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Takahashi A, Aleyasin H, Stavarache MA, Li L, Cathomas F, Parise LF, Lin HY, Burnett CJ, Aubry A, Flanigan ME, Brancato A, Menard C, Pfau ML, Kana V, Wang J, Hodes GE, Sasaki T, Kaplitt MG, Ogawa S, McEwen BS, Russo SJ. Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression. Mol Psychiatry. 2021 Apr 30;. doi: 10.1038/s41380-021-01110-4. [Epub ahead of print] PubMed PMID: 33931727.
Menard C, Siddiqui TJ, Sargin D, Lawson A, De Koninck Y, Illes J. The Canadian Brain Research Strategy: A Focus on Early Career Researchers. Can J Neurol Sci. 2021 Apr 27;:1-10. doi: 10.1017/cjn.2021.81. [Epub ahead of print] PubMed PMID: 33902769.
Dion-Albert L, Cadoret A, Doney E, Kaufmann FN, Dudek KA, Parise LF, Cathomas F, Samba N, Hudson N, Lebel M, Consortium S, Campbell M, Turecki G, Mechawar N, Menard C. Sex-specific blood-brain barrier alterations and vascular biomarkers underlie chronic stress responses in mice and human depression. bioRxiv : the preprint server for biology. 2021 April. doi: https://doi.org/10.1101/2021.04.23.441142.
Doney E, Cadoret A, Dion-Albert L, Lebel M, Menard C. Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders. Eur J Neurosci. 2021 Apr 20;. doi: 10.1111/ejn.15239. [Epub ahead of print] Review. PubMed PMID: 33876886.
Dudek KA, Dion-Albert L, Kaufmann FN, Tuck E, Lebel M, Menard C. Neurobiology of resilience in depression: immune and vascular insights from human and animal studies. Eur J Neurosci. 2021 Jan;53(1):183-221. doi: 10.1111/ejn.14547. Epub 2019 Sep 13. Review. PubMed PMID: 31421056; PubMed Central PMCID: PMC7891571.
Dudek KA, Kaufmann FN, Lavoie O, Menard C. Central and peripheral stress-induced epigenetic mechanisms of resilience. Curr Opin Psychiatry. 2021 Jan;34(1):1-9. doi: 10.1097/YCO.0000000000000664. PubMed PMID: 33141775.
Heshmati M, Christoffel DJ, LeClair K, Cathomas F, Golden SA, Aleyasin H, Turecki G, Friedman AK, Han MH, Menard C, Russo SJ. Depression and Social Defeat Stress Are Associated with Inhibitory Synaptic Changes in the Nucleus Accumbens. J Neurosci. 2020 Aug 5;40(32):6228-6233. doi: 10.1523/JNEUROSCI.2568-19.2020. Epub 2020 Jun 19. PubMed PMID: 32561672; PubMed Central PMCID: PMC7406280.
Guevara CA, Matikainen-Ankney BA, Kezunovic N, LeClair K, Conway AP, Menard C, Flanigan ME, Pfau M, Russo SJ, Benson DL, Huntley GW. LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress. J Neurophysiol. 2020 Jun 1;123(6):2382-2389. doi: 10.1152/jn.00137.2020. Epub 2020 May 6. PubMed PMID: 32374202; PubMed Central PMCID: PMC7311730.
Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Durand-de Cuttoli R, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ. Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. Nat Neurosci. 2020 May;23(5):638-650. doi: 10.1038/s41593-020-0617-7. Epub 2020 Apr 13. PubMed PMID: 32284606; PubMed Central PMCID: PMC7195257.
Dudek KA, Dion-Albert L, Lebel M, LeClair K, Labrecque S, Tuck E, Ferrer Perez C, Golden SA, Tamminga C, Turecki G, Mechawar N, Russo SJ, Menard C. Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression. Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3326-3336. doi: 10.1073/pnas.1914655117. Epub 2020 Jan 23. PubMed PMID: 31974313; PubMed Central PMCID: PMC7022213.
Pfau ML, Menard C, Cathomas F, Desland F, Kana V, Chan KL, Shimo Y, LeClair K, Flanigan ME, Aleyasin H, Walker DM, Bouchard S, Mack M, Hodes GE, Merad MM, Russo SJ. Role of Monocyte-Derived MicroRNA106b∼25 in Resilience to Social Stress. Biol Psychiatry. 2019 Sep 15;86(6):474-482. doi: 10.1016/j.biopsych.2019.02.023. Epub 2019 Mar 29. PubMed PMID: 31101319; PubMed Central PMCID: PMC6717005.
Nasca C, Menard C, Hodes G, Bigio B, Pena C, Lorsch Z, Zelli D, Ferris A, Kana V, Purushothaman I, Dobbin J, Nassim M, DeAngelis P, Merad M, Rasgon N, Meaney M, Nestler EJ, McEwen BS, Russo SJ. Multidimensional Predictors of Susceptibility and Resilience to Social Defeat Stress. Biol Psychiatry. 2019 Sep 15;86(6):483-491. doi: 10.1016/j.biopsych.2019.06.030. Epub 2019 Jul 29. PubMed PMID: 31466563; PubMed Central PMCID: PMC6730655.
Kaufmann FN, Menard C. Inflamed Astrocytes: A Path to Depression Led by Menin. Neuron. 2018 Nov 7;100(3):511-513. doi: 10.1016/j.neuron.2018.10.039. PubMed PMID: 30408435.
Matikainen-Ankney BA, Kezunovic N, Menard C, Flanigan ME, Zhong Y, Russo SJ, Benson DL, Huntley GW. Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood. J Neurosci. 2018 Nov 7;38(45):9700-9711. doi: 10.1523/JNEUROSCI.1457-18.2018. Epub 2018 Sep 24. PubMed PMID: 30249796; PubMed Central PMCID: PMC6222060.
Menard C, Russo SJ. Non-invasive chemogenetics. Nat Biomed Eng. 2018 Jul;2(7):467-468. doi: 10.1038/s41551-018-0269-z. PubMed PMID: 30948827.
Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR. VGF function in depression and antidepressant efficacy. Mol Psychiatry. 2018 Jul;23(7):1632-1642. doi: 10.1038/mp.2017.233. Epub 2017 Nov 21. PubMed PMID: 29158577; PubMed Central PMCID: PMC5962361.
Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ. Cell-Type-Specific Role of ΔFosB in Nucleus Accumbens In Modulating Intermale Aggression. J Neurosci. 2018 Jun 27;38(26):5913-5924. doi: 10.1523/JNEUROSCI.0296-18.2018. Epub 2018 Jun 11. PubMed PMID: 29891732; PubMed Central PMCID: PMC6021989.
Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kasarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ. Corrigendum: Sex-specific transcriptional signatures in human depression. Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525d. PubMed PMID: 29634684.
Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J. The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline. Curr Biol. 2018 Apr 2;28(7):1079-1089.e4. doi: 10.1016/j.cub.2018.02.047. Epub 2018 Mar 22. PubMed PMID: 29576474; PubMed Central PMCID: PMC5901906.
Wang J, Hodes GE, Zhang H, Zhang S, Zhao W, Golden SA, Bi W, Menard C, Kana V, Leboeuf M, Xie M, Bregman D, Pfau ML, Flanigan ME, Esteban-Fernández A, Yemul S, Sharma A, Ho L, Dixon R, Merad M, Han MH, Russo SJ, Pasinetti GM. Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nat Commun. 2018 Feb 2;9(1):477. doi: 10.1038/s41467-017-02794-5. PubMed PMID: 29396460; PubMed Central PMCID: PMC5797143.
Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Hodes GE, Lepack AE, Bicks LK, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ. Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1111-1116. doi: 10.1073/pnas.1719014115. Epub 2018 Jan 16. PubMed PMID: 29339486; PubMed Central PMCID: PMC5798379.
Pfau ML, Ménard C, Russo SJ. Inflammatory Mediators in Mood Disorders: Therapeutic Opportunities. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:411-428. doi: 10.1146/annurev-pharmtox-010617-052823. Epub 2017 Oct 6. Review. PubMed PMID: 28992428; PubMed Central PMCID: PMC5826556.
Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonté B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY, Merad M, Russo SJ. Social stress induces neurovascular pathology promoting depression. Nat Neurosci. 2017 Dec;20(12):1752-1760. doi: 10.1038/s41593-017-0010-3. Epub 2017 Nov 13. PubMed PMID: 29184215; PubMed Central PMCID: PMC5726568.
Takahashi A, Chung JR, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ. Establishment of a repeated social defeat stress model in female mice. Sci Rep. 2017 Oct 9;7(1):12838. doi: 10.1038/s41598-017-12811-8. PubMed PMID: 28993631; PubMed Central PMCID: PMC5634448.
Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill M, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ. Sex-specific transcriptional signatures in human depression. Nat Med. 2017 Sep;23(9):1102-1111. doi: 10.1038/nm.4386. Epub 2017 Aug 21. PubMed PMID: 28825715; PubMed Central PMCID: PMC5734943.
Brancato A, Bregman D, Ahn HF, Pfau ML, Menard C, Cannizzaro C, Russo SJ, Hodes GE. Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens. Neuroscience. 2017 May 14;350:180-189. doi: 10.1016/j.neuroscience.2017.03.014. Epub 2017 Mar 18. PubMed PMID: 28323008; PubMed Central PMCID: PMC5427664.
Ménard C, Pfau ML, Hodes GE, Russo SJ. Immune and Neuroendocrine Mechanisms of Stress Vulnerability and Resilience. Neuropsychopharmacology. 2017 Jan;42(1):62-80. doi: 10.1038/npp.2016.90. Epub 2016 Jun 13. Review. PubMed PMID: 27291462; PubMed Central PMCID: PMC5143517.
Pfau ML, Purushothaman I, Feng J, Golden SA, Aleyasin H, Lorsch ZS, Cates HM, Flanigan ME, Menard C, Heshmati M, Wang Z, Ma'ayan A, Shen L, Hodes GE, Russo SJ. Integrative Analysis of Sex-Specific microRNA Networks Following Stress in Mouse Nucleus Accumbens. Front Mol Neurosci. 2016;9:144. doi: 10.3389/fnmol.2016.00144. eCollection 2016. PubMed PMID: 28066174; PubMed Central PMCID: PMC5179560.
Hodes GE, Ménard C, Russo SJ. Integrating Interleukin-6 into depression diagnosis and treatment. Neurobiol Stress. 2016 Oct;4:15-22. doi: 10.1016/j.ynstr.2016.03.003. eCollection 2016 Oct. Review. PubMed PMID: 27981186; PubMed Central PMCID: PMC5146277.
Golden SA, Heshmati M, Flanigan M, Christoffel DJ, Guise K, Pfau ML, Aleyasin H, Menard C, Zhang H, Hodes GE, Bregman D, Khibnik L, Tai J, Rebusi N, Krawitz B, Chaudhury D, Walsh JJ, Han MH, Shapiro ML, Russo SJ. Basal forebrain projections to the lateral habenula modulate aggression reward. Nature. 2016 Jun 30;534(7609):688-92. doi: 10.1038/nature18601. PubMed PMID: 27357796; PubMed Central PMCID: PMC4930107.
Ménard C, Hodes GE, Russo SJ. Pathogenesis of depression: Insights from human and rodent studies. Neuroscience. 2016 May 3;321:138-162. doi: 10.1016/j.neuroscience.2015.05.053. Epub 2015 May 30. Review. PubMed PMID: 26037806; PubMed Central PMCID: PMC4664582.
Hodes GE, Pfau ML, Purushothaman I, Ahn HF, Golden SA, Christoffel DJ, Magida J, Brancato A, Takahashi A, Flanigan ME, Ménard C, Aleyasin H, Koo JW, Lorsch ZS, Feng J, Heshmati M, Wang M, Turecki G, Neve R, Zhang B, Shen L, Nestler EJ, Russo SJ. Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress. J Neurosci. 2015 Dec 16;35(50):16362-76. doi: 10.1523/JNEUROSCI.1392-15.2015. PubMed PMID: 26674863; PubMed Central PMCID: PMC4679819.
Hodes GE, Kana V, Menard C, Merad M, Russo SJ. Neuroimmune mechanisms of depression. Nat Neurosci. 2015 Oct;18(10):1386-93. doi: 10.1038/nn.4113. Epub 2015 Sep 25. Review. PubMed PMID: 26404713; PubMed Central PMCID: PMC4843114.
Bastianetto S, Ménard C, Quirion R. Neuroprotective action of resveratrol. Biochim Biophys Acta. 2015 Jun;1852(6):1195-201. doi: 10.1016/j.bbadis.2014.09.011. Epub 2014 Oct 2. Review. PubMed PMID: 25281824.
Ménard C, Quirion R, Vigneault E, Bouchard S, Ferland G, El Mestikawy S, Gaudreau P. Glutamate presynaptic vesicular transporter and postsynaptic receptor levels correlate with spatial memory status in aging rat models. Neurobiol Aging. 2015 Mar;36(3):1471-82. doi: 10.1016/j.neurobiolaging.2014.11.013. Epub 2014 Nov 26. PubMed PMID: 25556161.
Ménard C, Gaudreau P, Quirion R. Signaling pathways relevant to cognition-enhancing drug targets. Handb Exp Pharmacol. 2015;228:59-98. doi: 10.1007/978-3-319-16522-6_3. Review. PubMed PMID: 25977080.
Ménard C, Quirion R, Bouchard S, Ferland G, Gaudreau P. Glutamatergic signaling and low prodynorphin expression are associated with intact memory and reduced anxiety in rat models of healthy aging. Front Aging Neurosci. 2014;6:81. doi: 10.3389/fnagi.2014.00081. eCollection 2014. PubMed PMID: 24847259; PubMed Central PMCID: PMC4019859.
Ménard C, Herzog H, Schwarzer C, Quirion R. Possible role of dynorphins in Alzheimer's disease and age-related cognitive deficits. Neurodegener Dis. 2014;13(2-3):82-5. doi: 10.1159/000353848. Epub 2013 Aug 22. PubMed PMID: 23970097.
Menard C, Bastianetto S, Quirion R. Neuroprotective effects of resveratrol and epigallocatechin gallate polyphenols are mediated by the activation of protein kinase C gamma. Front Cell Neurosci. 2013;7:281. doi: 10.3389/fncel.2013.00281. eCollection 2013. PubMed PMID: 24421757; PubMed Central PMCID: PMC3872731.
Farso M, Ménard C, Colby-Milley J, Quirion R. Immune marker CD68 correlates with cognitive impairment in normally aged rats. Neurobiol Aging. 2013 Aug;34(8):1971-6. doi: 10.1016/j.neurobiolaging.2013.02.008. Epub 2013 Mar 21. PubMed PMID: 23523271.
Ménard C, Tse YC, Cavanagh C, Chabot JG, Herzog H, Schwarzer C, Wong TP, Quirion R. Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging. J Neurosci. 2013 Jul 31;33(31):12792-804. doi: 10.1523/JNEUROSCI.0290-13.2013. PubMed PMID: 23904614; PubMed Central PMCID: PMC6618545.
Morales-Medina JC, Juarez I, Venancio-García E, Cabrera SN, Menard C, Yu W, Flores G, Mechawar N, Quirion R. Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat. Neuroscience. 2013 Apr 16;236:233-43. doi: 10.1016/j.neuroscience.2013.01.037. Epub 2013 Jan 26. PubMed PMID: 23357118.
Ménard C, Quirion R. Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brain. Front Pharmacol. 2012;3:182. doi: 10.3389/fphar.2012.00182. eCollection 2012. PubMed PMID: 23091460; PubMed Central PMCID: PMC3469824.
Ménard C, Quirion R. Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways. PLoS One. 2012;7(1):e28666. doi: 10.1371/journal.pone.0028666. Epub 2012 Jan 6. PubMed PMID: 22238580; PubMed Central PMCID: PMC3253083.
Benoit CE, Rowe WB, Menard C, Sarret P, Quirion R. Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory. Trends Pharmacol Sci. 2011 Jan;32(1):43-52. doi: 10.1016/j.tips.2010.10.002. Epub 2010 Dec 2. Review. PubMed PMID: 21129790.
Ménard C, Patenaude C, Gagné AM, Massicotte G. AMPA receptor-mediated cell death is reduced by docosahexaenoic acid but not by eicosapentaenoic acid in area CA1 of hippocampal slice cultures. J Neurosci Res. 2009 Mar;87(4):876-86. doi: 10.1002/jnr.21916. PubMed PMID: 18951489.
Ménard C, Chartier E, Patenaude C, Robinson P, Cyr M, Baudry M, Massicotte G. Calcium-independent phospholipase A(2) influences AMPA-mediated toxicity of hippocampal slices by regulating the GluR1 subunit in synaptic membranes. Hippocampus. 2007;17(11):1109-20. doi: 10.1002/hipo.20343. PubMed PMID: 17696174.
Martel MA, Patenaude C, Ménard C, Alaux S, Cummings BS, Massicotte G. A novel role for calcium-independent phospholipase A in alpha-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation. Eur J Neurosci. 2006 Jan;23(2):505-13. doi: 10.1111/j.1460-9568.2005.04565.x. PubMed PMID: 16420457.
Ménard C, Patenaude C, Massicotte G. Phosphorylation of AMPA receptor subunits is differentially regulated by phospholipase A2 inhibitors. Neurosci Lett. 2005 Nov 25;389(1):51-6. doi: 10.1016/j.neulet.2005.07.012. PubMed PMID: 16099093.
Ménard C, Valastro B, Martel MA, Chartier E, Marineau A, Baudry M, Massicotte G. AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A(2) and 5-lipoxygenase activities. Hippocampus. 2005;15(3):370-80. doi: 10.1002/hipo.20061. PubMed PMID: 15630695.
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