My Bibliography

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Bogan JE Jr, Huston CD, Meyers MJ, Logel R, Garcia AP, Mason AK, Garner MM. Randomized clinical trial evaluating triazolopyridazine SLU-2633 as a treatment for gastric cryptosporidiosis in eastern indigo snakes (Drymarchon couperi). Parasitol Int. 2026 Dec;115:103301. doi: 10.1016/j.parint.2026.103301. Epub 2026 May 21. PubMed PMID: 42173191; PubMed Central PMCID: PMC13334549.

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Walden HM, Tsimpili H, Woodson ME, Zoidis G, Tavis JE. Hepatitis B virus ribonuclease H inhibitors: Coming of age?. Antiviral Res. 2026 May;249:106396. doi: 10.1016/j.antiviral.2026.106396. Epub 2026 Mar 17. Review. PubMed PMID: 41856207; PubMed Central PMCID: PMC13224728.

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Elsworth B, Keroack CD, Rezvani Y, Paul AS, Barazorda KA, Bauer NC, Tennessen JA, Sack SA, Moreira CK, Gubbels MJ, Meyers MJ, Zarringhalam K, Duraisingh MT. Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases. Nat Microbiol. 2026 Feb;11(2):492-506. doi: 10.1038/s41564-025-02238-7. Epub 2026 Jan 27. PubMed PMID: 41593365; PubMed Central PMCID: PMC12872469.

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Ponzar N, Pagotto A, Bandyopadhayay S, Meyers MJ, De Filippis V, Flaumenhaft R, Pozzi N. Molecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b'-ligands. Redox Biol. 2026 Mar;90:104044. doi: 10.1016/j.redox.2026.104044. Epub 2026 Jan 21. PubMed PMID: 41610518; PubMed Central PMCID: PMC12870469.

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Jin Y, Sun Y, Zhao S, Wang S, Dou Y, Wang K, Li Q, Tavis JE, Wu Z, Zhan P, Liu X. Design, Synthesis, and Biological Evaluation of Highly Potent Boronic Acid (Boronate Ester)-Bearing Heteroaryldihydropyrimidine Derivatives as HBV Capsid Assembly Modulators. J Med Chem. 2025 Dec 25;68(24):25939-25960. doi: 10.1021/acs.jmedchem.5c01837. Epub 2025 Dec 8. PubMed PMID: 41358483; PubMed Central PMCID: PMC13006845.

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Guin S, Alden KM, Harshbarger E, Ristow LC, Jezewski AJ, Krysan DJ, Meyers MJ. Second generation repurposing of phenothiazine antipsychotic drugs as antifungal lead molecules via optimization of phenoxazine derivatives. Eur J Med Chem. 2026 Jan 15;302(Pt 3):118373. doi: 10.1016/j.ejmech.2025.118373. Epub 2025 Nov 21. PubMed PMID: 41297389; PubMed Central PMCID: PMC12674827.

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Woodson ME, Walden HF, Mottaleb MA, Makri M, Prifti G-M, Moianos D, Pardali V, Zoidis G, Tavis JE. Correction for Woodson et al., "Efficacy and in vitro pharmacological assessment of novel N-hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors". Antimicrob Agents Chemother. 2025 Dec 10;69(12):e0119925. doi: 10.1128/aac.01199-25. Epub 2025 Nov 6. PubMed PMID: 41196267; PubMed Central PMCID: PMC12691581.

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Chotzalli D, Pardali V, Walden HM, Perivolaris D, Moianos D, Makri M, Drakopoulos A, Giannakopoulou E, Tajwar R, Woodson ME, Tavis JE, Zoidis G. Discovery of N-Hydroxypyridinedione-Based Inhibitors of HBV RNase H: Design, Synthesis, and Extended SAR Studies. Int J Mol Sci. 2025 Oct 21;26(20). doi: 10.3390/ijms262010239. PubMed PMID: 41155527; PubMed Central PMCID: PMC12564302.

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Kennedy PT, Allweiss L, Bertoletti A, Cornberg M, Gehring AJ, Guidotti LG, Kerth HA, Lemoine M, Levrero M, Lim SG, Tavis JE, Testoni B, Tu T, International Coalition to Eliminate HBV. Scientific and medical evidence informing expansion of hepatitis B treatment guidelines. Lancet Gastroenterol Hepatol. 2025 Oct;10(10):941-951. doi: 10.1016/S2468-1253(25)00053-6. Epub 2025 Jul 23. Review. PubMed PMID: 40714040; PubMed Central PMCID: PMC12797741.

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Iannacone M, Beccaria CG, Allweiss L, Lucifora J, Tavis JE, Gehring AJ, Dandri M. Targeting HBV with RNA interference: Paths to cure. Sci Transl Med. 2025 Jul 2;17(805):eadv3678. doi: 10.1126/scitranslmed.adv3678. Epub 2025 Jul 2. Review. PubMed PMID: 40601778; PubMed Central PMCID: PMC12801669.

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Dews EA, Teixeira JE, Huston CD, Meyers MJ, Hyson PR. A propidium iodide-based in vitro screen of the "Bug Box" against Babesia duncani reveals potent inhibitors. Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0003525. doi: 10.1128/aac.00035-25. Epub 2025 Jun 9. PubMed PMID: 40488628; PubMed Central PMCID: PMC12217462.

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Brosend SC, Guin S, Giovine G, Gadalla C, Campos MA, Mara A, Jentsch NG, Thakellapalli H, Alden KM, Beattie SR, Krysan DJ, Meyers MJ. Antifungal Structure-Activity Relationship Studies of Broad-Spectrum Phenothiazines. ACS Omega. 2025 May 13;10(18):18347-18355. doi: 10.1021/acsomega.4c09833. eCollection 2025 May 13. PubMed PMID: 40385163; PubMed Central PMCID: PMC12079586.

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Bradley DP, Valkner CJ, Li Q, Gasonoo M, Meyers MJ, Prifti GM, Moianos D, Zoidis G, Zlotnick A, Tavis JE. Discovery of bimodal hepatitis B virus ribonuclease H and capsid assembly inhibitors. PLoS Pathog. 2025 Feb;21(2):e1012920. doi: 10.1371/journal.ppat.1012920. eCollection 2025 Feb. PubMed PMID: 39928681; PubMed Central PMCID: PMC11828405.

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Li Q, Tavis JE. In Vitro Enzymatic and Cell Culture-Based Assays for Measuring Activity of HBV Ribonuclease H Inhibitors. Methods Mol Biol. 2024;2837:257-270. doi: 10.1007/978-1-0716-4027-2_22. PubMed PMID: 39044091; PubMed Central PMCID: PMC11514518.

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Gasonoo M, Guin S, Teixeira JE, Oboh E, Gokanapalle A, Miller P, Oliva J, Sverdrup FM, Huston CD, Meyers MJ. Discovery of an Orally Efficacious Pyrazolo[3,4-d]pyrimidine Benzoxaborole as a Potent Inhibitor of Cryptosporidium. J Med Chem. 2025 Jan 9;68(1):832-849. doi: 10.1021/acs.jmedchem.4c02805. Epub 2024 Dec 23. PubMed PMID: 39714730; PubMed Central PMCID: PMC12674823.

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Woodson ME, Walden HF, Mottaleb MA, Makri M, Prifti G-M, Moianos D, Pardali V, Zoidis G, Tavis JE. Efficacy and in vitro pharmacological assessment of novel N-hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors. Antimicrob Agents Chemother. 2025 Jan 31;69(1):e0145524. doi: 10.1128/aac.01455-24. Epub 2024 Nov 27. PubMed PMID: 39601549; PubMed Central PMCID: PMC11784145.

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Caldwell N, Peet C, Miller P, Colon BL, Taylor MG, Cocco M, Dawson A, Lukac I, Teixeira JE, Robinson L, Frame L, Seizova S, Damerow S, Tamaki F, Post J, Riley J, Mutter N, Hanna JC, Ferguson L, Hu X, Tinti M, Forte B, Norcross NR, Campbell PS, Svensen N, Caldwell FC, Jansen C, Postis V, Read KD, Huston CD, Gilbert IH, Baragaña B, Pawlowic MC. Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy. Sci Transl Med. 2024 Oct 23;16(770):eadm8631. doi: 10.1126/scitranslmed.adm8631. Epub 2024 Oct 23. PubMed PMID: 39441903; PubMed Central PMCID: PMC7617456.

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Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Analogs of the anti-malaria drug mefloquine have broad-spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24. Epub 2024 Oct 4. PubMed PMID: 39365066; PubMed Central PMCID: PMC11539235.

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Ajiboye J, Teixeira JE, Gasonoo M, Mattice EB, Korwin-Mihavics B, Miller P, Cameron AC, Stebbins E, Campbell SD, Griggs DW, Spangenberg T, Meyers MJ, Huston CD. Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice. Nat Commun. 2024 Sep 27;15(1):8272. doi: 10.1038/s41467-024-52658-y. PubMed PMID: 39333545; PubMed Central PMCID: PMC11436873.

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Moianos D, Makri M, Prifti GM, Chiotellis A, Pappas A, Woodson ME, Tajwar R, Tavis JE, Zoidis G. N-Hydroxypiridinedione: A Privileged Heterocycle for Targeting the HBV RNase H. Molecules. 2024 Jun 20;29(12). doi: 10.3390/molecules29122942. PubMed PMID: 38931006; PubMed Central PMCID: PMC11206691.

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Guin S, Alden KM, Krysan DJ, Meyers MJ. Synthesis and Antifungal Activity of Stereoisomers of Mefloquine Analogs. ACS Med Chem Lett. 2024 Jun 13;15(6):822-827. doi: 10.1021/acsmedchemlett.4c00031. eCollection 2024 Jun 13. PubMed PMID: 38894917; PubMed Central PMCID: PMC11181485.

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Tu T, Wettengel J, Xia Y, Testoni B, Littlejohn M, Le Bert N, Ebert G, Verrier ER, Tavis JE, Cohen C. Major open questions in the hepatitis B and D field - Proceedings of the inaugural International emerging hepatitis B and hepatitis D researchers workshop. Virology. 2024 Jul;595:110089. doi: 10.1016/j.virol.2024.110089. Epub 2024 Apr 16. PubMed PMID: 38640789; PubMed Central PMCID: PMC11517827.

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Cancilla D, Rettig MP, Karpova D, Thakellapalli H, Singh M, Meyers MJ, Ruminski PG, Christ S, Chendamarai E, Gao F, Gehrs L, Ritchey JK, Prinsen M, DiPersio JF. Targeting CXCR4, VLA-4, and CXCR2 for hematopoietic stem cell mobilization. Blood Adv. 2024 Mar 26;8(6):1379-1383. doi: 10.1182/bloodadvances.2023011653. PubMed PMID: 38190608; PubMed Central PMCID: PMC10945136.

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Keroack CD, Elsworth B, Tennessen JA, Paul AS, Hua R, Ramirez-Ramirez L, Ye S, Moreira CK, Meyers MJ, Zarringhalam K, Duraisingh MT. Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2312987121. doi: 10.1073/pnas.2312987121. Epub 2024 Feb 20. PubMed PMID: 38377214; PubMed Central PMCID: PMC10907312.

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Giannakopoulou E, Pardali V, Edwards TC, Woodson M, Tajwar R, Tavis JE, Zoidis G. Identification and assessment of the 1,6-dihydroxy-pyridin-2-one moiety as privileged scaffold for HBV ribonuclease H inhibition. Antiviral Res. 2024 Mar;223:105833. doi: 10.1016/j.antiviral.2024.105833. Epub 2024 Feb 5. PubMed PMID: 38325606; PubMed Central PMCID: PMC11533872.

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Woodson ME, Mottaleb MA, Murelli RP, Tavis JE. In vitro evaluation of tropolone absorption, metabolism, and clearance. Antiviral Res. 2023 Dec;220:105762. doi: 10.1016/j.antiviral.2023.105762. Epub 2023 Nov 22. PubMed PMID: 37996012; PubMed Central PMCID: PMC10843707.

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Vanneste M, Venzke A, Guin S, Fuller AJ, Jezewski AJ, Beattie SR, Krysan DJ, Meyers MJ, Henry MD. The anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition. Front Oncol. 2023;13:1295185. doi: 10.3389/fonc.2023.1295185. eCollection 2023. PubMed PMID: 37909019; PubMed Central PMCID: PMC10613967.

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Miron-Ocampo A, Beattie SR, Guin S, Conway T, Meyers MJ, Moye-Rowley WS, Krysan DJ. CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms. Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0056723. doi: 10.1128/aac.00567-23. Epub 2023 Sep 13. PubMed PMID: 37702508; PubMed Central PMCID: PMC10583685.

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Gilbert IH, Vinayak S, Striepen B, Manjunatha UH, Khalil IA, Van Voorhis WC, Cryptosporidiosis Therapeutics Advocacy Group CTAG, Cryptosporidiosis Therapeutics Advocacy CTAG. Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease. BMJ Glob Health. 2023 Aug;8(8). doi: 10.1136/bmjgh-2023-012540. PubMed PMID: 37541693; PubMed Central PMCID: PMC10407372.

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Wang X, Edwards RL, Ball HS, Heidel KM, Brothers RC, Johnson C, Haymond A, Girma M, Dailey A, Roma JS, Boshoff HI, Osbourn DM, Meyers MJ, Couch RD, Odom John AR, Dowd CS. MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase. ACS Infect Dis. 2023 Jul 14;9(7):1387-1395. doi: 10.1021/acsinfecdis.3c00132. Epub 2023 Jun 13. PubMed PMID: 37310810; PubMed Central PMCID: PMC10880585.

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Keroack CD, Elsworth B, Tennessen JA, Paul AS, Hua R, Ramirez-Ramirez L, Ye S, Moreira CM, Meyers MJ, Zarringhalam K, Duraisingh MT. Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance. bioRxiv. 2023 Jun 13;. doi: 10.1101/2023.06.13.544849. PubMed PMID: 37398106; PubMed Central PMCID: PMC10312741.

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Schubert TJ, Oboh E, Peek H, Philo E, Teixeira JE, Stebbins EE, Miller P, Oliva J, Sverdrup FM, Griggs DW, Huston CD, Meyers MJ. Structure-Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine. J Med Chem. 2023 Jun 22;66(12):7834-7848. doi: 10.1021/acs.jmedchem.3c00110. Epub 2023 Jun 2. PubMed PMID: 37267631; PubMed Central PMCID: PMC11103792.

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Oboh E, Teixeira JE, Schubert TJ, Maribona AS, Denman BN, Patel R, Huston CD, Meyers MJ. Structure-Activity relationships of replacements for the triazolopyridazine of Anti-Cryptosporidium lead SLU-2633. Bioorg Med Chem. 2023 May 15;86:117295. doi: 10.1016/j.bmc.2023.117295. Epub 2023 Apr 28. PubMed PMID: 37148788; PubMed Central PMCID: PMC10201403.

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Wang S, Ren Y, Li Q, Wang Y, Jiang X, Xu S, Zhang X, Zhao S, Bradley DP, Woodson ME, Zhao F, Wu S, Li Y, Tian Y, Liu X, Tavis JE, Zhan P. Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators. Bioorg Chem. 2022 Dec;129:106192. doi: 10.1016/j.bioorg.2022.106192. Epub 2022 Oct 13. PubMed PMID: 36265355; PubMed Central PMCID: PMC10591450.

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Tajwar R, Bradley DP, Ponzar NL, Tavis JE. Predicted structure of the hepatitis B virus polymerase reveals an ancient conserved protein fold. Protein Sci. 2022 Oct;31(10):e4421. doi: 10.1002/pro.4421. PubMed PMID: 36173165; PubMed Central PMCID: PMC9601786.

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Zangi M, Donald KA, Casals AG, Franson AD, Yu AJ, Marker EM, Woodson ME, Campbell SD, Mottaleb MA, Narayana Hajay Kumar TV, Reddy MS, Raghava Reddy LV, Sadhukhan SK, Griggs DW, Morrison LA, Meyers MJ. Synthetic derivatives of the antifungal drug ciclopirox are active against herpes simplex virus 2. Eur J Med Chem. 2022 Aug 5;238:114443. doi: 10.1016/j.ejmech.2022.114443. Epub 2022 May 14. PubMed PMID: 35635945; PubMed Central PMCID: PMC11103786.

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Donlin MJ, Meyers MJ. Repurposing and optimization of drugs for discovery of novel antifungals. Drug Discov Today. 2022 Jul;27(7):2008-2014. doi: 10.1016/j.drudis.2022.04.021. Epub 2022 Apr 27. Review. PubMed PMID: 35489676; PubMed Central PMCID: PMC11182377.

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Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet P, Muller FL, Jez J, Odom John AR. Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife. 2021 Nov 25;10. doi: 10.7554/eLife.75743. PubMed PMID: 34821554; PubMed Central PMCID: PMC8616559.

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Girma MB, Ball HS, Wang X, Brothers RC, Jackson ER, Meyers MJ, Dowd CS, Couch RD. Mechanism of Action of N-Acyl and N-Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum, a Causative Agent of Malaria. ACS Omega. 2021 Oct 26;6(42):27630-27639. doi: 10.1021/acsomega.1c01711. eCollection 2021 Oct 26. PubMed PMID: 34722963; PubMed Central PMCID: PMC8552233.

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Chauhan R, Li Q, Woodson ME, Gasonoo M, Meyers MJ, Tavis JE. Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0146021. doi: 10.1128/AAC.01460-21. Epub 2021 Sep 13. PubMed PMID: 34516242; PubMed Central PMCID: PMC8597750.

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Oboh E, Schubert TJ, Teixeira JE, Stebbins EE, Miller P, Philo E, Thakellapalli H, Campbell SD, Griggs DW, Huston CD, Meyers MJ. Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin. J Med Chem. 2021 Aug 12;64(15):11729-11745. doi: 10.1021/acs.jmedchem.1c01136. Epub 2021 Aug 3. PubMed PMID: 34342443; PubMed Central PMCID: PMC8792998.

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Kirby SA, Dowd CS. Phosphoryl Prodrugs: Characteristics to Improve Drug Development. Med Chem Res. 2022 Feb;31(2):207-216. doi: 10.1007/s00044-021-02766-x. Epub 2021 Jul 23. PubMed PMID: 35492863; PubMed Central PMCID: PMC9053384.

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Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet PJ, Muller FL, Jez JM, Odom John AR. Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife. 2021 Jul 19;10. doi: 10.7554/eLife.66657. PubMed PMID: 34279224; PubMed Central PMCID: PMC8318587.

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Huston CD. The Clofazimine for Treatment of Cryptosporidiosis in HIV-Infected Adults (CRYPTOFAZ) and Lessons Learned for Anticryptosporidial Drug Development. Clin Infect Dis. 2021 Jul 15;73(2):192-194. doi: 10.1093/cid/ciaa425. PubMed PMID: 32277815; PubMed Central PMCID: PMC8427724.

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Hasan MM, Stebbins EE, Choy RKM, Gillespie JR, de Hostos EL, Miller P, Mushtaq A, Ranade RM, Teixeira JE, Verlinde CLMJ, Sateriale A, Zhang Z, Osbourn DM, Griggs DW, Fan E, Buckner FS, Huston CD. Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection. Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.00023-21. Print 2021 May 18. PubMed PMID: 33753338; PubMed Central PMCID: PMC8316126.

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Prifti GM, Moianos D, Giannakopoulou E, Pardali V, Tavis JE, Zoidis G. Recent Advances in Hepatitis B Treatment. Pharmaceuticals (Basel). 2021 May 1;14(5). doi: 10.3390/ph14050417. Review. PubMed PMID: 34062711; PubMed Central PMCID: PMC8147224.

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Lin J, Zangi M, Kumar TVNH, Shakar Reddy M, Reddy LVR, Sadhukhan SK, Bradley DP, Moreira-Walsh B, Edwards TC, O'Dea AT, Tavis JE, Meyers MJ, Donlin MJ. Synthetic Derivatives of Ciclopirox are Effective Inhibitors of Cryptococcus neoformans. ACS Omega. 2021 Mar 30;6(12):8477-8487. doi: 10.1021/acsomega.1c00273. eCollection 2021 Mar 30. PubMed PMID: 33817509; PubMed Central PMCID: PMC8015083.

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Mikati MO, Miller JJ, Osbourn DM, Barekatain Y, Ghebremichael N, Shah IT, Burnham CD, Heidel KM, Yan VC, Muller FL, Dowd CS, Edwards RL, Odom John AR. Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB. ACS Infect Dis. 2020 Nov 13;6(11):3064-3075. doi: 10.1021/acsinfecdis.0c00582. Epub 2020 Oct 29. PubMed PMID: 33118347; PubMed Central PMCID: PMC8543975.

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Choy RKM, Huston CD. Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration. PLoS Negl Trop Dis. 2020 Jul;14(7):e0008252. doi: 10.1371/journal.pntd.0008252. eCollection 2020 Jul. PubMed PMID: 32614819; PubMed Central PMCID: PMC7332027.

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Edwards RL, Heueck I, Lee SG, Shah IT, Miller JJ, Jezewski AJ, Mikati MO, Wang X, Brothers RC, Heidel KM, Osbourn DM, Burnham CD, Alvarez S, Fritz SA, Dowd CS, Jez JM, Odom John AR. Potent, specific MEPicides for treatment of zoonotic staphylococci. PLoS Pathog. 2020 Jun;16(6):e1007806. doi: 10.1371/journal.ppat.1007806. eCollection 2020 Jun. PubMed PMID: 32497104; PubMed Central PMCID: PMC7297381.