singh I, Bilgen M. Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury. J Magn Reson Imaging. 2011 Jun;33(6):1301-11. doi: 10.1002/jmri.22574. PubMed PMID: 21590998.

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Huang J, Viswakarma N, Yu S, Jia Y, Bai L, Vluggens A, Cherkaoui-Malki M, Khan M, Singh I, Yang G, Rao MS, Borensztajn J, Reddy JK. Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol. 2011 Aug;179(2):703-13. doi: 10.1016/j.ajpath.2011.04.030. Epub 2011 Jun 12. PubMed PMID: 21801867; PubMed Central PMCID: PMC3157234.

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Khan M, Sakakima H, Dhammu TS, Shunmugavel A, Im YB, Gilg AG, Singh AK, Singh I. S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats. J Neuroinflammation. 2011 Jul 6;8:78. doi: 10.1186/1742-2094-8-78. PubMed PMID: 21733162; PubMed Central PMCID: PMC3158546.

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Singh J, Khan M, Singh I. HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes. J Lipid Res. 2011 Nov;52(11):2056-69. doi: 10.1194/jlr.M017491. Epub 2011 Sep 4. PubMed PMID: 21891797; PubMed Central PMCID: PMC3196237.

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Shunmugavel A, Khan M, Chou PC, Singh I. Spinal cord injury induced arrest in estrous cycle of rats is ameliorated by S-nitrosoglutathione: novel therapeutic agent to treat amenorrhea. J Sex Med. 2012 Jan;9(1):148-58. doi: 10.1111/j.1743-6109.2011.02526.x. Epub 2011 Oct 24. PubMed PMID: 22024253; PubMed Central PMCID: PMC3809072.