My Bibliography

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Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. Review. PubMed PMID: 31292558; PubMed Central PMCID: PMC7205183.

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Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008. PubMed PMID: 29220665; PubMed Central PMCID: PMC5823264.

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Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stančáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 Nov 7;8(1):1414. doi: 10.1038/s41467-017-01008-2. PubMed PMID: 29116125; PubMed Central PMCID: PMC5676783.

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Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell. 2017 Oct;16(5):1043-1050. doi: 10.1111/acel.12632. Epub 2017 Jul 11. PubMed PMID: 28699239; PubMed Central PMCID: PMC5595671.

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Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M. Unmasking Transcriptional Heterogeneity in Senescent Cells. Curr Biol. 2017 Sep 11;27(17):2652-2660.e4. doi: 10.1016/j.cub.2017.07.033. Epub 2017 Aug 30. PubMed PMID: 28844647; PubMed Central PMCID: PMC5788810.

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Zillikens MC, Demissie S, Hsu YH, Yerges-Armstrong LM, Chou WC, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, Kutalik Z, Luan J, Malkin I, Ried JS, Smith AV, Thorleifsson G, Vandenput L, Hua Zhao J, Zhang W, Aghdassi A, Åkesson K, Amin N, Baier LJ, Barroso I, Bennett DA, Bertram L, Biffar R, Bochud M, Boehnke M, Borecki IB, Buchman AS, Byberg L, Campbell H, Campos Obanda N, Cauley JA, Cawthon PM, Cederberg H, Chen Z, Cho NH, Jin Choi H, Claussnitzer M, Collins F, Cummings SR, De Jager PL, Demuth I, Dhonukshe-Rutten RAM, Diatchenko L, Eiriksdottir G, Enneman AW, Erdos M, Eriksson JG, Eriksson J, Estrada K, Evans DS, Feitosa MF, Fu M, Garcia M, Gieger C, Girke T, Glazer NL, Grallert H, Grewal J, Han BG, Hanson RL, Hayward C, Hofman A, Hoffman EP, Homuth G, Hsueh WC, Hubal MJ, Hubbard A, Huffman KM, Husted LB, Illig T, Ingelsson E, Ittermann T, Jansson JO, Jordan JM, Jula A, Karlsson M, Khaw KT, Kilpeläinen TO, Klopp N, Kloth JSL, Koistinen HA, Kraus WE, Kritchevsky S, Kuulasmaa T, Kuusisto J, Laakso M, Lahti J, Lang T, Langdahl BL, Launer LJ, Lee JY, Lerch MM, Lewis JR, Lind L, Lindgren C, Liu Y, Liu T, Liu Y, Ljunggren Ö, Lorentzon M, Luben RN, Maixner W, McGuigan FE, Medina-Gomez C, Meitinger T, Melhus H, Mellström D, Melov S, Michaëlsson K, Mitchell BD, Morris AP, Mosekilde L, Newman A, Nielson CM, O'Connell JR, Oostra BA, Orwoll ES, Palotie A, Parker SCJ, Peacock M, Perola M, Peters A, Polasek O, Prince RL, Räikkönen K, Ralston SH, Ripatti S, Robbins JA, Rotter JI, Rudan I, Salomaa V, Satterfield S, Schadt EE, Schipf S, Scott L, Sehmi J, Shen J, Soo Shin C, Sigurdsson G, Smith S, Soranzo N, Stančáková A, Steinhagen-Thiessen E, Streeten EA, Styrkarsdottir U, Swart KMA, Tan ST, Tarnopolsky MA, Thompson P, Thomson CA, Thorsteinsdottir U, Tikkanen E, Tranah GJ, Tuomilehto J, van Schoor NM, Verma A, Vollenweider P, Völzke H, Wactawski-Wende J, Walker M, Weedon MN, Welch R, Wichmann HE, Widen E, Williams FMK, Wilson JF, Wright NC, Xie W, Yu L, Zhou Y, Chambers JC, Döring A, van Duijn CM, Econs MJ, Gudnason V, Kooner JS, Psaty BM, Spector TD, Stefansson K, Rivadeneira F, Uitterlinden AG, Wareham NJ, Ossowski V, Waterworth D, Loos RJF, Karasik D, Harris TB, Ohlsson C, Kiel DP. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun. 2017 Jul 19;8(1):80. doi: 10.1038/s41467-017-00031-7. PubMed PMID: 28724990; PubMed Central PMCID: PMC5517526.

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Simpson PC, Myagmar BE, Swigart PM, Melov S, Baker AJ. Response by Simpson et al to Letter Regarding Article, "Adrenergic Receptors in Individual Ventricular Myocytes: the Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent". Circ Res. 2017 Jun 9;120(12):e56-e57. doi: 10.1161/CIRCRESAHA.117.311146. PubMed PMID: 28596177; PubMed Central PMCID: PMC5501172.

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Myagmar BE, Flynn JM, Cowley PM, Swigart PM, Montgomery MD, Thai K, Nair D, Gupta R, Deng DX, Hosoda C, Melov S, Baker AJ, Simpson PC. Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent. Circ Res. 2017 Mar 31;120(7):1103-1115. doi: 10.1161/CIRCRESAHA.117.310520. Epub 2017 Feb 20. PubMed PMID: 28219977; PubMed Central PMCID: PMC5376223.

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Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. Nutr Healthy Aging. 2017 Mar 31;4(2):147-156. doi: 10.3233/NHA-160017. PubMed PMID: 28447069; PubMed Central PMCID: PMC5389018.

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Cannon L, Zambon AC, Cammarato A, Zhang Z, Vogler G, Munoz M, Taylor E, Cartry J, Bernstein SI, Melov S, Bodmer R. Expression patterns of cardiac aging in Drosophila. Aging Cell. 2017 Feb;16(1):82-92. doi: 10.1111/acel.12559. PubMed PMID: 28090760; PubMed Central PMCID: PMC5242310.

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Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. PubMed PMID: 27979832; PubMed Central PMCID: PMC5296251.

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Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL. Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing. Cell Rep. 2017 Jan 10;18(2):545-556. doi: 10.1016/j.celrep.2016.12.034. PubMed PMID: 28076796; PubMed Central PMCID: PMC5234864.

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Melov S. Uncovering the Dark Energy of Aging. Cell Syst. 2016 Oct 26;3(4):328-330. doi: 10.1016/j.cels.2016.10.001. PubMed PMID: 27788357.

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Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016 Oct 25;17(5):1227-1237. doi: 10.1016/j.celrep.2016.09.086. PubMed PMID: 27783938; PubMed Central PMCID: PMC5689451.

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Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, Brookes PS, Ainscow EK. Suppressors of Superoxide-H₂O₂ Production at Site I_Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab. 2016 Oct 11;24(4):582-592. doi: 10.1016/j.cmet.2016.08.012. Epub 2016 Sep 22. PubMed PMID: 27667666; PubMed Central PMCID: PMC5061631.

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Ring KL, An MC, Zhang N, O'Brien RN, Ramos EM, Gao F, Atwood R, Bailus BJ, Melov S, Mooney SD, Coppola G, Ellerby LM. Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells. Stem Cell Reports. 2015 Dec 8;5(6):1023-1038. doi: 10.1016/j.stemcr.2015.11.005. PubMed PMID: 26651603; PubMed Central PMCID: PMC4682390.

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Velarde MC, Demaria M, Melov S, Campisi J. Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10407-12. doi: 10.1073/pnas.1505675112. Epub 2015 Aug 3. PubMed PMID: 26240345; PubMed Central PMCID: PMC4547253.

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Seals DR, Melov S. Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY). 2014 Sep;6(9):718-30. doi: 10.18632/aging.100694. PubMed PMID: 25324468; PubMed Central PMCID: PMC4221919.

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Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. Medical research: treat ageing. Nature. 2014 Jul 24;511(7510):405-7. doi: 10.1038/511405a. PubMed PMID: 25056047.

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Zykovich A, Hubbard A, Flynn JM, Tarnopolsky M, Fraga MF, Kerksick C, Ogborn D, MacNeil L, Mooney SD, Melov S. Genome-wide DNA methylation changes with age in disease-free human skeletal muscle. Aging Cell. 2014 Apr;13(2):360-6. doi: 10.1111/acel.12180. Epub 2013 Dec 2. PubMed PMID: 24304487; PubMed Central PMCID: PMC3954952.

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Chen D, Li PW, Goldstein BA, Cai W, Thomas EL, Chen F, Hubbard AE, Melov S, Kapahi P. Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep. 2013 Dec 26;5(6):1600-10. doi: 10.1016/j.celrep.2013.11.018. Epub 2013 Dec 12. PubMed PMID: 24332851; PubMed Central PMCID: PMC3904953.

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Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, Zykovich A, Mooney SD, Strong R, Rosen CJ, Kapahi P, Nelson MD, Kennedy BK, Melov S. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 2013 Oct;12(5):851-62. doi: 10.1111/acel.12109. Epub 2013 Jul 7. PubMed PMID: 23734717; PubMed Central PMCID: PMC4098908.

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Flynn JM, Melov S. SOD2 in mitochondrial dysfunction and neurodegeneration. Free Radic Biol Med. 2013 Sep;62:4-12. doi: 10.1016/j.freeradbiomed.2013.05.027. Epub 2013 May 29. Review. PubMed PMID: 23727323; PubMed Central PMCID: PMC3811078.

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Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow GJ, Melov S. Age-related micro-RNA abundance in individual C. elegans. Aging (Albany NY). 2013 Jun;5(6):394-411. doi: 10.18632/aging.100564. PubMed PMID: 23793570; PubMed Central PMCID: PMC3824409.

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Flynn JM, Spusta SC, Rosen CJ, Melov S. Single cell gene expression profiling of cortical osteoblast lineage cells. Bone. 2013 Mar;53(1):174-81. doi: 10.1016/j.bone.2012.11.043. Epub 2012 Dec 10. PubMed PMID: 23238121; PubMed Central PMCID: PMC3589579.

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Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. J Neurosci. 2012 Nov 21;32(47):16775-84. doi: 10.1523/JNEUROSCI.2414-12.2012. PubMed PMID: 23175831; PubMed Central PMCID: PMC3736741.

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Flynn JM, Czerwieniec GA, Choi SW, Day NU, Gibson BW, Hubbard A, Melov S. Proteogenomics of synaptosomal mitochondrial oxidative stress. Free Radic Biol Med. 2012 Sep 1;53(5):1048-60. doi: 10.1016/j.freeradbiomed.2012.07.004. Epub 2012 Jul 13. PubMed PMID: 22796328; PubMed Central PMCID: PMC3436120.

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Siddiqui A, Chinta SJ, Mallajosyula JK, Rajagopolan S, Hanson I, Rane A, Melov S, Andersen JK. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease. Free Radic Biol Med. 2012 Aug 15;53(4):993-1003. doi: 10.1016/j.freeradbiomed.2012.05.024. Epub 2012 Jun 15. PubMed PMID: 22705949; PubMed Central PMCID: PMC3418424.

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An MC, Zhang N, Scott G, Montoro D, Wittkop T, Mooney S, Melov S, Ellerby LM. Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells. Cell Stem Cell. 2012 Aug 3;11(2):253-63. doi: 10.1016/j.stem.2012.04.026. Epub 2012 Jun 28. PubMed PMID: 22748967; PubMed Central PMCID: PMC3608272.

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Katewa SD, Demontis F, Kolipinski M, Hubbard A, Gill MS, Perrimon N, Melov S, Kapahi P. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 2012 Jul 3;16(1):97-103. doi: 10.1016/j.cmet.2012.06.005. PubMed PMID: 22768842; PubMed Central PMCID: PMC3400463.

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Kusko RL, Banerjee C, Long KK, Darcy A, Otis J, Sebastiani P, Melov S, Tarnopolsky M, Bhasin S, Montano M. Premature expression of a muscle fibrosis axis in chronic HIV infection. Skelet Muscle. 2012 Jun 7;2(1):10. doi: 10.1186/2044-5040-2-10. PubMed PMID: 22676806; PubMed Central PMCID: PMC3407733.

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McGee MD, Day N, Graham J, Melov S. cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY). 2012 Apr;4(4):256-69. doi: 10.18632/aging.100448. PubMed PMID: 22562940; PubMed Central PMCID: PMC3378273.

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Crane JD, Ogborn DI, Cupido C, Melov S, Hubbard A, Bourgeois JM, Tarnopolsky MA. Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage. Sci Transl Med. 2012 Feb 1;4(119):119ra13. doi: 10.1126/scitranslmed.3002882. PubMed PMID: 22301554.

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Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012 Jan;4(1):3-12. doi: 10.18632/aging.100423. PubMed PMID: 22278880; PubMed Central PMCID: PMC3292901.

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Flynn JM, Santana LF, Melov S. Single cell transcriptional profiling of adult mouse cardiomyocytes. J Vis Exp. 2011 Dec 28;(58):e3302. doi: 10.3791/3302. PubMed PMID: 22231655; PubMed Central PMCID: PMC3369660.

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Madden DT, Davila-Kruger D, Melov S, Bredesen DE. Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members. PLoS One. 2011;6(12):e28530. doi: 10.1371/journal.pone.0028530. Epub 2011 Dec 9. PubMed PMID: 22174832; PubMed Central PMCID: PMC3235131.

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Campisi J, Andersen JK, Kapahi P, Melov S. Cellular senescence: a link between cancer and age-related degenerative disease?. Semin Cancer Biol. 2011 Dec;21(6):354-9. doi: 10.1016/j.semcancer.2011.09.001. Epub 2011 Sep 10. Review. PubMed PMID: 21925603; PubMed Central PMCID: PMC3230665.

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Kirkwood TB, Melov S. On the programmed/non-programmed nature of ageing within the life history. Curr Biol. 2011 Sep 27;21(18):R701-7. doi: 10.1016/j.cub.2011.07.020. Review. PubMed PMID: 21959160.

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McGee MD, Weber D, Day N, Vitelli C, Crippen D, Herndon LA, Hall DH, Melov S. Loss of intestinal nuclei and intestinal integrity in aging C. elegans. Aging Cell. 2011 Aug;10(4):699-710. doi: 10.1111/j.1474-9726.2011.00713.x. Epub 2011 May 25. PubMed PMID: 21501374; PubMed Central PMCID: PMC3135675.

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Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 2011 Jul 6;14(1):55-66. doi: 10.1016/j.cmet.2011.05.010. PubMed PMID: 21723504; PubMed Central PMCID: PMC3220185.

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Powolny AA, Singh SV, Melov S, Hubbard A, Fisher AL. The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation. Exp Gerontol. 2011 Jun;46(6):441-52. doi: 10.1016/j.exger.2011.01.005. Epub 2011 Feb 2. PubMed PMID: 21296648; PubMed Central PMCID: PMC3104016.

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Flynn JM, Choi SW, Day NU, Gerencser AA, Hubbard A, Melov S. Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice. Free Radic Biol Med. 2011 Apr 1;50(7):866-73. doi: 10.1016/j.freeradbiomed.2010.12.030. Epub 2011 Jan 6. PubMed PMID: 21215798; PubMed Central PMCID: PMC3061438.

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Safdar A, Bourgeois JM, Ogborn DI, Little JP, Hettinga BP, Akhtar M, Thompson JE, Melov S, Mocellin NJ, Kujoth GC, Prolla TA, Tarnopolsky MA. Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4135-40. doi: 10.1073/pnas.1019581108. Epub 2011 Feb 22. PubMed PMID: 21368114; PubMed Central PMCID: PMC3053975.

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McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 8;12(3):260-72. doi: 10.1016/j.cmet.2010.08.004. PubMed PMID: 20816092; PubMed Central PMCID: PMC2945254.

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MacNeil LG, Melov S, Hubbard AE, Baker SK, Tarnopolsky MA. Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PLoS One. 2010 May 18;5(5):e10695. doi: 10.1371/journal.pone.0010695. PubMed PMID: 20502695; PubMed Central PMCID: PMC2872670.

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Abadi A, Glover EI, Isfort RJ, Raha S, Safdar A, Yasuda N, Kaczor JJ, Melov S, Hubbard A, Qu X, Phillips SM, Tarnopolsky M. Limb immobilization induces a coordinate down-regulation of mitochondrial and other metabolic pathways in men and women. PLoS One. 2009 Aug 5;4(8):e6518. doi: 10.1371/journal.pone.0006518. PubMed PMID: 19654872; PubMed Central PMCID: PMC2716517.

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Bell R, Hubbard A, Chettier R, Chen D, Miller JP, Kapahi P, Tarnopolsky M, Sahasrabuhde S, Melov S, Hughes RE. A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet. 2009 Mar;5(3):e1000414. doi: 10.1371/journal.pgen.1000414. Epub 2009 Mar 13. PubMed PMID: 19293945; PubMed Central PMCID: PMC2657003.

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Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S. Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med. 2009 Feb 1;46(3):387-96. doi: 10.1016/j.freeradbiomed.2008.10.036. Epub 2008 Oct 30. PubMed PMID: 19038329; PubMed Central PMCID: PMC2665299.

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Golden TR, Hubbard A, Dando C, Herren MA, Melov S. Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. Aging Cell. 2008 Dec;7(6):850-65. doi: 10.1111/j.1474-9726.2008.00433.x. PubMed PMID: 18778409; PubMed Central PMCID: PMC2613281.

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Mahoney DJ, Safdar A, Parise G, Melov S, Fu M, MacNeil L, Kaczor J, Payne ET, Tarnopolsky MA. Gene expression profiling in human skeletal muscle during recovery from eccentric exercise. Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1901-10. doi: 10.1152/ajpregu.00847.2007. Epub 2008 Mar 5. PubMed PMID: 18321953; PubMed Central PMCID: PMC2707850.