My Bibliography

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Boorman J, Zeng X, Lin J, van den Akker F. Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI-EtgA fusion protein. Protein Sci. 2024 Mar;33(3):e4930. doi: 10.1002/pro.4930. PubMed PMID: 38380768; PubMed Central PMCID: PMC10880428.

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Mack AR, Kumar V, Taracila MA, Mojica MF, O'Shea M, Schinabeck W, Silver G, Hujer AM, Papp-Wallace KM, Chen S, Haider S, Caselli E, Prati F, van den Akker F, Bonomo RA. Natural protein engineering in the Ω-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas-derived cephalosporinase. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0079123. doi: 10.1128/aac.00791-23. Epub 2023 Oct 18. PubMed PMID: 37850746; PubMed Central PMCID: PMC10648885.

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Kumar V, Boorman J, Greenlee WJ, Zeng X, Lin J, van den Akker F. Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds. Protein Sci. 2023 Jul;32(7):e4683. doi: 10.1002/pro.4683. PubMed PMID: 37209283; PubMed Central PMCID: PMC10273340.

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Zhou HL, Hausladen A, Anand P, Rajavel M, Stomberski CT, Zhang R, Premont RT, Greenlee WJ, van den Akker F, Stamler JS. Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury. J Med Chem. 2023 Apr 27;66(8):5657-5668. doi: 10.1021/acs.jmedchem.2c02089. Epub 2023 Apr 7. PubMed PMID: 37027003; PubMed Central PMCID: PMC10416317.

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Alsenani TA, Rodríguez MM, Ghiglione B, Taracila MA, Mojica MF, Rojas LJ, Hujer AM, Gutkind G, Bethel CR, Rather PN, Introvigne ML, Prati F, Caselli E, Power P, van den Akker F, Bonomo RA. Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M β-Lactamases: Biochemical and Structural Analyses. Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0093022. doi: 10.1128/aac.00930-22. Epub 2023 Jan 5. PubMed PMID: 36602311; PubMed Central PMCID: PMC9872677.

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Taracila MA, Bethel CR, Hujer AM, Papp-Wallace KM, Barnes MD, Rutter JD, VanPelt J, Shurina BA, van den Akker F, Clancy CJ, Nguyen MH, Cheng S, Shields RK, Page RC, Bonomo RA. Different Conformations Revealed by NMR Underlie Resistance to Ceftazidime/Avibactam and Susceptibility to Meropenem and Imipenem among D179Y Variants of KPC β-Lactamase. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0212421. doi: 10.1128/aac.02124-21. Epub 2022 Mar 21. PubMed PMID: 35311523; PubMed Central PMCID: PMC9017342.

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Alsenani TA, Viviani SL, Kumar V, Taracila MA, Bethel CR, Barnes MD, Papp-Wallace KM, Shields RK, Nguyen MH, Clancy CJ, Bonomo RA, van den Akker F. Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0241421. doi: 10.1128/aac.02414-21. Epub 2022 Mar 28. PubMed PMID: 35341315; PubMed Central PMCID: PMC9017313.

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Kumar V, Viviani SL, Ismail J, Agarwal S, Bonomo RA, van den Akker F. Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3. PLoS One. 2021;16(10):e0258359. doi: 10.1371/journal.pone.0258359. eCollection 2021. PubMed PMID: 34653211; PubMed Central PMCID: PMC8519428.

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Goldberg JA, Kumar V, Spencer EJ, Hoyer D, Marshall SH, Hujer AM, Hujer KM, Bethel CR, Papp-Wallace KM, Perez F, Jacobs MR, van Duin D, Kreiswirth BN, van den Akker F, Plummer MS, Bonomo RA. A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp. Eur J Med Chem. 2021 Aug 5;220:113436. doi: 10.1016/j.ejmech.2021.113436. Epub 2021 Apr 8. PubMed PMID: 33933754; PubMed Central PMCID: PMC11444265.

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Hahn MG, Lampe T, El Sheikh S, Griebenow N, Woltering E, Schlemmer KH, Dietz L, Gerisch M, Wunder F, Becker-Pelster EM, Mondritzki T, Tinel H, Knorr A, Kern A, Lang D, Hueser J, Schomber T, Benardeau A, Eitner F, Truebel H, Mittendorf J, Kumar V, van den Akker F, Schaefer M, Geiss V, Sandner P, Stasch JP. Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042). J Med Chem. 2021 May 13;64(9):5323-5344. doi: 10.1021/acs.jmedchem.0c02154. Epub 2021 Apr 19. PubMed PMID: 33872507.

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Kumar V, Mathure SA, Lee M, Boorman J, Zeng X, Lin J, Hesek D, Lastochkin E, Mobashery S, van den Akker F. Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase of Campylobacter jejuni. Biochemistry. 2021 Apr 13;60(14):1133-1144. doi: 10.1021/acs.biochem.1c00027. Epub 2021 Mar 22. PubMed PMID: 33749238; PubMed Central PMCID: PMC9067259.

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Rajavel M, Kumar V, Nguyen H, Wyatt J, Marshall SH, Papp-Wallace KM, Deshpande P, Bhavsar S, Yeole R, Bhagwat S, Patel M, Bonomo RA, van den Akker F. Structural Characterization of Diazabicyclooctane β-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa. mBio. 2021 Feb 16;12(1). doi: 10.1128/mBio.03058-20. PubMed PMID: 33593978; PubMed Central PMCID: PMC8545096.

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Goldberg JA, Nguyen H, Kumar V, Spencer EJ, Hoyer D, Marshall EK, Cmolik A, O'Shea M, Marshall SH, Hujer AM, Hujer KM, Rudin SD, Domitrovic TN, Bethel CR, Papp-Wallace KM, Logan LK, Perez F, Jacobs MR, van Duin D, Kreiswirth BM, Bonomo RA, Plummer MS, van den Akker F. A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli. J Med Chem. 2020 Jun 11;63(11):5990-6002. doi: 10.1021/acs.jmedchem.0c00255. Epub 2020 Jun 2. PubMed PMID: 32420736; PubMed Central PMCID: PMC7590959.

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Kumar V, Tang C, Bethel CR, Papp-Wallace KM, Wyatt J, Desarbre E, Bonomo RA, van den Akker F. Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3. Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.00106-20. Print 2020 Apr 21. PubMed PMID: 32152075; PubMed Central PMCID: PMC7179584.

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Mack AR, Barnes MD, Taracila MA, Hujer AM, Hujer KM, Cabot G, Feldgarden M, Haft DH, Klimke W, van den Akker F, Vila AJ, Smania A, Haider S, Papp-Wallace KM, Bradford PA, Rossolini GM, Docquier JD, Frère JM, Galleni M, Hanson ND, Oliver A, Plésiat P, Poirel L, Nordmann P, Palzkill TG, Jacoby GA, Bush K, Bonomo RA. A Standard Numbering Scheme for Class C β-Lactamases. Antimicrob Agents Chemother. 2020 Feb 21;64(3). doi: 10.1128/AAC.01841-19. Print 2020 Feb 21. PubMed PMID: 31712217; PubMed Central PMCID: PMC7038296.

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Papp-Wallace KM, Kumar V, Zeiser ET, Becka SA, van den Akker F. Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem. Antibiotics (Basel). 2019 Sep 11;8(3). doi: 10.3390/antibiotics8030145. PubMed PMID: 31514291; PubMed Central PMCID: PMC6783824.

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Mesiano SA, Peters GA, Amini P, Wilson RA, Tochtrop GP, van Den Akker F. Progestin therapy to prevent preterm birth: History and effectiveness of current strategies and development of novel approaches. Placenta. 2019 Apr;79:46-52. doi: 10.1016/j.placenta.2019.01.018. Epub 2019 Jan 28. Review. PubMed PMID: 30745115; PubMed Central PMCID: PMC6766339.

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Barnes MD, Kumar V, Bethel CR, Moussa SH, O'Donnell J, Rutter JD, Good CE, Hujer KM, Hujer AM, Marshall SH, Kreiswirth BN, Richter SS, Rather PN, Jacobs MR, Papp-Wallace KM, van den Akker F, Bonomo RA. Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. mBio. 2019 Mar 12;10(2). doi: 10.1128/mBio.00159-19. PubMed PMID: 30862744; PubMed Central PMCID: PMC6414696.

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Stomberski CT, Zhou HL, Wang L, van den Akker F, Stamler JS. Molecular recognition of S-nitrosothiol substrate by its cognate protein denitrosylase. J Biol Chem. 2019 Feb 1;294(5):1568-1578. doi: 10.1074/jbc.RA118.004947. Epub 2018 Dec 11. PubMed PMID: 30538128; PubMed Central PMCID: PMC6364788.

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Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Akdemir ZC, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA. Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet. 2018 Jun 1;27(11):1913-1926. doi: 10.1093/hmg/ddy098. PubMed PMID: 29566152; PubMed Central PMCID: PMC5961111.

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Vijayaraghavan J, Kumar V, Krishnan NP, Kaufhold RT, Zeng X, Lin J, van den Akker F. Structural studies and molecular dynamics simulations suggest a processive mechanism of exolytic lytic transglycosylase from Campylobacter jejuni. PLoS One. 2018;13(5):e0197136. doi: 10.1371/journal.pone.0197136. eCollection 2018. PubMed PMID: 29758058; PubMed Central PMCID: PMC5951611.

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Papp-Wallace KM, Nguyen NQ, Jacobs MR, Bethel CR, Barnes MD, Kumar V, Bajaksouzian S, Rudin SD, Rather PN, Bhavsar S, Ravikumar T, Deshpande PK, Patil V, Yeole R, Bhagwat SS, Patel MV, van den Akker F, Bonomo RA. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J Med Chem. 2018 May 10;61(9):4067-4086. doi: 10.1021/acs.jmedchem.8b00091. Epub 2018 Apr 20. PubMed PMID: 29627985; PubMed Central PMCID: PMC6131718.

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van den Akker F, Bonomo RA. Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches. Front Microbiol. 2018;9:622. doi: 10.3389/fmicb.2018.00622. eCollection 2018. Review. PubMed PMID: 29675000; PubMed Central PMCID: PMC5895744.

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Vijayaraghavan J, Kramp K, Harris ME, van den Akker F. Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain. FEBS Lett. 2016 Oct;590(20):3669-3680. doi: 10.1002/1873-3468.12427. Epub 2016 Oct 4. PubMed PMID: 27654641; PubMed Central PMCID: PMC5077689.

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Nguyen NQ, Krishnan NP, Rojas LJ, Prati F, Caselli E, Romagnoli C, Bonomo RA, van den Akker F. Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1760-6. doi: 10.1128/AAC.02643-15. PubMed PMID: 26729491; PubMed Central PMCID: PMC4775972.

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Krishnan NP, Nguyen NQ, Papp-Wallace KM, Bonomo RA, van den Akker F. Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study. PLoS One. 2015;10(9):e0136813. doi: 10.1371/journal.pone.0136813. eCollection 2015. PubMed PMID: 26340563; PubMed Central PMCID: PMC4560403.

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Che T, Rodkey EA, Bethel CR, Shanmugam S, Ding Z, Pusztai-Carey M, Nottingham M, Chai W, Buynak JD, Bonomo RA, van den Akker F, Carey PR. Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone. Biochemistry. 2015 Jan 27;54(3):734-43. doi: 10.1021/bi501197t. Epub 2015 Jan 8. PubMed PMID: 25536850; PubMed Central PMCID: PMC4310624.

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Rodkey EA, Winkler ML, Bethel CR, Pagadala SR, Buynak JD, Bonomo RA, van den Akker F. Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition. PLoS One. 2014;9(1):e85892. doi: 10.1371/journal.pone.0085892. eCollection 2014. PubMed PMID: 24454944; PubMed Central PMCID: PMC3894197.

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Rodkey EA, McLeod DC, Bethel CR, Smith KM, Xu Y, Chai W, Che T, Carey PR, Bonomo RA, van den Akker F, Buynak JD. β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme. J Am Chem Soc. 2013 Dec 11;135(49):18358-69. doi: 10.1021/ja403598g. Epub 2013 Dec 3. PubMed PMID: 24219313; PubMed Central PMCID: PMC4042847.

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Rekowski MVW, Kumar V, Zhou Z, Moschner J, Marazioti A, Bantzi M, Spyroulias GA, van den Akker F, Giannis A, Papapetropoulos A. Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics. J Med Chem. 2013 Nov 14;56(21):8948-8952. doi: 10.1021/jm400539d. Epub 2013 Oct 24. PubMed PMID: 24090476; PubMed Central PMCID: PMC3902542.

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Kumar V, Martin F, Hahn MG, Schaefer M, Stamler JS, Stasch JP, van den Akker F. Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous nostoc H-NOX domain complexes. Biochemistry. 2013 May 21;52(20):3601-8. doi: 10.1021/bi301657w. Epub 2013 May 7. PubMed PMID: 23614626; PubMed Central PMCID: PMC3775905.

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Winkler ML, Rodkey EA, Taracila MA, Drawz SM, Bethel CR, Papp-Wallace KM, Smith KM, Xu Y, Dwulit-Smith JR, Romagnoli C, Caselli E, Prati F, van den Akker F, Bonomo RA. Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) β-lactamase. J Med Chem. 2013 Feb 14;56(3):1084-97. doi: 10.1021/jm301490d. Epub 2013 Feb 4. PubMed PMID: 23252553; PubMed Central PMCID: PMC3943433.

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Ke W, Pattanaik P, Bethel CR, Sheri A, Buynak JD, Bonomo RA, van den Akker F. Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation. PLoS One. 2012;7(11):e49035. doi: 10.1371/journal.pone.0049035. Epub 2012 Nov 8. PubMed PMID: 23145056; PubMed Central PMCID: PMC3493512.

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Rodkey EA, Drawz SM, Sampson JM, Bethel CR, Bonomo RA, van den Akker F. Crystal structure of a preacylation complex of the β-lactamase inhibitor sulbactam bound to a sulfenamide bond-containing thiol-β-lactamase. J Am Chem Soc. 2012 Oct 10;134(40):16798-804. doi: 10.1021/ja3073676. Epub 2012 Sep 26. PubMed PMID: 22974281; PubMed Central PMCID: PMC4037319.

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Ke W, Laurent AH, Armstrong MD, Chen Y, Smith WE, Liang J, Wright CM, Ostermeier M, van den Akker F. Structure of an engineered β-lactamase maltose binding protein fusion protein: insights into heterotropic allosteric regulation. PLoS One. 2012;7(6):e39168. doi: 10.1371/journal.pone.0039168. Epub 2012 Jun 14. PubMed PMID: 22720063; PubMed Central PMCID: PMC3375305.

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Ke W, Rodkey EA, Sampson JM, Skalweit MJ, Sheri A, Pagadala SR, Nottingham MD, Buynak JD, Bonomo RA, van den Akker F. The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants. ChemMedChem. 2012 Jun;7(6):1002-8. doi: 10.1002/cmdc.201200006. Epub 2012 Mar 21. PubMed PMID: 22438274; PubMed Central PMCID: PMC3523351.

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Ke W, Bethel CR, Papp-Wallace KM, Pagadala SR, Nottingham M, Fernandez D, Buynak JD, Bonomo RA, van den Akker F. Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226. Antimicrob Agents Chemother. 2012 May;56(5):2713-8. doi: 10.1128/AAC.06099-11. Epub 2012 Feb 13. PubMed PMID: 22330909; PubMed Central PMCID: PMC3346646.

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Baskaran P, Heckler EJ, van den Akker F, Beuve A. Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity. PLoS One. 2011;6(11):e26976. doi: 10.1371/journal.pone.0026976. Epub 2011 Nov 9. PubMed PMID: 22096512; PubMed Central PMCID: PMC3212528.

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Baskaran P, Heckler EJ, van den Akker F, Beuve A. Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation. Biochemistry. 2011 May 24;50(20):4291-7. doi: 10.1021/bi2004087. Epub 2011 May 2. PubMed PMID: 21491881; PubMed Central PMCID: PMC3313552.

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Sampson JM, Ke W, Bethel CR, Pagadala SR, Nottingham MD, Bonomo RA, Buynak JD, van den Akker F. Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrob Agents Chemother. 2011 May;55(5):2303-9. doi: 10.1128/AAC.01360-10. Epub 2011 Feb 28. PubMed PMID: 21357298; PubMed Central PMCID: PMC3088229.

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Nottingham M, Bethel CR, Pagadala SR, Harry E, Pinto A, Lemons ZA, Drawz SM, Akker Fv, Carey PR, Bonomo RA, Buynak JD. Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy. Bioorg Med Chem Lett. 2011 Jan 1;21(1):387-93. doi: 10.1016/j.bmcl.2010.10.134. Epub 2010 Nov 5. PubMed PMID: 21129961; PubMed Central PMCID: PMC3167381.

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Ke W, Sampson JM, Ori C, Prati F, Drawz SM, Bethel CR, Bonomo RA, van den Akker F. Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors. Antimicrob Agents Chemother. 2011 Jan;55(1):174-83. doi: 10.1128/AAC.00930-10. Epub 2010 Nov 1. PubMed PMID: 21041505; PubMed Central PMCID: PMC3019678.

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Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD. Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase. J Am Chem Soc. 2010 Sep 29;132(38):13320-31. doi: 10.1021/ja104092z. PubMed PMID: 20822105; PubMed Central PMCID: PMC3393087.

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Tsai AL, Berka V, Martin F, Ma X, van den Akker F, Fabian M, Olson JS. Is Nostoc H-NOX a NO sensor or redox switch?. Biochemistry. 2010 Aug 10;49(31):6587-99. doi: 10.1021/bi1002234. PubMed PMID: 20572679; PubMed Central PMCID: PMC2914821.

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Martin F, Baskaran P, Ma X, Dunten PW, Schaefer M, Stasch JP, Beuve A, van den Akker F. Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase. J Biol Chem. 2010 Jul 16;285(29):22651-7. doi: 10.1074/jbc.M110.111559. Epub 2010 May 12. PubMed PMID: 20463019; PubMed Central PMCID: PMC2903410.

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Ma X, Beuve A, van den Akker F. Crystal structure of the signaling helix coiled-coil domain of the beta1 subunit of the soluble guanylyl cyclase. BMC Struct Biol. 2010 Jan 27;10:2. doi: 10.1186/1472-6807-10-2. PubMed PMID: 20105301; PubMed Central PMCID: PMC2828450.

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Pattanaik P, Fromondi L, Ng KP, He J, van den Akker F. Expression, purification, and characterization of the intra-cellular domain of the ANP receptor. Biochimie. 2009 Jul;91(7):888-93. doi: 10.1016/j.biochi.2009.04.011. Epub 2009 Apr 22. PubMed PMID: 19393286; PubMed Central PMCID: PMC2700830.

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Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA. Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone. J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27. PubMed PMID: 18955486; PubMed Central PMCID: PMC2613614.

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Ma X, Sayed N, Baskaran P, Beuve A, van den Akker F. PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure. J Biol Chem. 2008 Jan 11;283(2):1167-78. doi: 10.1074/jbc.M706218200. Epub 2007 Nov 15. PubMed PMID: 18006497; PubMed Central PMCID: PMC3010369.

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Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR. Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors. Biochemistry. 2007 Jul 24;46(29):8689-99. doi: 10.1021/bi700581q. Epub 2007 Jun 27. PubMed PMID: 17595114; NIHMSID:NIHMS258914.