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Yadav J, El Hassani M, Sodhi J, Lauschke VM, Hartman JH, Russell LE. Recent developments in in vitro and in vivo models for improved translation of preclinical pharmacokinetics and pharmacodynamics data. Drug Metab Rev. 2021 May;53(2):207-233. doi: 10.1080/03602532.2021.1922435. Epub 2021 May 25. PubMed PMID: 33989099; PubMed Central PMCID: PMC8381685.
Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Nucleic Acids Res. 2021 Feb 26;49(4):2065-2084. doi: 10.1093/nar/gkab041. PubMed PMID: 33555350; PubMed Central PMCID: PMC7913688.
Hartman JH, Widmayer SJ, Bergemann CM, King DE, Morton KS, Romersi RF, Jameson LE, Leung MCK, Andersen EC, Taubert S, Meyer JN. Xenobiotic metabolism and transport in Caenorhabditis elegans. J Toxicol Environ Health B Crit Rev. 2021 Feb 17;24(2):51-94. doi: 10.1080/10937404.2021.1884921. Epub 2021 Feb 22. PubMed PMID: 33616007; PubMed Central PMCID: PMC7958427.
Leuthner TC, Hartman JH, Ryde IT, Meyer JN. PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species. Methods Mol Biol. 2021;2310:91-111. doi: 10.1007/978-1-0716-1433-4_8. PubMed PMID: 34096001.
Russell LE, Schleiff MA, Gonzalez E, Bart AG, Broccatelli F, Hartman JH, Humphreys WG, Lauschke VM, Martin I, Nwabufo C, Prasad B, Scott EE, Segall M, Takahashi R, Taub ME, Sodhi JK. Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX). Drug Metab Rev. 2020 Aug;52(3):395-407. doi: 10.1080/03602532.2020.1765793. Epub 2020 May 26. Review. PubMed PMID: 32456484; PubMed Central PMCID: PMC7466845.
Harris JB, Hartman JH, Luz AL, Wilson JY, Dinyari A, Meyer JN. Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture. Toxicology. 2020 Jul;440:152473. doi: 10.1016/j.tox.2020.152473. Epub 2020 May 1. PubMed PMID: 32360973; PubMed Central PMCID: PMC7313633.
Phillips AL, Herkert NJ, Ulrich JC, Hartman JH, Ruis MT, Cooper EM, Ferguson PL, Stapleton HM. In Vitro Metabolism of Isopropylated and tert-Butylated Triarylphosphate Esters Using Human Liver Subcellular Fractions. Chem Res Toxicol. 2020 Jun 15;33(6):1428-1441. doi: 10.1021/acs.chemrestox.0c00002. Epub 2020 Mar 18. PubMed PMID: 32129605; PubMed Central PMCID: PMC7508416.
Zhang J, Hartman JH, Chen C, Yang S, Li Q, Tian Z, Huang PH, Wang L, Meyer JN, Huang TJ. Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics. Lab Chip. 2020 May 19;20(10):1729-1739. doi: 10.1039/d0lc00051e. PubMed PMID: 32292982; PubMed Central PMCID: PMC7239761.
Hartman JH, Richie CT, Gordon KL, Mello DF, Castillo P, Zhu A, Wang Y, Hoffer BJ, Sherwood DR, Meyer JN, Harvey BK. MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa. Eur J Cell Biol. 2019 Dec;98(5-8):151043. doi: 10.1016/j.ejcb.2019.05.002. Epub 2019 May 21. PubMed PMID: 31138438; PubMed Central PMCID: PMC7336501.
Laranjeiro R, Harinath G, Hewitt JE, Hartman JH, Royal MA, Meyer JN, Vanapalli SA, Driscoll M. Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23829-23839. doi: 10.1073/pnas.1909210116. Epub 2019 Nov 4. PubMed PMID: 31685639; PubMed Central PMCID: PMC6876156.
Smith LL, Ryde IT, Hartman JH, Romersi RF, Markovich Z, Meyer JN. Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans. Neurotoxicology. 2019 Sep;74:209-220. doi: 10.1016/j.neuro.2019.07.002. Epub 2019 Jul 16. PubMed PMID: 31323240; PubMed Central PMCID: PMC6751008.
Bachman H, Fu H, Huang PH, Tian Z, Embry-Seckler J, Rufo J, Xie Z, Hartman JH, Zhao S, Yang S, Meyer JN, Huang TJ. Open source acoustofluidics. Lab Chip. 2019 Jul 21;19(14):2404-2414. doi: 10.1039/c9lc00340a. Epub 2019 Jun 26. PubMed PMID: 31240285; PubMed Central PMCID: PMC6934416.
Hartman JH, Gonzalez-Hunt C, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN. Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration. Int J Mol Sci. 2019 Jun 29;20(13). doi: 10.3390/ijms20133202. PubMed PMID: 31261893; PubMed Central PMCID: PMC6651461.
Zhang J, Yang S, Chen C, Hartman JH, Huang PH, Wang L, Tian Z, Zhang P, Faulkenberry D, Meyer JN, Huang TJ. Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans. Lab Chip. 2019 Mar 13;19(6):984-992. doi: 10.1039/c8lc01012a. PubMed PMID: 30768117; PubMed Central PMCID: PMC6659422.
Cothren SD, Meyer JN, Hartman JH. Blinded Visual Scoring of Images Using the Freely-available Software Blinder. Bio Protoc. 2018 Dec 5;8(23). doi: 10.21769/BioProtoc.3103. PubMed PMID: 30761327; PubMed Central PMCID: PMC6370323.
Pouncey DL, Hartman JH, Moore PC, Dillinger DJ, Dickerson KW, Sappington DR, Smith ES 3rd, Boysen G, Miller GP. Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of 29 patients. Blood Coagul Fibrinolysis. 2018 Nov;29(7):602-612. doi: 10.1097/MBC.0000000000000752. PubMed PMID: 30334816.
Hartman JH, Smith LL, Gordon KL, Laranjeiro R, Driscoll M, Sherwood DR, Meyer JN. Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity. Sci Rep. 2018 May 29;8(1):8359. doi: 10.1038/s41598-018-26552-9. PubMed PMID: 29844465; PubMed Central PMCID: PMC5974391.
Meyer JN, Hartman JH, Mello DF. Mitochondrial Toxicity. Toxicol Sci. 2018 Mar 1;162(1):15-23. doi: 10.1093/toxsci/kfy008. Review. PubMed PMID: 29340618; PubMed Central PMCID: PMC5837373.
Hartman JH, Kozal JS, Di Giulio RT, Meyer JN. Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like. Environ Toxicol Pharmacol. 2017 Sep;54:142-145. doi: 10.1016/j.etap.2017.07.004. Epub 2017 Jul 10. PubMed PMID: 28728133; PubMed Central PMCID: PMC5563387.
Hartman JH, Miller GP, Meyer JN. Toxicological Implications of Mitochondrial Localization of CYP2E1. Toxicol Res (Camb). 2017;6(3):273-289. doi: 10.1039/C7TX00020K. Epub 2017 Mar 14. PubMed PMID: 28989700; PubMed Central PMCID: PMC5627779.
Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 Mar 1;378:114-124. doi: 10.1016/j.tox.2017.01.005. Epub 2017 Jan 9. PubMed PMID: 28082109; PubMed Central PMCID: PMC5319481.
Bostian AC, Maddukuri L, Reed MR, Savenka T, Hartman JH, Davis L, Pouncey DL, Miller GP, Eoff RL. Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016 Jan 19;29(1):101-8. doi: 10.1021/acs.chemrestox.5b00452. Epub 2015 Dec 30. PubMed PMID: 26651356; PubMed Central PMCID: PMC4718841.
Hartman JH, Martin HC, Caro AA, Pearce AR, Miller GP. Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates. Toxicology. 2015 Dec 2;338:47-58. doi: 10.1016/j.tox.2015.10.001. Epub 2015 Oct 14. PubMed PMID: 26463279; PubMed Central PMCID: PMC4658230.
Hartman JH, Letzig LG, Roberts DW, James LP, Fifer EK, Miller GP. Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. Biochem Pharmacol. 2015 Oct 1;97(3):341-9. doi: 10.1016/j.bcp.2015.07.026. Epub 2015 Jul 28. PubMed PMID: 26225832; PubMed Central PMCID: PMC5584065.
Levy JW, Hartman JH, Perry MD Jr, Miller GP. Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations. J Mol Graph Model. 2015 Mar;56:43-52. doi: 10.1016/j.jmgm.2014.11.013. Epub 2014 Dec 6. PubMed PMID: 25544389; PubMed Central PMCID: PMC4314338.
Pugh CP, Pouncey DL, Hartman JH, Nshimiyimana R, Desrochers LP, Goodwin TE, Boysen G, Miller GP. Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites. Arch Biochem Biophys. 2014 Dec 15;564:244-53. doi: 10.1016/j.abb.2014.10.006. Epub 2014 Oct 19. PubMed PMID: 25447818; PubMed Central PMCID: PMC4258421.
Hartman JH, Miller GP, Boysen G. Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity. Toxicology. 2014 Apr 6;318:51-8. doi: 10.1016/j.tox.2014.02.003. Epub 2014 Feb 18. PubMed PMID: 24561005; PubMed Central PMCID: PMC4747242.
Hartman JH, Knott K, Miller GP. CYP2E1 hydroxylation of aniline involves negative cooperativity. Biochem Pharmacol. 2014 Feb 1;87(3):523-33. doi: 10.1016/j.bcp.2013.12.003. Epub 2013 Dec 15. PubMed PMID: 24345333.
Pianalto KM, Hartman JH, Boysen G, Miller GP. Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites. Toxicol Lett. 2013 Nov 25;223(2):221-7. doi: 10.1016/j.toxlet.2013.08.025. Epub 2013 Sep 8. PubMed PMID: 24021170; PubMed Central PMCID: PMC3831829.
Hartman JH, Boysen G, Miller GP. Cooperative effects for CYP2E1 differ between styrene and its metabolites. Xenobiotica. 2013 Sep;43(9):755-64. doi: 10.3109/00498254.2012.760764. Epub 2013 Jan 18. PubMed PMID: 23327532; PubMed Central PMCID: PMC3979932.
Hartman JH, Bradley AM, Laddusaw RM, Perry MD Jr, Miller GP. Structure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes. Arch Biochem Biophys. 2013 Sep 1;537(1):12-20. doi: 10.1016/j.abb.2013.06.011. Epub 2013 Jun 27. PubMed PMID: 23811196; PubMed Central PMCID: PMC3781954.
Coggins GE, Maddukuri L, Penthala NR, Hartman JH, Eddy S, Ketkar A, Crooks PA, Eoff RL. N-Aroyl indole thiobarbituric acids as inhibitors of DNA repair and replication stress response polymerases. ACS Chem Biol. 2013 Aug 16;8(8):1722-9. doi: 10.1021/cb400305r. Epub 2013 May 28. PubMed PMID: 23679919; PubMed Central PMCID: PMC3746001.
Hartman JH, Cothren SD, Park SH, Yun CH, Darsey JA, Miller GP. Predicting CYP2C19 catalytic parameters for enantioselective oxidations using artificial neural networks and a chirality code. Bioorg Med Chem. 2013 Jul 1;21(13):3749-59. doi: 10.1016/j.bmc.2013.04.044. Epub 2013 Apr 22. PubMed PMID: 23673224; PubMed Central PMCID: PMC3674096.
Hartman JH, Boysen G, Miller GP. CYP2E1 metabolism of styrene involves allostery. Drug Metab Dispos. 2012 Oct;40(10):1976-83. doi: 10.1124/dmd.112.046698. Epub 2012 Jul 17. PubMed PMID: 22807108; PubMed Central PMCID: PMC3463823.
Kim SY, Kang JY, Hartman JH, Park SH, Jones DR, Yun CH, Boysen G, Miller GP. Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins. Drug Metab Lett. 2012 Sep 1;6(3):157-64. doi: 10.2174/1872312811206030002. PubMed PMID: 23331088; PubMed Central PMCID: PMC3713490.
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