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de Witte LD, Wang Z, Snijders GLJL, Mendelev N, Liu Q, Sneeboer MAM, Boks MPM, Ge Y, Haghighi F. Contribution of Age, Brain Region, Mood Disorder Pathology, and Interindividual Factors on the Methylome of Human Microglia. Biol Psychiatry. 2022 Mar 15;91(6):572-581. doi: 10.1016/j.biopsych.2021.10.020. Epub 2021 Oct 30. PubMed PMID: 35027166.
Mountney A, Blaze J, Wang Z, Umali M, Flerlage WJ, Dougherty J, Ge Y, Shear D, Haghighi F. Penetrating Ballistic Brain Injury Produces Acute Alterations in Sleep and Circadian-Related Genes in the Rodent Cortex: A Preliminary Study. Front Neurol. 2021;12:745330. doi: 10.3389/fneur.2021.745330. eCollection 2021. PubMed PMID: 34777213; PubMed Central PMCID: PMC8580116.
Blaze J, Navickas A, Phillips HL, Heissel S, Plaza-Jennings A, Miglani S, Asgharian H, Foo M, Katanski CD, Watkins CP, Pennington ZT, Javidfar B, Espeso-Gil S, Rostandy B, Alwaseem H, Hahn CG, Molina H, Cai DJ, Pan T, Yao WD, Goodarzi H, Haghighi F, Akbarian S. Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior. Nat Commun. 2021 Aug 13;12(1):4913. doi: 10.1038/s41467-021-24969-x. PubMed PMID: 34389722; PubMed Central PMCID: PMC8363735.
Chatterton Z, Mendelev N, Chen S, Carr W, Kamimori GH, Ge Y, Dwork AJ, Haghighi F. Bisulfite Amplicon Sequencing Can Detect Glia and Neuron Cell-Free DNA in Blood Plasma. Front Mol Neurosci. 2021;14:672614. doi: 10.3389/fnmol.2021.672614. eCollection 2021. PubMed PMID: 34276305; PubMed Central PMCID: PMC8283182.
Meore A, Sun S, Byma L, Alter S, Vitale A, Podolak E, Gibbard B, Adams T, Boyer J, Galfalvy H, Yehuda R, Feder A, Haghighi F. Pilot evaluation of horticultural therapy in improving overall wellness in veterans with history of suicidality. Complement Ther Med. 2021 Jun;59:102728. doi: 10.1016/j.ctim.2021.102728. Epub 2021 May 14. PubMed PMID: 33965561.
Alter S, Wilson C, Sun S, Harris RE, Wang Z, Vitale A, Hazlett EA, Goodman M, Ge Y, Yehuda R, Galfalvy H, Haghighi F. The association of childhood trauma with sleep disturbances and risk of suicide in US veterans. J Psychiatr Res. 2021 Apr;136:54-62. doi: 10.1016/j.jpsychires.2021.01.030. Epub 2021 Jan 29. PubMed PMID: 33561736.
Vitale A, Byma L, Sun S, Podolak E, Wang Z, Alter S, Galfalvy H, Geraci J, Langhoff E, Klingbeil H, Yehuda R, Haghighi F, Feder A. Effectiveness of Complementary and Integrative Approaches in Promoting Engagement and Overall Wellness Toward Suicide Prevention in Veterans. J Altern Complement Med. 2021 Mar;27(S1):S14-S27. doi: 10.1089/acm.2020.0245. PubMed PMID: 33788604; PubMed Central PMCID: PMC8035924.
Wang Z, Wilson CM, Ge Y, Nemes J, LaValle C, Boutté A, Carr W, Kamimori G, Haghighi F. DNA Methylation Patterns of Chronic Explosive Breaching in U.S. Military Warfighters. Front Neurol. 2020;11:1010. doi: 10.3389/fneur.2020.01010. eCollection 2020. PubMed PMID: 33192958; PubMed Central PMCID: PMC7645105.
Blaze J, Choi I, Wang Z, Umali M, Mendelev N, Tschiffely AE, Ahlers ST, Elder GA, Ge Y, Haghighi F. Blast-Related Mild TBI Alters Anxiety-Like Behavior and Transcriptional Signatures in the Rat Amygdala. Front Behav Neurosci. 2020;14:160. doi: 10.3389/fnbeh.2020.00160. eCollection 2020. PubMed PMID: 33192359; PubMed Central PMCID: PMC7604767.
Wang J, Blaze J, Haghighi F, Kim-Schulze S, Raval U, Trageser KJ, Pasinetti GM. Characterization of 3(3,4-dihydroxy-phenyl) propionic acid as a novel microbiome-derived epigenetic modifier in attenuation of immune inflammatory response in human monocytes. Mol Immunol. 2020 Sep;125:172-177. doi: 10.1016/j.molimm.2020.07.003. Epub 2020 Jul 21. PubMed PMID: 32707536; PubMed Central PMCID: PMC7423748.
Wang Z, Wilson CM, Mendelev N, Ge Y, Galfalvy H, Elder G, Ahlers S, Yarnell AM, LoPresti ML, Kamimori GH, Carr W, Haghighi F. Acute and Chronic Molecular Signatures and Associated Symptoms of Blast Exposure in Military Breachers. J Neurotrauma. 2020 May 15;37(10):1221-1232. doi: 10.1089/neu.2019.6742. Epub 2019 Dec 12. PubMed PMID: 31621494; PubMed Central PMCID: PMC7232647.
Weissman JD, Russell D, Haghighi F, Dixon L, Goodman M. Health coverage types and their relationship to mental and physical health in U.S. veterans. Prev Med Rep. 2019 Mar;13:85-92. doi: 10.1016/j.pmedr.2018.11.016. eCollection 2019 Mar. PubMed PMID: 30568865; PubMed Central PMCID: PMC6290380.
Blaze J, Wang J, Ho L, Mendelev N, Haghighi F, Pasinetti GM. Polyphenolic Compounds Alter Stress-Induced Patterns of Global DNA Methylation in Brain and Blood. Mol Nutr Food Res. 2018 Apr;62(8):e1700722. doi: 10.1002/mnfr.201700722. Epub 2018 Mar 22. PubMed PMID: 29473292; PubMed Central PMCID: PMC5953514.
Perez-Garcia G, Gama Sosa MA, De Gasperi R, Lashof-Sullivan M, Maudlin-Jeronimo E, Stone JR, Haghighi F, Ahlers ST, Elder GA. Chronic post-traumatic stress disorder-related traits in a rat model of low-level blast exposure. Behav Brain Res. 2018 Mar 15;340:117-125. doi: 10.1016/j.bbr.2016.09.061. Epub 2016 Sep 28. PubMed PMID: 27693852.
Chatterton Z, Hartley BJ, Seok MH, Mendelev N, Chen S, Milekic M, Rosoklija G, Stankov A, Trencevsja-Ivanovska I, Brennand K, Ge Y, Dwork AJ, Haghighi F. In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. Epigenetics Chromatin. 2017;10:4. doi: 10.1186/s13072-017-0111-y. eCollection 2017. PubMed PMID: 28149327; PubMed Central PMCID: PMC5270321.
Perez-Garcia G, Gama Sosa MA, De Gasperi R, Lashof-Sullivan M, Maudlin-Jeronimo E, Stone JR, Haghighi F, Ahlers ST, Elder GA. Exposure to a Predator Scent Induces Chronic Behavioral Changes in Rats Previously Exposed to Low-level Blast: Implications for the Relationship of Blast-Related TBI to PTSD. Front Neurol. 2016;7:176. doi: 10.3389/fneur.2016.00176. eCollection 2016. PubMed PMID: 27803688; PubMed Central PMCID: PMC5067529.
Galfalvy H, Haghighi F, Hodgkinson C, Goldman D, Oquendo MA, Burke A, Huang YY, Giegling I, Rujescu D, Bureau A, Turecki G, Mann JJ. A genome-wide association study of suicidal behavior. Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):557-63. doi: 10.1002/ajmg.b.32330. Epub 2015 Jun 16. PubMed PMID: 26079190.
Haghighi F, Ge Y, Chen S, Xin Y, Umali MU, De Gasperi R, Gama Sosa MA, Ahlers ST, Elder GA. Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury. J Neurotrauma. 2015 Aug 15;32(16):1200-9. doi: 10.1089/neu.2014.3640. Epub 2015 May 7. PubMed PMID: 25594545; PubMed Central PMCID: PMC4532898.
Milekic MH, Xin Y, O'Donnell A, Kumar KK, Bradley-Moore M, Malaspina D, Moore H, Brunner D, Ge Y, Edwards J, Paul S, Haghighi FG, Gingrich JA. Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression. Mol Psychiatry. 2015 Aug;20(8):995-1001. doi: 10.1038/mp.2014.84. Epub 2014 Aug 5. PubMed PMID: 25092244; NIHMSID:NIHMS930043.
Gross JA, Bureau A, Croteau J, Galfalvy H, Oquendo MA, Haghighi F, Mérette C, Giegling I, Hodgkinson C, Goldman D, Rujescu D, Mann JJ, Turecki G. A genome-wide copy number variant study of suicidal behavior. PLoS One. 2015;10(5):e0128369. doi: 10.1371/journal.pone.0128369. eCollection 2015. PubMed PMID: 26010658; PubMed Central PMCID: PMC4444178.
Haghighi F, Galfalvy H, Chen S, Huang YY, Cooper TB, Burke AK, Oquendo MA, Mann JJ, Sublette ME. DNA methylation perturbations in genes involved in polyunsaturated Fatty Acid biosynthesis associated with depression and suicide risk. Front Neurol. 2015;6:92. doi: 10.3389/fneur.2015.00092. eCollection 2015. PubMed PMID: 25972837; PubMed Central PMCID: PMC4412056.
Elder GA, Gama Sosa MA, De Gasperi R, Stone JR, Dickstein DL, Haghighi F, Hof PR, Ahlers ST. Vascular and inflammatory factors in the pathophysiology of blast-induced brain injury. Front Neurol. 2015;6:48. doi: 10.3389/fneur.2015.00048. eCollection 2015. Review. PubMed PMID: 25852632; PubMed Central PMCID: PMC4360816.
Haghighi F, Xin Y, Chanrion B, O'Donnell AH, Ge Y, Dwork AJ, Arango V, Mann JJ. Increased DNA methylation in the suicide brain. Dialogues Clin Neurosci. 2014 Sep;16(3):430-8. PubMed PMID: 25364291; PubMed Central PMCID: PMC4214183.
Hodges LM, Fyer AJ, Weissman MM, Logue MW, Haghighi F, Evgrafov O, Rotondo A, Knowles JA, Hamilton SP. Evidence for linkage and association of GABRB3 and GABRA5 to panic disorder. Neuropsychopharmacology. 2014 Sep;39(10):2423-31. doi: 10.1038/npp.2014.92. Epub 2014 May 23. PubMed PMID: 24755890; PubMed Central PMCID: PMC4138754.
Galfalvy H, Zalsman G, Huang YY, Murphy L, Rosoklija G, Dwork AJ, Haghighi F, Arango V, Mann JJ. A pilot genome wide association and gene expression array study of suicide with and without major depression. World J Biol Psychiatry. 2013 Dec;14(8):574-82. doi: 10.3109/15622975.2011.597875. Epub 2011 Nov 7. PubMed PMID: 22059935; PubMed Central PMCID: PMC3493880.
Lister R, Mukamel EA, Nery JR, Urich M, Puddifoot CA, Johnson ND, Lucero J, Huang Y, Dwork AJ, Schultz MD, Yu M, Tonti-Filippini J, Heyn H, Hu S, Wu JC, Rao A, Esteller M, He C, Haghighi FG, Sejnowski TJ, Behrens MM, Ecker JR. Global epigenomic reconfiguration during mammalian brain development. Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4. PubMed PMID: 23828890; PubMed Central PMCID: PMC3785061.
Deo AJ, Huang YY, Hodgkinson CA, Xin Y, Oquendo MA, Dwork AJ, Arango V, Brent DA, Goldman D, Mann JJ, Haghighi F. A large-scale candidate gene analysis of mood disorders: evidence of neurotrophic tyrosine kinase receptor and opioid receptor signaling dysfunction. Psychiatr Genet. 2013 Apr;23(2):47-55. doi: 10.1097/YPG.0b013e32835d7028. PubMed PMID: 23277131; PubMed Central PMCID: PMC3869619.
Fyer AJ, Costa R, Haghighi F, Logue MW, Knowles JA, Weissman MM, Hodge SE, Hamilton SP. Linkage analysis of alternative anxiety phenotypes in multiply affected panic disorder families. Psychiatr Genet. 2012 Jun;22(3):123-9. doi: 10.1097/YPG.0b013e328353956a. PubMed PMID: 22525237; PubMed Central PMCID: PMC3767163.
Wilson ST, Stanley B, Brent DA, Oquendo MA, Huang YY, Haghighi F, Hodgkinson CA, Mann JJ. Interaction between tryptophan hydroxylase I polymorphisms and childhood abuse is associated with increased risk for borderline personality disorder in adulthood. Psychiatr Genet. 2012 Feb;22(1):15-24. doi: 10.1097/YPG.0b013e32834c0c4c. PubMed PMID: 21989108; PubMed Central PMCID: PMC3241896.
Xin Y, Chanrion B, O'Donnell AH, Milekic M, Costa R, Ge Y, Haghighi FG. MethylomeDB: a database of DNA methylation profiles of the brain. Nucleic Acids Res. 2012 Jan;40(Database issue):D1245-9. doi: 10.1093/nar/gkr1193. Epub 2011 Dec 2. PubMed PMID: 22140101; PubMed Central PMCID: PMC3245019.
Xin Y, O'Donnell AH, Ge Y, Chanrion B, Milekic M, Rosoklija G, Stankov A, Arango V, Dwork AJ, Gingrich JA, Haghighi FG. Role of CpG context and content in evolutionary signatures of brain DNA methylation. Epigenetics. 2011 Nov;6(11):1308-18. doi: 10.4161/epi.6.11.17876. Epub 2011 Nov 1. PubMed PMID: 22048252; PubMed Central PMCID: PMC3775885.
Xin Y, Ge Y, Haghighi FG. Methyl-Analyzer--whole genome DNA methylation profiling. Bioinformatics. 2011 Aug 15;27(16):2296-7. doi: 10.1093/bioinformatics/btr356. Epub 2011 Jun 17. PubMed PMID: 21685051; PubMed Central PMCID: PMC3150045.
Mann JJ, Haghighi F. Genes and environment: multiple pathways to psychopathology. Biol Psychiatry. 2010 Sep 1;68(5):403-4. doi: 10.1016/j.biopsych.2010.07.006. PubMed PMID: 20705146.
Kinnally EL, Capitanio JP, Leibel R, Deng L, LeDuc C, Haghighi F, Mann JJ. Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes Brain Behav. 2010 Aug;9(6):575-82. doi: 10.1111/j.1601-183X.2010.00588.x. Epub 2010 Apr 12. PubMed PMID: 20398062; PubMed Central PMCID: PMC2921011.
Edwards JR, O'Donnell AH, Rollins RA, Peckham HE, Lee C, Milekic MH, Chanrion B, Fu Y, Su T, Hibshoosh H, Gingrich JA, Haghighi F, Nutter R, Bestor TH. Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns. Genome Res. 2010 Jul;20(7):972-80. doi: 10.1101/gr.101535.109. Epub 2010 May 20. PubMed PMID: 20488932; PubMed Central PMCID: PMC2892098.
Xin Y, Chanrion B, Liu MM, Galfalvy H, Costa R, Ilievski B, Rosoklija G, Arango V, Dwork AJ, Mann JJ, Tycko B, Haghighi F. Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices. PLoS One. 2010 Jun 28;5(6):e11357. doi: 10.1371/journal.pone.0011357. PubMed PMID: 20596539; PubMed Central PMCID: PMC2893206.
Deo AJ, Costa R, DeLisi LE, DeSalle R, Haghighi F. A novel analytical framework for dissecting the genetic architecture of behavioral symptoms in neuropsychiatric disorders. PLoS One. 2010 Mar 16;5(3):e9714. doi: 10.1371/journal.pone.0009714. PubMed PMID: 20300526; PubMed Central PMCID: PMC2838792.
Hodges LM, Weissman MM, Haghighi F, Costa R, Bravo O, Evgrafov O, Knowles JA, Fyer AJ, Hamilton SP. Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder. Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):65-73. doi: 10.1002/ajmg.b.30773. PubMed PMID: 18452185.
Haghighi F, Bach-Mizrachi H, Huang YY, Arango V, Shi S, Dwork AJ, Rosoklija G, Sheng HT, Morozova I, Ju J, Russo JJ, Mann JJ. Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression. Mol Psychiatry. 2008 Aug;13(8):813-20. doi: 10.1038/ Epub 2008 Jan 8. PubMed PMID: 18180764.
Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, Li K, Murty VV, Schupf N, Vilain E, Morris M, Haghighi F, Tycko B. Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation. Nat Genet. 2008 Jul;40(7):904-8. doi: 10.1038/ng.174. Epub 2008 Jun 22. PubMed PMID: 18568024; NIHMSID:NIHMS303145.
Zalsman G, Huang YY, Oquendo MA, Brent DA, Giner L, Haghighi F, Burke AK, Ellis SP, Currier D, Mann JJ. No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders. Arch Suicide Res. 2008;12(4):327-35. doi: 10.1080/13811110802324912. PubMed PMID: 18828035; PubMed Central PMCID: PMC3773865.
Fyer AJ, Hamilton SP, Durner M, Haghighi F, Heiman GA, Costa R, Evgrafov O, Adams P, de Leon AB, Taveras N, Klein DF, Hodge SE, Weissman MM, Knowles JA. A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci. Biol Psychiatry. 2006 Aug 15;60(4):388-401. doi: 10.1016/j.biopsych.2006.04.018. PubMed PMID: 16919526.
Yuan E, Haghighi F, White S, Costa R, McMinn J, Chun K, Minden M, Tycko B. A single nucleotide polymorphism chip-based method for combined genetic and epigenetic profiling: validation in decitabine therapy and tumor/normal comparisons. Cancer Res. 2006 Apr 1;66(7):3443-51. doi: 10.1158/0008-5472.CAN-05-3739. PubMed PMID: 16585166.
Rollins RA, Haghighi F, Edwards JR, Das R, Zhang MQ, Ju J, Bestor TH. Large-scale structure of genomic methylation patterns. Genome Res. 2006 Feb;16(2):157-63. doi: 10.1101/gr.4362006. Epub 2005 Dec 19. PubMed PMID: 16365381; PubMed Central PMCID: PMC1361710.
Terwilliger JD, Haghighi F, Hiekkalinna TS, Göring HH. A bias-ed assessment of the use of SNPs in human complex traits. Curr Opin Genet Dev. 2002 Dec;12(6):726-34. doi: 10.1016/s0959-437x(02)00357-x. Review. PubMed PMID: 12433588.
Hamilton SP, Slager SL, Heiman GA, Deng Z, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA. Evidence for a susceptibility locus for panic disorder near the catechol-O-methyltransferase gene on chromosome 22. Biol Psychiatry. 2002 Apr 1;51(7):591-601. doi: 10.1016/s0006-3223(01)01322-1. PubMed PMID: 11950461.
Haghighi F, Hodge SE. Likelihood formulation of parent-of-origin effects on segregation analysis, including ascertainment. Am J Hum Genet. 2002 Jan;70(1):142-56. doi: 10.1086/324709. Epub 2001 Nov 30. PubMed PMID: 11741195; PubMed Central PMCID: PMC384884.
Slager SL, Foroud T, Haghighi F, Spence MA, Hodge SE. Stoppage: an issue for segregation analysis. Genet Epidemiol. 2001 Apr;20(3):328-39. doi: 10.1002/gepi.4. PubMed PMID: 11255242.
Hamilton SP, Slager SL, Heiman GA, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA. No genetic linkage or association between a functional promoter polymorphism in the monoamine oxidase-A gene and panic disorder. Mol Psychiatry. 2000 Sep;5(5):465-6. doi: 10.1038/ PubMed PMID: 11032378.
Hamilton SP, Haghighi F, Heiman GA, Klein DF, Hodge SE, Fyer AJ, Weissman MM, Knowles JA. Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. Am J Med Genet. 2000 Jun 12;96(3):324-30. doi: 10.1002/1096-8628(20000612)96:3<324::aid-ajmg18>;2-w. PubMed PMID: 10898909.
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