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Afshar Bakooshli M, Lippmann ES, Mulcahy B, Iyer N, Nguyen CT, Tung K, Stewart BA, van den Dorpel H, Fuehrmann T, Shoichet M, Bigot A, Pegoraro E, Ahn H, Ginsberg H, Zhen M, Ashton RS, Gilbert PM. A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction. Elife. 2019 May 14;8. doi: 10.7554/eLife.44530. PubMed PMID: 31084710; PubMed Central PMCID: PMC6516829.
Ao Y, Zeng K, Yu B, Miao Y, Hung W, Yu Z, Xue Y, Tan TTY, Xu T, Zhen M, Yang X, Zhang Y, Gao S. An Upconversion Nanoparticle Enables Near Infrared-Optogenetic Manipulation of the Caenorhabditis elegans Motor Circuit. ACS Nano. 2019 Mar 26;13(3):3373-3386. doi: 10.1021/acsnano.8b09270. Epub 2019 Jan 29. PubMed PMID: 30681836.
Mulcahy B, Witvliet D, Holmyard D, Mitchell J, Chisholm AD, Meirovitch Y, Samuel ADT, Zhen M. Corrigendum: A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System. Front Neural Circuits. 2019;13:16. doi: 10.3389/fncir.2019.00016. eCollection 2019. PubMed PMID: 30949033; PubMed Central PMCID: PMC6436607.
Mulcahy B, Witvliet D, Holmyard D, Mitchell J, Chisholm AD, Meirovitch Y, Samuel ADT, Zhen M. A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System. Front Neural Circuits. 2018;12:94. doi: 10.3389/fncir.2018.00094. eCollection 2018. PubMed PMID: 30524248; PubMed Central PMCID: PMC6262311.
Kaltdorf KV, Theiss M, Markert SM, Zhen M, Dandekar T, Stigloher C, Kollmannsberger P. Automated classification of synaptic vesicles in electron tomograms of C. elegans using machine learning. PLoS One. 2018;13(10):e0205348. doi: 10.1371/journal.pone.0205348. eCollection 2018. PubMed PMID: 30296290; PubMed Central PMCID: PMC6175533.
Wen Q, Gao S, Zhen M. Caenorhabditis elegans excitatory ventral cord motor neurons derive rhythm for body undulation. Philos Trans R Soc Lond B Biol Sci. 2018 Sep 10;373(1758). doi: 10.1098/rstb.2017.0370. Review. PubMed PMID: 30201835; PubMed Central PMCID: PMC6158216.
Xu T, Huo J, Shao S, Po M, Kawano T, Lu Y, Wu M, Zhen M, Wen Q. Descending pathway facilitates undulatory wave propagation in Caenorhabditis elegans through gap junctions. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4493-E4502. doi: 10.1073/pnas.1717022115. Epub 2018 Apr 23. PubMed PMID: 29686107; PubMed Central PMCID: PMC5948959.
Chitturi J, Hung W, Rahman AMA, Wu M, Lim MA, Calarco J, Baran R, Huang X, Dennis JW, Zhen M. The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans. PLoS Genet. 2018 Apr;14(4):e1007303. doi: 10.1371/journal.pgen.1007303. eCollection 2018 Apr. PubMed PMID: 29649217; PubMed Central PMCID: PMC5931689.
Gao S, Guan SA, Fouad AD, Meng J, Kawano T, Huang YC, Li Y, Alcaire S, Hung W, Lu Y, Qi YB, Jin Y, Alkema M, Fang-Yen C, Zhen M. Excitatory motor neurons are local oscillators for backward locomotion. Elife. 2018 Jan 23;7. doi: 10.7554/eLife.29915. PubMed PMID: 29360035; PubMed Central PMCID: PMC5780044.
Park S, Bin NR, Yu B, Wong R, Sitarska E, Sugita K, Ma K, Xu J, Tien CW, Algouneh A, Turlova E, Wang S, Siriya P, Shahid W, Kalia L, Feng ZP, Monnier PP, Sun HS, Zhen M, Gao S, Rizo J, Sugita S. UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans. J Neurosci. 2017 Sep 6;37(36):8797-8815. doi: 10.1523/JNEUROSCI.0338-17.2017. Epub 2017 Aug 8. PubMed PMID: 28821673; PubMed Central PMCID: PMC5588468.
Opperman KJ, Mulcahy B, Giles AC, Risley MG, Birnbaum RL, Tulgren ED, Dawson-Scully K, Zhen M, Grill B. The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development. Cell Rep. 2017 Apr 25;19(4):822-835. doi: 10.1016/j.celrep.2017.04.003. PubMed PMID: 28445732; PubMed Central PMCID: PMC5475272.
Meng J, Ma X, Tao H, Jin X, Witvliet D, Mitchell J, Zhu M, Dong MQ, Zhen M, Jin Y, Qi YB. Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation. Dev Cell. 2017 Apr 24;41(2):180-194.e7. doi: 10.1016/j.devcel.2017.03.022. PubMed PMID: 28441531; PubMed Central PMCID: PMC5493483.
Lim M, Chitturi J, Laskova V, Meng J, Findeis D, Wiekenberg A, Mulcahy B, Luo L, Li Y, Lu Y, Hung W, Qu Y, Ho C, Holmyard D, Ji N, McWhirter RD, Samuel AD, Miller DM, Schnabel R, Calarco JA, Zhen M. Correction: Neuroendocrine modulation sustains the C. elegans forward motor state. Elife. 2017 Mar 8;6. doi: 10.7554/eLife.26528. PubMed PMID: 28271995; PubMed Central PMCID: PMC5342822.
Ardeshiri R, Mulcahy B, Zhen M, Rezai P. A hybrid microfluidic device for on-demand orientation and multidirectional imaging of C. elegans organs and neurons. Biomicrofluidics. 2016 Nov;10(6):064111. doi: 10.1063/1.4971157. eCollection 2016 Nov. PubMed PMID: 27990213; PubMed Central PMCID: PMC5135714.
Markert SM, Britz S, Proppert S, Lang M, Witvliet D, Mulcahy B, Sauer M, Zhen M, Bessereau JL, Stigloher C. Filling the gap: adding super-resolution to array tomography for correlated ultrastructural and molecular identification of electrical synapses at the C. elegans connectome. Neurophotonics. 2016 Oct;3(4):041802. doi: 10.1117/1.NPh.3.4.041802. Epub 2016 May 4. PubMed PMID: 27175373; PubMed Central PMCID: PMC4855082.
Venkatachalam V, Ji N, Wang X, Clark C, Mitchell JK, Klein M, Tabone CJ, Florman J, Ji H, Greenwood J, Chisholm AD, Srinivasan J, Alkema M, Zhen M, Samuel AD. Pan-neuronal imaging in roaming Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1082-8. doi: 10.1073/pnas.1507109113. Epub 2015 Dec 28. PubMed PMID: 26711989; PubMed Central PMCID: PMC4776525.
Park S, Bin NR, Michael Rajah M, Kim B, Chou TC, Kang SY, Sugita K, Parsaud L, Smith M, Monnier PP, Ikura M, Zhen M, Sugita S. Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans. Mol Biol Cell. 2016 Feb 15;27(4):669-85. doi: 10.1091/mbc.E15-09-0638. Epub 2015 Dec 23. PubMed PMID: 26700321; PubMed Central PMCID: PMC4750926.
Murakami T, Qamar S, Lin JQ, Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, Ferry RR, Dong L, Tartaglia GG, Favrin G, Lin WL, Dickson DW, Zhen M, Ron D, Schmitt-Ulms G, Fraser PE, Shneider NA, Holt C, Vendruscolo M, Kaminski CF, St George-Hyslop P. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron. 2015 Nov 18;88(4):678-90. doi: 10.1016/j.neuron.2015.10.030. Epub 2015 Oct 29. PubMed PMID: 26526393; PubMed Central PMCID: PMC4660210.
Zhen M, Samuel AD. C. elegans locomotion: small circuits, complex functions. Curr Opin Neurobiol. 2015 Aug;33:117-26. doi: 10.1016/j.conb.2015.03.009. Epub 2015 Apr 4. Review. PubMed PMID: 25845627.
Aoyagi K, Rossignol E, Hamdan FF, Mulcahy B, Xie L, Nagamatsu S, Rouleau GA, Zhen M, Michaud JL. A Gain-of-Function Mutation in NALCN in a Child with Intellectual Disability, Ataxia, and Arthrogryposis. Hum Mutat. 2015 Aug;36(8):753-7. doi: 10.1002/humu.22797. Epub 2015 Jun 22. PubMed PMID: 25864427.
Maro GS, Gao S, Olechwier AM, Hung WL, Liu M, Özkan E, Zhen M, Shen K. MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin. Neuron. 2015 Jun 17;86(6):1420-32. doi: 10.1016/j.neuron.2015.05.015. Epub 2015 May 28. PubMed PMID: 26028574; PubMed Central PMCID: PMC4672740.
Wang J, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M, Huang X. The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development. 2015 Apr 15;142(8):1447-57. doi: 10.1242/dev.119479. Epub 2015 Mar 19. PubMed PMID: 25790851.
Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC, Derry WB. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. Nat Commun. 2015 Mar 6;6:6449. doi: 10.1038/ncomms7449. PubMed PMID: 25743393.
Gao S, Xie L, Kawano T, Po MD, Guan S, Zhen M, Pirri JK, Alkema MJ. The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion. Nat Commun. 2015 Feb 26;6:6323. doi: 10.1038/ncomms7323. PubMed PMID: 25716181.
Norris AD, Gao S, Norris ML, Ray D, Ramani AK, Fraser AG, Morris Q, Hughes TR, Zhen M, Calarco JA. A pair of RNA-binding proteins controls networks of splicing events contributing to specialization of neural cell types. Mol Cell. 2014 Jun 19;54(6):946-59. doi: 10.1016/j.molcel.2014.05.004. Epub 2014 Jun 5. PubMed PMID: 24910101; PubMed Central PMCID: PMC4096705.
Hung WL, Wang Y, Chitturi J, Zhen M. A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Development. 2014 Apr;141(8):1767-79. doi: 10.1242/dev.103846. Epub 2014 Mar 26. PubMed PMID: 24671950; PubMed Central PMCID: PMC3978837.
Hung WL, Hwang C, Gao S, Liao EH, Chitturi J, Wang Y, Li H, Stigloher C, Bessereau JL, Zhen M. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J. 2013 Jun 12;32(12):1745-60. doi: 10.1038/emboj.2013.91. Epub 2013 May 10. PubMed PMID: 23665919; PubMed Central PMCID: PMC3680742.
Qi YB, Po MD, Mac P, Kawano T, Jorgensen EM, Zhen M, Jin Y. Hyperactivation of B-type motor neurons results in aberrant synchrony of the Caenorhabditis elegans motor circuit. J Neurosci. 2013 Mar 20;33(12):5319-25. doi: 10.1523/JNEUROSCI.4017-12.2013. PubMed PMID: 23516296; PubMed Central PMCID: PMC3655201.
Xie L, Gao S, Alcaire SM, Aoyagi K, Wang Y, Griffin JK, Stagljar I, Nagamatsu S, Zhen M. NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion. Neuron. 2013 Mar 20;77(6):1069-82. doi: 10.1016/j.neuron.2013.01.018. PubMed PMID: 23522043.
Wen Q, Po MD, Hulme E, Chen S, Liu X, Kwok SW, Gershow M, Leifer AM, Butler V, Fang-Yen C, Kawano T, Schafer WR, Whitesides G, Wyart M, Chklovskii DB, Zhen M, Samuel AD. Proprioceptive coupling within motor neurons drives C. elegans forward locomotion. Neuron. 2012 Nov 21;76(4):750-61. doi: 10.1016/j.neuron.2012.08.039. PubMed PMID: 23177960; PubMed Central PMCID: PMC3508473.
Najarro EH, Wong L, Zhen M, Carpio EP, Goncharov A, Garriga G, Lundquist EA, Jin Y, Ackley BD. Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development. J Neurosci. 2012 Mar 21;32(12):4196-211. doi: 10.1523/JNEUROSCI.3094-11.2012. PubMed PMID: 22442082; PubMed Central PMCID: PMC3325105.
Po MD, Calarco JA, Zhen M. Releasing the inner inhibition for axon regeneration. Neuron. 2012 Jan 26;73(2):207-9. doi: 10.1016/j.neuron.2012.01.002. PubMed PMID: 22284174.
Murakami T, Yang SP, Xie L, Kawano T, Fu D, Mukai A, Bohm C, Chen F, Robertson J, Suzuki H, Tartaglia GG, Vendruscolo M, Kaminski Schierle GS, Chan FT, Moloney A, Crowther D, Kaminski CF, Zhen M, St George-Hyslop P. ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism. Hum Mol Genet. 2012 Jan 1;21(1):1-9. doi: 10.1093/hmg/ddr417. Epub 2011 Sep 23. PubMed PMID: 21949354; PubMed Central PMCID: PMC3235006.
Kawano T, Po MD, Gao S, Leung G, Ryu WS, Zhen M. An imbalancing act: gap junctions reduce the backward motor circuit activity to bias C. elegans for forward locomotion. Neuron. 2011 Nov 17;72(4):572-86. doi: 10.1016/j.neuron.2011.09.005. PubMed PMID: 22099460.
Mok CA, Healey MP, Shekhar T, Leroux MR, Héon E, Zhen M. Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans. PLoS Genet. 2011 Oct;7(10):e1002335. doi: 10.1371/journal.pgen.1002335. Epub 2011 Oct 13. PubMed PMID: 22022287; PubMed Central PMCID: PMC3192831.
Sancar F, Touroutine D, Gao S, Oh HJ, Gendrel M, Bessereau JL, Kim H, Zhen M, Richmond JE. The dystrophin-associated protein complex maintains muscle excitability by regulating Ca(2+)-dependent K(+) (BK) channel localization. J Biol Chem. 2011 Sep 23;286(38):33501-10. doi: 10.1074/jbc.M111.227678. Epub 2011 Jul 27. PubMed PMID: 21795674; PubMed Central PMCID: PMC3190934.
Calarco JA, Zhen M, Blencowe BJ. Networking in a global world: establishing functional connections between neural splicing regulators and their target transcripts. RNA. 2011 May;17(5):775-91. doi: 10.1261/rna.2603911. Epub 2011 Mar 17. Review. PubMed PMID: 21415141; PubMed Central PMCID: PMC3078728.
Bouhours M, Po MD, Gao S, Hung W, Li H, Georgiou J, Roder JC, Zhen M. A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel. Mol Brain. 2011 Apr 13;4:16. doi: 10.1186/1756-6606-4-16. PubMed PMID: 21489288; PubMed Central PMCID: PMC3102621.
Stigloher C, Zhan H, Zhen M, Richmond J, Bessereau JL. The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions. J Neurosci. 2011 Mar 23;31(12):4388-96. doi: 10.1523/JNEUROSCI.6164-10.2011. PubMed PMID: 21430140; PubMed Central PMCID: PMC3077722.
Souza RP, Rosa DV, Romano-Silva MA, Zhen M, Meltzer HY, Lieberman JA, Remington G, Kennedy JL, Wong AH. Lack of association of NALCN genetic variants with schizophrenia. Psychiatry Res. 2011 Feb 28;185(3):450-2. doi: 10.1016/j.psychres.2010.07.009. Epub 2010 Jul 31. PubMed PMID: 20674038.
Gao S, Zhen M. Action potentials drive body wall muscle contractions in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2557-62. doi: 10.1073/pnas.1012346108. Epub 2011 Jan 19. PubMed PMID: 21248227; PubMed Central PMCID: PMC3038695.
Ramani AK, Calarco JA, Pan Q, Mavandadi S, Wang Y, Nelson AC, Lee LJ, Morris Q, Blencowe BJ, Zhen M, Fraser AG. Genome-wide analysis of alternative splicing in Caenorhabditis elegans. Genome Res. 2011 Feb;21(2):342-8. doi: 10.1101/gr.114645.110. Epub 2010 Dec 22. PubMed PMID: 21177968; PubMed Central PMCID: PMC3032936.
Kim JS, Hung W, Zhen M. The long and the short of SAD-1 kinase. Commun Integr Biol. 2010 May;3(3):251-5. doi: 10.4161/cib.3.3.11455. PubMed PMID: 20714407; PubMed Central PMCID: PMC2918770.
Po MD, Hwang C, Zhen M. PHRs: bridging axon guidance, outgrowth and synapse development. Curr Opin Neurobiol. 2010 Feb;20(1):100-7. doi: 10.1016/j.conb.2009.12.007. Epub 2010 Jan 14. Review. PubMed PMID: 20079626.
Kim JS, Hung W, Narbonne P, Roy R, Zhen M. C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization. Development. 2010 Jan;137(1):93-102. doi: 10.1242/dev.041459. PubMed PMID: 20023164.
Mok CA, Héon E, Zhen M. Ciliary dysfunction and obesity. Clin Genet. 2010 Jan;77(1):18-27. doi: 10.1111/j.1399-0004.2009.01305.x. Epub 2009 Nov 20. PubMed PMID: 19968672.
Calarco JA, Superina S, O'Hanlon D, Gabut M, Raj B, Pan Q, Skalska U, Clarke L, Gelinas D, van der Kooy D, Zhen M, Ciruna B, Blencowe BJ. Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell. 2009 Sep 4;138(5):898-910. doi: 10.1016/j.cell.2009.06.012. PubMed PMID: 19737518.
Yeh E, Kawano T, Ng S, Fetter R, Hung W, Wang Y, Zhen M. Caenorhabditis elegans innexins regulate active zone differentiation. J Neurosci. 2009 Apr 22;29(16):5207-17. doi: 10.1523/JNEUROSCI.0637-09.2009. PubMed PMID: 19386917; PubMed Central PMCID: PMC6665469.
Liewald JF, Brauner M, Stephens GJ, Bouhours M, Schultheis C, Zhen M, Gottschalk A. Optogenetic analysis of synaptic function. Nat Methods. 2008 Oct;5(10):895-902. doi: 10.1038/nmeth.1252. Epub 2008 Sep 14. PubMed PMID: 18794862.
Kim JS, Lilley BN, Zhang C, Shokat KM, Sanes JR, Zhen M. A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Dev. 2008 Sep 22;3:23. doi: 10.1186/1749-8104-3-23. PubMed PMID: 18808695; PubMed Central PMCID: PMC2564922.
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