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Temple JL, Bradshaw HB, Wood E, Berkley KJ. Effects of hypogastric neurectomy on escape responses to uterine distention in the rat. Pain. 1999 Aug;Suppl 6:S13-20. doi: 10.1016/s0304-3959(99)00133-5. PubMed PMID: 10491968.
Bradshaw HB, Temple JL, Wood E, Berkley KJ. Estrous variations in behavioral responses to vaginal and uterine distention in the rat. Pain. 1999 Aug;82(2):187-97. doi: 10.1016/s0304-3959(99)00049-4. PubMed PMID: 10467923.
Bradshaw H, Miller J, Ling Q, Malsnee K, Ruda MA. Sex differences and phases of the estrous cycle alter the response of spinal cord dynorphin neurons to peripheral inflammation and hyperalgesia. Pain. 2000 Mar;85(1-2):93-9. doi: 10.1016/s0304-3959(99)00253-5. PubMed PMID: 10692607.
Bradshaw HB, Berkley KJ. Estrous changes in responses of rat gracile nucleus neurons to stimulation of skin and pelvic viscera. J Neurosci. 2000 Oct 15;20(20):7722-7. PubMed PMID: 11027234; PubMed Central PMCID: PMC6772892.
Berkley KJ, Cason A, Jacobs H, Bradshaw H, Wood E. Vaginal hyperalgesia in a rat model of endometriosis. Neurosci Lett. 2001 Jun 29;306(3):185-8. doi: 10.1016/s0304-3940(01)01906-1. PubMed PMID: 11406326.
Bradshaw HB, Berkley KJ. Estrogen replacement reverses ovariectomy-induced vaginal hyperalgesia in the rat. Maturitas. 2002 Feb 26;41(2):157-65. doi: 10.1016/s0378-5122(01)00261-4. PubMed PMID: 11836047.
Bradshaw HB, Berkley KJ. The influence of ovariectomy with or without estrogen replacement on responses of rat gracile nucleus neurons to stimulation of hindquarter skin and pelvic viscera. Brain Res. 2003 Oct 3;986(1-2):82-90. doi: 10.1016/s0006-8993(03)03175-5. PubMed PMID: 12965232.
Bradshaw HB, Walker JM. The expanding field of cannabimimetic and related lipid mediators. Br J Pharmacol. 2005 Feb;144(4):459-65. doi: 10.1038/sj.bjp.0706093. Review. PubMed PMID: 15655504; PubMed Central PMCID: PMC1576036.
Walker JM, Krey JF, Chen JS, Vefring E, Jahnsen JA, Bradshaw H, Huang SM. Targeted lipidomics: fatty acid amides and pain modulation. Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):35-45. doi: 10.1016/j.prostaglandins.2004.09.017. Epub 2004 Nov 24. Review. PubMed PMID: 16099389.
Tan B, Bradshaw HB, Rimmerman N, Srinivasan H, Yu YW, Krey JF, Monn MF, Chen JS, Hu SS, Pickens SR, Walker JM. Targeted lipidomics: discovery of new fatty acyl amides. AAPS J. 2006 Jul 14;8(3):E461-5. doi: 10.1208/aapsj080354. Review. PubMed PMID: 17025263; PubMed Central PMCID: PMC2761052.
Bradshaw HB, Rimmerman N, Krey JF, Walker JM. Sex and hormonal cycle differences in rat brain levels of pain-related cannabimimetic lipid mediators. Am J Physiol Regul Integr Comp Physiol. 2006 Aug;291(2):R349-58. doi: 10.1152/ajpregu.00933.2005. Epub 2006 Mar 23. PubMed PMID: 16556899.
Burstein SH, Adams JK, Bradshaw HB, Fraioli C, Rossetti RG, Salmonsen RA, Shaw JW, Walker JM, Zipkin RE, Zurier RB. Potential anti-inflammatory actions of the elmiric (lipoamino) acids. Bioorg Med Chem. 2007 May 15;15(10):3345-55. doi: 10.1016/j.bmc.2007.03.026. Epub 2007 Mar 13. PubMed PMID: 17383881; PubMed Central PMCID: PMC1896102.
Rubio M, McHugh D, Fernández-Ruiz J, Bradshaw H, Walker JM. Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. Neurosci Lett. 2007 Jun 29;421(3):270-4. doi: 10.1016/j.neulet.2007.05.052. Epub 2007 Jun 2. PubMed PMID: 17574742; PubMed Central PMCID: PMC2966860.
Rimmerman N, Hughes HV, Bradshaw HB, Pazos MX, Mackie K, Prieto AL, Walker JM. Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. Br J Pharmacol. 2008 Jan;153(2):380-9. doi: 10.1038/sj.bjp.0707561. Epub 2007 Oct 29. PubMed PMID: 17965731; PubMed Central PMCID: PMC2219527.
Hu SS, Bradshaw HB, Chen JS, Tan B, Walker JM. Prostaglandin E2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. Br J Pharmacol. 2008 Apr;153(7):1538-49. doi: 10.1038/bjp.2008.33. Epub 2008 Feb 25. PubMed PMID: 18297109; PubMed Central PMCID: PMC2437899.
Rimmerman N, Bradshaw HB, Hughes HV, Chen JS, Hu SS, McHugh D, Vefring E, Jahnsen JA, Thompson EL, Masuda K, Cravatt BF, Burstein S, Vasko MR, Prieto AL, O'Dell DK, Walker JM. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Mol Pharmacol. 2008 Jul;74(1):213-24. doi: 10.1124/mol.108.045997. Epub 2008 Apr 18. PubMed PMID: 18424551.
Huang SM, Lee H, Chung MK, Park U, Yu YY, Bradshaw HB, Coulombe PA, Walker JM, Caterina MJ. Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. J Neurosci. 2008 Dec 17;28(51):13727-37. doi: 10.1523/JNEUROSCI.5741-07.2008. PubMed PMID: 19091963; PubMed Central PMCID: PMC2676929.
Rimmerman N, Bradshaw HB, Basnet A, Tan B, Widlanski TS, Walker JM. Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors. Prostaglandins Other Lipid Mediat. 2009 Jan;88(1-2):10-7. doi: 10.1016/j.prostaglandins.2008.08.004. Epub 2008 Sep 2. PubMed PMID: 18812233; PubMed Central PMCID: PMC2639396.
Bradshaw HB, Rimmerman N, Hu SS, Burstein S, Walker JM. Novel endogenous N-acyl glycines identification and characterization. Vitam Horm. 2009;81:191-205. doi: 10.1016/S0083-6729(09)81008-X. Review. PubMed PMID: 19647113.
Koppel J, Bradshaw H, Goldberg TE, Khalili H, Marambaud P, Walker MJ, Pazos M, Gordon ML, Christen E, Davies P. Endocannabinoids in Alzheimer's disease and their impact on normative cognitive performance: a case-control and cohort study. Lipids Health Dis. 2009 Jan 14;8:2. doi: 10.1186/1476-511X-8-2. PubMed PMID: 19144193; PubMed Central PMCID: PMC2631501.
Bradshaw HB, Rimmerman N, Hu SS, Benton VM, Stuart JM, Masuda K, Cravatt BF, O'Dell DK, Walker JM. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. BMC Biochem. 2009 May 21;10:14. doi: 10.1186/1471-2091-10-14. PubMed PMID: 19460156; PubMed Central PMCID: PMC2689249.
Bradshaw HB, Lee SH, McHugh D. Orphan endogenous lipids and orphan GPCRs: a good match. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):131-4. doi: 10.1016/j.prostaglandins.2009.04.006. Epub 2009 Apr 18. Review. PubMed PMID: 19379823; PubMed Central PMCID: PMC2740803.
Dowie MJ, Bradshaw HB, Howard ML, Nicholson LF, Faull RL, Hannan AJ, Glass M. Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. Neuroscience. 2009 Sep 29;163(1):456-65. doi: 10.1016/j.neuroscience.2009.06.014. Epub 2009 Jun 10. PubMed PMID: 19524019.
Hu SS, Bradshaw HB, Benton VM, Chen JS, Huang SM, Minassi A, Bisogno T, Masuda K, Tan B, Roskoski R Jr, Cravatt BF, Di Marzo V, Walker JM. The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine. Prostaglandins Leukot Essent Fatty Acids. 2009 Oct;81(4):291-301. doi: 10.1016/j.plefa.2009.05.026. Epub 2009 Jun 30. PubMed PMID: 19570666; PubMed Central PMCID: PMC2757501.
Bradshaw H. CB1-induced side effects of specific COX-2 inhibitors: a feature, not a bug. Pain. 2010 Jan;148(1):5. doi: 10.1016/j.pain.2009.10.015. Epub 2009 Nov 13. PubMed PMID: 19913999.
Hirota Y, Daikoku T, Tranguch S, Xie H, Bradshaw HB, Dey SK. Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest. 2010 Mar;120(3):803-15. doi: 10.1172/JCI40051. PubMed PMID: 20124728; PubMed Central PMCID: PMC2827950.
McHugh D, Hu SS, Rimmerman N, Juknat A, Vogel Z, Walker JM, Bradshaw HB. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci. 2010 Mar 26;11:44. doi: 10.1186/1471-2202-11-44. PubMed PMID: 20346144; PubMed Central PMCID: PMC2865488.
Sun X, Xie H, Yang J, Wang H, Bradshaw HB, Dey SK. Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16887-92. doi: 10.1073/pnas.1010892107. Epub 2010 Sep 13. PubMed PMID: 20837524; PubMed Central PMCID: PMC2947871.
Smoum R, Bar A, Tan B, Milman G, Attar-Namdar M, Ofek O, Stuart JM, Bajayo A, Tam J, Kram V, O'Dell D, Walker MJ, Bradshaw HB, Bab I, Mechoulam R. Oleoyl serine, an endogenous N-acyl amide, modulates bone remodeling and mass. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17710-5. doi: 10.1073/pnas.0912479107. Epub 2010 Sep 27. PubMed PMID: 20876113; PubMed Central PMCID: PMC2955099.
Lee SH, Raboune S, Walker JM, Bradshaw HB. Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain. Int J Mol Sci. 2010 Oct 15;11(10):3965-76. doi: 10.3390/ijms11103965. PubMed PMID: 21152313; PubMed Central PMCID: PMC2996792.
Rimmerman N, Juknat A, Kozela E, Levy R, Bradshaw HB, Vogel Z. The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells. Cell Mol Neurobiol. 2011 Aug;31(6):921-30. doi: 10.1007/s10571-011-9692-3. Epub 2011 Apr 30. PubMed PMID: 21533611.
Bab I, Smoum R, Bradshaw H, Mechoulam R. Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family. Br J Pharmacol. 2011 Aug;163(7):1441-6. doi: 10.1111/j.1476-5381.2011.01474.x. Review. PubMed PMID: 21557736; PubMed Central PMCID: PMC3165954.
Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis. 2011 Aug;17(8):1651-64. doi: 10.1002/ibd.21538. Epub 2010 Nov 15. PubMed PMID: 21744421; PubMed Central PMCID: PMC3116968.
Berlanga O, Bradshaw HB, Vilella-Mitjana F, Garrido-Gómez T, Simón C. How endometrial secretomics can help in predicting implantation. Placenta. 2011 Sep;32 Suppl 3:S271-5. doi: 10.1016/j.placenta.2011.06.002. Epub 2011 Jun 23. Review. PubMed PMID: 21700334.
McHugh D, Page J, Dunn E, Bradshaw HB. Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012 Apr;165(8):2414-24. doi: 10.1111/j.1476-5381.2011.01497.x. PubMed PMID: 21595653; PubMed Central PMCID: PMC3423258.
Rimmerman N, Bradshaw HB, Kozela E, Levy R, Juknat A, Vogel Z. Compartmentalization of endocannabinoids into lipid rafts in a microglial cell line devoid of caveolin-1. Br J Pharmacol. 2012 Apr;165(8):2436-49. doi: 10.1111/j.1476-5381.2011.01380.x. PubMed PMID: 21449981; PubMed Central PMCID: PMC3423248.
Ho JM, Smith NS, Adams SA, Bradshaw HB, Demas GE. Photoperiodic changes in endocannabinoid levels and energetic responses to altered signalling at CB1 receptors in Siberian hamsters. J Neuroendocrinol. 2012 Jul;24(7):1030-9. doi: 10.1111/j.1365-2826.2012.02312.x. PubMed PMID: 22420341; PubMed Central PMCID: PMC4060156.
McHugh D, Wager-Miller J, Page J, Bradshaw HB. siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration. J Mol Signal. 2012 Jul 26;7(1):10. doi: 10.1186/1750-2187-7-10. PubMed PMID: 22834922; PubMed Central PMCID: PMC3493281.
Guindon J, Lai Y, Takacs SM, Bradshaw HB, Hohmann AG. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacol Res. 2013 Jan;67(1):94-109. doi: 10.1016/j.phrs.2012.10.013. Epub 2012 Nov 2. PubMed PMID: 23127915; PubMed Central PMCID: PMC3525790.
Bradshaw HB, Raboune S, Hollis JL. Opportunistic activation of TRP receptors by endogenous lipids: exploiting lipidomics to understand TRP receptor cellular communication. Life Sci. 2013 Mar 19;92(8-9):404-9. doi: 10.1016/j.lfs.2012.11.008. Epub 2012 Nov 20. Review. PubMed PMID: 23178153; PubMed Central PMCID: PMC3587287.
Leishman E, Kokesh KJ, Bradshaw HB. Lipids and addiction: how sex steroids, prostaglandins, and cannabinoids interact with drugs of abuse. Ann N Y Acad Sci. 2013 Apr;1282:25-38. doi: 10.1111/nyas.12081. Epub 2013 Mar 19. Review. PubMed PMID: 23510307.
Wu CS, Chen H, Sun H, Zhu J, Jew CP, Wager-Miller J, Straiker A, Spencer C, Bradshaw H, Mackie K, Lu HC. GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination. PLoS One. 2013;8(4):e60314. doi: 10.1371/journal.pone.0060314. Epub 2013 Apr 2. PubMed PMID: 23565223; PubMed Central PMCID: PMC3614963.
Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A. A GPR18-based signalling system regulates IOP in murine eye. Br J Pharmacol. 2013 Jun;169(4):834-43. doi: 10.1111/bph.12136. PubMed PMID: 23461720; PubMed Central PMCID: PMC3687663.
Tortoriello G, Rhodes BP, Takacs SM, Stuart JM, Basnet A, Raboune S, Widlanski TS, Doherty P, Harkany T, Bradshaw HB. Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides. PLoS One. 2013;8(7):e67865. doi: 10.1371/journal.pone.0067865. Print 2013. PubMed PMID: 23874457; PubMed Central PMCID: PMC3708943.
Slusar JE, Cairns EA, Szczesniak AM, Bradshaw HB, Di Polo A, Kelly ME. The fatty acid amide hydrolase inhibitor, URB597, promotes retinal ganglion cell neuroprotection in a rat model of optic nerve axotomy. Neuropharmacology. 2013 Sep;72:116-25. doi: 10.1016/j.neuropharm.2013.04.018. Epub 2013 May 3. PubMed PMID: 23643752.
Cha J, Bartos A, Egashira M, Haraguchi H, Saito-Fujita T, Leishman E, Bradshaw H, Dey SK, Hirota Y. Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions. J Clin Invest. 2013 Sep;123(9):4063-75. doi: 10.1172/JCI70098. Epub 2013 Aug 27. PubMed PMID: 23979163; PubMed Central PMCID: PMC3754274.
Stuart JM, Paris JJ, Frye C, Bradshaw HB. Brain levels of prostaglandins, endocannabinoids, and related lipids are affected by mating strategies. Int J Endocrinol. 2013;2013:436252. doi: 10.1155/2013/436252. Epub 2013 Nov 27. PubMed PMID: 24369463; PubMed Central PMCID: PMC3863470.
Rimmerman N, Ben-Hail D, Porat Z, Juknat A, Kozela E, Daniels MP, Connelly PS, Leishman E, Bradshaw HB, Shoshan-Barmatz V, Vogel Z. Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death. Cell Death Dis. 2013 Dec 5;4:e949. doi: 10.1038/cddis.2013.471. PubMed PMID: 24309936; PubMed Central PMCID: PMC3877544.
McHugh D, Roskowski D, Xie S, Bradshaw HB. Δ(9)-THC and N-arachidonoyl glycine regulate BV-2 microglial morphology and cytokine release plasticity: implications for signaling at GPR18. Front Pharmacol. 2014;4:162. doi: 10.3389/fphar.2013.00162. eCollection 2014. PubMed PMID: 24427137; PubMed Central PMCID: PMC3877838.
Meccariello R, Battista N, Bradshaw HB, Wang H. Updates in reproduction coming from the endocannabinoid system. Int J Endocrinol. 2014;2014:412354. doi: 10.1155/2014/412354. Epub 2014 Jan 16. Review. PubMed PMID: 24550985; PubMed Central PMCID: PMC3914453.
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