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Keiper T, Santoso S, Nawroth PP, Orlova V, Chavakis T. The role of junctional adhesion molecules in cell-cell interactions. Histol Histopathol. 2005 Jan;20(1):197-203. doi: 10.14670/HH-20.197. Review. PubMed PMID: 15578438.
Chavakis T, Athanasopoulos A, Rhee JS, Orlova V, Schmidt-Wöll T, Bierhaus A, May AE, Celik I, Nawroth PP, Preissner KT. Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment. Blood. 2005 Feb 1;105(3):1036-43. doi: 10.1182/blood-2004-01-0166. Epub 2004 Sep 21. PubMed PMID: 15383457.
Santoso S, Orlova VV, Song K, Sachs UJ, Andrei-Selmer CL, Chavakis T. The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions. J Biol Chem. 2005 Oct 28;280(43):36326-33. doi: 10.1074/jbc.M505059200. Epub 2005 Aug 23. PubMed PMID: 16118203.
Chavakis T, Orlova V. The role of junctional adhesion molecules in interactions between vascular cells. Methods Mol Biol. 2006;341:37-50. doi: 10.1385/1-59745-113-4:37. Review. PubMed PMID: 16799187.
Sotiriou SN, Orlova VV, Al-Fakhri N, Ihanus E, Economopoulou M, Isermann B, Bdeir K, Nawroth PP, Preissner KT, Gahmberg CG, Koschinsky ML, Chavakis T. Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin. FASEB J. 2006 Mar;20(3):559-61. doi: 10.1096/fj.05-4857fje. Epub 2006 Jan 10. PubMed PMID: 16403785.
Athanasopoulos AN, Economopoulou M, Orlova VV, Sobke A, Schneider D, Weber H, Augustin HG, Eming SA, Schubert U, Linn T, Nawroth PP, Hussain M, Hammes HP, Herrmann M, Preissner KT, Chavakis T. The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood. 2006 Apr 1;107(7):2720-7. doi: 10.1182/blood-2005-08-3140. Epub 2005 Nov 29. PubMed PMID: 16317095; PubMed Central PMCID: PMC1895382.
Orlova VV, Economopoulou M, Lupu F, Santoso S, Chavakis T. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. J Exp Med. 2006 Nov 27;203(12):2703-14. doi: 10.1084/jem.20051730. Epub 2006 Nov 20. PubMed PMID: 17116731; PubMed Central PMCID: PMC2118160.
Sobke AC, Selimovic D, Orlova V, Hassan M, Chavakis T, Athanasopoulos AN, Schubert U, Hussain M, Thiel G, Preissner KT, Herrmann M. The extracellular adherence protein from Staphylococcus aureus abrogates angiogenic responses of endothelial cells by blocking Ras activation. FASEB J. 2006 Dec;20(14):2621-3. doi: 10.1096/fj.06-5764fje. Epub 2006 Oct 31. PubMed PMID: 17077291.
Orlova VV, Choi EY, Xie C, Chavakis E, Bierhaus A, Ihanus E, Ballantyne CM, Gahmberg CG, Bianchi ME, Nawroth PP, Chavakis T. A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J. 2007 Feb 21;26(4):1129-39. doi: 10.1038/sj.emboj.7601552. Epub 2007 Feb 1. PubMed PMID: 17268551; PubMed Central PMCID: PMC1852832.
Orlova VV, Chavakis T. Regulation of vascular endothelial permeability by junctional adhesion molecules (JAM). Thromb Haemost. 2007 Aug;98(2):327-32. PubMed PMID: 17721614.
Sachs UJ, Andrei-Selmer CL, Maniar A, Weiss T, Paddock C, Orlova VV, Choi EY, Newman PJ, Preissner KT, Chavakis T, Santoso S. The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31). J Biol Chem. 2007 Aug 10;282(32):23603-12. doi: 10.1074/jbc.M701120200. Epub 2007 Jun 19. PubMed PMID: 17580308.
Choi EY, Orlova VV, Fagerholm SC, Nurmi SM, Zhang L, Ballantyne CM, Gahmberg CG, Chavakis T. Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins. Blood. 2008 Apr 1;111(7):3607-14. doi: 10.1182/blood-2007-07-103077. Epub 2008 Jan 31. PubMed PMID: 18239087; PubMed Central PMCID: PMC2275024.
Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T. Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med. 2009 May;15(5):553-8. doi: 10.1038/nm.1947. Epub 2009 Apr 19. PubMed PMID: 19377486; PubMed Central PMCID: PMC2713773.
Chavakis T, Orlova VV, Langer HF. A possible crosstalk between DNA repair pathways and angiogenesis. Cell Cycle. 2009 Nov 1;8(21):3438-9. doi: 10.4161/cc.8.21.9750. Epub 2009 Nov 7. PubMed PMID: 19838053; PubMed Central PMCID: PMC2783752.
Brocker C, Lassen N, Estey T, Pappa A, Cantore M, Orlova VV, Chavakis T, Kavanagh KL, Oppermann U, Vasiliou V. Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. J Biol Chem. 2010 Jun 11;285(24):18452-63. doi: 10.1074/jbc.M109.077925. Epub 2010 Mar 5. PubMed PMID: 20207735; PubMed Central PMCID: PMC2881771.
Langer HF, Chung KJ, Orlova VV, Choi EY, Kaul S, Kruhlak MJ, Alatsatianos M, DeAngelis RA, Roche PA, Magotti P, Li X, Economopoulou M, Rafail S, Lambris JD, Chavakis T. Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood. 2010 Nov 25;116(22):4395-403. doi: 10.1182/blood-2010-01-261503. Epub 2010 Jul 12. PubMed PMID: 20625009; PubMed Central PMCID: PMC2996109.
Pellegrini M, Claps G, Orlova VV, Barrios F, Dolci S, Geremia R, Rossi P, Rossi G, Arnold B, Chavakis T, Feigenbaum L, Sharan SK, Nussenzweig A. Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase. J Cell Sci. 2011 Jan 1;124(Pt 1):91-9. doi: 10.1242/jcs.072959. Epub 2010 Dec 8. PubMed PMID: 21147852; PubMed Central PMCID: PMC3001409.
Langer HF, Orlova VV, Xie C, Kaul S, Schneider D, Lonsdorf AS, Fahrleitner M, Choi EY, Dutoit V, Pellegrini M, Grossklaus S, Nawroth PP, Baretton G, Santoso S, Hwang ST, Arnold B, Chavakis T. A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis. Cancer Res. 2011 Jun 15;71(12):4096-105. doi: 10.1158/0008-5472.CAN-10-2794. Epub 2011 May 18. PubMed PMID: 21593193; PubMed Central PMCID: PMC3117056.
Orlova VV, Liu Z, Goumans MJ, ten Dijke P. Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways. Histol Histopathol. 2011 Sep;26(9):1219-30. doi: 10.14670/HH-26.1219. Review. PubMed PMID: 21751154.
van der Meer AD, Orlova VV, ten Dijke P, van den Berg A, Mummery CL. Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device. Lab Chip. 2013 Sep 21;13(18):3562-8. doi: 10.1039/c3lc50435b. PubMed PMID: 23702711.
Orlova VV, Drabsch Y, Freund C, Petrus-Reurer S, van den Hil FE, Muenthaisong S, Dijke PT, Mummery CL. Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts. Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):177-86. doi: 10.1161/ATVBAHA.113.302598. Epub 2013 Oct 24. PubMed PMID: 24158517.
Orlova VV, Drabsch Y, ten Dijke P, Mummery CL. Assessment of functional competence of endothelial cells from human pluripotent stem cells in zebrafish embryos. Methods Mol Biol. 2014;1213:107-19. doi: 10.1007/978-1-4939-1453-1_10. PubMed PMID: 25173378.
Orlova VV, van den Hil FE, Petrus-Reurer S, Drabsch Y, Ten Dijke P, Mummery CL. Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells. Nat Protoc. 2014;9(6):1514-31. doi: 10.1038/nprot.2014.102. Epub 2014 May 29. PubMed PMID: 24874816.
Orlova VV, Mummery CL. What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease. Cell Stem Cell. 2015 May 7;16(5):455-7. doi: 10.1016/j.stem.2015.04.006. PubMed PMID: 25957898.
Birket MJ, Ribeiro MC, Verkerk AO, Ward D, Leitoguinho AR, den Hartogh SC, Orlova VV, Devalla HD, Schwach V, Bellin M, Passier R, Mummery CL. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nat Biotechnol. 2015 Sep;33(9):970-9. doi: 10.1038/nbt.3271. Epub 2015 Jul 20. PubMed PMID: 26192318.
Economopoulou M, Avramovic N, Klotzsche-von Ameln A, Korovina I, Sprott D, Samus M, Gercken B, Troullinaki M, Grossklaus S, Funk RH, Li X, Imhof BA, Orlova VV, Chavakis T. Endothelial-specific deficiency of Junctional Adhesion Molecule-C promotes vessel normalisation in proliferative retinopathy. Thromb Haemost. 2015 Nov 25;114(6):1241-9. doi: 10.1160/TH15-01-0051. Epub 2015 Aug 27. PubMed PMID: 26311310.
Cai J, Orlova VV, Cai X, Eekhoff EMW, Zhang K, Pei D, Pan G, Mummery CL, Ten Dijke P. Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva. Stem Cell Reports. 2015 Dec 8;5(6):963-970. doi: 10.1016/j.stemcr.2015.10.020. Epub 2015 Nov 26. PubMed PMID: 26626181; PubMed Central PMCID: PMC4682290.
Sanchez-Duffhues G, Orlova V, Ten Dijke P. In Brief: Endothelial-to-mesenchymal transition. J Pathol. 2016 Feb;238(3):378-80. doi: 10.1002/path.4653. Epub 2016 Jan 4. PubMed PMID: 26446982.
Orlova VV, Chuva de Sousa Lopes S, Valdimarsdottir G. BMP-SMAD signaling: From pluripotent stem cells to cardiovascular commitment. Cytokine Growth Factor Rev. 2016 Feb;27:55-63. doi: 10.1016/j.cytogfr.2015.11.007. Epub 2015 Nov 24. PubMed PMID: 26651597.
Orlova V, Mummery C. SnapShot: Key Advances in hiPSC Disease Modeling. Cell Stem Cell. 2016 Mar 3;18(3):422. doi: 10.1016/j.stem.2016.02.013. PubMed PMID: 26942854.
Passier R, Orlova V, Mummery C. Complex Tissue and Disease Modeling using hiPSCs. Cell Stem Cell. 2016 Mar 3;18(3):309-21. doi: 10.1016/j.stem.2016.02.011. Review. PubMed PMID: 26942851.
Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LG, Orlova VV, Mummery CL. Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells. Development. 2017 Mar 15;144(6):1008-1017. doi: 10.1242/dev.143438. PubMed PMID: 28279973; PubMed Central PMCID: PMC5358113.
Giacomelli E, Bellin M, Orlova VV, Mummery CL. Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue. Curr Protoc Hum Genet. 2017 Oct 18;95:21.9.1-21.9.22. doi: 10.1002/cphg.46. PubMed PMID: 29044469.
Guadix JA, Orlova VV, Giacomelli E, Bellin M, Ribeiro MC, Mummery CL, Pérez-Pomares JM, Passier R. Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells. Stem Cell Reports. 2017 Dec 12;9(6):1754-1764. doi: 10.1016/j.stemcr.2017.10.023. Epub 2017 Nov 22. PubMed PMID: 29173898; PubMed Central PMCID: PMC5785703.
Schwach V, Verkerk AO, Mol M, Monshouwer-Kloots JJ, Devalla HD, Orlova VV, Anastassiadis K, Mummery CL, Davis RP, Passier R. A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes. Stem Cell Reports. 2017 Dec 12;9(6):1765-1779. doi: 10.1016/j.stemcr.2017.10.024. Epub 2017 Nov 22. PubMed PMID: 29173897; PubMed Central PMCID: PMC5785710.
Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL. MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo. Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review. PubMed PMID: 29282212; PubMed Central PMCID: PMC5805275.
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