Skip to main page content
Accesskeys
  • Page of 1
  1. Veldkamp CT, Ziarek JJ, Su J, Basnet H, Lennertz R, Weiner JJ, Peterson FC, Baker JE, Volkman BF. Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. Protein Sci. 2009 Jul;18(7):1359-69. doi: 10.1002/pro.167. PubMed PMID: 19551879; PubMed Central PMCID: PMC2775206.
  2. Veldkamp CT, Ziarek JJ, Peterson FC, Chen Y, Volkman BF. Targeting SDF-1/CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design. J Am Chem Soc. 2010 Jun 2;132(21):7242-3. doi: 10.1021/ja1002263. PubMed PMID: 20459090; PubMed Central PMCID: PMC2941798.
  3. Ziarek JJ, Peterson FC, Lytle BL, Volkman BF. Binding site identification and structure determination of protein-ligand complexes by NMR a semiautomated approach. Methods Enzymol. 2011;493:241-75. doi: 10.1016/B978-0-12-381274-2.00010-8. PubMed PMID: 21371594; PubMed Central PMCID: PMC3635485.
  4. Ziarek JJ, Heroux MS, Veldkamp CT, Peterson FC, Volkman BF. Sulfotyrosine recognition as marker for druggable sites in the extracellular space. Int J Mol Sci. 2011;12(6):3740-56. doi: 10.3390/ijms12063740. Epub 2011 Jun 8. PubMed PMID: 21747703; PubMed Central PMCID: PMC3131587.
  5. Saini V, Staren DM, Ziarek JJ, Nashaat ZN, Campbell EM, Volkman BF, Marchese A, Majetschak M. The CXC chemokine receptor 4 ligands ubiquitin and stromal cell-derived factor-1α function through distinct receptor interactions. J Biol Chem. 2011 Sep 23;286(38):33466-77. doi: 10.1074/jbc.M111.233742. Epub 2011 Jul 13. PubMed PMID: 21757744; PubMed Central PMCID: PMC3190899.
  6. Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, Heveker N, Volkman BF, Dwinell MB. Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17655-60. doi: 10.1073/pnas.1101133108. Epub 2011 Oct 11. PubMed PMID: 21990345; PubMed Central PMCID: PMC3203819.
  7. Ziarek JJ, Liu Y, Smith E, Zhang G, Peterson FC, Chen J, Yu Y, Chen Y, Volkman BF, Li R. Fragment-based optimization of small molecule CXCL12 inhibitors for antagonizing the CXCL12/CXCR4 interaction. Curr Top Med Chem. 2012;12(24):2727-40. PubMed PMID: 23368099; PubMed Central PMCID: PMC3839847.
  8. Ziarek JJ, Volkman BF. NMR in the Analysis of Functional Chemokine Interactions and Drug Discovery. Drug Discov Today Technol. 2012;9(4):e293-e299. doi: 10.1016/j.ddtec.2012.04.003. PubMed PMID: 23166561; PubMed Central PMCID: PMC3499625.
  9. Love M, Sandberg JL, Ziarek JJ, Gerarden KP, Rode RR, Jensen DR, McCaslin DR, Peterson FC, Veldkamp CT. Solution structure of CCL21 and identification of a putative CCR7 binding site. Biochemistry. 2012 Jan 24;51(3):733-5. doi: 10.1021/bi201601k. Epub 2012 Jan 17. PubMed PMID: 22221265; PubMed Central PMCID: PMC3272885.
  10. Mysinger MM, Weiss DR, Ziarek JJ, Gravel S, Doak AK, Karpiak J, Heveker N, Shoichet BK, Volkman BF. Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5517-22. doi: 10.1073/pnas.1120431109. Epub 2012 Mar 19. PubMed PMID: 22431600; PubMed Central PMCID: PMC3325704.
  11. Takekoshi T, Ziarek JJ, Volkman BF, Hwang ST. A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability. Mol Cancer Ther. 2012 Nov;11(11):2516-25. doi: 10.1158/1535-7163.MCT-12-0494. Epub 2012 Aug 6. PubMed PMID: 22869557; PubMed Central PMCID: PMC3496366.
  12. Ziarek JJ, Veldkamp CT, Zhang F, Murray NJ, Kartz GA, Liang X, Su J, Baker JE, Linhardt RJ, Volkman BF. Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus. J Biol Chem. 2013 Jan 4;288(1):737-46. doi: 10.1074/jbc.M112.394064. Epub 2012 Nov 12. PubMed PMID: 23148226; PubMed Central PMCID: PMC3537072.
  13. Ziarek JJ, Getschman AE, Butler SJ, Taleski D, Stephens B, Kufareva I, Handel TM, Payne RJ, Volkman BF. Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chem Biol. 2013 Sep 20;8(9):1955-63. doi: 10.1021/cb400274z. Epub 2013 Jun 26. PubMed PMID: 23802178; PubMed Central PMCID: PMC3783652.
  14. Luna RE, Akabayov SR, Ziarek JJ, Wagner G. Examining weak protein-protein interactions in start codon recognition via NMR spectroscopy. FEBS J. 2014 Apr;281(8):1965-73. doi: 10.1111/febs.12667. Epub 2014 Jan 2. Review. PubMed PMID: 24393460; PubMed Central PMCID: PMC3991732.
  15. Verkaar F, van Offenbeek J, van der Lee MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AEI, Vischer HF, Zaman GJR, Smit MJ. Chemokine cooperativity is caused by competitive glycosaminoglycan binding. J Immunol. 2014 Apr 15;192(8):3908-3914. doi: 10.4049/jimmunol.1302159. Epub 2014 Mar 17. PubMed PMID: 24639348; PubMed Central PMCID: PMC4198333.
  16. Wommack AJ, Ziarek JJ, Tomaras J, Chileveru HR, Zhang Y, Wagner G, Nolan EM. Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. J Am Chem Soc. 2014 Oct 1;136(39):13494-7. doi: 10.1021/ja505957w. Epub 2014 Sep 23. PubMed PMID: 25181039; PubMed Central PMCID: PMC4183617.
  17. Smith EW, Liu Y, Getschman AE, Peterson FC, Ziarek JJ, Li R, Volkman BF, Chen Y. Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine. J Med Chem. 2014 Nov 26;57(22):9693-9. doi: 10.1021/jm501194p. Epub 2014 Nov 13. PubMed PMID: 25356720; PubMed Central PMCID: PMC4255719.
  18. Kleist AB, Getschman AE, Ziarek JJ, Nevins AM, Gauthier PA, Chevigné A, Szpakowska M, Volkman BF. New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model. Biochem Pharmacol. 2016 Aug 15;114:53-68. doi: 10.1016/j.bcp.2016.04.007. Epub 2016 Apr 19. Review. PubMed PMID: 27106080; PubMed Central PMCID: PMC5145291.
  19. Ziarek JJ, Kleist AB, London N, Raveh B, Montpas N, Bonneterre J, St-Onge G, DiCosmo-Ponticello CJ, Koplinski CA, Roy I, Stephens B, Thelen S, Veldkamp CT, Coffman FD, Cohen MC, Dwinell MB, Thelen M, Peterson FC, Heveker N, Volkman BF. Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. Sci Signal. 2017 Mar 21;10(471). doi: 10.1126/scisignal.aah5756. PubMed PMID: 28325822; PubMed Central PMCID: PMC5648539.
  20. Ziarek JJ, Baptista D, Wagner G. Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology. J Mol Med (Berl). 2018 Jan;96(1):1-8. doi: 10.1007/s00109-017-1560-2. Epub 2017 Jun 23. Review. PubMed PMID: 28643003; PubMed Central PMCID: PMC5742078.
  21. Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H. 15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1710-E1719. doi: 10.1073/pnas.1717560115. Epub 2018 Feb 5. PubMed PMID: 29432148; PubMed Central PMCID: PMC5828609.
  22. Gruenhagen TC, Ziarek JJ, Schlebach JP. Bicelle size modulates the rate of bacteriorhodopsin folding. Protein Sci. 2018 Jun;27(6):1109-1112. doi: 10.1002/pro.3414. Epub 2018 Apr 25. PubMed PMID: 29604129; PubMed Central PMCID: PMC5980500.
  23. Hitchinson B, Eby JM, Gao X, Guite-Vinet F, Ziarek JJ, Abdelkarim H, Lee Y, Okamoto Y, Shikano S, Majetschak M, Heveker N, Volkman BF, Tarasova NI, Gaponenko V. Biased antagonism of CXCR4 avoids antagonist tolerance. Sci Signal. 2018 Oct 16;11(552). doi: 10.1126/scisignal.aat2214. PubMed PMID: 30327409; PubMed Central PMCID: PMC6422681.
  • Page of 1