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Lambert É, Puwakdandawa K, Tao YF, Robert F. From structure to molecular condensates: emerging mechanisms for Mediator function. FEBS J. 2023 Jan;290(2):286-309. doi: 10.1111/febs.16250. Epub 2021 Nov 11. Review. PubMed PMID: 34698446.
Jeronimo C, Robert F. The histone chaperone FACT: a guardian of chromatin structure integrity. Transcription. 2022 Feb-Jun;13(1-3):16-38. doi: 10.1080/21541264.2022.2069995. Epub 2022 Apr 29. Review. PubMed PMID: 35485711; PubMed Central PMCID: PMC9467567.
Jeronimo C, Angel A, Nguyen VQ, Kim JM, Poitras C, Lambert E, Collin P, Mellor J, Wu C, Robert F. FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner. Mol Cell. 2021 Sep 2;81(17):3542-3559.e11. doi: 10.1016/j.molcel.2021.07.010. Epub 2021 Aug 10. PubMed PMID: 34380014; PubMed Central PMCID: PMC9149603.
Saleh MM, Jeronimo C, Robert F, Zentner GE. Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters. PLoS Genet. 2021 Aug;17(8):e1009529. doi: 10.1371/journal.pgen.1009529. eCollection 2021 Aug. PubMed PMID: 34383744; PubMed Central PMCID: PMC8384189.
Eyboulet F, Jeronimo C, Côté J, Robert F. The deubiquitylase Ubp15 couples transcription to mRNA export. Elife. 2020 Nov 23;9. doi: 10.7554/eLife.61264. PubMed PMID: 33226341; PubMed Central PMCID: PMC7682988.
Jeronimo C, Poitras C, Robert F. Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications. Cell Rep. 2019 Jul 30;28(5):1206-1218.e8. doi: 10.1016/j.celrep.2019.06.097. PubMed PMID: 31365865.
Collin P, Jeronimo C, Poitras C, Robert F. RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway. Mol Cell. 2019 Feb 21;73(4):655-669.e7. doi: 10.1016/j.molcel.2018.12.002. Epub 2019 Jan 10. PubMed PMID: 30639244.
Robert F. Bidirectional terminators: an underestimated aspect of gene regulation. Curr Genet. 2018 Apr;64(2):389-391. doi: 10.1007/s00294-017-0763-y. Epub 2017 Oct 10. Review. PubMed PMID: 29018946.
Robert F. Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency. Mol Cell. 2017 Oct 19;68(2):263-264. doi: 10.1016/j.molcel.2017.10.005. PubMed PMID: 29053954.
Jeronimo C, Robert F. The Mediator Complex: At the Nexus of RNA Polymerase II Transcription. Trends Cell Biol. 2017 Oct;27(10):765-783. doi: 10.1016/j.tcb.2017.07.001. Epub 2017 Aug 1. Review. PubMed PMID: 28778422.
Uwimana N, Collin P, Jeronimo C, Haibe-Kains B, Robert F. Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes. Nucleic Acids Res. 2017 Jun 20;45(11):6417-6426. doi: 10.1093/nar/gkx242. PubMed PMID: 28383698; PubMed Central PMCID: PMC5499651.
Jeronimo C, Robert F. A Spiking Strategy for ChIP-chip Data Normalization in S. cerevisiae. Methods Mol Biol. 2017;1528:211-227. doi: 10.1007/978-1-4939-6630-1_13. PubMed PMID: 27854024.
Steunou AL, Cramet M, Rossetto D, Aristizabal MJ, Lacoste N, Drouin S, Côté V, Paquet E, Utley RT, Krogan N, Robert F, Kobor MS, Côté J. Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol Cell Biol. 2016 Nov 15;36(22):2768-2781. doi: 10.1128/MCB.00112-16. Print 2016 Nov 15. PubMed PMID: 27550811; PubMed Central PMCID: PMC5086519.
Jeronimo C, Langelier MF, Bataille AR, Pascal JM, Pugh BF, Robert F. Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo. Mol Cell. 2016 Nov 3;64(3):455-466. doi: 10.1016/j.molcel.2016.09.002. Epub 2016 Oct 20. PubMed PMID: 27773677; PubMed Central PMCID: PMC5824718.
Botezatu L, Michel LC, Helness A, Vadnais C, Makishima H, Hönes JM, Robert F, Vassen L, Thivakaran A, Al-Matary Y, Lams RF, Schütte J, Giebel B, Görgens A, Heuser M, Medyouf H, Maciejewski J, Dührsen U, Möröy T, Khandanpour C. Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML. Exp Hematol. 2016 Aug;44(8):713-726.e14. doi: 10.1016/j.exphem.2016.05.004. Epub 2016 May 20. PubMed PMID: 27216773.
Fraszczak J, Helness A, Chen R, Vadnais C, Robert F, Khandanpour C, Möröy T. Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1. PLoS One. 2016;11(7):e0160344. doi: 10.1371/journal.pone.0160344. eCollection 2016. PubMed PMID: 27467586; PubMed Central PMCID: PMC4965025.
Jeronimo C, Collin P, Robert F. The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain. J Mol Biol. 2016 Jun 19;428(12):2607-2622. doi: 10.1016/j.jmb.2016.02.006. Epub 2016 Feb 12. Review. PubMed PMID: 26876604.
Gaudreau MC, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, Wilhelm B, Robert F, Heyd F, Möröy T. Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells. Sci Rep. 2016 Jun 7;6:27379. doi: 10.1038/srep27379. PubMed PMID: 27271479; PubMed Central PMCID: PMC4895350.
Hönes JM, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, Hergenhan SM, Thivakaran A, Schütte J, Al-Matary YS, Lams RF, Fraszscak J, Makishima H, Radivoyevitch T, Przychodzen B, da Conceição Castro SV, Görgens A, Giebel B, Klein-Hitpass L, Lennartz K, Heuser M, Thiede C, Ehninger G, Dührsen U, Maciejewski JP, Möröy T, Khandanpour C. GFI1 as a novel prognostic and therapeutic factor for AML/MDS. Leukemia. 2016 Jun;30(6):1237-45. doi: 10.1038/leu.2016.11. Epub 2016 Feb 5. PubMed PMID: 26847026.
Jeronimo C, Robert F. Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants. Bioessays. 2016 May;38(5):420-6. doi: 10.1002/bies.201500122. Epub 2016 Mar 15. PubMed PMID: 26990181.
Jeronimo C, Watanabe S, Kaplan CD, Peterson CL, Robert F. The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. Mol Cell. 2015 Jun 18;58(6):1113-23. doi: 10.1016/j.molcel.2015.03.030. Epub 2015 May 7. PubMed PMID: 25959393; PubMed Central PMCID: PMC4475440.
Cheng X, Auger A, Altaf M, Drouin S, Paquet E, Utley RT, Robert F, Côté J. Eaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis. Eukaryot Cell. 2015 Jun;14(6):535-44. doi: 10.1128/EC.00004-15. Epub 2015 Apr 3. PubMed PMID: 25841019; PubMed Central PMCID: PMC4452573.
Burugula BB, Jeronimo C, Pathak R, Jones JW, Robert F, Govind CK. Histone deacetylases and phosphorylated polymerase II C-terminal domain recruit Spt6 for cotranscriptional histone reassembly. Mol Cell Biol. 2014 Nov 15;34(22):4115-29. doi: 10.1128/MCB.00695-14. Epub 2014 Sep 2. PubMed PMID: 25182531; PubMed Central PMCID: PMC4248711.
Gasmi N, Jacques PE, Klimova N, Guo X, Ricciardi A, Robert F, Turcotte B. The switch from fermentation to respiration in Saccharomyces cerevisiae is regulated by the Ert1 transcriptional activator/repressor. Genetics. 2014 Oct;198(2):547-60. doi: 10.1534/genetics.114.168609. Epub 2014 Aug 13. PubMed PMID: 25123508; PubMed Central PMCID: PMC4196612.
Shahbabian K, Jeronimo C, Forget A, Robert F, Chartrand P. Co-transcriptional recruitment of Puf6 by She2 couples translational repression to mRNA localization. Nucleic Acids Res. 2014 Jul;42(13):8692-704. doi: 10.1093/nar/gku597. Epub 2014 Jul 10. PubMed PMID: 25013181; PubMed Central PMCID: PMC4117797.
Coulombe C, Poitras C, Nordell-Markovits A, Brunelle M, Lavoie MA, Robert F, Jacques PÉ. VAP: a versatile aggregate profiler for efficient genome-wide data representation and discovery. Nucleic Acids Res. 2014 Jul;42(Web Server issue):W485-93. doi: 10.1093/nar/gku302. Epub 2014 Apr 21. PubMed PMID: 24753414; PubMed Central PMCID: PMC4086060.
Jeronimo C, Robert F. Kin28 regulates the transient association of Mediator with core promoters. Nat Struct Mol Biol. 2014 May;21(5):449-55. doi: 10.1038/nsmb.2810. Epub 2014 Apr 6. PubMed PMID: 24704787; PubMed Central PMCID: PMC3997488.
Praktiknjo SD, Llamas B, Scott-Boyer MP, Picard S, Robert F, Langlais D, Haibe-Kains B, Faubert D, Silversides DW, Deschepper CF. Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice. Endocrinology. 2013 Dec;154(12):4746-56. doi: 10.1210/en.2013-1699. Epub 2013 Oct 8. PubMed PMID: 24105479.
Jeronimo C, Bataille AR, Robert F. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Chem Rev. 2013 Nov 13;113(11):8491-522. doi: 10.1021/cr4001397. Epub 2013 Jul 10. Review. PubMed PMID: 23837720.
Woo S, Zhang X, Sauteraud R, Robert F, Gottardo R. PING 2.0: an R/Bioconductor package for nucleosome positioning using next-generation sequencing data. Bioinformatics. 2013 Aug 15;29(16):2049-50. doi: 10.1093/bioinformatics/btt348. Epub 2013 Jun 20. PubMed PMID: 23786769; PubMed Central PMCID: PMC3722530.
Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC. A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS Genet. 2012;8(8):e1002822. doi: 10.1371/journal.pgen.1002822. Epub 2012 Aug 2. PubMed PMID: 22876190; PubMed Central PMCID: PMC3410854.
Soontorngun N, Baramee S, Tangsombatvichit C, Thepnok P, Cheevadhanarak S, Robert F, Turcotte B. Genome-wide location analysis reveals an important overlap between the targets of the yeast transcriptional regulators Rds2 and Adr1. Biochem Biophys Res Commun. 2012 Jul 13;423(4):632-7. doi: 10.1016/j.bbrc.2012.05.151. Epub 2012 Jun 8. PubMed PMID: 22687600.
Bataille AR, Jeronimo C, Jacques PÉ, Laramée L, Fortin MÈ, Forest A, Bergeron M, Hanes SD, Robert F. A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes. Mol Cell. 2012 Jan 27;45(2):158-70. doi: 10.1016/j.molcel.2011.11.024. PubMed PMID: 22284676.
Poschmann J, Drouin S, Jacques PE, El Fadili K, Newmarch M, Robert F, Ramotar D. The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses. PLoS One. 2011;6(8):e23159. doi: 10.1371/journal.pone.0023159. Epub 2011 Aug 24. PubMed PMID: 21887235; PubMed Central PMCID: PMC3160861.
Ivanovska I, Jacques PÉ, Rando OJ, Robert F, Winston F. Control of chromatin structure by spt6: different consequences in coding and regulatory regions. Mol Cell Biol. 2011 Feb;31(3):531-41. doi: 10.1128/MCB.01068-10. Epub 2010 Nov 22. PubMed PMID: 21098123; PubMed Central PMCID: PMC3028613.
Gonsalves SE, Moses AM, Razak Z, Robert F, Westwood JT. Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster. PLoS One. 2011 Jan 14;6(1):e15934. doi: 10.1371/journal.pone.0015934. PubMed PMID: 21264254; PubMed Central PMCID: PMC3021535.
Drouin S, Laramée L, Jacques PÉ, Forest A, Bergeron M, Robert F. DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes. PLoS Genet. 2010 Oct 28;6(10):e1001173. doi: 10.1371/journal.pgen.1001173. PubMed PMID: 21060864; PubMed Central PMCID: PMC2965751.
Hardy S, Robert F. Random deposition of histone variants: A cellular mistake or a novel regulatory mechanism?. Epigenetics. 2010 Jul 1;5(5):368-72. doi: 10.4161/epi.5.5.11787. Epub 2010 Jul 1. Review. PubMed PMID: 20448466.
Szilard RK, Jacques PE, Laramée L, Cheng B, Galicia S, Bataille AR, Yeung M, Mendez M, Bergeron M, Robert F, Durocher D. Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nat Struct Mol Biol. 2010 Mar;17(3):299-305. doi: 10.1038/nsmb.1754. Epub 2010 Feb 7. PubMed PMID: 20139982; PubMed Central PMCID: PMC3081315.
Turcotte B, Liang XB, Robert F, Soontorngun N. Transcriptional regulation of nonfermentable carbon utilization in budding yeast. FEMS Yeast Res. 2010 Feb;10(1):2-13. doi: 10.1111/j.1567-1364.2009.00555.x. Epub 2009 Jul 18. Review. PubMed PMID: 19686338; PubMed Central PMCID: PMC5003605.
Hardy S, Jacques PE, Gévry N, Forest A, Fortin ME, Laflamme L, Gaudreau L, Robert F. The euchromatic and heterochromatic landscapes are shaped by antagonizing effects of transcription on H2A.Z deposition. PLoS Genet. 2009 Oct;5(10):e1000687. doi: 10.1371/journal.pgen.1000687. Epub 2009 Oct 16. PubMed PMID: 19834540; PubMed Central PMCID: PMC2754525.
Ghazal G, Gagnon J, Jacques PE, Landry JR, Robert F, Elela SA. Yeast RNase III triggers polyadenylation-independent transcription termination. Mol Cell. 2009 Oct 9;36(1):99-109. doi: 10.1016/j.molcel.2009.07.029. PubMed PMID: 19818713.
Gévry N, Hardy S, Jacques PE, Laflamme L, Svotelis A, Robert F, Gaudreau L. Histone H2A.Z is essential for estrogen receptor signaling. Genes Dev. 2009 Jul 1;23(13):1522-33. doi: 10.1101/gad.1787109. Epub 2009 Jun 10. PubMed PMID: 19515975; PubMed Central PMCID: PMC2704467.
Bataille AR, Robert F. Profiling genome-wide histone modifications and variants by ChIP-chip on tiling microarrays in S. cerevisiae. Methods Mol Biol. 2009;543:267-79. doi: 10.1007/978-1-60327-015-1_18. PubMed PMID: 19378172.
Truscott M, Harada R, Vadnais C, Robert F, Nepveu A. p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes. Mol Cell Biol. 2008 May;28(10):3127-38. doi: 10.1128/MCB.02089-07. Epub 2008 Mar 17. PubMed PMID: 18347061; PubMed Central PMCID: PMC2423173.
Znaidi S, Weber S, Al-Abdin OZ, Bomme P, Saidane S, Drouin S, Lemieux S, De Deken X, Robert F, Raymond M. Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance. Eukaryot Cell. 2008 May;7(5):836-47. doi: 10.1128/EC.00070-08. Epub 2008 Apr 4. PubMed PMID: 18390649; PubMed Central PMCID: PMC2394978.
Harada R, Vadnais C, Sansregret L, Leduy L, Bérubé G, Robert F, Nepveu A. Genome-wide location analysis and expression studies reveal a role for p110 CUX1 in the activation of DNA replication genes. Nucleic Acids Res. 2008 Jan;36(1):189-202. doi: 10.1093/nar/gkm970. Epub 2007 Nov 14. PubMed PMID: 18003658; PubMed Central PMCID: PMC2248751.
Soontorngun N, Larochelle M, Drouin S, Robert F, Turcotte B. Regulation of gluconeogenesis in Saccharomyces cerevisiae is mediated by activator and repressor functions of Rds2. Mol Cell Biol. 2007 Nov;27(22):7895-905. doi: 10.1128/MCB.01055-07. Epub 2007 Sep 17. PubMed PMID: 17875938; PubMed Central PMCID: PMC2169140.
Rufiange A, Jacques PE, Bhat W, Robert F, Nourani A. Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1. Mol Cell. 2007 Aug 3;27(3):393-405. doi: 10.1016/j.molcel.2007.07.011. PubMed PMID: 17679090.
Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X, Scheffler IE, Mock DC, Bataille AR, Robert F, Lee CH, Giguère V, Evans RM. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 2007 Aug 1;21(15):1909-20. doi: 10.1101/gad.1553007. PubMed PMID: 17671090; PubMed Central PMCID: PMC1935029.
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