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Aparicio JM, Xu Y, Li Y, Colantuoni C, Dastgheyb R, Williams DW, Asahchop EL, McMillian JM, Power C, Fujiwara E, Gill MJ, Rubin LH. Plasma microRNAs are associated with domain-specific cognitive function in people with HIV. AIDS. 2021 Jun 1;. doi: 10.1097/QAD.0000000000002966. [Epub ahead of print] PubMed PMID: 34074816; NIHMSID:NIHMS1708705.
O'Halloran JA, Wang K, Spence AB, Williams DW, Dastgheyb R, Fitzgerald KC, Kamkwalala AR, Maki PM, Sharma A, Gustafson DR, Milam J, Weber KM, Adimora AA, Ofotokun I, Fischl MA, Konkle-Parker D, Lahiri CD, Sheth AN, Xu Y, Rubin LH. Integrase Strand Transfer Inhibitor Start or Switch Impacts Learning in Women With HIV. J Acquir Immune Defic Syndr. 2021 Apr 15;86(5):593-599. doi: 10.1097/QAI.0000000000002608. PubMed PMID: 33394812; NIHMSID:NIHMS1668135.
Tran A, Thakur KT, Nakasujja N, Nakigozi G, Kisakye A, Batte J, Mayanja R, Anok A, Gray RH, Wawer MJ, Rubin LH, Sacktor N, Saylor D. Evaluation of a screening tool for the identification of neurological disorders in rural Uganda. J Neurol Sci. 2021 Feb 15;421:117273. doi: 10.1016/j.jns.2020.117273. Epub 2020 Dec 24. PubMed PMID: 33423010; PubMed Central PMCID: PMC7914201.
Skácel J, Slusher BS, Tsukamoto T. Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network. J Med Chem. 2021 Jan 14;64(1):279-297. doi: 10.1021/acs.jmedchem.0c01664. Epub 2021 Jan 4. Review. PubMed PMID: 33395289; PubMed Central PMCID: PMC8023021.
Kamkwalala AR, Wang K, O'Halloran J, Williams DW, Dastgheyb R, Fitzgerald KC, Spence AB, Maki PM, Gustafson DR, Milam J, Sharma A, Weber KM, Adimora AA, Ofotokun I, Sheth AN, Lahiri CD, Fischl MA, Konkle-Parker D, Xu Y, Rubin LH. Starting or Switching to an Integrase Inhibitor-Based Regimen Affects PTSD Symptoms in Women with HIV. AIDS Behav. 2021 Jan;25(1):225-236. doi: 10.1007/s10461-020-02967-2. PubMed PMID: 32638219; PubMed Central PMCID: PMC7948485.
Braxton AM, Chalmin AL, Najarro KM, Brockhurst JK, Johnson KT, Lyons CE, Daly B, Cryer CG, Vijay S, Cyphers G, Guerrero-Martin SM, Aston SA, McGee K, Su YP, Arav-Boger R, Metcalf Pate KA. Platelet-endothelial associations may promote cytomegalovirus replication in the salivary gland in mice. Platelets. 2020 Oct 2;31(7):860-868. doi: 10.1080/09537104.2019.1689383. Epub 2019 Nov 14. PubMed PMID: 31726921; PubMed Central PMCID: PMC7220825.
Holroyd KB, Vishnevetsky A, Srinivasan M, Saylor D. Neurologic Complications of Acute HIV Infection. Curr Treat Options Infect Dis. 2020 Sep;12(3):227-242. doi: 10.1007/s40506-020-00228-3. Epub 2020 Jun 8. PubMed PMID: 33551684; PubMed Central PMCID: PMC7864540.
Vornov JJ, Peters D, Nedelcovych M, Hollinger K, Rais R, Slusher BS. Looking for Drugs in All the Wrong Places: Use of GCPII Inhibitors Outside the Brain. Neurochem Res. 2020 Jun;45(6):1256-1267. doi: 10.1007/s11064-019-02909-y. Epub 2019 Nov 20. Review. PubMed PMID: 31749072; PubMed Central PMCID: PMC7237296.
Deme P, Rojas C, Slusher BS, Rais R, Afghah Z, Geiger JD, Haughey NJ. Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?. Exp Neurol. 2020 May;327:113181. doi: 10.1016/j.expneurol.2020.113181. Epub 2020 Jan 11. Review. PubMed PMID: 31930991; PubMed Central PMCID: PMC7233457.
Kamkwalala AR, Wang X, Maki PM, Williams DW, Valcour VG, Damron A, Tien PC, Weber KM, Cohen MH, Sundermann EE, Meyer VJ, Little DM, Xu Y, Rubin LH. Brief Report: Higher Peripheral Monocyte Activation Markers Are Associated With Smaller Frontal and Temporal Cortical Volumes in Women With HIV. J Acquir Immune Defic Syndr. 2020 May 1;84(1):54-59. doi: 10.1097/QAI.0000000000002283. PubMed PMID: 31914004; PubMed Central PMCID: PMC7388688.
Rubin LH, Langenecker SA, Phan KL, Keating SM, Neigh GN, Weber KM, Maki PM. Remitted depression and cognition in HIV: The role of cortisol and inflammation. Psychoneuroendocrinology. 2020 Apr;114:104609. doi: 10.1016/j.psyneuen.2020.104609. Epub 2020 Feb 7. PubMed PMID: 32062371; PubMed Central PMCID: PMC7254879.
Awori V, Nakigozi G, Kisakye A, Batte J, Anok A, Mayanja R, Nakasujja N, Robertson KR, Gray RH, Wawer MJ, Sacktor N, Saylor D. The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda. J Neurovirol. 2020 Apr;26(2):252-256. doi: 10.1007/s13365-019-00806-2. Epub 2019 Nov 12. PubMed PMID: 31721082; PubMed Central PMCID: PMC8012007.
Saleem M, Herrmann N, Dinoff A, Marzolini S, Mielke MM, Andreazza A, Oh PI, Vattem Venkata SL, Haughey NJ, Lanctôt KL. Association Between Sphingolipids and Cardiopulmonary Fitness in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation. J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):671-679. doi: 10.1093/gerona/gly273. PubMed PMID: 30535238; PubMed Central PMCID: PMC7931966.
Molinaro M, Sacktor N, Nakigozi G, Anok A, Batte J, Kisakye A, Myanja R, Nakasujja N, Robertson KR, Gray RH, Wawer MJ, Saylor D. Utility of the International HIV Dementia Scale for HIV-Associated Neurocognitive Disorder. J Acquir Immune Defic Syndr. 2020 Mar 1;83(3):278-283. doi: 10.1097/QAI.0000000000002257. PubMed PMID: 32032278; PubMed Central PMCID: PMC7197883.
Saylor D, Kumar A, Nakigozi G, Anok A, Batte J, Kisakye A, Mayanja R, Nakasujja N, Robertson KR, Gray RH, Wawer MJ, Pardo CA, Sacktor N. Interleukin-6 is associated with mortality and neuropsychiatric outcomes in antiretroviral-naïve adults in Rakai, Uganda. J Neurovirol. 2019 Dec;25(6):735-740. doi: 10.1007/s13365-019-00759-6. Epub 2019 Jun 4. PubMed PMID: 31165368; PubMed Central PMCID: PMC6891138.
Rubin LH, Saylor D, Nakigozi G, Nakasujja N, Robertson K, Kisakye A, Batte J, Mayanja R, Anok A, Lofgren SM, Boulware DR, Dastgheyb R, Reynolds SJ, Quinn TC, Gray RH, Wawer MJ, Sacktor N. Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda. J Neurovirol. 2019 Dec;25(6):800-813. doi: 10.1007/s13365-019-00768-5. Epub 2019 Jun 19. PubMed PMID: 31218522; PubMed Central PMCID: PMC7296988.
Cotto B, Natarajaseenivasan K, Langford D. Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND. J Neurovirol. 2019 Oct;25(5):722-733. doi: 10.1007/s13365-019-00721-6. Epub 2019 Jan 22. Review. PubMed PMID: 30671779; PubMed Central PMCID: PMC6646105.
Rojas C, Sala M, Thomas AG, Datta Chaudhuri A, Yoo SW, Li Z, Dash RP, Rais R, Haughey NJ, Nencka R, Slusher B. A novel and potent brain penetrant inhibitor of extracellular vesicle release. Br J Pharmacol. 2019 Oct;176(19):3857-3870. doi: 10.1111/bph.14789. Epub 2019 Sep 4. PubMed PMID: 31273753; PubMed Central PMCID: PMC6780992.
Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, Volsky DJ, Slusher BS. Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders. J Neuroimmune Pharmacol. 2019 Sep;14(3):391-400. doi: 10.1007/s11481-019-09859-w. Epub 2019 Jun 17. PubMed PMID: 31209775; PubMed Central PMCID: PMC8207835.
Rubin LH, Springer G, Martin EM, Seaberg EC, Sacktor NC, Levine A, Valcour VG, Young MA, Becker JT, Maki PM. Elevated Depressive Symptoms Are a Stronger Predictor of Executive Dysfunction in HIV-Infected Women Than in Men. J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):274-283. doi: 10.1097/QAI.0000000000002029. PubMed PMID: 30893126; PubMed Central PMCID: PMC7254882.
Kisakye A, Saylor D, Sacktor N, Nakigozi G, Nakasujja N, Robertson K, Anok A, Wawer M, Gray R. Caregiver versus self-reported activities of daily living among HIV-positive persons in Rakai, Uganda. AIDS Care. 2019 Jul;31(7):836-839. doi: 10.1080/09540121.2018.1557591. Epub 2018 Dec 15. PubMed PMID: 30554522; PubMed Central PMCID: PMC6510610.
Saylor D, Nakigozi G, Pardo CA, Kisakye A, Kumar A, Nakasujja N, Robertson KR, Gray RH, Wawer MJ, Sacktor N. Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda. J Neurovirol. 2019 Jun;25(3):410-414. doi: 10.1007/s13365-018-00719-6. Epub 2019 Jan 22. PubMed PMID: 30671778; PubMed Central PMCID: PMC6635069.
Sacktor N, Saylor D, Nakigozi G, Nakasujja N, Robertson K, Grabowski MK, Kisakye A, Batte J, Mayanja R, Anok A, Gray RH, Wawer MJ. Effect of HIV Subtype and Antiretroviral Therapy on HIV-Associated Neurocognitive Disorder Stage in Rakai, Uganda. J Acquir Immune Defic Syndr. 2019 Jun 1;81(2):216-223. doi: 10.1097/QAI.0000000000001992. PubMed PMID: 30865184; PubMed Central PMCID: PMC6522269.
Robertson KR, Jiang H, Kumwenda J, Supparatpinyo K, Marra CM, Berzins B, Hakim J, Sacktor N, Campbell TB, Schouten J, Mollan K, Tripathy S, Kumarasamy N, La Rosa A, Santos B, Silva MT, Kanyama C, Firhnhaber C, Murphy R, Hall C, Marcus C, Naini L, Masih R, Hosseinipour MC, Mngqibisa R, Badal-Faesen S, Yosief S, Vecchio A, Nair A. Human Immunodeficiency Virus-associated Neurocognitive Impairment in Diverse Resource-limited Settings. Clin Infect Dis. 2019 May 2;68(10):1733-1738. doi: 10.1093/cid/ciy767. PubMed PMID: 30219843; PubMed Central PMCID: PMC6495019.
Kim BH, Kelschenbach J, Borjabad A, Hadas E, He H, Potash MJ, Nedelcovych MT, Rais R, Haughey NJ, McArthur JC, Slusher BS, Volsky DJ. Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice. AIDS. 2019 May 1;33(6):973-984. doi: 10.1097/QAD.0000000000002150. PubMed PMID: 30946151; PubMed Central PMCID: PMC6457131.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 May;44(6):1178. doi: 10.1038/s41386-019-0354-3. Epub 2019 Mar 13. PubMed PMID: 30862949; PubMed Central PMCID: PMC6461747.
Sohail S, Nakigozi G, Anok A, Batte J, Kisakye A, Mayanja R, Nakasujja N, Robertson KR, Gray RH, Wawer MJ, Sacktor N, Saylor D. Headache prevalence and its functional impact among HIV-infected adults in rural Rakai District, Uganda. J Neurovirol. 2019 Apr;25(2):248-253. doi: 10.1007/s13365-018-0710-9. Epub 2019 Jan 3. PubMed PMID: 30607892; PubMed Central PMCID: PMC6506364.
Khuder SS, Chen S, Letendre S, Marcotte T, Grant I, Franklin D, Rubin LH, Margolick JB, Jacobson LP, Sacktor N, D'Souza G, Stosor V, Lake JE, Rapocciolo G, McArthur JC, Dickens AM, Haughey NJ. Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology. 2019 Mar 19;92(12):e1344-e1353. doi: 10.1212/WNL.0000000000007125. Epub 2019 Feb 20. PubMed PMID: 30787163; PubMed Central PMCID: PMC6511093.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. doi: 10.1038/s41386-018-0177-7. Epub 2018 Aug 13. PubMed PMID: 30127344; PubMed Central PMCID: PMC6372721.
Rubin LH, Maki PM. HIV, Depression, and Cognitive Impairment in the Era of Effective Antiretroviral Therapy. Curr HIV/AIDS Rep. 2019 Feb;16(1):82-95. doi: 10.1007/s11904-019-00421-0. Review. PubMed PMID: 30661180; PubMed Central PMCID: PMC6420829.
Barinka C, Novakova Z, Hin N, Bím D, Ferraris DV, Duvall B, Kabarriti G, Tsukamoto R, Budesinsky M, Motlova L, Rojas C, Slusher BS, Rokob TA, Rulíšek L, Tsukamoto T. Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors. Bioorg Med Chem. 2019 Jan 15;27(2):255-264. doi: 10.1016/j.bmc.2018.11.022. Epub 2018 Nov 14. PubMed PMID: 30552009; PubMed Central PMCID: PMC6374116.
Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. doi: 10.1038/s41598-018-36144-2. PubMed PMID: 30531925; PubMed Central PMCID: PMC6286365.
Saylor D. Neurologic Complications of Human Immunodeficiency Virus Infection. Continuum (Minneap Minn). 2018 Oct;24(5, Neuroinfectious Disease):1397-1421. doi: 10.1212/CON.0000000000000647. Review. PubMed PMID: 30273245; PubMed Central PMCID: PMC8006925.
Rojas C, Stathis M, Coughlin JM, Pomper M, Slusher BS. The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site. J Neuroimmune Pharmacol. 2018 Mar;13(1):1-5. doi: 10.1007/s11481-017-9765-2. Epub 2017 Sep 5. PubMed PMID: 28875261; PubMed Central PMCID: PMC5790609.
Chan P, Saleem M, Herrmann N, Mielke MM, Haughey NJ, Oh PI, Kiss A, Lanctôt KL. Ceramide Accumulation Is Associated with Declining Verbal Memory in Coronary Artery Disease Patients: An Observational Study. J Alzheimers Dis. 2018;64(4):1235-1246. doi: 10.3233/JAD-180030. PubMed PMID: 30010121; PubMed Central PMCID: PMC6087453.
Megra BW, Eugenin EA, Berman JW. The Role of Shed PrPc in the Neuropathogenesis of HIV Infection. J Immunol. 2017 Jul 1;199(1):224-232. doi: 10.4049/jimmunol.1601041. Epub 2017 May 22. PubMed PMID: 28533442; PubMed Central PMCID: PMC5640173.
Ubaida-Mohien C, Lamberty B, Dickens AM, Mielke MM, Marcotte T, Sacktor N, Grant I, Letendre S, Franklin D, Cibrowski P, Tharakan R, McArthur JC, Fox H, Haughey NJ. Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients. AIDS. 2017 Jun 19;31(10):1365-1378. doi: 10.1097/QAD.0000000000001503. PubMed PMID: 28574961; PubMed Central PMCID: PMC5501712.
Yoo SW, Bae M, Tovar-Y-Romo LB, Haughey NJ. Hippocampal encoding of interoceptive context during fear conditioning. Transl Psychiatry. 2017 Jan 3;7(1):e991. doi: 10.1038/tp.2016.254. PubMed PMID: 28045462; PubMed Central PMCID: PMC5545722.
Mielke MM, Haughey NJ, Han D, An Y, Bandaru VVR, Lyketsos CG, Ferrucci L, Resnick SM. The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer's Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging. J Alzheimers Dis. 2017;60(3):819-828. doi: 10.3233/JAD-160925. PubMed PMID: 28035934; PubMed Central PMCID: PMC5493514.
Saleem M, Herrmann N, Dinoff A, Mielke MM, Oh PI, Shammi P, Cao X, Venkata SLV, Haughey NJ, Lanctôt KL. A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise. J Alzheimers Dis. 2017;60(3):829-841. doi: 10.3233/JAD-161292. PubMed PMID: 28598843; PubMed Central PMCID: PMC5753402.
Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol. 2017 Jan;187(1):91-109. doi: 10.1016/j.ajpath.2016.09.006. PubMed PMID: 27993242; PubMed Central PMCID: PMC5225305.
Rico JE, Mathews AT, Lovett J, Haughey NJ, McFadden JW. Palmitic acid feeding increases ceramide supply in association with increased milk yield, circulating nonesterified fatty acids, and adipose tissue responsiveness to a glucose challenge. J Dairy Sci. 2016 Nov;99(11):8817-8830. doi: 10.3168/jds.2016-11296. Epub 2016 Sep 13. PubMed PMID: 27638262.
Fabbri E, Yang A, Simonsick EM, Chia CW, Zoli M, Haughey NJ, Mielke MM, Ferrucci L, Coen PM. Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging. Aging Cell. 2016 Oct;15(5):825-31. doi: 10.1111/acel.12491. Epub 2016 May 2. PubMed PMID: 27135629; PubMed Central PMCID: PMC5013023.
Valdez AN, Rubin LH, Neigh GN. Untangling the Gordian knot of HIV, stress, and cognitive impairment. Neurobiol Stress. 2016 Oct;4:44-54. doi: 10.1016/j.ynstr.2016.02.005. eCollection 2016 Oct. Review. PubMed PMID: 27981189; PubMed Central PMCID: PMC5146199.
Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS One. 2016;11(7):e0158641. doi: 10.1371/journal.pone.0158641. eCollection 2016. PubMed PMID: 27379802; PubMed Central PMCID: PMC4933366.
Gonzalez CE, Venkatraman VK, An Y, Landman BA, Davatzikos C, Ratnam Bandaru VV, Haughey NJ, Ferrucci L, Mielke MM, Resnick SM. Peripheral sphingolipids are associated with variation in white matter microstructure in older adults. Neurobiol Aging. 2016 Jul;43:156-63. doi: 10.1016/j.neurobiolaging.2016.04.008. Epub 2016 Apr 21. PubMed PMID: 27255825; PubMed Central PMCID: PMC4894643.
Almad AA, Doreswamy A, Gross SK, Richard JP, Huo Y, Haughey N, Maragakis NJ. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia. 2016 Jul;64(7):1154-69. doi: 10.1002/glia.22989. Epub 2016 Apr 16. PubMed PMID: 27083773; PubMed Central PMCID: PMC5635605.
Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment. Nat Rev Neurol. 2016 May;12(5):309. doi: 10.1038/nrneurol.2016.53. Epub 2016 Apr 15. PubMed PMID: 27080521; PubMed Central PMCID: PMC5842923.
Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nat Rev Neurol. 2016 Apr;12(4):234-48. doi: 10.1038/nrneurol.2016.27. Epub 2016 Mar 11. Review. PubMed PMID: 26965674; PubMed Central PMCID: PMC4937456.
Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Erratum to: Interaction of Paroxetine with Mitochondrial Proteins Mediates Neuroprotection. Neurotherapeutics. 2016 Jan;13(1):237. doi: 10.1007/s13311-015-0406-2. PubMed PMID: 26692391; PubMed Central PMCID: PMC4720660.
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