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Kim TK, Sharma B, Williams CG, Ruffner MA, Malik A, McFarland EG, Elisseeff JH. Experimental model for cartilage tissue engineering to regenerate the zonal organization of articular cartilage. Osteoarthritis Cartilage. 2003 Sep;11(9):653-64. doi: 10.1016/s1063-4584(03)00120-1. PubMed PMID: 12954236.
Hoe YS, Gurewitsch ED, Shaahinfar A, Hu ES, Sampattavanich S, Ruffner M, Ching KH, Allen RH. Measuring bioimpedance in the human uterine cervix: towards early detection of preterm labor. Conf Proc IEEE Eng Med Biol Soc. 2004;2004:2368-72. doi: 10.1109/IEMBS.2004.1403686. PubMed PMID: 17270746.
Hoe, Y.S.G., Gurewitsch, E.D., Shaahinfar, A., Hu, E.S., Sampattavanich, S., Ruffner, M., Ching, K.H.S., Allen, R.H.. Measuring bioimpedance in the human uterine cervix: Towards early detection of preterm labor. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; 2004; c2004.
Elisseeff J, Ruffner M, Kim T, Williams C. Cellular Photoencapsulation in Hydrogels. In: Vunjak-Novakovic G, Freshney R, editors. Culture of Cells for Tissue Engineering [Internet] Hoboken, NJ, USA: John Wiley & Sons, Inc.; 2005-04. 213-238p. Available from:
Elisseef J, Kim T, Ruffner MA, Williams CG. Cellular Photoencapsulation in Hydrogels. In: Freshney I, Vunjak-Novakovic G, editors. Culture of Cells for Tissue Engineering Hoboken, NJ: John Wiley and Sons; 2006. Chapter 9.
Bianco NR, Kim SH, Ruffner MA, Robbins PD. Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum. 2009 Feb;60(2):380-9. doi: 10.1002/art.24229. PubMed PMID: 19180475; PubMed Central PMCID: PMC3491653.
Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol. 2009 Nov;39(11):3084-90. doi: 10.1002/eji.200939407. PubMed PMID: 19757438; PubMed Central PMCID: PMC3075967.
Ruffner MA, Plevy SE, Cheung AT. Gene therapy for the treatment of inflammatory bowel disease. In: Chernajovsky Y, Rpbbins P, editors. Gene Therapy for Autoimmune Disease Basel: Springer; 2010. p.19-37.
Gaddy DL, Ruffner MA, Robbins PD. "Autoimmune Disorders". In: Herzog R, Zolotukhin S, editors. A Guide to Human Gene Therapy New Jersey: World Scientific; 2010.
Ruffner, M.A., Plevy, S.E., Cheung, A.T.. Gene therapy for the treatment of inflammatory bowel disease. In: Milestones in Drug Therapy [Internet] 2010. 19-37p. Available from:
Ruffner MA, Robbins PD. Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS One. 2010 Jul 29;5(7):e11848. doi: 10.1371/journal.pone.0011848. PubMed PMID: 20686610; PubMed Central PMCID: PMC2912295.
Ruffner MA, Finegold DN, MacGinnitie AJ. Infant with unusual food reactions. Acta Paediatr. 2011 Oct;100(10):1289, 1394-5. doi: 10.1111/j.1651-2227.2011.02316.x. PubMed PMID: 21916981.
The Johns Hopkins University, Maryland, assignee. Devices, systems and methods for bioimpedance measurement of cervical tissue and methods for diagnosis and treatment of human cervix. USA US8060195B2. 2011 November.
Yang C, Ruffner MA, Kim SH, Robbins PD. Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. Eur J Immunol. 2012 Jul;42(7):1778-84. doi: 10.1002/eji.201141978. PubMed PMID: 22585706; PubMed Central PMCID: PMC3471134.
Ruffner MA, Ruymann K, Barni S, Cianferoni A, Brown-Whitehorn T, Spergel JM. Food protein-induced enterocolitis syndrome: insights from review of a large referral population. J Allergy Clin Immunol Pract. 2013 Jul-Aug;1(4):343-9. doi: 10.1016/j.jaip.2013.05.011. Epub 2013 Jun 28. PubMed PMID: 24565539.
Henrickson SE, Ruffner MA, Kwan M. Unintended Immunological Consequences of Biologic Therapy. Curr Allergy Asthma Rep. 2016 Jun;16(6):46. doi: 10.1007/s11882-016-0624-7. Review. PubMed PMID: 27324478; PubMed Central PMCID: PMC5481723.
Ruffner MA, Spergel JM. Non-IgE-mediated food allergy syndromes. Ann Allergy Asthma Immunol. 2016 Nov;117(5):452-454. doi: 10.1016/j.anai.2016.04.014. Epub 2016 Oct 24. Review. PubMed PMID: 27788868; PubMed Central PMCID: PMC5116302.
Ruffner MA, Sullivan KE, Henrickson SE. Recurrent and Sustained Viral Infections in Primary Immunodeficiencies. Front Immunol. 2017;8:665. doi: 10.3389/fimmu.2017.00665. eCollection 2017. Review. PubMed PMID: 28674531; PubMed Central PMCID: PMC5474473.
Ruffner MA, Aksamit TR, Thomashow B, Choate R, DiMango A, Turino GM, O'Donnell AE, Johnson MM, Olivier KN, Fennelly K, Daley CL, Winthrop KL, Metersky ML, Salathe MA, Knowles MR, Daniels MLA, Noone PG, Tino G, Griffith DE, Sullivan KE. Frequency of untreated hypogammaglobulinemia in bronchiectasis. Ann Allergy Asthma Immunol. 2017 Jul;119(1):83-85. doi: 10.1016/j.anai.2017.04.020. Epub 2017 May 20. PubMed PMID: 28539185; PubMed Central PMCID: PMC6660915.
Ruffner MA, Spergel JM. Eosinophilic Esophagitis in Children. Curr Allergy Asthma Rep. 2017 Aug;17(8):54. doi: 10.1007/s11882-017-0721-2. Review. PubMed PMID: 28653125.
Cianferoni A, Ruffner MA, Guzek R, Guan S, Brown-Whitehorn T, Muir A, Spergel JM. Elevated expression of activated T(H)2 cells and milk-specific T(H)2 cells in milk-induced eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2018 Feb;120(2):177-183.e2. doi: 10.1016/j.anai.2017.11.006. Epub 2017 Dec 28. PubMed PMID: 29289462; PubMed Central PMCID: PMC5875940.
Ruffner MA, Brown-Whitehorn TF, Verma R, Cianferoni A, Gober L, Shuker M, Muir AB, Liacouras CA, Spergel JM. Clinical tolerance in eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2018 Mar-Apr;6(2):661-663. doi: 10.1016/j.jaip.2017.06.035. Epub 2017 Aug 12. PubMed PMID: 28811175; PubMed Central PMCID: PMC5809321.
Ruffner MA, Sullivan KE. Complications Associated with Underweight Primary Immunodeficiency Patients: Prevalence and Associations Within the USIDNET Registry. J Clin Immunol. 2018 Apr;38(3):283-293. doi: 10.1007/s10875-018-0492-0. Epub 2018 Apr 4. PubMed PMID: 29619656; PubMed Central PMCID: PMC6422024.
Godwin B, Liacouras C, Mehta V, Eisenberg J, Agawu A, Brown-Whitehorn T, Ruffner MA, Verma R, Cianferoni A, Spergel JM, Muir AB. A Review of Tertiary Referrals for Management of Pediatric Esophageal Eosinophilia. Front Pediatr. 2018;6:173. doi: 10.3389/fped.2018.00173. eCollection 2018. PubMed PMID: 29974044; PubMed Central PMCID: PMC6019483.
Fahey LM, Guzek R, Ruffner MA, Sullivan KE, Spergel J, Cianferoni A. EMSY is increased and activates TSLP & CCL5 expression in eosinophilic esophagitis. Pediatr Allergy Immunol. 2018 Aug;29(5):565-568. doi: 10.1111/pai.12907. Epub 2018 May 29. PubMed PMID: 29663593.
Crowley B, Ruffner M, McDonald McGinn DM, Sullivan KE. Variable immune deficiency related to deletion size in chromosome 22q11.2 deletion syndrome. Am J Med Genet A. 2018 Oct;176(10):2082-2086. doi: 10.1002/ajmg.a.38597. Epub 2018 Jan 17. Review. PubMed PMID: 29341423; PubMed Central PMCID: PMC6470357.
Ruffner MA, Henrickson SE, Chilutti M, Grundmeier R, Spergel JM, Brown-Whitehorn TF. Improving allergy office scheduling increases patient follow up and reduces asthma readmission after pediatric asthma hospitalization. Ann Allergy Asthma Immunol. 2018 Nov;121(5):561-567. doi: 10.1016/j.anai.2018.08.015. Epub 2018 Aug 28. PubMed PMID: 30170026; PubMed Central PMCID: PMC6236684.
Ruffner MA, Spergel JM. Pediatric eosinophilic esophagitis: updates for the primary care setting. Curr Opin Pediatr. 2018 Dec;30(6):829-836. doi: 10.1097/MOP.0000000000000698. Review. PubMed PMID: 30239371; PubMed Central PMCID: PMC6410723.
Ruffner MA, Brown-Whitehorn T. Vomiting, lethargy, and pallor. In: Rezaei N, editor. Pediatric Allergy Switzerland: Springer Cham; 2019.
Ruffner MA, Spergel JM. Epidemiology of Food Protein-Induced Enterocolitis Syndrome. In: Cianferoni A, Brown-Whitehorn T, editors. Food Protein-Induced Enterocolitis Syndrome (FPIES) Switzerland: Springer Cham; 2019. p.13-23.
Ruffner MA, Kennedy K, Cianferoni A. Pathophysiology of eosinophilic esophagitis: recent advances and their clinical implications. Expert Rev Clin Immunol. 2019 Jan;15(1):83-95. doi: 10.1080/1744666X.2019.1544893. Epub 2018 Nov 19. Review. PubMed PMID: 30394139; PubMed Central PMCID: PMC9044497.
Wang KY, Lee J, Cianferoni A, Ruffner MA, Dean A, Molleston JM, Pawlowski NA, Heimall J, Saltzman RW, Ram GS, Fiedler J, Gober LM, Spergel JM, Brown-Whitehorn TF. Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center. J Allergy Clin Immunol Pract. 2019 Feb;7(2):444-450. doi: 10.1016/j.jaip.2018.09.009. Epub 2018 Sep 20. PubMed PMID: 30243880.
Ruffner M, Song L, Maurer K, Shi L, Carroll M, Wang J, Muir A, Spergel J, Sullivan K. Toll-like receptor 2 stimulation augments esophageal epithelial barrier integrity. [preprint]. 2019 February. doi: 10.1101/539759.
Ruffner MA, Capucilli P, Hill DA, Spergel JM. Screening children for eosinophilic esophagitis: allergic and other risk factors. Expert Rev Clin Immunol. 2019 Apr;15(4):315-318. doi: 10.1080/1744666X.2019.1579643. Epub 2019 Feb 20. PubMed PMID: 30722709; PubMed Central PMCID: PMC6687298.
Kennedy K, Muir AB, Grossman A, Brown-Whitehorn T, Cianferoni A, Spergel JM, Furuta GT, Wilkins BJ, Shuker M, Ruffner MA. Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. J Allergy Clin Immunol Pract. 2019 Jul-Aug;7(6):2059-2061. doi: 10.1016/j.jaip.2019.01.053. Epub 2019 Feb 11. PubMed PMID: 30763733; PubMed Central PMCID: PMC7064262.
Bosticardo M, Yamazaki Y, Cowan J, Giardino G, Corsino C, Scalia G, Prencipe R, Ruffner M, Hill DA, Sakovich I, Yemialyanava I, Tam JS, Padem N, Elder ME, Sleasman JW, Perez E, Niebur H, Seroogy CM, Sharapova S, Gebbia J, Kleiner GI, Peake J, Abbott JK, Gelfand EW, Crestani E, Biggs C, Butte MJ, Hartog N, Hayward A, Chen K, Heimall J, Seeborg F, Bartnikas LM, Cooper MA, Pignata C, Bhandoola A, Notarangelo LD. Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis. Am J Hum Genet. 2019 Sep 5;105(3):549-561. doi: 10.1016/j.ajhg.2019.07.014. Epub 2019 Aug 22. PubMed PMID: 31447097; PubMed Central PMCID: PMC6731368.
Le Coz C, Bengsch B, Khanna C, Trofa M, Ohtani T, Nolan BE, Henrickson SE, Lambert MP, Kim TO, Despotovic JM, Feldman S, Fadugba OO, Takach P, Ruffner M, Jyonouchi S, Heimall J, Sullivan KE, Wherry EJ, Romberg N. Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage. J Allergy Clin Immunol. 2019 Dec;144(6):1660-1673. doi: 10.1016/j.jaci.2019.08.007. Epub 2019 Aug 22. PubMed PMID: 31445098; PubMed Central PMCID: PMC6900457.
Ruffner MA, Song L, Maurer K, Shi L, Carroll MC, Wang JX, Muir AB, Spergel JM, Sullivan KE. Toll-like receptor 2 stimulation augments esophageal barrier integrity. Allergy. 2019 Dec;74(12):2449-2460. doi: 10.1111/all.13968. Epub 2019 Jul 25. PubMed PMID: 31267532; PubMed Central PMCID: PMC7083217.
Fenninger F, Stanwood S, Lu C, Pfeifer C, Henrickson S, Khan O, O’Boyle K, Maurer K, Ruffner M, Herati R, Romberg N, John Wherry E, Sullivan K, Jefferies W. Mutation of an L-Type Calcium Channel Gene Leads to a Novel Human Primary Cellular Immunodeficiency. [preprint]. 2019 December. doi: 10.1101/864280.
Cafone J, Ruffner MA, Spergel JM. The Role of Eosinophils in Immunotherapy. Curr Allergy Asthma Rep. 2020 Jan 7;20(1):1. doi: 10.1007/s11882-020-0895-x. Review. PubMed PMID: 31912246; PubMed Central PMCID: PMC9188741.
Ruffner MA, Cianferoni A. Phenotypes and endotypes in eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2020 Mar;124(3):233-239. doi: 10.1016/j.anai.2019.12.011. Epub 2019 Dec 17. Review. PubMed PMID: 31862435.
Ruffner MA, Wang KY, Dudley JW, Cianferoni A, Grundmeier RW, Spergel JM, Brown-Whitehorn TF, Hill DA. Elevated Atopic Comorbidity in Patients with Food Protein-Induced Enterocolitis. J Allergy Clin Immunol Pract. 2020 Mar;8(3):1039-1046. doi: 10.1016/j.jaip.2019.10.047. Epub 2019 Nov 20. PubMed PMID: 31759160; PubMed Central PMCID: PMC7064432.
Ruffner M, Spergel J, Cianferoni A, Brown-Whitehorn TF. Reply to "Oral food challenge protocol for food protein-induced enterocolitis syndrome: time for a change?". J Allergy Clin Immunol Pract. 2020 Sep;8(8):2843-2844. doi: 10.1016/j.jaip.2020.06.022. PubMed PMID: 32888542.
Ruffner MA, Hu A, Dilollo J, Benocek K, Shows D, Gluck M, Spergel JM, Ziegler SF, Hill DA, Cerosaletti K. Conserved IFN Signature between Adult and Pediatric Eosinophilic Esophagitis. J Immunol. 2021 Mar 15;206(6):1361-1371. doi: 10.4049/jimmunol.2000973. Epub 2021 Feb 8. PubMed PMID: 33558373; PubMed Central PMCID: PMC7946729.
Benitez AJ, Tanes C, Mattei L, Hofstaedter CE, Kim DK, Gross J, Ruffner MA, Albenberg L, Spergel J, Bittinger K, Muir AB. Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis. Allergy. 2021 May;76(5):1549-1552. doi: 10.1111/all.14602. Epub 2020 Oct 19. PubMed PMID: 32990947; PubMed Central PMCID: PMC8130179.
Chiang AWT, Duong LD, Shoda T, Nhu QM, Ruffner M, Hara T, Aaron B, Joplin E, Manresa MC, Abonia JP, Dellon ES, Hirano I, Gonsalves N, Gupta SK, Furuta GT, Rothenberg ME, Lewis NE, Muir AB, Aceves SS. Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders. J Pediatr Gastroenterol Nutr. 2021 May 1;72(5):718-722. doi: 10.1097/MPG.0000000000003032. PubMed PMID: 33394891; PubMed Central PMCID: PMC8048378.
Ruffner MA, Spergel JM, Brown-Whitehorn TF. CON: Peripheral intravenous access should always be secured before initiating food protein-induced enterocolitis syndrome oral food challenge. Ann Allergy Asthma Immunol. 2021 May;126(5):462-463. doi: 10.1016/j.anai.2020.12.018. PubMed PMID: 33941318.
Ruffner MA, Zhang Z, Maurer K, Muir AB, Cianferoni A, Sullivan KE, Spergel JM. RNA sequencing identifies global transcriptional changes in peripheral CD4(+) cells during active oesophagitis and following epicutaneous immunotherapy in eosinophilic oesophagitis. Clin Transl Immunology. 2021;10(7):e1314. doi: 10.1002/cti2.1314. eCollection 2021. PubMed PMID: 34322233; PubMed Central PMCID: PMC8296633.
Hara T, Kasagi Y, Wang J, Sasaki M, Aaron B, Karami A, Shimonosono M, Shimonosono R, Maekawa H, Dolinsky L, Wilkins B, Klein J, Wei J, Nunes K, Lynch K, Spergel JM, Hamilton KE, Ruffner MA, Karakasheva TA, Whelan KA, Nakagawa H, Muir AB. CD73(+) Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis. Cell Mol Gastroenterol Hepatol. 2022;13(5):1449-1467. doi: 10.1016/j.jcmgh.2022.01.018. Epub 2022 Jan 30. PubMed PMID: 35108658; PubMed Central PMCID: PMC8957025.
Spergel BL, Ruffner MA, Godwin BC, Liacouras CA, Cianferoni A, Gober L, Hill DA, Brown-Whitehorn TF, Chaiboonma K, Aceves SA, Muir AM, Spergel JM. Improvement in eosinophilic esophagitis when using dupilumab for other indications or compassionate use. Ann Allergy Asthma Immunol. 2022 May;128(5):589-593. doi: 10.1016/j.anai.2022.01.019. Epub 2022 Jan 25. PubMed PMID: 35085819.
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