Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Herup-Wheeler T, Shi M, Harvey ME, Talwar C, Kommagani R, MacLean JA 2nd, Hayashi K. High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia. Front Endocrinol (Lausanne). 2024;15:1336496. doi: 10.3389/fendo.2024.1336496. eCollection 2024. PubMed PMID: 38559689; PubMed Central PMCID: PMC10978581.
Oh Y, Kasu M, Bottoms CJ, Douglas JC, Sekulovski N, Hayashi K, MacLean Ii JA. Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†. Biol Reprod. 2023 Oct 13;109(4):520-532. doi: 10.1093/biolre/ioad077. PubMed PMID: 37471646; PubMed Central PMCID: PMC10577278.
Zhao L, Shi M, Winuthayanon S, MacLean JA 2nd, Hayashi K. Niclosamide targets the dynamic progression of macrophages for the resolution of endometriosis in a mouse model. Commun Biol. 2022 Nov 11;5(1):1225. doi: 10.1038/s42003-022-04211-0. PubMed PMID: 36369244; PubMed Central PMCID: PMC9652344.
Lyu Z, Ding S, Du D, Qiu K, Liu J, Hayashi K, Zhang X, Lin Y. Recent advances in biomedical applications of 2D nanomaterials with peroxidase-like properties. Adv Drug Deliv Rev. 2022 Jun;185:114269. doi: 10.1016/j.addr.2022.114269. Epub 2022 Apr 6. Review. PubMed PMID: 35398244.
MacLean JA 2nd, Hayashi K. Progesterone Actions and Resistance in Gynecological Disorders. Cells. 2022 Feb 13;11(4). doi: 10.3390/cells11040647. Review. PubMed PMID: 35203298; PubMed Central PMCID: PMC8870180.
Shi M, Langholt EM, Butler LC, Harvey ME, Wheeler EC, Zhao L, MacLean JA, Oh Y, Sabrowsky E, Yu S, Watson S, Davis JF, Hayashi K. Vapor Cannabis Exposure Generationally Affects Male Reproductive Functions in Mice. Toxicol Sci. 2022 Jan 24;185(2):128-142. doi: 10.1093/toxsci/kfab137. PubMed PMID: 34865136.
Kramer AC, Erikson DW, McLendon BA, Seo H, Hayashi K, Spencer TE, Bazer FW, Burghardt RC, Johnson GA. SPP1 expression in the mouse uterus and placenta: implications for implantation†. Biol Reprod. 2021 Oct 11;105(4):892-904. doi: 10.1093/biolre/ioab125. PubMed PMID: 34165144.
Sekulovski N, MacLean JA, Bheemireddy SR, Yu Z, Okuda H, Pru C, Plunkett KN, Matzuk M, Hayashi K. Niclosamide's potential direct targets in ovarian cancer†. Biol Reprod. 2021 Aug 3;105(2):403-412. doi: 10.1093/biolre/ioab071. PubMed PMID: 33855343; PubMed Central PMCID: PMC8335355.
Shi M, Sekulovski N, Whorton AE, MacLean JA 2nd, Greaves E, Hayashi K. Efficacy of niclosamide on the intra-abdominal inflammatory environment in endometriosis. FASEB J. 2021 May;35(5):e21584. doi: 10.1096/fj.202002541RRR. PubMed PMID: 33860549; PubMed Central PMCID: PMC10777336.
Sekulovski N, Whorton AE, Shi M, Hayashi K, MacLean JA 2nd. Insulin signaling is an essential regulator of endometrial proliferation and implantation in mice. FASEB J. 2021 Apr;35(4):e21440. doi: 10.1096/fj.202002448R. PubMed PMID: 33749878; PubMed Central PMCID: PMC8916120.
Shi M, Whorton AE, Sekulovski N, Paquet M, MacLean JA, Song Y, Van Dyke T, Hayashi K. Inactivation of TRP53, PTEN, RB1, and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis. Biol Reprod. 2020 Apr 24;102(5):1055-1064. doi: 10.1093/biolre/ioaa008. PubMed PMID: 31930396; PubMed Central PMCID: PMC7305658.
Sekulovski N, Whorton AE, Tanaka T, Hirota Y, Shi M, MacLean JA, de Mola JRL, Groesch K, Diaz-Sylvester P, Wilson T, Hayashi K. Niclosamide suppresses macrophage-induced inflammation in endometriosis†. Biol Reprod. 2020 Apr 24;102(5):1011-1019. doi: 10.1093/biolre/ioaa010. PubMed PMID: 31950153; PubMed Central PMCID: PMC7186788.
Sekulovski N, Whorton AE, Shi M, Hayashi K, MacLean JA 2nd. Periovulatory insulin signaling is essential for ovulation, granulosa cell differentiation, and female fertility. FASEB J. 2020 Feb;34(2):2376-2391. doi: 10.1096/fj.201901791R. Epub 2019 Dec 12. PubMed PMID: 31908002; PubMed Central PMCID: PMC7781071.
Shi M, Whorton AE, Sekulovski N, MacLean JA, Hayashi K. Prenatal Exposure to Bisphenol A, E, and S Induces Transgenerational Effects on Male Reproductive Functions in Mice. Toxicol Sci. 2019 Dec 1;172(2):303-315. doi: 10.1093/toxsci/kfz207. PubMed PMID: 31532523.
Shi M, Whorton AE, Sekulovski N, MacLean JA, Hayashi K. Prenatal Exposure to Bisphenol A, E, and S Induces Transgenerational Effects on Female Reproductive Functions in Mice. Toxicol Sci. 2019 Aug 1;170(2):320-329. doi: 10.1093/toxsci/kfz124. PubMed PMID: 31132128.
Shi M, Sekulovski N, MacLean JA, Whorton A, Hayashi K. Prenatal Exposure to Bisphenol A Analogues on Female Reproductive Functions in Mice. Toxicol Sci. 2019 Apr 1;168(2):561-571. doi: 10.1093/toxsci/kfz014. PubMed PMID: 30629253.
Sekulovski N, Whorton AE, Shi M, MacLean JA II, Hayashi K. Endometriotic inflammatory microenvironment induced by macrophages can be targeted by niclosamide†. Biol Reprod. 2019 Feb 1;100(2):398-408. doi: 10.1093/biolre/ioy222. PubMed PMID: 30329025; PubMed Central PMCID: PMC6378864.
Shi M, Sekulovski N, MacLean JA 2nd, Hayashi K. Prenatal Exposure to Bisphenol A Analogues on Male Reproductive Functions in Mice. Toxicol Sci. 2018 Jun 1;163(2):620-631. doi: 10.1093/toxsci/kfy061. PubMed PMID: 29741722.
Shi M, Sekulovski N, MacLean JA 2nd, Hayashi K. Effects of bisphenol A analogues on reproductive functions in mice. Reprod Toxicol. 2017 Oct;73:280-291. doi: 10.1016/j.reprotox.2017.06.134. Epub 2017 Jul 1. PubMed PMID: 28676390.
Prather GR, MacLean JA 2nd, Shi M, Boadu DK, Paquet M, Hayashi K. Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model. Biol Reprod. 2016 Oct 1;95(4):76. doi: 10.1095/biolreprod.116.140236. Epub 2016 Aug 17. PubMed PMID: 27535961; PubMed Central PMCID: PMC5333938.
León S, Fernandois D, Sull A, Sull J, Calder M, Hayashi K, Bhattacharya M, Power S, Vilos GA, Vilos AG, Tena-Sempere M, Babwah AV. Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function. Sci Rep. 2016 Jul 1;6:29073. doi: 10.1038/srep29073. PubMed PMID: 27364226; PubMed Central PMCID: PMC4929565.
MacLean JA 2nd, King ML, Okuda H, Hayashi K. WNT7A Regulation by miR-15b in Ovarian Cancer. PLoS One. 2016;11(5):e0156109. doi: 10.1371/journal.pone.0156109. eCollection 2016. PubMed PMID: 27195958; PubMed Central PMCID: PMC4873135.
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, Hayashi K, Honda H, Kikuchi A, Price C, Boerboom D. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016 Apr;30(4):1534-47. doi: 10.1096/fj.15-280313. Epub 2015 Dec 14. PubMed PMID: 26667040; PubMed Central PMCID: PMC4799500.
Welborn JP, Davis MG, Ebers SD, Stodden GR, Hayashi K, Cheatwood JL, Rao MK, MacLean JA 2nd. Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice. Biol Reprod. 2015 Jul;93(1):8. doi: 10.1095/biolreprod.114.124834. Epub 2015 May 13. PubMed PMID: 25972016; PubMed Central PMCID: PMC4706311.
King ML, Lindberg ME, Stodden GR, Okuda H, Ebers SD, Johnson A, Montag A, Lengyel E, MacLean Ii JA, Hayashi K. WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene. 2015 Jun;34(26):3452-62. doi: 10.1038/onc.2014.277. Epub 2014 Sep 1. PubMed PMID: 25174399; PubMed Central PMCID: PMC4345161.
Stodden GR, Lindberg ME, King ML, Paquet M, MacLean JA, Mann JL, DeMayo FJ, Lydon JP, Hayashi K. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene. 2015 May 7;34(19):2471-82. doi: 10.1038/onc.2014.193. Epub 2014 Jul 7. PubMed PMID: 24998851; PubMed Central PMCID: PMC4551401.
Cooke PS, Spencer TE, Bartol FF, Hayashi K. Uterine glands: development, function and experimental model systems. Mol Hum Reprod. 2013 Sep;19(9):547-58. doi: 10.1093/molehr/gat031. Epub 2013 Apr 25. Review. PubMed PMID: 23619340; PubMed Central PMCID: PMC3749806.
Lindberg ME, Stodden GR, King ML, MacLean JA 2nd, Mann JL, DeMayo FJ, Lydon JP, Hayashi K. Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus. Biol Reprod. 2013 Jul;89(1):8. doi: 10.1095/biolreprod.113.109462. Print 2013 Jul. PubMed PMID: 23740945; PubMed Central PMCID: PMC4076352.
Brown RM, Davis MG, Hayashi K, MacLean JA. Regulated expression of Rhox8 in the mouse ovary: evidence for the role of progesterone and RHOX5 in granulosa cells. Biol Reprod. 2013 May;88(5):126. doi: 10.1095/biolreprod.112.103267. Print 2013 May. PubMed PMID: 23536368; PubMed Central PMCID: PMC4013910.
MacLean JA 2nd, Hayashi K, Turner TT, Wilkinson MF. The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis. Biol Reprod. 2012 Jun;86(6):189. doi: 10.1095/biolreprod.112.099184. Print 2012 Jun. PubMed PMID: 22423045; PubMed Central PMCID: PMC3386150.
Reardon SN, King ML, MacLean JA 2nd, Mann JL, DeMayo FJ, Lydon JP, Hayashi K. CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus. Biol Reprod. 2012 May;86(5):141, 1-10. doi: 10.1095/biolreprod.112.098871. Print 2012 May. PubMed PMID: 22378759; PubMed Central PMCID: PMC3364924.
Cooke PS, Ekman GC, Kaur J, Davila J, Bagchi IC, Clark SG, Dziuk PJ, Hayashi K, Bartol FF. Brief exposure to progesterone during a critical neonatal window prevents uterine gland formation in mice. Biol Reprod. 2012 Mar;86(3):63. doi: 10.1095/biolreprod.111.097188. Print 2012 Mar. PubMed PMID: 22133692; PubMed Central PMCID: PMC3316263.
Yoshioka S, King ML, Ran S, Okuda H, MacLean JA 2nd, McAsey ME, Sugino N, Brard L, Watabe K, Hayashi K. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Mol Cancer Res. 2012 Mar;10(3):469-82. doi: 10.1158/1541-7786.MCR-11-0177. Epub 2012 Jan 9. PubMed PMID: 22232518; PubMed Central PMCID: PMC3307825.
Dunlap KA, Filant J, Hayashi K, Rucker EB 3rd, Song G, Deng JM, Behringer RR, DeMayo FJ, Lydon J, Jeong JW, Spencer TE. Postnatal deletion of Wnt7a inhibits uterine gland morphogenesis and compromises adult fertility in mice. Biol Reprod. 2011 Aug;85(2):386-96. doi: 10.1095/biolreprod.111.091769. Epub 2011 Apr 20. PubMed PMID: 21508348; PubMed Central PMCID: PMC3142262.
Hayashi K, Yoshioka S, Reardon SN, Rucker EB 3rd, Spencer TE, DeMayo FJ, Lydon JP, MacLean JA 2nd. WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development. Biol Reprod. 2011 Feb;84(2):308-19. doi: 10.1095/biolreprod.110.088161. Epub 2010 Oct 20. PubMed PMID: 20962251; PubMed Central PMCID: PMC3071266.
Ross JW, Ashworth MD, Mathew D, Reagan P, Ritchey JW, Hayashi K, Spencer TE, Lucy M, Geisert RD. Activation of the transcription factor, nuclear factor kappa-B, during the estrous cycle and early pregnancy in the pig. Reprod Biol Endocrinol. 2010 Apr 28;8:39. doi: 10.1186/1477-7827-8-39. PubMed PMID: 20426870; PubMed Central PMCID: PMC2876169.
Trott JF, Horigan KC, Gloviczki JM, Costa KM, Freking BA, Farmer C, Hayashi K, Spencer T, Morabito JE, Hovey RC. Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin. J Endocrinol. 2009 Jul;202(1):153-66. doi: 10.1677/JOE-08-0486. Epub 2009 Apr 28. PubMed PMID: 19401343.
Hayashi K, Erikson DW, Tilford SA, Bany BM, Maclean JA 2nd, Rucker EB 3rd, Johnson GA, Spencer TE. Wnt genes in the mouse uterus: potential regulation of implantation. Biol Reprod. 2009 May;80(5):989-1000. doi: 10.1095/biolreprod.108.075416. Epub 2009 Jan 21. PubMed PMID: 19164167; PubMed Central PMCID: PMC2804842.
Satterfield MC, Hayashi K, Song G, Black SG, Bazer FW, Spencer TE. Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus. Biol Reprod. 2008 Dec;79(6):1226-36. doi: 10.1095/biolreprod.108.071787. Epub 2008 Aug 27. PubMed PMID: 18753603.
Hayashi K, O'Connell AR, Juengel JL, McNatty KP, Davis GH, Bazer FW, Spencer TE. Postnatal uterine development in Inverdale ewe lambs. Reproduction. 2008 Mar;135(3):357-65. doi: 10.1530/REP-07-0323. PubMed PMID: 18299429.
Satterfield MC, Song G, Hayashi K, Bazer FW, Spencer TE. Progesterone regulation of the endometrial WNT system in the ovine uterus. Reprod Fertil Dev. 2008;20(8):935-46. doi: 10.1071/rd08069. PubMed PMID: 19007558.
Satterfield MC, Dunlap KA, Hayashi K, Burghardt RC, Spencer TE, Bazer FW. Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Endocrinology. 2007 Aug;148(8):3922-31. doi: 10.1210/en.2007-0321. Epub 2007 May 3. PubMed PMID: 17478549.
Hayashi K, Burghardt RC, Bazer FW, Spencer TE. WNTs in the ovine uterus: potential regulation of periimplantation ovine conceptus development. Endocrinology. 2007 Jul;148(7):3496-506. doi: 10.1210/en.2007-0283. Epub 2007 Apr 12. PubMed PMID: 17431004.
Dunlap KA, Palmarini M, Varela M, Burghardt RC, Hayashi K, Farmer JL, Spencer TE. Endogenous retroviruses regulate periimplantation placental growth and differentiation. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14390-5. doi: 10.1073/pnas.0603836103. Epub 2006 Sep 15. PubMed PMID: 16980413; PubMed Central PMCID: PMC1599973.
Hayashi K, Spencer TE. WNT pathways in the neonatal ovine uterus: potential specification of endometrial gland morphogenesis by SFRP2. Biol Reprod. 2006 Apr;74(4):721-33. doi: 10.1095/biolreprod.105.049718. Epub 2006 Jan 11. PubMed PMID: 16407498.
Hayashi K, Spencer TE. Estrogen disruption of neonatal ovine uterine development: effects on gene expression assessed by suppression subtraction hybridization. Biol Reprod. 2005 Oct;73(4):752-60. doi: 10.1095/biolreprod.105.042812. Epub 2005 Jun 22. PubMed PMID: 15972882.
Hayashi K, Carpenter KD, Welsh TH Jr, Burghardt RC, Spicer LJ, Spencer TE. The IGF system in the neonatal ovine uterus. Reproduction. 2005 Mar;129(3):337-47. doi: 10.1530/rep.1.00342. PubMed PMID: 15749960.
Spencer TE, Carpenter KD, Hayashi K, Hu J. Uterine glands. In: Davies J, editor. Branching Morphogenesis Austin, TX: Landes Biosciences; 2005.
Spencer TE, Hayashi K, Hu J, Carpenter KD. Comparative developmental biology of the mammalian uterus. Curr Top Dev Biol. 2005;68:85-122. doi: 10.1016/S0070-2153(05)68004-0. Review. PubMed PMID: 16124997.
Hayashi K, Carpenter KD, Spencer TE. Neonatal estrogen exposure disrupts uterine development in the postnatal sheep. Endocrinology. 2004 Jul;145(7):3247-57. doi: 10.1210/en.2004-0178. Epub 2004 Apr 1. PubMed PMID: 15059950.
What would you like to do?