My Bibliography

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Title: Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. Journal of visualized experiments : JoVE. . NIHMSID: NIHMS1574616.

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Nakatsu MN, Sainson RC, Aoto JN, Taylor KL, Aitkenhead M, Pérez-del-Pulgar S, Carpenter PM, Hughes CC. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res. 2003 Sep;66(2):102-12. doi: 10.1016/s0026-2862(03)00045-1. PubMed PMID: 12935768.

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Nakatsu MN, Sainson RC, Pérez-del-Pulgar S, Aoto JN, Aitkenhead M, Taylor KL, Carpenter PM, Hughes CC. VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model. Lab Invest. 2003 Dec;83(12):1873-85. doi: 10.1097/01.lab.0000107160.81875.33. PubMed PMID: 14691306.

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Sainson RC, Aoto J, Nakatsu MN, Holderfield M, Conn E, Koller E, Hughes CC. Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB J. 2005 Jun;19(8):1027-9. doi: 10.1096/fj.04-3172fje. Epub 2005 Mar 17. PubMed PMID: 15774577.

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Aoto J, Ting P, Maghsoodi B, Xu N, Henkemeyer M, Chen L. Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. J Neurosci. 2007 Jul 11;27(28):7508-19. doi: 10.1523/JNEUROSCI.0705-07.2007. PubMed PMID: 17626212; PubMed Central PMCID: PMC6672605.

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Aoto J, Chen L. Bidirectional ephrin/Eph signaling in synaptic functions. Brain Res. 2007 Dec 12;1184:72-80. doi: 10.1016/j.brainres.2006.11.033. Epub 2006 Dec 12. Review. PubMed PMID: 17166489; PubMed Central PMCID: PMC2170431.

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Maghsoodi B, Poon MM, Nam CI, Aoto J, Ting P, Chen L. Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):16015-20. doi: 10.1073/pnas.0804801105. Epub 2008 Oct 7. PubMed PMID: 18840692; PubMed Central PMCID: PMC2572971.

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Aoto J, Nam CI, Poon MM, Ting P, Chen L. Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron. 2008 Oct 23;60(2):308-20. doi: 10.1016/j.neuron.2008.08.012. PubMed PMID: 18957222; PubMed Central PMCID: PMC2634746.

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Sarti F, Schroeder J, Aoto J, Chen L. Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity. Front Mol Neurosci. 2012;5:16. doi: 10.3389/fnmol.2012.00016. eCollection 2012. PubMed PMID: 22419906; PubMed Central PMCID: PMC3279749.

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Anderson GR, Galfin T, Xu W, Aoto J, Malenka RC, Südhof TC. Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18120-5. doi: 10.1073/pnas.1216398109. Epub 2012 Oct 16. PubMed PMID: 23074245; PubMed Central PMCID: PMC3497786.

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Aoto J, Martinelli DC, Malenka RC, Tabuchi K, Südhof TC. Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell. 2013 Jul 3;154(1):75-88. doi: 10.1016/j.cell.2013.05.060. PubMed PMID: 23827676; PubMed Central PMCID: PMC3756801.

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Aoto J, Földy C, Ilcus SM, Tabuchi K, Südhof TC. Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nat Neurosci. 2015 Jul;18(7):997-1007. doi: 10.1038/nn.4037. Epub 2015 Jun 1. PubMed PMID: 26030848; PubMed Central PMCID: PMC4482778.

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Anderson GR, Aoto J, Tabuchi K, Földy C, Covy J, Yee AX, Wu D, Lee SJ, Chen L, Malenka RC, Südhof TC. β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 2015 Jul 30;162(3):593-606. doi: 10.1016/j.cell.2015.06.056. Epub 2015 Jul 23. PubMed PMID: 26213384; PubMed Central PMCID: PMC4709013.

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Pak C, Danko T, Zhang Y, Aoto J, Anderson G, Maxeiner S, Yi F, Wernig M, Südhof TC. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell. 2015 Sep 3;17(3):316-28. doi: 10.1016/j.stem.2015.07.017. Epub 2015 Aug 13. PubMed PMID: 26279266; PubMed Central PMCID: PMC4560990.

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Chanda S, Aoto J, Lee SJ, Wernig M, Südhof TC. Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Mol Psychiatry. 2016 Feb;21(2):169-77. doi: 10.1038/mp.2015.20. Epub 2015 Mar 17. PubMed PMID: 25778475; PubMed Central PMCID: PMC4573762.

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Földy C, Darmanis S, Aoto J, Malenka RC, Quake SR, Südhof TC. Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5222-31. doi: 10.1073/pnas.1610155113. Epub 2016 Aug 16. PubMed PMID: 27531958; PubMed Central PMCID: PMC5024636.

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Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca(2+)-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 Oct 23;25(4):974-987.e4. doi: 10.1016/j.celrep.2018.09.085. PubMed PMID: 30355502; PubMed Central PMCID: PMC6263960.

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Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 Mar 6;101(5):863-875.e6. doi: 10.1016/j.neuron.2019.01.002. Epub 2019 Jan 28. PubMed PMID: 30704911; PubMed Central PMCID: PMC6524650.

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Dai J, Aoto J, Südhof TC. Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron. 2019 Jun 5;102(5):993-1008.e5. doi: 10.1016/j.neuron.2019.03.032. Epub 2019 Apr 17. PubMed PMID: 31005376; PubMed Central PMCID: PMC6554035.

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Meador K, Wysoczynski CL, Norris AJ, Aoto J, Bruchas MR, Tucker CL. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res. 2019 Sep 26;47(17):e97. doi: 10.1093/nar/gkz585. PubMed PMID: 31287871; PubMed Central PMCID: PMC6753482.

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Restrepo S, Langer NJ, Nelson KA, Aoto J. Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses. J Neurosci. 2019 Nov 13;39(46):9065-9082. doi: 10.1523/JNEUROSCI.1261-19.2019. Epub 2019 Oct 2. PubMed PMID: 31578233; PubMed Central PMCID: PMC6855690.

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Restrepo S, Schwartz SL, Kennedy MJ, Aoto J. Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. J Vis Exp. 2020 May 22;(159). doi: 10.3791/61237. PubMed PMID: 32510501.

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Cai Y, Nielsen BE, Boxer EE, Aoto J, Ford CP. Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments. Neuron. 2021 Apr 7;109(7):1137-1149.e5. doi: 10.1016/j.neuron.2021.01.028. Epub 2021 Feb 17. PubMed PMID: 33600762; PubMed Central PMCID: PMC8035293.

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Mermer F, Poliquin S, Rigsby K, Rastogi A, Shen W, Romero-Morales A, Nwosu G, McGrath P, Demerast S, Aoto J, Bilousova G, Lal D, Gama V, Kang JQ. Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons. Brain. 2021 Sep 4;144(8):2499-2512. doi: 10.1093/brain/awab207. PubMed PMID: 34028503; PubMed Central PMCID: PMC8418336.

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Boxer EE, Seng C, Lukacsovich D, Kim J, Schwartz S, Kennedy MJ, Földy C, Aoto J. Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum. Cell Rep. 2021 Dec 7;37(10):110098. doi: 10.1016/j.celrep.2021.110098. PubMed PMID: 34879268; PubMed Central PMCID: PMC8763380.

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Boxer EE, Aoto J. Neurexins and their ligands at inhibitory synapses. Front Synaptic Neurosci. 2022;14:1087238. doi: 10.3389/fnsyn.2022.1087238. eCollection 2022. Review. PubMed PMID: 36618530; PubMed Central PMCID: PMC9812575.

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Boxer EE, Kim J, Dunn B, Aoto J. Ventral Subiculum Inputs to Nucleus Accumbens Medial Shell Preferentially Innervate D2R Medium Spiny Neurons and Contain Calcium Permeable AMPARs. J Neurosci. 2023 Feb 15;43(7):1166-1177. doi: 10.1523/JNEUROSCI.1907-22.2022. Epub 2023 Jan 6. PubMed PMID: 36609456; PubMed Central PMCID: PMC9962776.

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Lloyd BA, Han Y, Roth R, Zhang B, Aoto J. Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nat Commun. 2023 Aug 5;14(1):4706. doi: 10.1038/s41467-023-40419-2. PubMed PMID: 37543682; PubMed Central PMCID: PMC10404257.

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Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep;621(7977):146-153. doi: 10.1038/s41586-023-06465-y. Epub 2023 Aug 30. PubMed PMID: 37648853; PubMed Central PMCID: PMC10482691.

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Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J, Beier KT. Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis. Res Sq. 2023 Nov 21;. doi: 10.21203/rs.3.rs-3559525/v1. PubMed PMID: 38045269; PubMed Central PMCID: PMC10690331.

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Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, Smith KR, Kennedy MJ. Acute reorganization of postsynaptic GABA(A) receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Rep. 2023 Nov 28;42(11):113331. doi: 10.1016/j.celrep.2023.113331. Epub 2023 Oct 31. PubMed PMID: 37910506; PubMed Central PMCID: PMC10782565.

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Miller CN, Li Y, Beier KT, Aoto J. Acute stress causes sex-dependent changes to ventral subiculum synapses, circuitry, and anxiety-like behavior. bioRxiv. 2024 Aug 3;. doi: 10.1101/2024.08.02.606264. PubMed PMID: 39131353; PubMed Central PMCID: PMC11312572.

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Stokes EG, Kim H, Ko J, Aoto J. A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3α Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses. J Neurosci. 2024 Oct 9;44(41). doi: 10.1523/JNEUROSCI.1847-23.2024. PubMed PMID: 39231636; PubMed Central PMCID: PMC11466067.

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Stokes EG, Vasquez JJ, Azouz G, Nguyen M, Tierno A, Zhuang Y, Galinato VM, Hui M, Toledano M, Tyler I, Shi X, Hunt RF, Aoto J, Beier KT. Cationic peptides cause memory loss through endophilin-mediated endocytosis. Nature. 2025 Feb;638(8050):479-489. doi: 10.1038/s41586-024-08413-w. Epub 2025 Jan 15. PubMed PMID: 39814881.