My Bibliography

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Choi H, Panja S, Nguyen HN, Stark RJ, Lamb FS. Smooth Muscle LRRC8A Knockout Preserves Vascular Function in Ang II Hypertension. Hypertension. 2026 Jan;83(1):40-53. doi: 10.1161/HYPERTENSIONAHA.125.25222. Epub 2025 Nov 4. PubMed PMID: 41185995; PubMed Central PMCID: PMC12875604.

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Lamb FS, Stark RJ. Smooth Muscle-Induced Endothelial Dysfunction in Obesity; Don't Just Blame the Middleman. Circ Res. 2025 Aug 29;137(6):829-831. doi: 10.1161/CIRCRESAHA.125.327129. Epub 2025 Aug 28. PubMed PMID: 40875794; PubMed Central PMCID: PMC12616535.

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Dos Passos RR, Santos CV, Priviero F, Briones AM, Tostes RC, Webb RC, Bomfim GF. Immunomodulatory Activity of Cytokines in Hypertension: A Vascular Perspective. Hypertension. 2024 Jul;81(7):1411-1423. doi: 10.1161/HYPERTENSIONAHA.124.21712. Epub 2024 Apr 30. Review. PubMed PMID: 38686582; PubMed Central PMCID: PMC11168883.

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Lamb FS, Choi H, Miller MR, Stark RJ. Vascular Inflammation and Smooth Muscle Contractility: The Role of Nox1-Derived Superoxide and LRRC8 Anion Channels. Hypertension. 2024 Apr;81(4):752-763. doi: 10.1161/HYPERTENSIONAHA.123.19434. Epub 2024 Jan 4. Review. PubMed PMID: 38174563; PubMed Central PMCID: PMC10954410.

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Choi H, Miller MR, Nguyen HN, Surratt VE, Koch SR, Stark RJ, Lamb FS. Extracellular SOD modulates canonical TNFα signaling and α5β1 integrin transactivation in vascular smooth muscle cells. Free Radic Biol Med. 2023 Nov 20;209(Pt 1):152-164. doi: 10.1016/j.freeradbiomed.2023.10.397. Epub 2023 Oct 16. PubMed PMID: 37852546; PubMed Central PMCID: PMC10841345.

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Choi H, Miller MR, Nguyen HN, Rohrbough JC, Koch SR, Boatwright N, Yarboro MT, Sah R, McDonald WH, Reese JJ, Stark RJ, Lamb FS. LRRC8A anion channels modulate vascular reactivity via association with myosin phosphatase rho interacting protein. FASEB J. 2023 Jul;37(7):e23028. doi: 10.1096/fj.202300561R. PubMed PMID: 37310356; PubMed Central PMCID: PMC10591482.

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Priviero F. Epigenetic modifications and fetal programming: Molecular mechanisms to control hypertension inheritance. Biochem Pharmacol. 2023 Feb;208:115412. doi: 10.1016/j.bcp.2023.115412. Epub 2023 Jan 9. Review. PubMed PMID: 36632959; PubMed Central PMCID: PMC10012045.

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Stark RJ, Nguyen HN, Bacon MK, Rohrbough JC, Choi H, Lamb FS. Chloride Channel-3 (ClC-3) Modifies the Trafficking of Leucine-Rich Repeat-Containing 8A (LRRC8A) Anion Channels. J Membr Biol. 2023 Apr;256(2):125-135. doi: 10.1007/s00232-022-00271-9. Epub 2022 Nov 2. PubMed PMID: 36322172; PubMed Central PMCID: PMC10085862.

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Choi H, Rohrbough JC, Nguyen HN, Dikalova A, Lamb FS. Oxidant-resistant LRRC8A/C anion channels support superoxide production by NADPH oxidase 1. J Physiol. 2021 Jun;599(12):3013-3036. doi: 10.1113/JP281577. Epub 2021 May 26. PubMed PMID: 33932953; PubMed Central PMCID: PMC8600960.

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Miller MR, Koch SR, Choi H, Lamb FS, Stark RJ. Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge. Transl Res. 2021 Sep;235:115-128. doi: 10.1016/j.trsl.2021.04.001. Epub 2021 Apr 20. PubMed PMID: 33857660; PubMed Central PMCID: PMC8328918.

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Stark RJ, Krispinsky LT, Lamb FS. The Inverse Relationship Between Endothelium-Dependent Vasodilation and Blood Pressure is Lost After Cardiopulmonary Bypass. J Cardiovasc Transl Res. 2021 Dec;14(6):1114-1116. doi: 10.1007/s12265-021-10124-w. Epub 2021 Apr 9. PubMed PMID: 33835431; PubMed Central PMCID: PMC8501160.

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Lamb FS, Choi H, Miller MR, Stark RJ. TNFα and Reactive Oxygen Signaling in Vascular Smooth Muscle Cells in Hypertension and Atherosclerosis. Am J Hypertens. 2020 Oct 21;33(10):902-913. doi: 10.1093/ajh/hpaa089. Review. PubMed PMID: 32498083; PubMed Central PMCID: PMC7577645.

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Krispinsky LT, Stark RJ, Parra DA, Luan L, Bichell DP, Pietsch JB, Lamb FS. Endothelial-Dependent Vasomotor Dysfunction in Infants After Cardiopulmonary Bypass. Pediatr Crit Care Med. 2020 Jan;21(1):42-49. doi: 10.1097/PCC.0000000000002049. PubMed PMID: 31246738; PubMed Central PMCID: PMC8098768.

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Crockett SL, Harris M, Boatwright N, Su RL, Yarboro MT, Berger CD, Shelton EL, Reese J, Segar JL. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2020 May;87(6):991-997. doi: 10.1038/s41390-019-0716-x. Epub 2019 Dec 9. PubMed PMID: 31816622; PubMed Central PMCID: PMC7196482.

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Stark RJ, Choi H, Lamb FS. Neuronal ASIC1A As a Cerebral pH Sensor: Bringing the Flow. Circ Res. 2019 Oct 25;125(10):921-923. doi: 10.1161/CIRCRESAHA.119.315925. Epub 2019 Oct 24. PubMed PMID: 31647772; PubMed Central PMCID: PMC6993881.

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Choi H, Stark RJ, Raja BS, Dikalova A, Lamb FS. Apoptosis signal-regulating kinase 1 activation by Nox1-derived oxidants is required for TNFα receptor endocytosis. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1528-H1537. doi: 10.1152/ajpheart.00741.2018. Epub 2019 Mar 29. PubMed PMID: 30925081; PubMed Central PMCID: PMC6620688.

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Rohrbough J, Nguyen HN, Lamb FS. Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter. J Physiol. 2018 Sep;596(17):4091-4119. doi: 10.1113/JP276332. Epub 2018 Jul 29. PubMed PMID: 29917234; PubMed Central PMCID: PMC6117567.

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Stark RJ, Koch SR, Choi H, Mace EH, Dikalov SI, Sherwood ER, Lamb FS. Endothelial nitric oxide synthase modulates Toll-like receptor 4-mediated IL-6 production and permeability via nitric oxide-independent signaling. FASEB J. 2018 Feb;32(2):945-956. doi: 10.1096/fj.201700410R. Epub 2018 Jan 3. PubMed PMID: 29061842; PubMed Central PMCID: PMC5888395.

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Choi H, Ettinger N, Rohrbough J, Dikalova A, Nguyen HN, Lamb FS. LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis. Free Radic Biol Med. 2016 Dec;101:413-423. doi: 10.1016/j.freeradbiomed.2016.11.003. Epub 2016 Nov 9. PubMed PMID: 27838438; PubMed Central PMCID: PMC5206799.

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Koch SR, Lamb FS, Hellman J, Sherwood ER, Stark RJ. Potentiation and tolerance of toll-like receptor priming in human endothelial cells. Transl Res. 2017 Feb;180:53-67.e4. doi: 10.1016/j.trsl.2016.08.001. Epub 2016 Aug 8. PubMed PMID: 27567430; PubMed Central PMCID: PMC5253081.

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Kraemer MP, Choi H, Reese J, Lamb FS, Breyer RM. Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1. Vascul Pharmacol. 2016 Sep;84:47-54. doi: 10.1016/j.vph.2016.05.015. Epub 2016 May 31. PubMed PMID: 27260940; PubMed Central PMCID: PMC4976016.

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Stark RJ, Choi H, Koch SR, Fensterheim BA, Lamb FS, Sherwood ER. Endothelial cell tolerance to lipopolysaccharide challenge is induced by monophosphoryl lipid A. Clin Sci (Lond). 2016 Mar;130(6):451-61. doi: 10.1042/CS20150592. Epub 2015 Dec 15. PubMed PMID: 26669797; PubMed Central PMCID: PMC4744094.

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O'Lynnger TM, Shannon CN, Le TM, Greeno A, Chung D, Lamb FS, Wellons JC 3rd. Standardizing ICU management of pediatric traumatic brain injury is associated with improved outcomes at discharge. J Neurosurg Pediatr. 2016 Jan;17(1):19-26. doi: 10.3171/2015.5.PEDS1544. Epub 2015 Oct 9. PubMed PMID: 26451717.

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Choi H, Dikalova A, Stark RJ, Lamb FS. c-Jun N-terminal kinase attenuates TNFα signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells. Free Radic Biol Med. 2015 Sep;86:219-27. doi: 10.1016/j.freeradbiomed.2015.05.015. Epub 2015 May 19. PubMed PMID: 26001727.

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Lamb FS. Localising oxidant "stress" in the antiphospholipid syndrome. Thromb Haemost. 2015 May;113(5):915. doi: 10.1160/TH15-03-0218. Epub 2015 Apr 2. PubMed PMID: 25832773.

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Stark R, Choi H, Koch S, Lamb F, Sherwood E. Monophosphoryl lipid A inhibits the cytokine response of endothelial cells challenged with LPS. Innate Immun. 2015 Aug;21(6):565-74. doi: 10.1177/1753425914564172. Epub 2014 Dec 24. PubMed PMID: 25540284; PubMed Central PMCID: PMC4480205.

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Ettinger N, Pearson M, Lamb FS, Wellons JC 3rd. Pediatric posterior reversible encephalopathy syndrome presenting with isolated cerebellar edema and obstructive hydrocephalus. J Neurosurg Pediatr. 2014 Oct;14(4):344-7. doi: 10.3171/2014.6.PEDS13553. Epub 2014 Jul 25. PubMed PMID: 25062302; PubMed Central PMCID: PMC4332559.

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Choi H, Nguyen HN, Lamb FS. Inhibition of endocytosis exacerbates TNF-α-induced endothelial dysfunction via enhanced JNK and p38 activation. Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1154-63. doi: 10.1152/ajpheart.00885.2013. Epub 2014 Feb 21. PubMed PMID: 24561862.

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Garbrecht MR, Lamb FS. Placental HSD2 Expression and Activity Is Unaffected by Maternal Protein Consumption or Gender in C57BL/6 Mice. ISRN Endocrinol. 2013;2013:867938. doi: 10.1155/2013/867938. Print 2013. PubMed PMID: 23781346; PubMed Central PMCID: PMC3679810.

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Agarwal HS, Hardison DC, Saville BR, Donahue BS, Lamb FS, Bichell DP, Harris ZL. Residual lesions in postoperative pediatric cardiac surgery patients receiving extracorporeal membrane oxygenation support. J Thorac Cardiovasc Surg. 2014 Jan;147(1):434-41. doi: 10.1016/j.jtcvs.2013.03.021. Epub 2013 Apr 15. PubMed PMID: 23597724.

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Ganapathi SB, Wei SG, Zaremba A, Lamb FS, Shears SB. Functional regulation of ClC-3 in the migration of vascular smooth muscle cells. Hypertension. 2013 Jan;61(1):174-9. doi: 10.1161/HYPERTENSIONAHA.112.194209. Epub 2012 Nov 12. PubMed PMID: 23150504; PubMed Central PMCID: PMC3521842.

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Roghair RD, Volk KA, Lamb FS, Segar JL. Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. Am J Physiol Regul Integr Comp Physiol. 2012 Sep 1;303(5):R513-9. doi: 10.1152/ajpregu.00658.2011. Epub 2012 Jul 25. PubMed PMID: 22832534; PubMed Central PMCID: PMC3468415.

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Lamb FS, Hook JS, Hilkin BM, Huber JN, Volk AP, Moreland JG. Endotoxin priming of neutrophils requires endocytosis and NADPH oxidase-dependent endosomal reactive oxygen species. J Biol Chem. 2012 Apr 6;287(15):12395-404. doi: 10.1074/jbc.M111.306530. Epub 2012 Jan 10. PubMed PMID: 22235113; PubMed Central PMCID: PMC3320989.

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Vucovich M, Ehinger N, Poole SD, Lamb FS, Reese J. Spontaneous Rhythmic Contractions (Vasomotion) of the Isolated, Pressurized Ductus Arteriosus of Preterm, but Not Term, Fetal Mice. EJ Neonatol Res. 2012 Jan;2(1):13-24. PubMed PMID: 23710420; PubMed Central PMCID: PMC3661283.

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Bozeat ND, Xiang SY, Ye LL, Yao TY, Duan ML, Burkin DJ, Lamb FS, Duan DD. Activation of volume regulated chloride channels protects myocardium from ischemia/reperfusion damage in second-window ischemic preconditioning. Cell Physiol Biochem. 2011;28(6):1265-78. doi: 10.1159/000335858. Epub 2011 Dec 16. PubMed PMID: 22179014; PubMed Central PMCID: PMC3709186.

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Roghair RD, Wemmie JA, Volk KA, Scholz TD, Lamb FS, Segar JL. Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. Clin Sci (Lond). 2011 Nov;121(10):427-36. doi: 10.1042/CS20110153. PubMed PMID: 21615331; PubMed Central PMCID: PMC3677964.

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Chu X, Filali M, Stanic B, Takapoo M, Sheehan A, Bhalla R, Lamb FS, Miller FJ Jr. A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):345-51. doi: 10.1161/ATVBAHA.110.217604. Epub 2010 Nov 11. PubMed PMID: 21071705; PubMed Central PMCID: PMC3025755.

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Matsuda JJ, Filali MS, Moreland JG, Miller FJ, Lamb FS. Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. J Biol Chem. 2010 Jul 23;285(30):22864-73. doi: 10.1074/jbc.M109.099838. Epub 2010 May 17. PubMed PMID: 20479003; PubMed Central PMCID: PMC2906278.

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Volk KA, Roghair RD, Jung F, Scholz TD, Lamb FS, Segar JL. Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep. Am J Physiol Regul Integr Comp Physiol. 2010 Jun;298(6):R1607-14. doi: 10.1152/ajpregu.00824.2009. Epub 2010 Mar 24. PubMed PMID: 20335378; PubMed Central PMCID: PMC2886704.

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Miller FJ Jr, Chu X, Stanic B, Tian X, Sharma RV, Davisson RL, Lamb FS. A differential role for endocytosis in receptor-mediated activation of Nox1. Antioxid Redox Signal. 2010 Mar 1;12(5):583-93. doi: 10.1089/ars.2009.2857. PubMed PMID: 19737091; PubMed Central PMCID: PMC2861543.

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Matsuda JJ, Filali MS, Collins MM, Volk KA, Lamb FS. The ClC-3 Cl-/H+ antiporter becomes uncoupled at low extracellular pH. J Biol Chem. 2010 Jan 22;285(4):2569-79. doi: 10.1074/jbc.M109.018002. Epub 2009 Nov 19. PubMed PMID: 19926787; PubMed Central PMCID: PMC2807314.

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Lamb FS, Moreland JG, Miller FJ Jr. Electrophysiology of reactive oxygen production in signaling endosomes. Antioxid Redox Signal. 2009 Jun;11(6):1335-47. doi: 10.1089/ars.2008.2448. Review. PubMed PMID: 19207039; PubMed Central PMCID: PMC2872256.

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von Bergen NH, Koppenhafer SL, Spitz DR, Volk KA, Patel SS, Roghair RD, Lamb FS, Segar JL, Scholz TD. Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria. Clin Sci (Lond). 2009 Apr;116(8):659-68. doi: 10.1042/CS20080474. PubMed PMID: 19032144; PubMed Central PMCID: PMC3677965.

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Roghair RD, Segar JL, Volk KA, Chapleau MW, Dallas LM, Sorenson AR, Scholz TD, Lamb FS. Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice. Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R651-62. doi: 10.1152/ajpregu.90756.2008. Epub 2009 Jan 14. PubMed PMID: 19144750; PubMed Central PMCID: PMC2665850.

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Volk AP, Heise CK, Hougen JL, Artman CM, Volk KA, Wessels D, Soll DR, Nauseef WM, Lamb FS, Moreland JG. ClC-3 and IClswell are required for normal neutrophil chemotaxis and shape change. J Biol Chem. 2008 Dec 5;283(49):34315-26. doi: 10.1074/jbc.M803141200. Epub 2008 Oct 7. PubMed PMID: 18840613; PubMed Central PMCID: PMC2590705.

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Roghair RD, Miller FJ Jr, Scholz TD, Lamb FS, Segar JL. Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone. Pediatr Res. 2008 Apr;63(4):370-4. doi: 10.1203/PDR.0b013e3181659bfa. PubMed PMID: 18356741; PubMed Central PMCID: PMC3663587.

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Roghair RD, Segar JL, Kilpatrick RA, Segar EM, Scholz TD, Lamb FS. Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone. J Matern Fetal Neonatal Med. 2007 Nov;20(11):833-41. doi: 10.1080/14767050701626540. PubMed PMID: 17853187.

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Matsuda JJ, Filali MS, Volk KA, Collins MM, Moreland JG, Lamb FS. Overexpression of CLC-3 in HEK293T cells yields novel currents that are pH dependent. Am J Physiol Cell Physiol. 2008 Jan;294(1):C251-62. doi: 10.1152/ajpcell.00338.2007. Epub 2007 Oct 31. PubMed PMID: 17977943.

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George CL, Goss KL, Meyerholz DK, Lamb FS, Snyder JM. Surfactant-associated protein A provides critical immunoprotection in neonatal mice. Infect Immun. 2008 Jan;76(1):380-90. doi: 10.1128/IAI.01043-07. Epub 2007 Oct 29. PubMed PMID: 17967856; PubMed Central PMCID: PMC2223658.

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Moreland JG, Davis AP, Matsuda JJ, Hook JS, Bailey G, Nauseef WM, Lamb FS. Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3. J Biol Chem. 2007 Nov 23;282(47):33958-67. doi: 10.1074/jbc.M705289200. Epub 2007 Oct 1. PubMed PMID: 17908687.