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Ghosh S, Herberg S. ECM biomaterials for modeling of outflow cell biology in health and disease. Biomater Biosyst. 2024 Mar;13:100091. doi: 10.1016/j.bbiosy.2024.100091. eCollection 2024 Mar. PubMed PMID: 38528909; PubMed Central PMCID: PMC10961487.
Li H, Kuhn M, Kelly RA, Singh A, Palanivel KK, Salama I, De Ieso ML, Stamer WD, Ganapathy PS, Herberg S. Targeting YAP/TAZ mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology. Am J Physiol Cell Physiol. 2024 Feb 1;326(2):C513-C528. doi: 10.1152/ajpcell.00438.2023. Epub 2023 Dec 18. PubMed PMID: 38105758; PubMed Central PMCID: PMC11192480.
Li H, Kuhn M, Kelly RA, Singh A, Palanivel KK, Salama I, De Ieso ML, Stamer WD, Ganapathy PS, Herberg S. Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm's canal cell pathobiology. bioRxiv. 2023 Sep 9;. doi: 10.1101/2023.09.08.556840. PubMed PMID: 37781615; PubMed Central PMCID: PMC10541092.
Yoo H, Singh A, Li H, Strat AN, Bagué T, Ganapathy PS, Herberg S. Simvastatin Attenuates Glucocorticoid-Induced Human Trabecular Meshwork Cell Dysfunction via YAP/TAZ Inactivation. Curr Eye Res. 2023 Aug;48(8):736-749. doi: 10.1080/02713683.2023.2206067. Epub 2023 May 7. PubMed PMID: 37083467; PubMed Central PMCID: PMC10524554.
Li H, Singh A, Perkumas KM, Stamer WD, Ganapathy PS, Herberg S. YAP/TAZ Mediate TGFβ2-Induced Schlemm's Canal Cell Dysfunction. Invest Ophthalmol Vis Sci. 2022 Nov 1;63(12):15. doi: 10.1167/iovs.63.12.15. PubMed PMID: 36350617; PubMed Central PMCID: PMC9652721.
Li H, Henty-Ridilla JL, Bernstein AM, Ganapathy PS, Herberg S. TGFβ2 Regulates Human Trabecular Meshwork Cell Contractility via ERK and ROCK Pathways with Distinct Signaling Crosstalk Dependent on the Culture Substrate. Curr Eye Res. 2022 Aug;47(8):1165-1178. doi: 10.1080/02713683.2022.2071943. Epub 2022 May 19. PubMed PMID: 35481448; PubMed Central PMCID: PMC9782738.
Bagué T, Singh A, Ghosh R, Yoo H, Kelly C, deLong MA, Kopczynski CC, Herberg S. Effects of netarsudil-family Rho kinase inhibitors on human trabecular meshwork cell contractility and actin remodeling using a bioengineered ECM hydrogel. Front Ophthalmol. 2022 July; 2:948397. doi:
Strat AN, Kirschner A, Yoo H, Singh A, Bagué T, Li H, Herberg S, Ganapathy PS. Engineering a 3D hydrogel system to study optic nerve head astrocyte morphology and behavior. Exp Eye Res. 2022 Jul;220:109102. doi: 10.1016/j.exer.2022.109102. Epub 2022 May 5. PubMed PMID: 35525298; PubMed Central PMCID: PMC9233048.
Li H, Raghunathan V, Stamer WD, Ganapathy PS, Herberg S. Extracellular Matrix Stiffness and TGFβ2 Regulate YAP/TAZ Activity in Human Trabecular Meshwork Cells. Front Cell Dev Biol. 2022;10:844342. doi: 10.3389/fcell.2022.844342. eCollection 2022. PubMed PMID: 35300422; PubMed Central PMCID: PMC8923257.
McDowell CM, Kizhatil K, Elliott MH, Overby DR, van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WD. Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):12. doi: 10.1167/iovs.63.2.12. Review. PubMed PMID: 35129590; PubMed Central PMCID: PMC8842499.
Eisa NH, Sudharsan PT, Herrero SM, Herberg SA, Volkman BF, Aguilar-Pérez A, Kondrikov D, Elmansi AM, Reitman C, Shi X, Fulzele S, McGee-Lawrence ME, Isales CM, Hamrick MW, Johnson MH, Chen J, Hill WD. Age-associated changes in microRNAs affect the differentiation potential of human mesenchymal stem cells: Novel role of miR-29b-1-5p expression. Bone. 2021 Dec;153:116154. doi: 10.1016/j.bone.2021.116154. Epub 2021 Aug 14. PubMed PMID: 34403754; PubMed Central PMCID: PMC8935397.
Kirschner A, Strat AN, Yablonski J, Yoo H, Bagué T, Li H, Zhao J, Bollinger KE, Herberg S, Ganapathy PS. Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes. Exp Eye Res. 2021 Nov;212:108791. doi: 10.1016/j.exer.2021.108791. Epub 2021 Oct 14. PubMed PMID: 34656548; PubMed Central PMCID: PMC9192100.
Aleman J, Sivakumar H, DePalma T, Zhou Y, Mazzocchi AR, Huntwork R, Yoo K, Banks S, Clark C, Maycock A, Leaks K, Enck K, Opara E, Gatenholm P, Welker M, Soker S, Herberg S, Criswell T, Skardal A. Engineering a thixotropic and biochemically tunable hyaluronan and collagen bioink for biofabrication of multiple tissue construct types. [preprint]. 2021 September. Available from: doi: 10.1101/2021.09.01.458584.
Li H, Bagué T, Kirschner A, Strat AN, Roberts H, Weisenthal RW, Patteson AE, Annabi N, Stamer WD, Ganapathy PS, Herberg S. A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling. Exp Eye Res. 2021 Apr;205:108472. doi: 10.1016/j.exer.2021.108472. Epub 2021 Jan 29. PubMed PMID: 33516765; PubMed Central PMCID: PMC11097970.
Herberg S, Varghai D, Alt DS, Dang PN, Park H, Cheng Y, Shin JY, Dikina AD, Boerckel JD, Rolle MW, Alsberg E. Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration. Commun Biol. 2021 Jan 19;4(1):89. doi: 10.1038/s42003-020-01576-y. PubMed PMID: 33469154; PubMed Central PMCID: PMC7815708.
Devarasetty M, Dominijanni A, Herberg S, Shelkey E, Skardal A, Soker S. Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo. Sci Rep. 2020 Jun 17;10(1):9832. doi: 10.1038/s41598-020-66785-1. PubMed PMID: 32555362; PubMed Central PMCID: PMC7300090.
Aleman J, George SK, Herberg S, Devarasetty M, Porada CD, Skardal A, Almeida-Porada G. Deconstructed Microfluidic Bone Marrow On-A-Chip to Study Normal and Malignant Hemopoietic Cell-Niche Interactions. Small. 2019 Oct;15(43):e1902971. doi: 10.1002/smll.201902971. Epub 2019 Aug 29. PubMed PMID: 31464364; PubMed Central PMCID: PMC8011350.
Herberg S, McDermott AM, Dang PN, Alt DS, Tang R, Dawahare JH, Varghai D, Shin JY, McMillan A, Dikina AD, He F, Lee YB, Cheng Y, Umemori K, Wong PC, Park H, Boerckel JD, Alsberg E. Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair. Sci Adv. 2019 Aug;5(8):eaax2476. doi: 10.1126/sciadv.aax2476. eCollection 2019 Aug. PubMed PMID: 31489377; PubMed Central PMCID: PMC6713501.
McDermott AM, Herberg S, Mason DE, Collins JM, Pearson HB, Dawahare JH, Tang R, Patwa AN, Grinstaff MW, Kelly DJ, Alsberg E, Boerckel JD. Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration. Sci Transl Med. 2019 Jun 5;11(495). doi: 10.1126/scitranslmed.aav7756. PubMed PMID: 31167930; PubMed Central PMCID: PMC6959418.
Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD. What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands. Pharmacol Ther. 2019 Jun;198:90-108. doi: 10.1016/j.pharmthera.2019.02.005. Epub 2019 Feb 10. Review. PubMed PMID: 30759373; PubMed Central PMCID: PMC7883480.
Mazzocchi A, Devarasetty M, Herberg S, Petty WJ, Marini F, Miller L, Kucera G, Dukes DK, Ruiz J, Skardal A, Soker S. Pleural Effusion Aspirate for use in 3D Lung Cancer Modeling and Chemotherapy Screening. ACS Biomater Sci Eng. 2019 Apr 8;5(4):1937-1943. doi: 10.1021/acsbiomaterials.8b01356. Epub 2019 Mar 8. PubMed PMID: 31723594; PubMed Central PMCID: PMC6853614.
Howie RN, Herberg S, Durham E, Grey Z, Bennfors G, Elsalanty M, LaRue AC, Hill WD, Cray JJ. Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model. Int J Oral Sci. 2018 Sep 3;10(3):25. doi: 10.1038/s41368-018-0026-x. PubMed PMID: 30174329; PubMed Central PMCID: PMC6119683.
Nguyen MK, Jeon O, Dang PN, Huynh CT, Varghai D, Riazi H, McMillan A, Herberg S, Alsberg E. RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects. Acta Biomater. 2018 Jul 15;75:105-114. doi: 10.1016/j.actbio.2018.06.007. Epub 2018 Jun 7. PubMed PMID: 29885529; PubMed Central PMCID: PMC6119505.
Dikina AD, Alt DS, Herberg S, McMillan A, Strobel HA, Zheng Z, Cao M, Lai BP, Jeon O, Petsinger VI, Cotton CU, Rolle MW, Alsberg E. A Modular Strategy to Engineer Complex Tissues and Organs. Adv Sci (Weinh). 2018 May;5(5):1700402. doi: 10.1002/advs.201700402. eCollection 2018 May. PubMed PMID: 29876200; PubMed Central PMCID: PMC5978945.
Herberg S, Varghai D, Cheng Y, Dikina AD, Dang PN, Rolle MW, Alsberg E. High-density human mesenchymal stem cell rings with spatiotemporally-controlled morphogen presentation as building blocks for engineering bone diaphyseal tissue. Nanotheranostics. 2018;2(2):128-143. doi: 10.7150/ntno.23354. eCollection 2018. PubMed PMID: 29577017; PubMed Central PMCID: PMC5865267.
Dang PN, Herberg S, Varghai D, Riazi H, Varghai D, McMillan A, Awadallah A, Phillips LM, Jeon O, Nguyen MK, Dwivedi N, Yu X, Murphy WL, Alsberg E. Endochondral Ossification in Critical-Sized Bone Defects via Readily Implantable Scaffold-Free Stem Cell Constructs. Stem Cells Transl Med. 2017 Jul;6(7):1644-1659. doi: 10.1002/sctm.16-0222. Epub 2017 Jun 8. PubMed PMID: 28661587; PubMed Central PMCID: PMC5689752.
Herberg S, Aguilar-Perez A, Howie RN, Kondrikova G, Periyasamy-Thandavan S, Elsalanty ME, Shi X, Hill WD, Cray JJ. Mesenchymal stem cell expression of SDF-1β synergizes with BMP-2 to augment cell-mediated healing of critical-sized mouse calvarial defects. J Tissue Eng Regen Med. 2017 Jun;11(6):1806-1819. doi: 10.1002/term.2078. Epub 2015 Jul 31. PubMed PMID: 26227988; PubMed Central PMCID: PMC4733586.
Dang PN, Dwivedi N, Phillips LM, Yu X, Herberg S, Bowerman C, Solorio LD, Murphy WL, Alsberg E. Controlled Dual Growth Factor Delivery From Microparticles Incorporated Within Human Bone Marrow-Derived Mesenchymal Stem Cell Aggregates for Enhanced Bone Tissue Engineering via Endochondral Ossification. Stem Cells Transl Med. 2016 Feb;5(2):206-17. doi: 10.5966/sctm.2015-0115. Epub 2015 Dec 23. PubMed PMID: 26702127; PubMed Central PMCID: PMC4729553.
Hamrick MW, Dukes A, Arounleut P, Davis C, Periyasamy-Thandavan S, Mork S, Herberg S, Johnson MH, Isales CM, Hill WD, Otvos L Jr, Belin de Chantemèle EJ. The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice. Exp Gerontol. 2015 Oct;70:92-6. doi: 10.1016/j.exger.2015.07.014. Epub 2015 Jul 26. PubMed PMID: 26220769; PubMed Central PMCID: PMC4600673.
Periyasamy-Thandavan S, Herberg S, Arounleut P, Upadhyay S, Dukes A, Davis C, Johnson M, McGee-Lawrence M, Hamrick MW, Isales CM, Hill WD. Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells. Mol Cell Endocrinol. 2015 Jul 15;410:64-72. doi: 10.1016/j.mce.2015.03.001. Epub 2015 Mar 14. PubMed PMID: 25779533; PubMed Central PMCID: PMC4706462.
Herberg S, Kondrikova G, Hussein KA, Johnson MH, Elsalanty ME, Shi X, Hamrick MW, Isales CM, Hill WD. Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy. J Orthop Res. 2015 Feb;33(2):174-84. doi: 10.1002/jor.22749. Epub 2014 Oct 28. PubMed PMID: 25351363; PubMed Central PMCID: PMC4706461.
Herberg S, Kondrikova G, Hussein KA, Periyasamy-Thandavan S, Johnson MH, Elsalanty ME, Shi X, Hamrick MW, Isales CM, Hill WD. Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation. Tissue Eng Part A. 2014 Dec;20(23-24):3212-27. doi: 10.1089/ten.TEA.2013.0663. PubMed PMID: 24914464; PubMed Central PMCID: PMC4259199.
Herberg S, Kondrikova G, Periyasamy-Thandavan S, Howie RN, Elsalanty ME, Weiss L, Campbell P, Hill WD, Cray JJ. Inkjet-based biopatterning of SDF-1β augments BMP-2-induced repair of critical size calvarial bone defects in mice. Bone. 2014 Oct;67:95-103. doi: 10.1016/j.bone.2014.07.007. Epub 2014 Jul 10. PubMed PMID: 25016095; PubMed Central PMCID: PMC4149833.
Herberg S, Susin C, Pelaez M, Howie RN, Moreno de Freitas R, Lee J, Cray JJ Jr, Johnson MH, Elsalanty ME, Hamrick MW, Isales CM, Wikesjö UM, Hill WD. Low-dose bone morphogenetic protein-2/stromal cell-derived factor-1β cotherapy induces bone regeneration in critical-size rat calvarial defects. Tissue Eng Part A. 2014 May;20(9-10):1444-53. doi: 10.1089/ten.TEA.2013.0442. Epub 2014 Feb 19. PubMed PMID: 24341891; PubMed Central PMCID: PMC4012411.
Herberg S, Shi X, Johnson MH, Hamrick MW, Isales CM, Hill WD. Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells. PLoS One. 2013;8(3):e58207. doi: 10.1371/journal.pone.0058207. Epub 2013 Mar 5. PubMed PMID: 23472159; PubMed Central PMCID: PMC3589360.
Bowser M, Herberg S, Arounleut P, Shi X, Fulzele S, Hill WD, Isales CM, Hamrick MW. Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells. Exp Gerontol. 2013 Feb;48(2):290-7. doi: 10.1016/j.exger.2012.11.004. Epub 2012 Nov 21. PubMed PMID: 23178301; PubMed Central PMCID: PMC3678732.
Herberg S, Fulzele S, Yang N, Shi X, Hess M, Periyasamy-Thandavan S, Hamrick MW, Isales CM, Hill WD. Stromal cell-derived factor-1β potentiates bone morphogenetic protein-2-stimulated osteoinduction of genetically engineered bone marrow-derived mesenchymal stem cells in vitro. Tissue Eng Part A. 2013 Jan;19(1-2):1-13. doi: 10.1089/ten.TEA.2012.0085. Epub 2012 Aug 21. PubMed PMID: 22779446; PubMed Central PMCID: PMC3530941.
Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, Johnson MH, Hill WD, Ergul A, Fagan SC, Hess DC. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012 Oct;43(10):2794-9. doi: 10.1161/STROKEAHA.112.660373. Epub 2012 Aug 21. PubMed PMID: 22910893; PubMed Central PMCID: PMC3740528.
Herberg S, Hill WD. Two birds with one bone ?. IBMS boneKEy. 2012 July; 9, Article number: 115. doi: 10.1038/bonekey.2012.115.
Hamrick MW, Herberg S, Arounleut P, He HZ, Shiver A, Qi RQ, Zhou L, Isales CM, Mi QS. The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice. Biochem Biophys Res Commun. 2010 Sep 24;400(3):379-83. doi: 10.1016/j.bbrc.2010.08.079. Epub 2010 Aug 26. PubMed PMID: 20800581; PubMed Central PMCID: PMC3740337.
Fulzele S, Arounleut P, Cain M, Herberg S, Hunter M, Wenger K, Hamrick MW. Role of myostatin (GDF-8) signaling in the human anterior cruciate ligament. J Orthop Res. 2010 Aug;28(8):1113-8. doi: 10.1002/jor.21112. PubMed PMID: 20186835; PubMed Central PMCID: PMC3755889.
Kirkpatrick B, Nguyen L, Kondrikova G, Herberg S, Hill WD. Stability of human stromal-derived factor-1alpha (CXCL12alpha) after blood sampling. Ann Clin Lab Sci. 2010 Summer;40(3):257-60. PubMed PMID: 20689138.
Kwon DH, Bennett W, Herberg S, Bastone P, Pippig S, Rodriguez NA, Susin C, Wikesjö UM. Evaluation of an injectable rhGDF-5/PLGA construct for minimally invasive periodontal regenerative procedures: a histological study in the dog. J Clin Periodontol. 2010 Apr;37(4):390-7. doi: 10.1111/j.1600-051X.2010.01546.x. PubMed PMID: 20447263.
Herberg S, Siedler M, Pippig S, Schuetz A, Dony C, Kim CK, Wikesjö UM. Development of an injectable composite as a carrier for growth factor-enhanced periodontal regeneration. J Clin Periodontol. 2008 Nov;35(11):976-84. doi: 10.1111/j.1600-051X.2008.01323.x. PubMed PMID: 18976394.
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