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Gadenstaetter AJ, Schmutzler L, Grimm D, Landegger LD. Intranasal application of adeno-associated viruses: a systematic review. Transl Res. 2022 Oct;248:87-110. doi: 10.1016/j.trsl.2022.05.002. Epub 2022 May 18. Review. PubMed PMID: 35597541.
El Andari J, Renaud-Gabardos E, Tulalamba W, Weinmann J, Mangin L, Pham QH, Hille S, Bennett A, Attebi E, Bourges E, Leborgne C, Guerchet N, Fakhiri J, Krämer C, Wiedtke E, McKenna R, Guianvarc'h L, Toueille M, Ronzitti G, Hebben M, Mingozzi F, VandenDriessche T, Agbandje-McKenna M, Müller OJ, Chuah MK, Buj-Bello A, Grimm D. Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders. Sci Adv. 2022 Sep 23;8(38):eabn4704. doi: 10.1126/sciadv.abn4704. Epub 2022 Sep 21. PubMed PMID: 36129972.
Szumska J, Grimm D. Boosters for adeno-associated virus vector (AAV) (r)evolution. Cytotherapy. 2022 Aug 20;. doi: 10.1016/j.jcyt.2022.07.005. [Epub ahead of print] PubMed PMID: 35999132.
Becker J, Fischer N, Grimm D. Right on target: The next class of efficient, safe, and specific RNAi triggers. Mol Ther Nucleic Acids. 2022 Jun 14;28:363-365. doi: 10.1016/j.omtn.2022.03.027. eCollection 2022 Jun 14. PubMed PMID: 35505965; PubMed Central PMCID: PMC9035382.
Flitsch LJ, Börner K, Stüllein C, Ziegler S, Sonntag-Buck V, Wiedtke E, Semkova V, Au Yeung SWC, Schlee J, Hajo M, Mathews M, Ludwig BS, Kossatz S, Kessler H, Grimm D, Brüstle O. Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening. Sci Rep. 2022 May 19;12(1):8356. doi: 10.1038/s41598-022-12404-0. PubMed PMID: 35589936; PubMed Central PMCID: PMC9120183.
Bauer A, Puglisi M, Nagl D, Schick JA, Werner T, Klingl A, El Andari J, Hornung V, Kessler H, Götz M, Grimm D, Brack-Werner R. Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1. Adv Sci (Weinh). 2022 May;9(16):e2104979. doi: 10.1002/advs.202104979. Epub 2022 Apr 10. PubMed PMID: 35398994; PubMed Central PMCID: PMC9165502.
Melendez E, Chondronasiou D, Mosteiro L, Martínez de Villarreal J, Fernández-Alfara M, Lynch CJ, Grimm D, Real FX, Alcamí J, Climent N, Pietrocola F, Serrano M. Natural killer cells act as an extrinsic barrier for in vivo reprogramming. Development. 2022 Apr 15;149(8). doi: 10.1242/dev.200361. Epub 2022 Apr 22. PubMed PMID: 35420133; PubMed Central PMCID: PMC9124575.
Ernst L, Steinfeld B, Barayeu U, Klintzsch T, Kurth M, Grimm D, Dick TP, Rebelein JG, Bischofs IB, Keppler F. Methane formation driven by reactive oxygen species across all living organisms. Nature. 2022 Mar;603(7901):482-487. doi: 10.1038/s41586-022-04511-9. Epub 2022 Mar 9. PubMed PMID: 35264795.
Maurer L, El Andari J, Rapti K, Spreyer L, Steinmann E, Grimm D, Dao Thi VL. Induction of Hepatitis E Virus Anti-ORF3 Antibodies from Systemic Administration of a Muscle-Specific Adeno-Associated Virus (AAV) Vector. Viruses. 2022 Jan 27;14(2). doi: 10.3390/v14020266. PubMed PMID: 35215859; PubMed Central PMCID: PMC8878420.
Fakhiri J, Landegger LD, Grimm D. Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders. Hear Res. 2022 Jan;413:108092. doi: 10.1016/j.heares.2020.108092. Epub 2020 Oct 15. Review. PubMed PMID: 33268240.
Mann AM, Schäfer W, Adriouch S, Börner K, Grimm D, Braren I, Koch-Nolte F. Enhanced Transduction of P2X7-Expressing Cells with Recombinant rAAV Vectors. Methods Mol Biol. 2022;2510:129-144. doi: 10.1007/978-1-0716-2384-8_7. PubMed PMID: 35776323.
Kremer LPM, Cerrizuela S, Dehler S, Stiehl T, Weinmann J, Abendroth H, Kleber S, Laure A, El Andari J, Anders S, Marciniak-Czochra A, Grimm D, Martin-Villalba A. High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone. Mol Ther Methods Clin Dev. 2021 Dec 10;23:33-50. doi: 10.1016/j.omtm.2021.07.001. eCollection 2021 Dec 10. PubMed PMID: 34553001; PubMed Central PMCID: PMC8427210.
Cheng M, Dietz L, Gong Y, Eichler F, Nammour J, Ng C, Grimm D, Maguire CA. Neutralizing Antibody Evasion and Transduction with Purified Extracellular Vesicle-Enveloped Adeno-Associated Virus Vectors. Hum Gene Ther. 2021 Dec;32(23-24):1457-1470. doi: 10.1089/hum.2021.122. PubMed PMID: 34445894; PubMed Central PMCID: PMC8742275.
Fakhiri J, Grimm D. Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses. Mol Ther. 2021 Dec 1;29(12):3359-3382. doi: 10.1016/j.ymthe.2021.04.005. Epub 2021 Apr 5. Review. PubMed PMID: 33831556; PubMed Central PMCID: PMC8636155.
Hakim CH, Kumar SRP, Pérez-López DO, Wasala NB, Zhang D, Yue Y, Teixeira J, Pan X, Zhang K, Million ED, Nelson CE, Metzger S, Han J, Louderman JA, Schmidt F, Feng F, Grimm D, Smith BF, Yao G, Yang NN, Gersbach CA, Chen SJ, Herzog RW, Duan D. Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models. Nat Commun. 2021 Nov 24;12(1):6769. doi: 10.1038/s41467-021-26830-7. PubMed PMID: 34819506; PubMed Central PMCID: PMC8613397.
Marichal-Gallardo P, Börner K, Pieler MM, Sonntag-Buck V, Obr M, Bejarano D, Wolff MW, Kräusslich HG, Reichl U, Grimm D. Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography. Hum Gene Ther. 2021 Sep;32(17-18):959-974. doi: 10.1089/hum.2019.284. Epub 2021 Mar 30. PubMed PMID: 33554722.
Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong HW, Back MK, Hetsch F, D'Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodóvar C. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep. 2021 Aug 17;36(7):109522. doi: 10.1016/j.celrep.2021.109522. PubMed PMID: 34407407; PubMed Central PMCID: PMC9110807.
Meng N, Grimm D. Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR-Cas gene editing. Signal Transduct Target Ther. 2021 May 25;6(1):206. doi: 10.1038/s41392-021-00642-z. PubMed PMID: 34035211; PubMed Central PMCID: PMC8149719.
Hoffmann MD, Mathony J, Upmeier Zu Belzen J, Harteveld Z, Aschenbrenner S, Stengl C, Grimm D, Correia BE, Eils R, Niopek D. Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein. Nucleic Acids Res. 2021 Mar 18;49(5):e29. doi: 10.1093/nar/gkaa1198. PubMed PMID: 33330940; PubMed Central PMCID: PMC7969004.
Murenu E, Pavlou M, Richter L, Rapti K, Just S, Cehajic-Kapetanovic J, Tafrishi N, Hayes A, Scholey R, Lucas R, Büning H, Grimm D, Michalakis S. A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting. Mol Ther Methods Clin Dev. 2021 Mar 12;20:587-600. doi: 10.1016/j.omtm.2021.01.011. eCollection 2021 Mar 12. PubMed PMID: 33665228; PubMed Central PMCID: PMC7895692.
Medert R, Jungmann A, Hildebrand S, Busch M, Grimm D, Flockerzi V, Müller OJ, Most P, Schumacher D, Freichel M. Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart. Pflugers Arch. 2021 Mar;473(3):533-546. doi: 10.1007/s00424-021-02521-6. Epub 2021 Feb 13. PubMed PMID: 33580817; PubMed Central PMCID: PMC7940300.
Yu JC, Mietzsch M, Singh A, Jimenez Ybargollin A, Kailasan S, Chipman P, Bhattacharya N, Fakhiri J, Grimm D, Kapoor A, Kučinskaitė-Kodzė I, Žvirblienė A, Söderlund-Venermo M, McKenna R, Agbandje-McKenna M. Characterization of the GBoV1 Capsid and Its Antibody Interactions. Viruses. 2021 Feb 20;13(2). doi: 10.3390/v13020330. PubMed PMID: 33672786; PubMed Central PMCID: PMC7924616.
Bubeck F, Grimm D. 'Hit and run' therapy averts macular degeneration. Nat Biomed Eng. 2021 Feb;5(2):132-133. doi: 10.1038/s41551-021-00690-4. PubMed PMID: 33580229.
El Andari J, Grimm D. Production, Processing, and Characterization of Synthetic AAV Gene Therapy Vectors. Biotechnol J. 2021 Jan;16(1):e2000025. doi: 10.1002/biot.202000025. Epub 2020 Oct 7. Review. PubMed PMID: 32975881.
Senís E, Mosteiro L, Grimm D, Abad M. A Versatile In Vivo System to Study Myc in Cell Reprogramming. Methods Mol Biol. 2021;2318:267-279. doi: 10.1007/978-1-0716-1476-1_14. PubMed PMID: 34019296.
Weinmann J, Weis S, Sippel J, Tulalamba W, Remes A, El Andari J, Herrmann AK, Pham QH, Borowski C, Hille S, Schönberger T, Frey N, Lenter M, VandenDriessche T, Müller OJ, Chuah MK, Lamla T, Grimm D. Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants. Nat Commun. 2020 Oct 28;11(1):5432. doi: 10.1038/s41467-020-19230-w. PubMed PMID: 33116134; PubMed Central PMCID: PMC7595228.
Klein S, Müller TG, Khalid D, Sonntag-Buck V, Heuser AM, Glass B, Meurer M, Morales I, Schillak A, Freistaedter A, Ambiel I, Winter SL, Zimmermann L, Naumoska T, Bubeck F, Kirrmaier D, Ullrich S, Barreto Miranda I, Anders S, Grimm D, Schnitzler P, Knop M, Kräusslich HG, Dao Thi VL, Börner K, Chlanda P. SARS-CoV-2 RNA Extraction Using Magnetic Beads for Rapid Large-Scale Testing by RT-qPCR and RT-LAMP. Viruses. 2020 Aug 7;12(8). doi: 10.3390/v12080863. PubMed PMID: 32784757; PubMed Central PMCID: PMC7472728.
Mathony J, Harteveld Z, Schmelas C, Upmeier Zu Belzen J, Aschenbrenner S, Sun W, Hoffmann MD, Stengl C, Scheck A, Georgeon S, Rosset S, Wang Y, Grimm D, Eils R, Correia BE, Niopek D. Computational design of anti-CRISPR proteins with improved inhibition potency. Nat Chem Biol. 2020 Jul;16(7):725-730. doi: 10.1038/s41589-020-0518-9. Epub 2020 Apr 13. PubMed PMID: 32284602.
Fakhiri J, Linse KP, Mietzsch M, Xu M, Schneider MA, Meister M, Schildgen O, Schnitzler P, Soderlund-Venermo M, Agbandje-McKenna M, Grimm D. Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity. J Virol. 2020 May 18;94(11). doi: 10.1128/JVI.00170-20. Print 2020 May 18. PubMed PMID: 32213611; PubMed Central PMCID: PMC7269442.
Michler T, Kosinska AD, Festag J, Bunse T, Su J, Ringelhan M, Imhof H, Grimm D, Steiger K, Mogler C, Heikenwalder M, Michel ML, Guzman CA, Milstein S, Sepp-Lorenzino L, Knolle P, Protzer U. Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice. Gastroenterology. 2020 May;158(6):1762-1775.e9. doi: 10.1053/j.gastro.2020.01.032. Epub 2020 Jan 28. PubMed PMID: 32001321.
Börner K, Kienle E, Huang LY, Weinmann J, Sacher A, Bayer P, Stüllein C, Fakhiri J, Zimmermann L, Westhaus A, Beneke J, Beil N, Wiedtke E, Schmelas C, Miltner D, Rau A, Erfle H, Kräusslich HG, Müller M, Agbandje-McKenna M, Grimm D. Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening. Mol Ther. 2020 Apr 8;28(4):1016-1032. doi: 10.1016/j.ymthe.2020.02.009. Epub 2020 Feb 13. PubMed PMID: 32105604; PubMed Central PMCID: PMC7132618.
Tulalamba W, Weinmann J, Pham QH, El Andari J, VandenDriessche T, Chuah MK, Grimm D. Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors. Gene Ther. 2020 Apr;27(3-4):170-179. doi: 10.1038/s41434-019-0106-3. Epub 2019 Oct 17. PubMed PMID: 31624368.
Krooss SA, Dai Z, Schmidt F, Rovai A, Fakhiri J, Dhingra A, Yuan Q, Yang T, Balakrishnan A, Steinbrück L, Srivaratharajan S, Manns MP, Schambach A, Grimm D, Bohne J, Sharma AD, Büning H, Ott M. Ex Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template. iScience. 2020 Jan 24;23(1):100764. doi: 10.1016/j.isci.2019.100764. Epub 2019 Dec 12. PubMed PMID: 31887661; PubMed Central PMCID: PMC6941859.
Hentzschel F, Mitesser V, Fraschka SA, Krzikalla D, Carrillo EH, Berkhout B, Bártfai R, Mueller AK, Grimm D. Gene knockdown in malaria parasites via non-canonical RNAi. Nucleic Acids Res. 2020 Jan 10;48(1):e2. doi: 10.1093/nar/gkz927. PubMed PMID: 31680162; PubMed Central PMCID: PMC7145648.
Haar J, Krämer C, Grimm D. Lab-Scale Production of Recombinant Adeno-Associated Viruses (AAV) for Expression of Optogenetic Elements. Methods Mol Biol. 2020;2173:83-100. doi: 10.1007/978-1-0716-0755-8_5. PubMed PMID: 32651911.
Eichhoff AM, Börner K, Albrecht B, Schäfer W, Baum N, Haag F, Körbelin J, Trepel M, Braren I, Grimm D, Adriouch S, Koch-Nolte F. Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors. Mol Ther Methods Clin Dev. 2019 Dec 13;15:211-220. doi: 10.1016/j.omtm.2019.09.003. eCollection 2019 Dec 13. PubMed PMID: 31687421; PubMed Central PMCID: PMC6819893.
Domenger C, Grimm D. Next-generation AAV vectors-do not judge a virus (only) by its cover. Hum Mol Genet. 2019 Oct 1;28(R1):R3-R14. doi: 10.1093/hmg/ddz148. Review. PubMed PMID: 31261383.
Tabatabai J, Fakhiri J, Meyburg J, Linse KP, Xu M, Söderlund-Venermo M, Grimm D, Schnitzler P. Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome. Pediatr Infect Dis J. 2019 Sep;38(9):e219-e222. doi: 10.1097/INF.0000000000002354. PubMed PMID: 31033910.
Hoffmann MD, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, Mastel M, Börner K, Eils R, Grimm D, Niopek D. Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Nucleic Acids Res. 2019 Jul 26;47(13):e75. doi: 10.1093/nar/gkz271. PubMed PMID: 30982889; PubMed Central PMCID: PMC6648350.
Fakhiri J, Schneider MA, Puschhof J, Stanifer M, Schildgen V, Holderbach S, Voss Y, El Andari J, Schildgen O, Boulant S, Meister M, Clevers H, Yan Z, Qiu J, Grimm D. Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses. Mol Ther Methods Clin Dev. 2019 Mar 15;12:202-222. doi: 10.1016/j.omtm.2019.01.003. eCollection 2019 Mar 15. PubMed PMID: 30766894; PubMed Central PMCID: PMC6360332.
Herrmann AK, Bender C, Kienle E, Grosse S, El Andari J, Botta J, Schürmann N, Wiedtke E, Niopek D, Grimm D. A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses. ACS Synth Biol. 2019 Jan 18;8(1):194-206. doi: 10.1021/acssynbio.8b00373. Epub 2019 Jan 8. PubMed PMID: 30513195.
Fanucchi S, Fok ET, Dalla E, Shibayama Y, Börner K, Chang EY, Stoychev S, Imakaev M, Grimm D, Wang KC, Li G, Sung WK, Mhlanga MM. Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments. Nat Genet. 2019 Jan;51(1):138-150. doi: 10.1038/s41588-018-0298-2. Epub 2018 Dec 10. PubMed PMID: 30531872.
Herrmann AK, Große S, Börner K, Krämer C, Wiedtke E, Gunkel M, Grimm D. Impact of the Assembly-Activating Protein on Molecular Evolution of Synthetic Adeno-Associated Virus Capsids. Hum Gene Ther. 2019 Jan;30(1):21-35. doi: 10.1089/hum.2018.085. Epub 2018 Dec 18. PubMed PMID: 29978729.
Wolff G, Taranko AE, Meln I, Weinmann J, Sijmonsma T, Lerch S, Heide D, Billeter AT, Tews D, Krunic D, Fischer-Posovszky P, Müller-Stich BP, Herzig S, Grimm D, Heikenwälder M, Kao WW, Vegiopoulos A. Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis. Mol Metab. 2019 Jan;19:97-106. doi: 10.1016/j.molmet.2018.10.007. Epub 2018 Oct 23. PubMed PMID: 30409703; PubMed Central PMCID: PMC6323191.
Fakhiri J, Nickl M, Grimm D. Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors. Methods Mol Biol. 2019;1961:111-126. doi: 10.1007/978-1-4939-9170-9_8. PubMed PMID: 30912043.
Bubeck F, Hoffmann MD, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer MC, Börner K, Fakhiri J, Schmelas C, Dietz L, Grimm D, Correia BE, Eils R, Niopek D. Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9. Nat Methods. 2018 Nov;15(11):924-927. doi: 10.1038/s41592-018-0178-9. Epub 2018 Oct 30. PubMed PMID: 30377362.
Schmelas C, Grimm D. Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology. Biotechnol J. 2018 Sep;13(9):e1700432. doi: 10.1002/biot.201700432. Epub 2018 Feb 2. Review. PubMed PMID: 29316283.
Herrmann AK, Grimm D. High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious. J Mol Biol. 2018 Aug 17;430(17):2626-2640. doi: 10.1016/j.jmb.2018.05.022. Epub 2018 May 19. Review. PubMed PMID: 29782834.
Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D. AAVvector-mediated in vivo reprogramming into pluripotency. Nat Commun. 2018 Jul 9;9(1):2651. doi: 10.1038/s41467-018-05059-x. PubMed PMID: 29985406; PubMed Central PMCID: PMC6037684.
Cordas Dos Santos DM, Eilers J, Sosa Vizcaino A, Orlova E, Zimmermann M, Stanulla M, Schrappe M, Börner K, Grimm D, Muckenthaler MU, Kulozik AE, Kunz JB. MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB. BMC Cancer. 2018 Jun 18;18(1):663. doi: 10.1186/s12885-018-4525-0. PubMed PMID: 29914415; PubMed Central PMCID: PMC6006985.
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