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Levy G, Habib N, Guzzardi MA, Kitsberg D, Bomze D, Ezra E, Uygun BE, Uygun K, Trippler M, Schlaak JF, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y. Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection. Nat Chem Biol. 2016 Dec;12(12):1037-1045. doi: 10.1038/nchembio.2193. Epub 2016 Oct 10. PubMed PMID: 27723751; PubMed Central PMCID: PMC7046487.
Prill S, Bavli D, Levy G, Ezra E, Schmälzlin E, Jaeger MS, Schwarz M, Duschl C, Cohen M, Nahmias Y. Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone. Arch Toxicol. 2016 May;90(5):1181-91. doi: 10.1007/s00204-015-1537-2. Epub 2015 Jun 4. PubMed PMID: 26041127.
Bavli D, Prill S, Ezra E, Levy G, Cohen M, Vinken M, Vanfleteren J, Jaeger M, Nahmias Y. Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2231-40. doi: 10.1073/pnas.1522556113. Epub 2016 Apr 4. PubMed PMID: 27044092; PubMed Central PMCID: PMC4843487.
Bavli D, Ezra E, Kitsberg D, Vosk-Artzi M, Murthy SK, Nahmias Y. One step antibody-mediated isolation and patterning of multiple cell types in microfluidic devices. Biomicrofluidics. 2016 Mar;10(2):024112. doi: 10.1063/1.4944741. eCollection 2016 Mar. PubMed PMID: 27051469; PubMed Central PMCID: PMC4808062.
Levy G, Bomze D, Heinz S, Ramachandran SD, Noerenberg A, Cohen M, Shibolet O, Sklan E, Braspenning J, Nahmias Y. Long-term culture and expansion of primary human hepatocytes. Nat Biotechnol. 2015 Dec;33(12):1264-1271. doi: 10.1038/nbt.3377. Epub 2015 Oct 26. PubMed PMID: 26501953.
Keinan E, Ezra E, Nahmias Y. Opposing shear-induced forces dominate inertial focusing in curved channels and high Reynolds numbers. Appl. Phys. Lett. 2015 November; 107:193507. doi:
Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie CM. Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition. Stem Cell Reports. 2015 Nov 10;5(5):918-931. doi: 10.1016/j.stemcr.2015.09.004. Epub 2015 Oct 8. PubMed PMID: 26455413; PubMed Central PMCID: PMC4649136.
Ezra E, Maor I, Bavli D, Shalom I, Levy G, Prill S, Jaeger MS, Nahmias Y. Microprocessor-based integration of microfluidic control for the implementation of automated sensor monitoring and multithreaded optimization algorithms. Biomed Microdevices. 2015 Aug;17(4):82. doi: 10.1007/s10544-015-9989-y. PubMed PMID: 26227212.
Avior Y, Levy G, Zimerman M, Kitsberg D, Schwartz R, Sadeh R, Moussaieff A, Cohen M, Itskovitz-Eldor J, Nahmias Y. Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes. Hepatology. 2015 Jul;62(1):265-78. doi: 10.1002/hep.27803. Epub 2015 Apr 22. PubMed PMID: 25808545.
Bartok O, Teesalu M, Ashwall-Fluss R, Pandey V, Hanan M, Rovenko BM, Poukkula M, Havula E, Moussaieff A, Vodala S, Nahmias Y, Kadener S, Hietakangas V. The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing. EMBO J. 2015 Jun 3;34(11):1538-53. doi: 10.15252/embj.201591385. Epub 2015 Apr 27. PubMed PMID: 25916830; PubMed Central PMCID: PMC4474529.
Moussaieff A, Rouleau M, Kitsberg D, Cohen M, Levy G, Barasch D, Nemirovski A, Shen-Orr S, Laevsky I, Amit M, Bomze D, Elena-Herrmann B, Scherf T, Nissim-Rafinia M, Kempa S, Itskovitz-Eldor J, Meshorer E, Aberdam D, Nahmias Y. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metab. 2015 Mar 3;21(3):392-402. doi: 10.1016/j.cmet.2015.02.002. PubMed PMID: 25738455.
Levy G, Cohen M, Nahmias Y. In Vitro Cell Culture Models of Hepatic Steatosis. Methods Mol Biol. 2015;1250:377-90. doi: 10.1007/978-1-4939-2074-7_29. PubMed PMID: 26272159.
Cohen M, Levy G, Nahmias Y. Coculture and Long-Term Maintenance of Hepatocytes. Methods Mol Biol. 2015;1250:161-73. doi: 10.1007/978-1-4939-2074-7_11. PubMed PMID: 26272141.
Zhu B, Nahmias Y, Yarmush ML, Murthy SK. Microfluidic Isolation of CD34-Positive Skin Cells Enables Regeneration of Hair and Sebaceous Glands In Vivo. Stem Cells Transl Med. 2014 Nov;3(11):1354-62. doi: 10.5966/sctm.2014-0098. Epub 2014 Sep 9. PubMed PMID: 25205844; PubMed Central PMCID: PMC4214846.
Cohen M, Kitsberg D, Tsytkin S, Shulman M, Aroeti B, Nahmias Y. Live imaging of GLUT2 glucose-dependent trafficking and its inhibition in polarized epithelial cysts. Open Biol. 2014 Jul;4(7). doi: 10.1098/rsob.140091. PubMed PMID: 25056286; PubMed Central PMCID: PMC4118605.
Harrison BD, Hashemi J, Bibi M, Pulver R, Bavli D, Nahmias Y, Wellington M, Sapiro G, Berman J. A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole. PLoS Biol. 2014 Mar;12(3):e1001815. doi: 10.1371/journal.pbio.1001815. eCollection 2014 Mar. PubMed PMID: 24642609; PubMed Central PMCID: PMC3958355.
Zhu B, Smith J, Yarmush ML, Nahmias Y, Kirby BJ, Murthy SK. Microfluidic enrichment of mouse epidermal stem cells and validation of stem cell proliferation in vitro. Tissue Eng Part C Methods. 2013 Oct;19(10):765-73. doi: 10.1089/ten.TEC.2012.0638. Epub 2013 Mar 18. PubMed PMID: 23394261; PubMed Central PMCID: PMC3751333.
Keinan E, Ezra E, Nahmias Y. Frame rate free image velocimetry for microfluidic devices. Appl Phys Lett. 2013 Aug 5;103(6):63507. doi: 10.1063/1.4818142. Epub 2013 Aug 8. PubMed PMID: 24023394; PubMed Central PMCID: PMC3751964.
Avior Y, Bomze D, Ramon O, Nahmias Y. Flavonoids as dietary regulators of nuclear receptor activity. Food Funct. 2013 Jun;4(6):831-44. doi: 10.1039/c3fo60063g. Epub 2013 Apr 19. Review. PubMed PMID: 23598551; PubMed Central PMCID: PMC3781338.
Ezra E, Keinan E, Mandel Y, Boulton ME, Nahmias Y. Non-dimensional analysis of retinal microaneurysms: critical threshold for treatment. Integr Biol (Camb). 2013 Mar;5(3):474-80. doi: 10.1039/c3ib20259c. PubMed PMID: 23371018; PubMed Central PMCID: PMC3781337.
Bao J, Fisher JE, Lillegard JB, Wang W, Amiot B, Yu Y, Dietz AB, Nahmias Y, Nyberg SL. Serum-free medium and mesenchymal stromal cells enhance functionality and stabilize integrity of rat hepatocyte spheroids. Cell Transplant. 2013;22(2):299-308. doi: 10.3727/096368912X656054. Epub 2012 Sep 21. PubMed PMID: 23006214; PubMed Central PMCID: PMC3781336.
Shulman M, Nahmias Y. Long-term culture and coculture of primary rat and human hepatocytes. Methods Mol Biol. 2013;945:287-302. doi: 10.1007/978-1-62703-125-7_17. PubMed PMID: 23097113; PubMed Central PMCID: PMC3781339.
Spokoini R, Moldavski O, Nahmias Y, England JL, Schuldiner M, Kaganovich D. Confinement to organelle-associated inclusion structures mediates asymmetric inheritance of aggregated protein in budding yeast. Cell Rep. 2012 Oct 25;2(4):738-47. doi: 10.1016/j.celrep.2012.08.024. Epub 2012 Sep 27. PubMed PMID: 23022486.
Roelandt P, Obeid S, Paeshuyse J, Vanhove J, Van Lommel A, Nahmias Y, Nevens F, Neyts J, Verfaillie CM. Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus. J Hepatol. 2012 Aug;57(2):246-51. doi: 10.1016/j.jhep.2012.03.030. Epub 2012 Apr 17. PubMed PMID: 22521345; NIHMSID:NIHMS382884.
Nevo-Yassaf I, Yaffe Y, Asher M, Ravid O, Eizenberg S, Henis YI, Nahmias Y, Hirschberg K, Sklan EH. Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A. J Virol. 2012 Jun;86(12):6491-502. doi: 10.1128/JVI.00496-12. Epub 2012 Apr 4. PubMed PMID: 22491470; PubMed Central PMCID: PMC3393552.
Goldwasser J, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y. Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism. J Hepatol. 2011 Nov;55(5):963-71. doi: 10.1016/j.jhep.2011.02.011. Epub 2011 Feb 24. PubMed PMID: 21354229; PubMed Central PMCID: PMC3197749.
Merquiol E, Uzi D, Mueller T, Goldenberg D, Nahmias Y, Xavier RJ, Tirosh B, Shibolet O. HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. PLoS One. 2011;6(9):e24660. doi: 10.1371/journal.pone.0024660. Epub 2011 Sep 19. PubMed PMID: 21949742; PubMed Central PMCID: PMC3176279.
Shulman M, Cohen M, Soto-Gutierrez A, Yagi H, Wang H, Goldwasser J, Lee-Parsons CW, Benny-Ratsaby O, Yarmush ML, Nahmias Y. Enhancement of naringenin bioavailability by complexation with hydroxypropyl-β-cyclodextrin. [corrected]. PLoS One. 2011 Apr 6;6(4):e18033. doi: 10.1371/journal.pone.0018033. PubMed PMID: 21494673; PubMed Central PMCID: PMC3071816.
Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2011 Apr;108(4):839-52. doi: 10.1002/bit.22998. Epub 2010 Dec 4. PubMed PMID: 21404258; PubMed Central PMCID: PMC3277812.
Koria P, Yagi H, Kitagawa Y, Megeed Z, Nahmias Y, Sheridan R, Yarmush ML. Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds. Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1034-9. doi: 10.1073/pnas.1009881108. Epub 2010 Dec 30. PubMed PMID: 21193639; PubMed Central PMCID: PMC3024670.
Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML. Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1. Mol Ther. 2010 Oct;18(10):1857-64. doi: 10.1038/mt.2010.155. Epub 2010 Jul 27. PubMed PMID: 20664529; PubMed Central PMCID: PMC2951565.
Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, Nahmias Y. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha. PLoS One. 2010 Aug 25;5(8):e12399. doi: 10.1371/journal.pone.0012399. PubMed PMID: 20811644; PubMed Central PMCID: PMC2928300.
Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F, Hertl M, Nahmias Y, Yarmush ML, Uygun K. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul;16(7):814-20. doi: 10.1038/nm.2170. Epub 2010 Jun 13. PubMed PMID: 20543851; PubMed Central PMCID: PMC2930603.
Wagoner J, Negash A, Kane OJ, Martinez LE, Nahmias Y, Bourne N, Owen DM, Grove J, Brimacombe C, McKeating JA, Pécheur EI, Graf TN, Oberlies NH, Lohmann V, Cao F, Tavis JE, Polyak SJ. Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology. 2010 Jun;51(6):1912-21. doi: 10.1002/hep.23587. PubMed PMID: 20512985; PubMed Central PMCID: PMC2909978.
Kidambi S, Yarmush RS, Novik E, Chao P, Yarmush ML, Nahmias Y. Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15714-9. doi: 10.1073/pnas.0906820106. Epub 2009 Aug 31. PubMed PMID: 19720996; PubMed Central PMCID: PMC2747185.
Jindal R, Nahmias Y, Tilles AW, Berthiaume F, Yarmush ML. Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model. FASEB J. 2009 Jul;23(7):2288-98. doi: 10.1096/fj.08-114934. Epub 2009 Feb 26. PubMed PMID: 19246486; PubMed Central PMCID: PMC2704587.
Kidambi S, Yarmush J, Fong W, Kamath S, Schianodicola J, Nahmias Y. Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells. Neuroreport. 2009 May 6;20(7):657-62. doi: 10.1097/WNR.0b013e328329a449. PubMed PMID: 19349923; PubMed Central PMCID: PMC2801809.
Song Q, Uygun B, Banerjee I, Nahmias Y, Zhang Q, Berthiaume F, Latina M, Yarmush ML. Low Power Laser Irradiation Stimulates the Proliferation of Adult Human Retinal Pigment Epithelial Cells in Culture. Cell Mol Bioeng. 2009 Mar;2(1):87-103. doi: 10.1007/s12195-008-0041-7. Epub 2008 Dec 23. PubMed PMID: 26740823; PubMed Central PMCID: PMC4698896.
Tolboom H, Pouw RE, Izamis ML, Milwid JM, Sharma N, Soto-Gutierrez A, Nahmias Y, Uygun K, Berthiaume F, Yarmush ML. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation. 2009 Jan 27;87(2):170-7. doi: 10.1097/TP.0b013e318192df6b. PubMed PMID: 19155970; PubMed Central PMCID: PMC2743395.
Benny O, Fainaru O, Adini A, Cassiola F, Bazinet L, Adini I, Pravda E, Nahmias Y, Koirala S, Corfas G, D'Amato RJ, Folkman J. An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nat Biotechnol. 2008 Jul;26(7):799-807. doi: 10.1038/nbt1415. Epub 2008 Jun 29. PubMed PMID: 18587385; PubMed Central PMCID: PMC2803109.
Nahmias Y, Goldwasser J, Casali M, van Poll D, Wakita T, Chung RT, Yarmush ML. Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. Hepatology. 2008 May;47(5):1437-45. doi: 10.1002/hep.22197. PubMed PMID: 18393287; PubMed Central PMCID: PMC4500072.
van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology. 2008 May;47(5):1634-43. doi: 10.1002/hep.22236. PubMed PMID: 18395843.
Cho CH, Parashurama N, Park EY, Suganuma K, Nahmias Y, Park J, Tilles AW, Berthiaume F, Yarmush ML. Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure. FASEB J. 2008 Mar;22(3):898-909. doi: 10.1096/fj.06-7764com. Epub 2007 Oct 17. PubMed PMID: 17942827; NIHMSID:NIHMS335642.
Parashurama N, Nahmias Y, Cho CH, van Poll D, Tilles AW, Berthiaume F, Yarmush ML. Activin alters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gels. Stem Cells. 2008 Feb;26(2):474-84. doi: 10.1634/stemcells.2007-0303. Epub 2007 Dec 6. PubMed PMID: 18065398; PubMed Central PMCID: PMC2802581.
Nahmias Y, Berthiaume F, Yarmush ML. Integration of technologies for hepatic tissue engineering. Adv Biochem Eng Biotechnol. 2007;103:309-29. doi: 10.1007/10_029. Review. PubMed PMID: 17195468.
Nahmias Y, Kramvis Y, Barbe L, Casali M, Berthiaume F, Yarmush ML. A novel formulation of oxygen-carrying matrix enhances liver-specific function of cultured hepatocytes. FASEB J. 2006 Dec;20(14):2531-3. doi: 10.1096/fj.06-6192fje. Epub 2006 Oct 31. PubMed PMID: 17077286.
Nahmias Y, Schwartz RE, Hu WS, Verfaillie CM, Odde DJ. Endothelium-mediated hepatocyte recruitment in the establishment of liver-like tissue in vitro. Tissue Eng. 2006 Jun;12(6):1627-38. doi: 10.1089/ten.2006.12.1627. PubMed PMID: 16846358.
Nahmias Y, Casali M, Barbe L, Berthiaume F, Yarmush ML. Liver endothelial cells promote LDL-R expression and the uptake of HCV-like particles in primary rat and human hepatocytes. Hepatology. 2006 Feb;43(2):257-65. doi: 10.1002/hep.21016. PubMed PMID: 16440337.
Nahmias Y, Odde DJ. Micropatterning of living cells by laser-guided direct writing: application to fabrication of hepatic-endothelial sinusoid-like structures. Nat Protoc. 2006;1(5):2288-96. doi: 10.1038/nprot.2006.386. PubMed PMID: 17406470.
Nahmias Y, Schwartz RE, Verfaillie CM, Odde DJ. Laser-guided direct writing for three-dimensional tissue engineering. Biotechnol Bioeng. 2005 Oct 20;92(2):129-36. doi: 10.1002/bit.20585. PubMed PMID: 16025535.
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