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Nicotinamide N-methyltransferase expression decreases in iron overload exacerbating toxicity in mouse hepatocytes. Hepatology communications. NIHMSID: NIHMS898053.
Garman RD, Ko JL, Vulpe CD, Raulet DH. T-cell receptor variable region gene usage in T-cell populations. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3987-91. doi: 10.1073/pnas.83.11.3987. PubMed PMID: 3487085; PubMed Central PMCID: PMC323650.
Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Nat Genet. 1993 Jan;3(1):7-13. doi: 10.1038/ng0193-7. PubMed PMID: 8490659.
Levinson B, Gitschier J, Vulpe C, Whitney S, Yang S, Packman S. Are X-linked cutis laxa and Menkes disease allelic?. Nat Genet. 1993 Jan;3(1):6. doi: 10.1038/ng0193-6. PubMed PMID: 8490656.
Levinson B, Vulpe C, Elder B, Martin C, Verley F, Packman S, Gitschier J. The mottled gene is the mouse homologue of the Menkes disease gene. Nat Genet. 1994 Apr;6(4):369-73. doi: 10.1038/ng0494-369. PubMed PMID: 8054976.
Das S, Levinson B, Whitney S, Vulpe C, Packman S, Gitschier J. Diverse mutations in patients with Menkes disease often lead to exon skipping. Am J Hum Genet. 1994 Nov;55(5):883-9. PubMed PMID: 7977350; PubMed Central PMCID: PMC1918324.
Vulpe CD, Packman S. Cellular copper transport. Annu Rev Nutr. 1995;15:293-322. doi: 10.1146/annurev.nu.15.070195.001453. Review. PubMed PMID: 8527222.
Das S, Whitney S, Taylor J, Chen E, Levinson B, Vulpe C, Gitschier J, Packman S. Prenatal diagnosis of Menkes disease by mutation analysis. J Inherit Metab Dis. 1995;18(3):364-5. doi: 10.1007/bf00710435. PubMed PMID: 7474910.
Das S, Levinson B, Vulpe C, Whitney S, Gitschier J, Packman S. Similar splicing mutations of the Menkes/mottled copper-transporting ATPase gene in occipital horn syndrome and the blotchy mouse. Am J Hum Genet. 1995 Mar;56(3):570-6. PubMed PMID: 7887410; PubMed Central PMCID: PMC1801180.
Solioz M, Vulpe C. CPx-type ATPases: a class of P-type ATPases that pump heavy metals. Trends Biochem Sci. 1996 Jul;21(7):237-41. PubMed PMID: 8755241.
Vulpe C, Gitschier J. Ironing out anaemia. Nat Genet. 1997 Aug;16(4):319-20. doi: 10.1038/ng0897-319. PubMed PMID: 9241259.
Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet. 1999 Feb;21(2):195-9. doi: 10.1038/5979. PubMed PMID: 9988272.
Frazer DM, Vulpe CD, McKie AT, Wilkins SJ, Trinder D, Cleghorn GJ, Anderson GJ. Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Am J Physiol Gastrointest Liver Physiol. 2001 Oct;281(4):G931-9. doi: 10.1152/ajpgi.2001.281.4.G931. PubMed PMID: 11557513.
Anderson GJ, Frazer DM, McKie AT, Wilkins SJ, Vulpe CD. The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine. Cell Biochem Biophys. 2002;36(2-3):137-46. doi: 10.1385/CBB:36:2-3:137. Review. PubMed PMID: 12139399.
Méndez MA, Hödar C, Vulpe C, González M, Cambiazo V. Discriminant analysis to evaluate clustering of gene expression data. FEBS Lett. 2002 Jul 3;522(1-3):24-8. doi: 10.1016/s0014-5793(02)02873-9. PubMed PMID: 12095613.
Wintz H, Vulpe C. Plant copper chaperones. Biochem Soc Trans. 2002 Aug;30(4):732-5. doi: 10.1042/bst0300732. PubMed PMID: 12196180.
Anderson GJ, Frazer DM, Wilkins SJ, Becker EM, Millard KN, Murphy TL, McKie AT, Vulpe CD. Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. Biochem Soc Trans. 2002 Aug;30(4):724-6. doi: 10.1042/bst0300724. PubMed PMID: 12196177.
Wintz H, Fox T, Vulpe C. Responses of plants to iron, zinc and copper deficiencies. Biochem Soc Trans. 2002 Aug;30(4):766-8. doi: 10.1042/bst0300766. PubMed PMID: 12196190.
McKie AT, Latunde-Dada GO, Miret S, McGregor JA, Anderson GJ, Vulpe CD, Wrigglesworth JM, Simpson RJ. Molecular evidence for the role of a ferric reductase in iron transport. Biochem Soc Trans. 2002 Aug;30(4):722-4. doi: 10.1042/bst0300722. PubMed PMID: 12196176.
Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002 Sep;123(3):835-44. doi: 10.1053/gast.2002.35353. PubMed PMID: 12198710.
Latunde-Dada GO, Van der Westhuizen J, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT. Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism. Blood Cells Mol Dis. 2002 Nov-Dec;29(3):356-60. doi: 10.1006/bcmd.2002.0574. PubMed PMID: 12547225.
Anderson GJ, Frazer DM, McKie AT, Vulpe CD. The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption. Blood Cells Mol Dis. 2002 Nov-Dec;29(3):367-75. doi: 10.1006/bcmd.2002.0576. Review. PubMed PMID: 12547227.
De Freitas J, Wintz H, Kim JH, Poynton H, Fox T, Vulpe C. Yeast, a model organism for iron and copper metabolism studies. Biometals. 2003 Mar;16(1):185-97. doi: 10.1023/a:1020771000746. Review. PubMed PMID: 12572678.
Frazer DM, Wilkins SJ, Becker EM, Murphy TL, Vulpe CD, McKie AT, Anderson GJ. A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption. Gut. 2003 Mar;52(3):340-6. doi: 10.1136/gut.52.3.340. PubMed PMID: 12584213; PubMed Central PMCID: PMC1773562.
Chen H, Su T, Attieh ZK, Fox TC, McKie AT, Anderson GJ, Vulpe CD. Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency. Blood. 2003 Sep 1;102(5):1893-9. doi: 10.1182/blood-2003-02-0347. Epub 2003 May 1. PubMed PMID: 12730111.
Beutler E, Barton JC, Felitti VJ, Gelbart T, West C, Lee PL, Waalen J, Vulpe C. Ferroportin 1 (SCL40A1) variant associated with iron overload in African-Americans. Blood Cells Mol Dis. 2003 Nov-Dec;31(3):305-9. doi: 10.1016/s1079-9796(03)00165-7. PubMed PMID: 14636643.
Li L, Vulpe CD, Kaplan J. Functional studies of hephaestin in yeast: evidence for multicopper oxidase activity in the endocytic pathway. Biochem J. 2003 Nov 1;375(Pt 3):793-8. doi: 10.1042/BJ20030866. PubMed PMID: 12921533; PubMed Central PMCID: PMC1223732.
Wintz H, Fox T, Wu YY, Feng V, Chen W, Chang HS, Zhu T, Vulpe C. Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis. J Biol Chem. 2003 Nov 28;278(48):47644-53. doi: 10.1074/jbc.M309338200. Epub 2003 Sep 16. PubMed PMID: 13129917.
Kuo YM, Su T, Chen H, Attieh Z, Syed BA, McKie AT, Anderson GJ, Gitschier J, Vulpe CD. Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse. Gut. 2004 Feb;53(2):201-6. doi: 10.1136/gut.2003.019026. PubMed PMID: 14724150; PubMed Central PMCID: PMC1774920.
De Freitas JM, Kim JH, Poynton H, Su T, Wintz H, Fox T, Holman P, Loguinov A, Keles S, van der Laan M, Vulpe C. Exploratory and confirmatory gene expression profiling of mac1Delta. J Biol Chem. 2004 Feb 6;279(6):4450-8. doi: 10.1074/jbc.M212308200. Epub 2003 Oct 8. PubMed PMID: 14534306.
Loguinov AV, Mian IS, Vulpe CD. Exploratory differential gene expression analysis in microarray experiments with no or limited replication. Genome Biol. 2004;5(3):R18. doi: 10.1186/gb-2004-5-3-r18. Epub 2004 Mar 1. PubMed PMID: 15003121; PubMed Central PMCID: PMC395768.
Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, Fox TC, Usta J, Naylor CE, Evans RW, McKie AT, Anderson GJ, Vulpe CD. Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice. Blood. 2004 May 15;103(10):3933-9. doi: 10.1182/blood-2003-09-3139. Epub 2004 Jan 29. PubMed PMID: 14751926.
Frazer DM, Wilkins SJ, Millard KN, McKie AT, Vulpe CD, Anderson GJ. Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol. 2004 Aug;126(3):434-6. doi: 10.1111/j.1365-2141.2004.05044.x. PubMed PMID: 15257718.
Frazer DM, Inglis HR, Wilkins SJ, Millard KN, Steele TM, McLaren GD, McKie AT, Vulpe CD, Anderson GJ. Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut. 2004 Oct;53(10):1509-15. doi: 10.1136/gut.2003.037416. PubMed PMID: 15361505; PubMed Central PMCID: PMC1774251.
Latunde-Dada GO, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT. Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta. 2004 Oct 14;1690(2):169-76. doi: 10.1016/j.bbadis.2004.06.011. PubMed PMID: 15469906.
Keles S, van der Laan MJ, Vulpe C. Regulatory motif finding by logic regression. Bioinformatics. 2004 Nov 1;20(16):2799-811. doi: 10.1093/bioinformatics/bth333. Epub 2004 May 27. PubMed PMID: 15166027.
Armendariz AD, Gonzalez M, Loguinov AV, Vulpe CD. Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App. Physiol Genomics. 2004 Dec 15;20(1):45-54. doi: 10.1152/physiolgenomics.00196.2003. Epub 2004 Oct 5. PubMed PMID: 15467011.
McGregor JA, Shayeghi M, Vulpe CD, Anderson GJ, Pietrangelo A, Simpson RJ, McKie AT. Impaired iron transport activity of ferroportin 1 in hereditary iron overload. J Membr Biol. 2005 Jul;206(1):3-7. doi: 10.1007/s00232-005-0768-1. PubMed PMID: 16440176.
Anderson GJ, Frazer DM, McKie AT, Vulpe CD, Smith A. Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism. Biometals. 2005 Aug;18(4):339-48. doi: 10.1007/s10534-005-3708-8. Review. PubMed PMID: 16158226.
Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT. Identification of an intestinal heme transporter. Cell. 2005 Sep 9;122(5):789-801. doi: 10.1016/j.cell.2005.06.025. PubMed PMID: 16143108.
Frazer DM, Wilkins SJ, Vulpe CD, Anderson GJ. The role of duodenal cytochrome b in intestinal iron absorption remains unclear. Blood. 2005 Dec 15;106(13):4413; author reply 4414. doi: 10.1182/blood-2005-07-2923. PubMed PMID: 16326980; PubMed Central PMCID: PMC1895251.
Ghosh K, Thompson AM, Goldbeck RA, Shi X, Whitman S, Oh E, Zhiwu Z, Vulpe C, Holman TR. Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Biochemistry. 2005 Dec 20;44(50):16729-36. doi: 10.1021/bi0511585. PubMed PMID: 16342963; PubMed Central PMCID: PMC2577039.
Armendáriz AD, Olivares F, Pulgar R, Loguinov A, Cambiazo V, Vulpe CD, González M. Gene expression profiling in wild-type and metallothionein mutant fibroblast cell lines. Biol Res. 2006;39(1):125-42. doi: 10.4067/s0716-97602006000100015. PubMed PMID: 16629173.
Chen H, Huang G, Su T, Gao H, Attieh ZK, McKie AT, Anderson GJ, Vulpe CD. Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency. J Nutr. 2006 May;136(5):1236-41. doi: 10.1093/jn/136.5.1236. PubMed PMID: 16614410.
Wintz H, Yoo LJ, Loguinov A, Wu YY, Steevens JA, Holland RD, Beger RD, Perkins EJ, Hughes O, Vulpe CD. Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals. Toxicol Sci. 2006 Nov;94(1):71-82. doi: 10.1093/toxsci/kfl080. Epub 2006 Aug 17. PubMed PMID: 16917068.
Petrak J, Myslivcova D, Halada P, Cmejla R, Cmejlova J, Vyoral D, Vulpe CD. Iron-independent specific protein expression pattern in the liver of HFE-deficient mice. Int J Biochem Cell Biol. 2007;39(5):1006-15. doi: 10.1016/j.biocel.2007.01.021. Epub 2007 Jan 28. PubMed PMID: 17376729.
Poynton HC, Varshavsky JR, Chang B, Cavigiolio G, Chan S, Holman PS, Loguinov AV, Bauer DJ, Komachi K, Theil EC, Perkins EJ, Hughes O, Vulpe CD. Daphnia magna ecotoxicogenomics provides mechanistic insights into metal toxicity. Environ Sci Technol. 2007 Feb 1;41(3):1044-50. doi: 10.1021/es0615573. PubMed PMID: 17328222.
Petrak J, Myslivcova D, Man P, Cmejla R, Cmejlova J, Vyoral D, Elleder M, Vulpe CD. Proteomic analysis of hepatic iron overload in mice suggests dysregulation of urea cycle, impairment of fatty acid oxidation, and changes in the methylation cycle. Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1490-8. doi: 10.1152/ajpgi.00455.2006. Epub 2007 Feb 15. PubMed PMID: 17307722.
Jo WJ, Loguinov A, Chang M, Wintz H, Nislow C, Arkin AP, Giaever G, Vulpe CD. Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants. Toxicol Sci. 2008 Jan;101(1):140-51. doi: 10.1093/toxsci/kfm226. Epub 2007 Sep 4. PubMed PMID: 17785683.
Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren CE, Bahlo M, Nisselle AE, Vulpe CD, Anderson GJ, Southey MC, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, Gertig DM. Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med. 2008 Jan 17;358(3):221-30. doi: 10.1056/NEJMoa073286. PubMed PMID: 18199861.
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