From discoveries in ageing research to therapeutics for healthy ageing.
Nature.
2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. Review. PubMed PMID:
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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.
Cell Stem Cell.
2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008. PubMed PMID:
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Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Nat Commun.
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Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence.
Aging Cell.
2017 Oct;16(5):1043-1050. doi: 10.1111/acel.12632. Epub 2017 Jul 11. PubMed PMID:
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Unmasking Transcriptional Heterogeneity in Senescent Cells.
Curr Biol.
2017 Sep 11;27(17):2652-2660.e4. doi: 10.1016/j.cub.2017.07.033. Epub 2017 Aug 30. PubMed PMID:
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Nat Commun.
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Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent".
Circ Res.
2017 Jun 9;120(12):e56-e57. doi: 10.1161/CIRCRESAHA.117.311146. PubMed PMID:
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Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.
Circ Res.
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Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.
Nutr Healthy Aging.
2017 Mar 31;4(2):147-156. doi: 10.3233/NHA-160017. PubMed PMID:
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Expression patterns of cardiac aging in Drosophila.
Aging Cell.
2017 Feb;16(1):82-92. doi: 10.1111/acel.12559. PubMed PMID:
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Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Cancer Discov.
2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. PubMed PMID:
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Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.
Cell Rep.
2017 Jan 10;18(2):545-556. doi: 10.1016/j.celrep.2016.12.034. PubMed PMID:
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Uncovering the Dark Energy of Aging.
Cell Syst.
2016 Oct 26;3(4):328-330. doi: 10.1016/j.cels.2016.10.001. PubMed PMID:
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Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.
Cell Rep.
2016 Oct 25;17(5):1227-1237. doi: 10.1016/j.celrep.2016.09.086. PubMed PMID:
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Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.
Cell Metab.
2016 Oct 11;24(4):582-592. doi: 10.1016/j.cmet.2016.08.012. Epub 2016 Sep 22. PubMed PMID:
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Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.
Stem Cell Reports.
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Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.
Proc Natl Acad Sci U S A.
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Translational geroscience: emphasizing function to achieve optimal longevity.
Aging (Albany NY).
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Medical research: treat ageing.
Nature.
2014 Jul 24;511(7510):405-7. doi: 10.1038/511405a. PubMed PMID:
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Genome-wide DNA methylation changes with age in disease-free human skeletal muscle.
Aging Cell.
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Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.
Cell Rep.
2013 Dec 26;5(6):1600-10. doi: 10.1016/j.celrep.2013.11.018. Epub 2013 Dec 12. PubMed PMID:
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Late-life rapamycin treatment reverses age-related heart dysfunction.
Aging Cell.
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SOD2 in mitochondrial dysfunction and neurodegeneration.
Free Radic Biol Med.
2013 Sep;62:4-12. doi: 10.1016/j.freeradbiomed.2013.05.027. Epub 2013 May 29. Review. PubMed PMID:
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Age-related micro-RNA abundance in individual C. elegans.
Aging (Albany NY).
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Single cell gene expression profiling of cortical osteoblast lineage cells.
Bone.
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No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease.
J Neurosci.
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Proteogenomics of synaptosomal mitochondrial oxidative stress.
Free Radic Biol Med.
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Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease.
Free Radic Biol Med.
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Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.
Cell Stem Cell.
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Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster.
Cell Metab.
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Premature expression of a muscle fibrosis axis in chronic HIV infection.
Skelet Muscle.
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cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad.
Aging (Albany NY).
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Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage.
Sci Transl Med.
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Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin.
Aging (Albany NY).
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Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members.
PLoS One.
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Cellular senescence: a link between cancer and age-related degenerative disease?.
Semin Cancer Biol.
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On the programmed/non-programmed nature of ageing within the life history.
Curr Biol.
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Loss of intestinal nuclei and intestinal integrity in aging C. elegans.
Aging Cell.
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Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.
Cell Metab.
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The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation.
Exp Gerontol.
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Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice.
Free Radic Biol Med.
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Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice.
Proc Natl Acad Sci U S A.
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Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.
Cell Metab.
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Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes.
PLoS One.
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Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women.
PLoS One.
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A human protein interaction network shows conservation of aging processes between human and invertebrate species.
PLoS Genet.
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Free Radic Biol Med.
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Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans.
Aging Cell.
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Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.
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