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Simon H, Vartanian V, Wong MH, Nakabeppu Y, Sharma P, Lloyd RS, Sampath H. OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model. PLoS One. 2020;15(1):e0227501. doi: 10.1371/journal.pone.0227501. eCollection 2020. PubMed PMID: 31935236; PubMed Central PMCID: PMC6959583.
Sharma P, Sampath H. Mitochondrial DNA Integrity: Role in Health and Disease. Cells. 2019 Jan 29;8(2). doi: 10.3390/cells8020100. Review. PubMed PMID: 30700008; PubMed Central PMCID: PMC6406942.
Komakula SSB, Tumova J, Kumaraswamy D, Burchat N, Vartanian V, Ye H, Dobrzyn A, Lloyd RS, Sampath H. The DNA Repair Protein OGG1 Protects Against Obesity by Altering Mitochondrial Energetics in White Adipose Tissue. Sci Rep. 2018 Oct 5;8(1):14886. doi: 10.1038/s41598-018-33151-1. PubMed PMID: 30291284; PubMed Central PMCID: PMC6173743.
Vartanian V, Tumova J, Dobrzyn P, Dobrzyn A, Nakabeppu Y, Lloyd RS, Sampath H. 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle. PLoS One. 2017;12(7):e0181687. doi: 10.1371/journal.pone.0181687. eCollection 2017. PubMed PMID: 28727777; PubMed Central PMCID: PMC5519207.
Lam DD, de Souza FS, Nasif S, Yamashita M, López-Leal R, Otero-Corchon V, Meece K, Sampath H, Mercer AJ, Wardlaw SL, Rubinstein M, Low MJ. Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold. PLoS Genet. 2015 Feb;11(2):e1004935. doi: 10.1371/journal.pgen.1004935. eCollection 2015 Feb. PubMed PMID: 25671638; PubMed Central PMCID: PMC4335486.
Varlamov O, Chu M, Cornea A, Sampath H, Roberts CT Jr. Cell-autonomous heterogeneity of nutrient uptake in white adipose tissue of rhesus macaques. Endocrinology. 2015 Jan;156(1):80-9. doi: 10.1210/en.2014-1699. PubMed PMID: 25356825; PubMed Central PMCID: PMC4272393.
Gray NE, Sampath H, Zweig JA, Quinn JF, Soumyanath A. Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction. J Alzheimers Dis. 2015;45(3):933-46. doi: 10.3233/JAD-142217. PubMed PMID: 25633675; PubMed Central PMCID: PMC4412033.
Chu M, Sampath H, Cahana DY, Kahl CA, Somwar R, Cornea A, Roberts CT Jr, Varlamov O. Spatiotemporal dynamics of triglyceride storage in unilocular adipocytes. Mol Biol Cell. 2014 Dec 15;25(25):4096-105. doi: 10.1091/mbc.E14-06-1085. Epub 2014 Oct 8. PubMed PMID: 25298400; PubMed Central PMCID: PMC4263452.
Sampath H. Phenotypes of base excision repair deficient models. Environmental and molecular mutagenesis.. 2014 July;
Sampath H, Ntambi JM. Role of stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance. J Biol Chem. 2014 Jan 31;289(5):2482-8. doi: 10.1074/jbc.R113.516716. Epub 2013 Dec 19. Review. PubMed PMID: 24356954; PubMed Central PMCID: PMC3908384.
MacDonald MJ, Hasan NM, Dobrzyn A, Stoker SW, Ntambi JM, Liu X, Sampath H. Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. Arch Biochem Biophys. 2013 Apr 1;532(1):23-31. doi: 10.1016/ Epub 2013 Jan 25. PubMed PMID: 23357280; PubMed Central PMCID: PMC3596477.
Berkley EA, Peckham SD, Sampath H, Bodewes J, Ntambi JM, Van Deelen T. Ingestion of fat tissue from wolf prey species and its influence on fatty-acid composition in sled dogs. Wildlife Society Bulletin.. 2013; 38:51-59.
Sampath H, Vartanian V, Rollins MR, Sakumi K, Nakabeppu Y, Lloyd RS. 8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction. PLoS One. 2012;7(12):e51697. doi: 10.1371/journal.pone.0051697. Epub 2012 Dec 17. PubMed PMID: 23284747; PubMed Central PMCID: PMC3524114.
Sampath H, McCullough AK, Lloyd RS. Regulation of DNA glycosylases and their role in limiting disease. Free Radic Res. 2012 Apr;46(4):460-78. doi: 10.3109/10715762.2012.655730. Epub 2012 Feb 6. Review. PubMed PMID: 22300253; PubMed Central PMCID: PMC4894311.
Sampath H, Ntambi JM. The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation. Ann N Y Acad Sci. 2011 Dec;1243:47-53. doi: 10.1111/j.1749-6632.2011.06303.x. Review. PubMed PMID: 22211892.
Sampath H, Ntambi JM. The role of fatty acid desaturases in epidermal metabolism. Dermatoendocrinol. 2011 Apr;3(2):62-4. doi: 10.4161/derm.3.2.14832. Epub 2011 Apr 1. PubMed PMID: 21695013; PubMed Central PMCID: PMC3117003.
Sampath H, Batra AK, Vartanian V, Carmical JR, Prusak D, King IB, Lowell B, Earley LF, Wood TG, Marks DL, McCullough AK, R Stephen L. Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E724-34. doi: 10.1152/ajpendo.00387.2010. Epub 2011 Feb 1. PubMed PMID: 21285402; PubMed Central PMCID: PMC3074946.
Liu X, Miyazaki M, Flowers MT, Sampath H, Zhao M, Chu K, Paton CM, Joo DS, Ntambi JM. Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate. Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):31-8. doi: 10.1161/ATVBAHA.109.195636. Epub 2009 Nov 12. PubMed PMID: 19910642; PubMed Central PMCID: PMC2837593.
Sampath H, Flowers MT, Liu X, Paton CM, Sullivan R, Chu K, Zhao M, Ntambi JM. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J Biol Chem. 2009 Jul 24;284(30):19961-73. doi: 10.1074/jbc.M109.014225. Epub 2009 May 8. PubMed PMID: 19429677; PubMed Central PMCID: PMC2740422.
Miyazaki M, Sampath H, Liu X, Flowers MT, Chu K, Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem Biophys Res Commun. 2009 Mar 20;380(4):818-22. doi: 10.1016/j.bbrc.2009.01.183. Epub 2009 Feb 5. PubMed PMID: 19338759; PubMed Central PMCID: PMC2665189.
Dobrzyn P, Sampath H, Dobrzyn A, Miyazaki M, Ntambi JM. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E357-64. doi: 10.1152/ajpendo.00471.2007. Epub 2007 Nov 27. PubMed PMID: 18042664.
Sampath H, Ntambi JM. Role of Stearoyl-CoA desaturase in human metabolic disease. Future Lipidology. 2008; 3:163-73..
Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, Ntambi JM. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 2007 Dec;6(6):484-96. doi: 10.1016/j.cmet.2007.10.014. PubMed PMID: 18054317.
Sampath H, Miyazaki M, Dobrzyn A, Ntambi JM. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem. 2007 Jan 26;282(4):2483-93. doi: 10.1074/jbc.M610158200. Epub 2006 Nov 23. PubMed PMID: 17127673.
Muranga FI, Sampath H, Marlett JA, Ntambi JM. mpact of processing technique on the apparent bioavailability of cooking banana (matooke) starch. African Journal of Biochemistry Research.. 2007; 1(5).
Sampath H, Ntambi JM. Polyunsaturated fatty acids and regulation of gene expression. . In: Fatty acids in foods and their health implications, 3rd edition Boca Raton, FL: CRC Press. Third ed. Chow K, editor. Boca Raton, FL: CRC Press; 2007. 727-739p.
Sampath H, Ntambi JM. Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism. Curr Opin Clin Nutr Metab Care. 2006 Mar;9(2):84-8. doi: 10.1097/ Review. PubMed PMID: 16477170.
Sampath H, Ntambi JM. Regulation of gene expression by polyunsaturated fatty acids. Heart and Metabolism. 2006; 32:32-35.
Sampath H, Ntambi JM. The fate and intermediary metabolism of stearic acid. Lipids. 2005 Dec;40(12):1187-91. doi: 10.1007/s11745-005-1484-z. Review. PubMed PMID: 16477801.
Dobrzyn A, Dobrzyn P, Miyazaki M, Sampath H, Chu K, Ntambi JM. Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J Biol Chem. 2005 Jun 17;280(24):23356-62. doi: 10.1074/jbc.M502436200. Epub 2005 Apr 13. PubMed PMID: 15829484.
Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu Rev Nutr. 2005;25:317-40. doi: 10.1146/annurev.nutr.25.051804.101917. Review. PubMed PMID: 16011470.
Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of gene expression. Nutr Rev. 2004 Sep;62(9):333-9. doi: 10.1111/j.1753-4887.2004.tb00058.x. Review. PubMed PMID: 15497766.
Miyazaki M, Dobrzyn A, Sampath H, Lee SH, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J Biol Chem. 2004 Aug 13;279(33):35017-24. doi: 10.1074/jbc.M405327200. Epub 2004 Jun 4. PubMed PMID: 15180999.
Miyazaki M, Dobrzyn A, Man WC, Chu K, Sampath H, Kim HJ, Ntambi JM. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J Biol Chem. 2004 Jun 11;279(24):25164-71. doi: 10.1074/jbc.M402781200. Epub 2004 Apr 5. PubMed PMID: 15066988.
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