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  1. Edwards S, Simmons DL, Galindo DG, Doherty JM, Scott AM, Hughes PD, Wilcox RE. Antagonistic effects of dopaminergic signaling and ethanol on protein kinase A-mediated phosphorylation of DARPP-32 and the NR1 subunit of the NMDA receptor. Alcohol Clin Exp Res. 2002 Feb;26(2):173-80. PubMed PMID: 11964556.
  2. Bolaños CA, Perrotti LI, Edwards S, Eisch AJ, Barrot M, Olson VG, Russell DS, Neve RL, Nestler EJ. Phospholipase Cgamma in distinct regions of the ventral tegmental area differentially modulates mood-related behaviors. J Neurosci. 2003 Aug 20;23(20):7569-76. PubMed PMID: 12930795.
  3. Choi KH, Rahman Z, Edwards S, Hall S, Neve RL, Self DW. Opposite effects of GluR1 and PKA-resistant GluR1 overexpression in the ventral tegmental area on cocaine reinforcement. Ann N Y Acad Sci. 2003 Nov;1003:372-4. doi: 10.1196/annals.1300.029. PubMed PMID: 14684464.
  4. Perrotti LI, Bolaños CA, Choi KH, Russo SJ, Edwards S, Ulery PG, Wallace DL, Self DW, Nestler EJ, Barrot M. DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur J Neurosci. 2005 May;21(10):2817-24. doi: 10.1111/j.1460-9568.2005.04110.x. PubMed PMID: 15926929.
  5. Olson VG, Zabetian CP, Bolanos CA, Edwards S, Barrot M, Eisch AJ, Hughes T, Self DW, Neve RL, Nestler EJ. Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. J Neurosci. 2005 Jun 8;25(23):5553-62. doi: 10.1523/JNEUROSCI.0345-05.2005. PubMed PMID: 15944383; PubMed Central PMCID: PMC6724971.
  6. Edwards S, Self DW. Monogamy: dopamine ties the knot. Nat Neurosci. 2006 Jan;9(1):7-8. doi: 10.1038/nn0106-7. PubMed PMID: 16378085.
  7. Edwards S, Whisler KN, Fuller DC, Orsulak PJ, Self DW. Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration. Neuropsychopharmacology. 2007 Feb;32(2):354-66. doi: 10.1038/sj.npp.1301062. Epub 2006 Mar 15. PubMed PMID: 16541082.
  8. Edwards S, Graham DL, Bachtell RK, Self DW. Region-specific tolerance to cocaine-regulated cAMP-dependent protein phosphorylation following chronic self-administration. Eur J Neurosci. 2007 Apr;25(7):2201-13. doi: 10.1111/j.1460-9568.2007.05473.x. PubMed PMID: 17439498.
  9. Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci. 2007 Aug;10(8):1029-37. doi: 10.1038/nn1929. Epub 2007 Jul 8. PubMed PMID: 17618281.
  10. Edwards S, Graham DL, Whisler KN, Self DW. Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration. Synapse. 2009 Mar;63(3):224-35. doi: 10.1002/syn.20601. PubMed PMID: 19084907; PubMed Central PMCID: PMC2628418.
  11. Orio L, Edwards S, George O, Parsons LH, Koob GF. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. J Neurosci. 2009 Apr 15;29(15):4846-57. doi: 10.1523/JNEUROSCI.0563-09.2009. PubMed PMID: 19369553; PubMed Central PMCID: PMC2688678.
  12. Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolanos CA, DiLeone RJ, Parada LF, Nestler EJ, Self DW. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry. 2009 Apr 15;65(8):696-701. doi: 10.1016/j.biopsych.2008.09.032. Epub 2008 Nov 6. PubMed PMID: 18990365; PubMed Central PMCID: PMC2738869.
  13. Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurol. 2010 May 1;5(3):393-401. doi: 10.2217/fnl.10.14. PubMed PMID: 20563312; PubMed Central PMCID: PMC2886284.
  14. Enwright JF 3rd, Wald M, Paddock M, Hoffman E, Arey R, Edwards S, Spencer S, Nestler EJ, McClung CA. DeltaFosB indirectly regulates Cck promoter activity. Brain Res. 2010 May 6;1329:10-20. doi: 10.1016/j.brainres.2010.02.081. Epub 2010 Mar 11. PubMed PMID: 20226774; PubMed Central PMCID: PMC2876727.
  15. Taffe MA, Kotzebue RW, Crean RD, Crawford EF, Edwards S, Mandyam CD. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11104-9. doi: 10.1073/pnas.0912810107. Epub 2010 Jun 1. PubMed PMID: 20534463; PubMed Central PMCID: PMC2890755.
  16. Larson EB, Akkentli F, Edwards S, Graham DL, Simmons DL, Alibhai IN, Nestler EJ, Self DW. Striatal regulation of ΔFosB, FosB, and cFos during cocaine self-administration and withdrawal. J Neurochem. 2010 Oct;115(1):112-22. doi: 10.1111/j.1471-4159.2010.06907.x. Epub 2010 Aug 3. PubMed PMID: 20633205; PubMed Central PMCID: PMC2939959.
  17. Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW. Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. J Neurosci. 2011 May 25;31(21):7927-37. doi: 10.1523/JNEUROSCI.6014-10.2011. PubMed PMID: 21613507; PubMed Central PMCID: PMC3103081.
  18. Edwards S, Bachtell RK, Guzman D, Whisler KN, Self DW. Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration. Addict Biol. 2011 Jul;16(3):450-7. doi: 10.1111/j.1369-1600.2010.00296.x. Epub 2011 Feb 11. PubMed PMID: 21309958; PubMed Central PMCID: PMC3115519.
  19. Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. A vaccine strategy that induces protective immunity against heroin. J Med Chem. 2011 Jul 28;54(14):5195-204. doi: 10.1021/jm200461m. Epub 2011 Jun 30. PubMed PMID: 21692508; PubMed Central PMCID: PMC3142939.
  20. Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD. Developing a vaccine against multiple psychoactive targets: a case study of heroin. CNS Neurol Disord Drug Targets. 2011 Dec;10(8):865-75. Review. PubMed PMID: 22229311; PubMed Central PMCID: PMC3327724.
  21. Edwards S, Koob GF. Experimental psychiatric illness and drug abuse models: from human to animal, an overview. Methods Mol Biol. 2012;829:31-48. doi: 10.1007/978-1-61779-458-2_2. Review. PubMed PMID: 22231805; PubMed Central PMCID: PMC3285446.
  22. Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addict Biol. 2012 Jan;17(1):76-85. doi: 10.1111/j.1369-1600.2010.00291.x. Epub 2011 Feb 11. PubMed PMID: 21309953; PubMed Central PMCID: PMC3178679.
  23. Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism. Neuropharmacology. 2012 Feb;62(2):1142-51. doi: 10.1016/j.neuropharm.2011.11.006. Epub 2011 Nov 23. PubMed PMID: 22119954; PubMed Central PMCID: PMC3262951.
  24. Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology. 2012 Apr;37(5):1275-87. doi: 10.1038/npp.2011.315. Epub 2011 Dec 28. PubMed PMID: 22205547; PubMed Central PMCID: PMC3306889.
  25. Egli M, Koob GF, Edwards S. Alcohol dependence as a chronic pain disorder. Neurosci Biobehav Rev. 2012 Nov;36(10):2179-92. doi: 10.1016/j.neubiorev.2012.07.010. Epub 2012 Sep 11. Review. PubMed PMID: 22975446; PubMed Central PMCID: PMC3612891.
  26. Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology. 2013 May;38(6):976-84. doi: 10.1038/npp.2012.261. Epub 2012 Dec 18. PubMed PMID: 23303056; PubMed Central PMCID: PMC3629386.
  27. Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proc Natl Acad Sci U S A. 2013 May 28;110(22):9036-41. doi: 10.1073/pnas.1219159110. Epub 2013 May 6. PubMed PMID: 23650354; PubMed Central PMCID: PMC3670323.
  28. Edwards S, Baynes BB, Carmichael CY, Zamora-Martinez ER, Barrus M, Koob GF, Gilpin NW. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity. Transl Psychiatry. 2013 Aug 27;3:e296. doi: 10.1038/tp.2013.70. PubMed PMID: 23982628; PubMed Central PMCID: PMC3756295.
  29. Edwards S, Koob GF. Escalation of drug self-administration as a hallmark of persistent addiction liability. Behav Pharmacol. 2013 Sep;24(5-6):356-62. doi: 10.1097/FBP.0b013e3283644d15. Review. PubMed PMID: 23839030; PubMed Central PMCID: PMC3866817.
  30. Park PE, Vendruscolo LF, Schlosburg JE, Edwards S, Schulteis G, Koob GF. Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats. Int J Neuropsychopharmacol. 2013 Sep;16(8):1867-75. doi: 10.1017/S1461145713000308. Epub 2013 Apr 16. PubMed PMID: 23590881; PubMed Central PMCID: PMC3880138.
  31. Kallupi M, Wee S, Edwards S, Whitfield TW Jr, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biol Psychiatry. 2013 Oct 1;74(7):520-8. doi: 10.1016/j.biopsych.2013.04.028. Epub 2013 Jun 14. PubMed PMID: 23751206; PubMed Central PMCID: PMC3773286.
  32. Apkarian AV, Neugebauer V, Koob G, Edwards S, Levine JD, Ferrari L, Egli M, Regunathan S. Neural mechanisms of pain and alcohol dependence. Pharmacol Biochem Behav. 2013 Nov;112:34-41. doi: 10.1016/j.pbb.2013.09.008. Epub 2013 Oct 2. Review. PubMed PMID: 24095683; PubMed Central PMCID: PMC4887744.
  33. Katz PS, Edwards S, Molina PE. Neuroinflammation and Neurodegeneration . In: Cannabinoids. Peterson PK, Toborek M, editors. New York: Springer; 2014. Chapter 17; p.487-510.
  34. Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O. Addiction as a stress surfeit disorder. Neuropharmacology. 2014 Jan;76 Pt B:370-82. doi: 10.1016/j.neuropharm.2013.05.024. Epub 2013 Jun 6. Review. PubMed PMID: 23747571; PubMed Central PMCID: PMC3830720.
  35. Zamora-Martinez ER, Edwards S. Neuronal extracellular signal-regulated kinase (ERK) activity as marker and mediator of alcohol and opioid dependence. Front Integr Neurosci. 2014;8:24. doi: 10.3389/fnint.2014.00024. eCollection 2014. Review. PubMed PMID: 24653683; PubMed Central PMCID: PMC3949304.
  36. Mazei-Robison MS, Appasani R, Edwards S, Wee S, Taylor SR, Picciotto MR, Koob GF, Nestler EJ. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. PLoS One. 2014;9(4):e95962. doi: 10.1371/journal.pone.0095962. eCollection 2014. PubMed PMID: 24755634; PubMed Central PMCID: PMC3995955.
  37. Whitaker AM, Gilpin NW, Edwards S. Animal models of post-traumatic stress disorder and recent neurobiological insights. Behav Pharmacol. 2014 Sep;25(5-6):398-409. doi: 10.1097/FBP.0000000000000069. Review. PubMed PMID: 25083568; PubMed Central PMCID: PMC4163927.
  38. Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addict Biol. 2015 Jan;20(1):56-68. doi: 10.1111/adb.12077. Epub 2013 Jul 22. PubMed PMID: 23869743; PubMed Central PMCID: PMC3859819.
  39. Kim A, Zamora-Martinez ER, Edwards S, Mandyam CD. Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. Brain Struct Funct. 2015;220(3):1705-20. doi: 10.1007/s00429-014-0755-3. Epub 2014 Mar 26. PubMed PMID: 24667898; PubMed Central PMCID: PMC4177030.
  40. Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addict Biol. 2015 Mar;20(2):275-84. doi: 10.1111/adb.12120. Epub 2013 Dec 13. PubMed PMID: 24330252; PubMed Central PMCID: PMC4057367.
  41. Whitfield TW Jr, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. J Neurosci. 2015 Mar 11;35(10):4296-305. doi: 10.1523/JNEUROSCI.1978-13.2015. PubMed PMID: 25762676; PubMed Central PMCID: PMC4355200.
  42. Helms CM, Bell RL, Bennett AJ, Davies DL, Chester JA, Kosten TA, Leeman RF, Panicker S, Platt DM, Weiner JL, Edwards S. The importance of animals in advancing research on alcohol use disorders. Alcohol Clin Exp Res. 2015 Apr;39(4):575-8. doi: 10.1111/acer.12668. PubMed PMID: 25833015; PubMed Central PMCID: PMC5052074.
  43. Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. J Clin Invest. 2015 Aug 3;125(8):3193-7. doi: 10.1172/JCI79828. Epub 2015 Jun 29. PubMed PMID: 26121746; PubMed Central PMCID: PMC4563748.
  44. LeBlanc DM, McGinn MA, Itoga CA, Edwards S. The affective dimension of pain as a risk factor for drug and alcohol addiction. Alcohol. 2015 Dec;49(8):803-9. doi: 10.1016/j.alcohol.2015.04.005. Epub 2015 May 1. PubMed PMID: 26008713; PubMed Central PMCID: PMC4628900.
  45. Edwards S, Little HJ, Richardson HN, Vendruscolo LF. Divergent regulation of distinct glucocorticoid systems in alcohol dependence. Alcohol. 2015 Dec;49(8):811-6. doi: 10.1016/j.alcohol.2015.04.004. Epub 2015 Apr 30. Review. PubMed PMID: 26003866; PubMed Central PMCID: PMC4627854.
  46. Edwards S. Reinforcement principles for addiction medicine; from recreational drug use to psychiatric disorder. Prog Brain Res. 2016;223:63-76. doi: 10.1016/bs.pbr.2015.07.005. Epub 2015 Oct 1. Review. PubMed PMID: 26806771.
  47. Whitaker AM, Farooq MA, Edwards S, Gilpin NW. Post-traumatic stress avoidance is attenuated by corticosterone and associated with brain levels of steroid receptor co-activator-1 in rats. Stress. 2016;19(1):69-77. doi: 10.3109/10253890.2015.1094689. Epub 2015 Oct 20. PubMed PMID: 26482332; PubMed Central PMCID: PMC4938251.
  48. McGinn MA, Paulsen RI, Itoga CA, Farooq MA, Reppel JE, Edwards KN, Whitaker AM, Gilpin NW, Edwards S. Withdrawal from Chronic Nicotine Exposure Produces Region-Specific Tolerance to Alcohol-Stimulated GluA1 Phosphorylation. Alcohol Clin Exp Res. 2016 Dec;40(12):2537-2547. doi: 10.1111/acer.13258. Epub 2016 Oct 31. PubMed PMID: 27796078; PubMed Central PMCID: PMC5506685.
  49. Somkuwar SS, Fannon MJ, Staples MC, Zamora-Martinez ER, Navarro AI, Kim A, Quigley JA, Edwards S, Mandyam CD. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. Brain Struct Funct. 2016 Dec;221(9):4319-4335. doi: 10.1007/s00429-015-1163-z. Epub 2015 Dec 11. PubMed PMID: 26659122; PubMed Central PMCID: PMC4903099.
  50. Mayeux J, Katz P, Edwards S, Middleton JW, Molina PE. Inhibition of Endocannabinoid Degradation Improves Outcomes from Mild Traumatic Brain Injury: A Mechanistic Role for Synaptic Hyperexcitability. J Neurotrauma. 2017 Jan 15;34(2):436-443. doi: 10.1089/neu.2016.4452. Epub 2016 Jun 27. PubMed PMID: 27189876; PubMed Central PMCID: PMC5220555.