My Bibliography

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Li Q, Edwards TC, Ponzar NL, Tavis JE. A mid-throughput HBV replication inhibition assay capable of detecting ribonuclease H inhibitors. J Virol Methods. 2021 Jun;292:114127. doi: 10.1016/j.jviromet.2021.114127. Epub 2021 Mar 22. PubMed PMID: 33766659; PubMed Central PMCID: PMC8063683.

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Lin J, Zangi M, Kumar TVNH, Shakar Reddy M, Reddy LVR, Sadhukhan SK, Bradley DP, Moreira-Walsh B, Edwards TC, O'Dea AT, Tavis JE, Meyers MJ, Donlin MJ. Synthetic Derivatives of Ciclopirox are Effective Inhibitors of Cryptococcus neoformans. ACS Omega. 2021 Mar 30;6(12):8477-8487. doi: 10.1021/acsomega.1c00273. eCollection 2021 Mar 30. PubMed PMID: 33817509; PubMed Central PMCID: PMC8015083.

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Choy RKM, Huston CD. Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration. PLoS Negl Trop Dis. 2020 Jul;14(7):e0008252. doi: 10.1371/journal.pntd.0008252. eCollection 2020 Jul. PubMed PMID: 32614819; PubMed Central PMCID: PMC7332027.

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Harrison GA, Mayer Bridwell AE, Singh M, Jayaraman K, Weiss LA, Kinsella RL, Aneke JS, Flentie K, Schene ME, Gaggioli M, Solomon SD, Wildman SA, Meyers MJ, Stallings CL. Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis. mSphere. 2019 Sep 11;4(5). doi: 10.1128/mSphere.00606-19. PubMed PMID: 31511370; PubMed Central PMCID: PMC6739496.

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Oliva J, Galasinski S, Richey A, Campbell AE, Meyers MJ, Modi N, Zhong JW, Tawil R, Tapscott SJ, Sverdrup FM. Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy. J Pharmacol Exp Ther. 2019 Aug;370(2):219-230. doi: 10.1124/jpet.119.259663. Epub 2019 Jun 12. PubMed PMID: 31189728; PubMed Central PMCID: PMC6652132.

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Heidel KM, Dowd CS. Phosphonate prodrugs: an overview and recent advances. Future Med Chem. 2019 Jul;11(13):1625-1643. doi: 10.4155/fmc-2018-0591. Review. PubMed PMID: 31469328; PubMed Central PMCID: PMC6722485.

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Meyers MJ, Liu J, Liu Z, Ma H, Dai L, Adah D, Zhao S, Li X, Liu X, Lu Y, Huang Y, Tu Z, Chen X, Tortorella MD. 4-Aryl Pyrrolidines as Novel Orally Efficacious Antimalarial Agents. Part 2: 2-Aryl-N-(4-arylpyrrolidin-3-yl)acetamides. ACS Med Chem Lett. 2019 Jun 13;10(6):966-971. doi: 10.1021/acsmedchemlett.9b00123. eCollection 2019 Jun 13. PubMed PMID: 31223456; PubMed Central PMCID: PMC6580545.

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Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF. Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells. J Clin Invest. 2019 May 14;129(7):2745-2759. doi: 10.1172/JCI124738. PubMed PMID: 31085833; PubMed Central PMCID: PMC6597242.

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Tavis JE, Zoidis G, Meyers MJ, Murelli RP. Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H. ACS Infect Dis. 2019 May 10;5(5):655-658. doi: 10.1021/acsinfecdis.8b00045. Epub 2018 Mar 22. Review. PubMed PMID: 29565562; PubMed Central PMCID: PMC7202671.

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Meyers MJ, Liu J, Xu J, Leng F, Guan J, Liu Z, McNitt SA, Qin L, Dai L, Ma H, Adah D, Zhao S, Li X, Polino AJ, Nasamu AS, Goldberg DE, Liu X, Lu Y, Tu Z, Chen X, Tortorella MD. 4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides. J Med Chem. 2019 Apr 11;62(7):3503-3512. doi: 10.1021/acs.jmedchem.8b01972. Epub 2019 Mar 22. PubMed PMID: 30856324; PubMed Central PMCID: PMC6727846.

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Xu P, Ganaie SS, Wang X, Wang Z, Kleiboeker S, Horton NC, Heier RF, Meyers MJ, Tavis JE, Qiu J. Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development. Antimicrob Agents Chemother. 2019 Mar;63(3). doi: 10.1128/AAC.01879-18. Print 2019 Mar. PubMed PMID: 30530599; PubMed Central PMCID: PMC6395930.

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Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers N, Chen M, Choi C, Collis LP, Crouse K, Färnegårdh M, Fennell KF, Fish S, Flick AC, Goos-Nilsson A, Gullberg H, Harris PK, Heasley SE, Hegen M, Hromockyj AE, Hu X, Husman B, Janosik T, Jones P, Kaila N, Kallin E, Kauppi B, Kiefer JR, Knafels J, Koehler K, Kruger L, Kurumbail RG, Kyne RE Jr, Li W, Löfstedt J, Long SA, Menard CA, Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D, Nuhant P, Pelc MJ, Prinsen MJ, Rhönnstad P, Backström-Rydin E, Sandberg J, Sandström M, Shah F, Sjöberg M, Sundell A, Taylor AP, Thorarensen A, Trujillo JI, Trzupek JD, Unwalla R, Vajdos FF, Weinberg RA, Wood DC, Xing L, Zamaratski E, Zapf CW, Zhao Y, Wilhelmsson A, Berstein G. Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. J Med Chem. 2018 Dec 13;61(23):10415-10439. doi: 10.1021/acs.jmedchem.8b00392. Epub 2018 Sep 9. PubMed PMID: 30130103.

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Cao F, Orth C, Donlin MJ, Adegboyega P, Meyers MJ, Murelli RP, Elagawany M, Elgendy B, Tavis JE. Synthesis and Evaluation of Troponoids as a New Class of Antibiotics. ACS Omega. 2018 Nov 30;3(11):15125-15133. doi: 10.1021/acsomega.8b01754. Epub 2018 Nov 8. PubMed PMID: 30533576; PubMed Central PMCID: PMC6275967.

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Wang X, Edwards RL, Ball H, Johnson C, Haymond A, Girma M, Manikkam M, Brothers RC, McKay KT, Arnett SD, Osbourn DM, Alvarez S, Boshoff HI, Meyers MJ, Couch RD, Odom John AR, Dowd CS. MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria. J Med Chem. 2018 Oct 11;61(19):8847-8858. doi: 10.1021/acs.jmedchem.8b01026. Epub 2018 Sep 24. PubMed PMID: 30192536; PubMed Central PMCID: PMC6300130.

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Montoya MC, DiDone L, Heier RF, Meyers MJ, Krysan DJ. Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity. ACS Infect Dis. 2018 Apr 13;4(4):499-507. doi: 10.1021/acsinfecdis.7b00157. Epub 2017 Nov 2. PubMed PMID: 29058407.

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Jumani RS, Bessoff K, Love MS, Miller P, Stebbins EE, Teixeira JE, Campbell MA, Meyers MJ, Zambriski JA, Nunez V, Woods AK, McNamara CW, Huston CD. A Novel Piperazine-Based Drug Lead for Cryptosporidiosis from the Medicines for Malaria Venture Open-Access Malaria Box. Antimicrob Agents Chemother. 2018 Apr;62(4). doi: 10.1128/AAC.01505-17. Print 2018 Apr. PubMed PMID: 29339392; PubMed Central PMCID: PMC5913971.

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Stebbins E, Jumani RS, Klopfer C, Barlow J, Miller P, Campbell MA, Meyers MJ, Griggs DW, Huston CD. Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model. PLoS Negl Trop Dis. 2018 Jan;12(1):e0006183. doi: 10.1371/journal.pntd.0006183. eCollection 2018 Jan. PubMed PMID: 29309415; PubMed Central PMCID: PMC5774826.

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Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE. Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Science. 2017 Oct 27;358(6362):518-522. doi: 10.1126/science.aan1478. PubMed PMID: 29074774; PubMed Central PMCID: PMC5928414.

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Lee S, Harwood M, Girouard D, Meyers MJ, Campbell MA, Beamer G, Tzipori S. The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis. PLoS One. 2017;12(10):e0185906. doi: 10.1371/journal.pone.0185906. eCollection 2017. PubMed PMID: 28973041; PubMed Central PMCID: PMC5626496.

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Welch RD, Guo C, Sengupta M, Carpenter KJ, Stephens NA, Arnett SA, Meyers MJ, Sparks LM, Smith SR, Zhang J, Burris TP, Flaveny CA. Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome. Mol Metab. 2017 Jul;6(7):703-714. doi: 10.1016/j.molmet.2017.05.001. eCollection 2017 Jul. PubMed PMID: 28702326; PubMed Central PMCID: PMC5485243.

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Donlin MJ, Zunica A, Lipnicky A, Garimallaprabhakaran AK, Berkowitz AJ, Grigoryan A, Meyers MJ, Tavis JE, Murelli RP. Troponoids Can Inhibit Growth of the Human Fungal Pathogen Cryptococcus neoformans. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02574-16. Print 2017 Apr. PubMed PMID: 28167553; PubMed Central PMCID: PMC5365692.

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Lu G, Villa JA, Donlin MJ, Edwards TC, Cheng X, Heier RF, Meyers MJ, Tavis JE. Hepatitis B virus genetic diversity has minimal impact on sensitivity of the viral ribonuclease H to inhibitors. Antiviral Res. 2016 Nov;135:24-30. doi: 10.1016/j.antiviral.2016.09.009. Epub 2016 Sep 28. PubMed PMID: 27693161; PubMed Central PMCID: PMC5099120.

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Faidallah HM, Panda SS, Serrano JC, Girgis AS, Khan KA, Alamry KA, Therathanakorn T, Meyers MJ, Sverdrup FM, Eickhoff CS, Getchell SG, Katritzky AR. Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates. Bioorg Med Chem. 2016 Aug 15;24(16):3527-39. doi: 10.1016/j.bmc.2016.05.060. Epub 2016 May 30. Review. PubMed PMID: 27298002.

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Griggs DW, Prinsen MJ, Oliva J, Campbell MA, Arnett SD, Tajfirouz D, Ruminski PG, Yu Y, Bond BR, Ji Y, Neckermann G, Choy RK, de Hostos E, Meyers MJ. Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. J Pharmacol Exp Ther. 2016 May;357(2):423-31. doi: 10.1124/jpet.115.231167. Epub 2016 Feb 23. PubMed PMID: 26907621; PubMed Central PMCID: PMC4851326.

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Masaoka T, Zhao H, Hirsch DR, D'Erasmo MP, Meck C, Varnado B, Gupta A, Meyers MJ, Baines J, Beutler JA, Murelli RP, Tang L, Le Grice SF. Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors. Biochemistry. 2016 Feb 9;55(5):809-19. doi: 10.1021/acs.biochem.5b01254. Epub 2016 Feb 1. PubMed PMID: 26829613; PubMed Central PMCID: PMC4819167.

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Meyers MJ, Anderson EJ, McNitt SA, Krenning TM, Singh M, Xu J, Zeng W, Qin L, Xu W, Zhao S, Qin L, Eickhoff CS, Oliva J, Campbell MA, Arnett SD, Prinsen MJ, Griggs DW, Ruminski PG, Goldberg DE, Ding K, Liu X, Tu Z, Tortorella MD, Sverdrup FM, Chen X. Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents. Bioorg Med Chem. 2015 Aug 15;23(16):5144-50. doi: 10.1016/j.bmc.2015.02.050. Epub 2015 Mar 4. PubMed PMID: 25797165; PubMed Central PMCID: PMC4550221.

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Lu G, Lomonosova E, Cheng X, Moran EA, Meyers MJ, Le Grice SF, Thomas CJ, Jiang JK, Meck C, Hirsch DR, D'Erasmo MP, Suyabatmaz DM, Murelli RP, Tavis JE. Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity. Antimicrob Agents Chemother. 2015 Feb;59(2):1070-9. doi: 10.1128/AAC.04617-14. Epub 2014 Dec 1. PubMed PMID: 25451058; PubMed Central PMCID: PMC4335860.

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Cai CW, Lomonosova E, Moran EA, Cheng X, Patel KB, Bailly F, Cotelle P, Meyers MJ, Tavis JE. Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activity. Antiviral Res. 2014 Aug;108:48-55. doi: 10.1016/j.antiviral.2014.05.007. Epub 2014 May 20. PubMed PMID: 24858512; PubMed Central PMCID: PMC4101055.

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Casimiro-Garcia A, Piotrowski DW, Ambler C, Arhancet GB, Banker ME, Banks T, Boustany-Kari CM, Cai C, Chen X, Eudy R, Hepworth D, Hulford CA, Jennings SM, Loria PM, Meyers MJ, Petersen DN, Raheja NK, Sammons M, She L, Song K, Vrieze D, Wei L. Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist. J Med Chem. 2014 May 22;57(10):4273-88. doi: 10.1021/jm500206r. Epub 2014 Apr 30. PubMed PMID: 24738581.

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Meyers MJ, Tortorella MD, Xu J, Qin L, He Z, Lang X, Zeng W, Xu W, Qin L, Prinsen MJ, Sverdrup FM, Eickhoff CS, Griggs DW, Oliva J, Ruminski PG, Jacobsen EJ, Campbell MA, Wood DC, Goldberg DE, Liu X, Lu Y, Lu X, Tu Z, Lu X, Ding K, Chen X. Evaluation of aminohydantoins as a novel class of antimalarial agents. ACS Med Chem Lett. 2014 Jan 9;5(1):89-93. doi: 10.1021/ml400412x. eCollection 2014 Jan 9. PubMed PMID: 24900778; PubMed Central PMCID: PMC4027786.

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Panda SS, Ibrahim MA, Küçükbay H, Meyers MJ, Sverdrup FM, El-Feky SA, Katritzky AR. Synthesis and antimalarial bioassay of quinine - peptide conjugates. Chem Biol Drug Des. 2013 Oct;82(4):361-6. doi: 10.1111/cbdd.12134. PubMed PMID: 23497252.

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Tavis JE, Cheng X, Hu Y, Totten M, Cao F, Michailidis E, Aurora R, Meyers MJ, Jacobsen EJ, Parniak MA, Sarafianos SG. The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes. PLoS Pathog. 2013 Jan;9(1):e1003125. doi: 10.1371/journal.ppat.1003125. Epub 2013 Jan 22. PubMed PMID: 23349632; PubMed Central PMCID: PMC3551811.

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Panda SS, Bajaj K, Meyers MJ, Sverdrup FM, Katritzky AR. Quinine bis-conjugates with quinolone antibiotics and peptides: synthesis and antimalarial bioassay. Org Biomol Chem. 2012 Dec 7;10(45):8985-93. doi: 10.1039/c2ob26439k. Epub 2012 Oct 16. PubMed PMID: 23070233.

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Meyers MJ, Goldberg DE. Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts. Curr Top Med Chem. 2012;12(5):445-55. doi: 10.2174/156802612799362959. Review. PubMed PMID: 22242846.

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Meyers MJ. Editorial: the medicinal chemistry of novel approaches for the treatment of malaria. Curr Top Med Chem. 2012;12(5):371-2. doi: 10.2174/156802612799362931. PubMed PMID: 22242844.

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Meyers MJ, Long SA, Pelc MJ, Wang JL, Bowen SJ, Walker MC, Schweitzer BA, Madsen HM, Tenbrink RE, McDonald J, Smith SE, Foltin S, Beidler D, Thorarensen A. Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44. doi: 10.1016/j.bmcl.2011.08.055. Epub 2011 Aug 22. PubMed PMID: 21924614.

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Meyers MJ, Long SA, Pelc MJ, Wang JL, Bowen SJ, Schweitzer BA, Wilcox MV, McDonald J, Smith SE, Foltin S, Rumsey J, Yang YS, Walker MC, Kamtekar S, Beidler D, Thorarensen A. Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6545-53. doi: 10.1016/j.bmcl.2011.08.048. Epub 2011 Aug 19. PubMed PMID: 21924613.

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Meyers MJ, Arhancet GB, Hockerman SL, Chen X, Long SA, Mahoney MW, Rico JR, Garland DJ, Blinn JR, Collins JT, Yang S, Huang HC, McGee KF, Wendling JM, Dietz JD, Payne MA, Homer BL, Heron MI, Reitz DB, Hu X. Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. J Med Chem. 2010 Aug 26;53(16):5979-6002. doi: 10.1021/jm100505n. PubMed PMID: 20672822.

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Mourey RJ, Burnette BL, Brustkern SJ, Daniels JS, Hirsch JL, Hood WF, Meyers MJ, Mnich SJ, Pierce BS, Saabye MJ, Schindler JF, South SA, Webb EG, Zhang J, Anderson DR. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807. doi: 10.1124/jpet.110.166173. Epub 2010 Mar 17. PubMed PMID: 20237073.

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Meyers MJ, Pelc M, Kamtekar S, Day J, Poda GI, Hall MK, Michener ML, Reitz BA, Mathis KJ, Pierce BS, Parikh MD, Mischke DA, Long SA, Parlow JJ, Anderson DR, Thorarensen A. Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1543-7. doi: 10.1016/j.bmcl.2010.01.078. Epub 2010 Jan 21. PubMed PMID: 20137931.

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Meyers MJ, Muizebelt I, van Wiltenburg J, Brown DL, Thorarensen A. Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate. Org Lett. 2009 Aug 20;11(16):3523-5. doi: 10.1021/ol901325s. PubMed PMID: 19637855.

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Anderson DR, Meyers MJ, Kurumbail RG, Caspers N, Poda GI, Long SA, Pierce BS, Mahoney MW, Mourey RJ, Parikh MD. Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4882-4. doi: 10.1016/j.bmcl.2009.02.017. Epub 2009 Feb 8. PubMed PMID: 19616942.

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Anderson DR, Meyers MJ, Kurumbail RG, Caspers N, Poda GI, Long SA, Pierce BS, Mahoney MW, Mourey RJ. Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4878-81. doi: 10.1016/j.bmcl.2009.02.015. Epub 2009 Feb 8. PubMed PMID: 19616945.

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Trujillo JI, Meyers MJ, Anderson DR, Hegde S, Mahoney MW, Vernier WF, Buchler IP, Wu KK, Yang S, Hartmann SJ, Reitz DB. Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett. 2007 Aug 15;17(16):4657-63. doi: 10.1016/j.bmcl.2007.05.070. Epub 2007 May 25. PubMed PMID: 17570666.

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Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N, Poda GI, Schindler JF, Reitz DB, Mourey RJ. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. doi: 10.1021/jm0611004. Epub 2007 May 5. PubMed PMID: 17480064.

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Meyers MJ, Xiao H. Non-steroidal Mineralocorticoid Receptor Antagonists. Expert Opin Therapeutic Patents. 2007; 17:17-23.

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Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nat Struct Biol. 2002 May;9(5):359-64. doi: 10.1038/nsb787. PubMed PMID: 11953755.

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Meyers MJ, Sun J, Carlson KE, Marriner GA, Katzenellenbogen BS, Katzenellenbogen JA. Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem. 2001 Nov 22;44(24):4230-51. doi: 10.1021/jm010254a. PubMed PMID: 11708925.

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Meyers MJ, Sun J, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA. Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J Med Chem. 1999 Jul 1;42(13):2456-68. doi: 10.1021/jm990101b. PubMed PMID: 10395487.

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Sun J, Meyers MJ, Fink BE, Rajendran R, Katzenellenbogen JA, Katzenellenbogen BS. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999 Feb;140(2):800-4. doi: 10.1210/endo.140.2.6480. PubMed PMID: 9927308.