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Deme P, Rojas C, Slusher BS, Rais R, Afghah Z, Geiger JD, Haughey NJ. Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?. Exp Neurol. 2020 May;327:113181. doi: 10.1016/j.expneurol.2020.113181. Epub 2020 Jan 11. Review. PubMed PMID: 31930991; PubMed Central PMCID: PMC7233457.
Braxton AM, Chalmin AL, Najarro KM, Brockhurst JK, Johnson KT, Lyons CE, Daly B, Cryer CG, Vijay S, Cyphers G, Guerrero-Martin SM, Aston SA, McGee K, Su YP, Arav-Boger R, Metcalf Pate KA. Platelet-endothelial associations may promote cytomegalovirus replication in the salivary gland in mice. Platelets. 2019 Nov 14;:1-9. doi: 10.1080/09537104.2019.1689383. [Epub ahead of print] PubMed PMID: 31726921; PubMed Central PMCID: PMC7220825.
Cotto B, Natarajaseenivasan K, Langford D. Astrocyte activation and altered metabolism in normal aging, age-related CNS diseases, and HAND. J Neurovirol. 2019 Oct;25(5):722-733. doi: 10.1007/s13365-019-00721-6. Epub 2019 Jan 22. PubMed PMID: 30671779; PubMed Central PMCID: PMC6646105.
Rojas C, Sala M, Thomas AG, Datta Chaudhuri A, Yoo SW, Li Z, Dash RP, Rais R, Haughey NJ, Nencka R, Slusher B. A novel and potent brain penetrant inhibitor of extracellular vesicle release. Br J Pharmacol. 2019 Oct;176(19):3857-3870. doi: 10.1111/bph.14789. Epub 2019 Sep 4. PubMed PMID: 31273753; PubMed Central PMCID: PMC6780992.
Rubin LH, Springer G, Martin EM, Seaberg EC, Sacktor NC, Levine A, Valcour VG, Young MA, Becker JT, Maki PM. Elevated Depressive Symptoms Are a Stronger Predictor of Executive Dysfunction in HIV-Infected Women Than in Men. J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):274-283. doi: 10.1097/QAI.0000000000002029. PubMed PMID: 30893126; PubMed Central PMCID: PMC7254882.
Kim BH, Kelschenbach J, Borjabad A, Hadas E, He H, Potash MJ, Nedelcovych MT, Rais R, Haughey NJ, McArthur JC, Slusher BS, Volsky DJ. Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice. AIDS. 2019 May 1;33(6):973-984. doi: 10.1097/QAD.0000000000002150. PubMed PMID: 30946151; PubMed Central PMCID: PMC6457131.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 May;44(6):1178. doi: 10.1038/s41386-019-0354-3. Epub 2019 Mar 13. PubMed PMID: 30862949; PubMed Central PMCID: PMC6461747.
Khuder SS, Chen S, Letendre S, Marcotte T, Grant I, Franklin D, Rubin LH, Margolick JB, Jacobson LP, Sacktor N, D'Souza G, Stosor V, Lake JE, Rapocciolo G, McArthur JC, Dickens AM, Haughey NJ. Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology. 2019 Mar 19;92(12):e1344-e1353. doi: 10.1212/WNL.0000000000007125. Epub 2019 Feb 20. PubMed PMID: 30787163; PubMed Central PMCID: PMC6511093.
Zhu X, Nedelcovych MT, Thomas AG, Hasegawa Y, Moreno-Megui A, Coomer W, Vohra V, Saito A, Perez G, Wu Y, Alt J, Prchalova E, Tenora L, Majer P, Rais R, Rojas C, Slusher BS, Kamiya A. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. doi: 10.1038/s41386-018-0177-7. Epub 2018 Aug 13. PubMed PMID: 30127344; PubMed Central PMCID: PMC6372721.
Barinka C, Novakova Z, Hin N, Bím D, Ferraris DV, Duvall B, Kabarriti G, Tsukamoto R, Budesinsky M, Motlova L, Rojas C, Slusher BS, Rokob TA, Rulíšek L, Tsukamoto T. Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors. Bioorg Med Chem. 2019 Jan 15;27(2):255-264. doi: 10.1016/j.bmc.2018.11.022. Epub 2018 Nov 14. PubMed PMID: 30552009; PubMed Central PMCID: PMC6374116.
Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. doi: 10.1038/s41598-018-36144-2. PubMed PMID: 30531925; PubMed Central PMCID: PMC6286365.
Rojas C, Stathis M, Coughlin JM, Pomper M, Slusher BS. The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site. J Neuroimmune Pharmacol. 2018 Mar;13(1):1-5. doi: 10.1007/s11481-017-9765-2. Epub 2017 Sep 5. PubMed PMID: 28875261; PubMed Central PMCID: PMC5790609.
Chan P, Saleem M, Herrmann N, Mielke MM, Haughey NJ, Oh PI, Kiss A, Lanctôt KL. Ceramide Accumulation Is Associated with Declining Verbal Memory in Coronary Artery Disease Patients: An Observational Study. J Alzheimers Dis. 2018;64(4):1235-1246. doi: 10.3233/JAD-180030. PubMed PMID: 30010121; PubMed Central PMCID: PMC6087453.
Megra BW, Eugenin EA, Berman JW. The Role of Shed PrPc in the Neuropathogenesis of HIV Infection. J Immunol. 2017 Jul 1;199(1):224-232. doi: 10.4049/jimmunol.1601041. Epub 2017 May 22. PubMed PMID: 28533442; PubMed Central PMCID: PMC5640173.
Ubaida-Mohien C, Lamberty B, Dickens AM, Mielke MM, Marcotte T, Sacktor N, Grant I, Letendre S, Franklin D, Cibrowski P, Tharakan R, McArthur JC, Fox H, Haughey NJ. Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients. AIDS. 2017 Jun 19;31(10):1365-1378. doi: 10.1097/QAD.0000000000001503. PubMed PMID: 28574961; PubMed Central PMCID: PMC5501712.
Yoo SW, Bae M, Tovar-Y-Romo LB, Haughey NJ. Hippocampal encoding of interoceptive context during fear conditioning. Transl Psychiatry. 2017 Jan 3;7(1):e991. doi: 10.1038/tp.2016.254. PubMed PMID: 28045462; PubMed Central PMCID: PMC5545722.
Mielke MM, Haughey NJ, Han D, An Y, Bandaru VVR, Lyketsos CG, Ferrucci L, Resnick SM. The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer's Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging. J Alzheimers Dis. 2017;60(3):819-828. doi: 10.3233/JAD-160925. PubMed PMID: 28035934; PubMed Central PMCID: PMC5493514.
Saleem M, Herrmann N, Dinoff A, Mielke MM, Oh PI, Shammi P, Cao X, Venkata SLV, Haughey NJ, Lanctôt KL. A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise. J Alzheimers Dis. 2017;60(3):829-841. doi: 10.3233/JAD-161292. PubMed PMID: 28598843; PubMed Central PMCID: PMC5753402.
Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. Am J Pathol. 2017 Jan;187(1):91-109. doi: 10.1016/j.ajpath.2016.09.006. PubMed PMID: 27993242; PubMed Central PMCID: PMC5225305.
Rico JE, Mathews AT, Lovett J, Haughey NJ, McFadden JW. Palmitic acid feeding increases ceramide supply in association with increased milk yield, circulating nonesterified fatty acids, and adipose tissue responsiveness to a glucose challenge. J Dairy Sci. 2016 Nov;99(11):8817-8830. doi: 10.3168/jds.2016-11296. Epub 2016 Sep 13. PubMed PMID: 27638262.
Fabbri E, Yang A, Simonsick EM, Chia CW, Zoli M, Haughey NJ, Mielke MM, Ferrucci L, Coen PM. Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging. Aging Cell. 2016 Oct;15(5):825-31. doi: 10.1111/acel.12491. Epub 2016 May 2. PubMed PMID: 27135629; PubMed Central PMCID: PMC5013023.
Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS One. 2016;11(7):e0158641. doi: 10.1371/journal.pone.0158641. eCollection 2016. PubMed PMID: 27379802; PubMed Central PMCID: PMC4933366.
Gonzalez CE, Venkatraman VK, An Y, Landman BA, Davatzikos C, Ratnam Bandaru VV, Haughey NJ, Ferrucci L, Mielke MM, Resnick SM. Peripheral sphingolipids are associated with variation in white matter microstructure in older adults. Neurobiol Aging. 2016 Jul;43:156-63. doi: 10.1016/j.neurobiolaging.2016.04.008. Epub 2016 Apr 21. PubMed PMID: 27255825; PubMed Central PMCID: PMC4894643.
Almad AA, Doreswamy A, Gross SK, Richard JP, Huo Y, Haughey N, Maragakis NJ. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia. 2016 Jul;64(7):1154-69. doi: 10.1002/glia.22989. Epub 2016 Apr 16. PubMed PMID: 27083773; PubMed Central PMCID: PMC5635605.
Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment. Nat Rev Neurol. 2016 May;12(5):309. doi: 10.1038/nrneurol.2016.53. Epub 2016 Apr 15. PubMed PMID: 27080521; PubMed Central PMCID: PMC5842923.
Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment. Nat Rev Neurol. 2016 Apr;12(4):234-48. doi: 10.1038/nrneurol.2016.27. Epub 2016 Mar 11. Review. PubMed PMID: 26965674; PubMed Central PMCID: PMC4937456.
Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Erratum to: Interaction of Paroxetine with Mitochondrial Proteins Mediates Neuroprotection. Neurotherapeutics. 2016 Jan;13(1):237. doi: 10.1007/s13311-015-0406-2. PubMed PMID: 26692391; PubMed Central PMCID: PMC4720660.
Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ. Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell. 2015 Dec;14(6):1014-23. doi: 10.1111/acel.12369. Epub 2015 Jul 20. PubMed PMID: 26193443; PubMed Central PMCID: PMC4693456.
Rico JE, Bandaru VV, Dorskind JM, Haughey NJ, McFadden JW. Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation. J Dairy Sci. 2015 Nov;98(11):7757-70. doi: 10.3168/jds.2015-9519. Epub 2015 Sep 3. PubMed PMID: 26342987; PubMed Central PMCID: PMC6075710.
Peterlin BL, Mielke MM, Dickens AM, Chatterjee S, Dash P, Alexander G, Vieira RV, Bandaru VV, Dorskind JM, Tietjen GE, Haughey NH. Interictal, circulating sphingolipids in women with episodic migraine: A case-control study. Neurology. 2015 Oct 6;85(14):1214-23. doi: 10.1212/WNL.0000000000002004. Epub 2015 Sep 9. PubMed PMID: 26354990; PubMed Central PMCID: PMC4607595.
Figuera-Losada M, Stathis M, Dorskind JM, Thomas AG, Bandaru VV, Yoo SW, Westwood NJ, Rogers GW, McArthur JC, Haughey NJ, Slusher BS, Rojas C. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One. 2015;10(5):e0124481. doi: 10.1371/journal.pone.0124481. eCollection 2015. PubMed PMID: 26010541; PubMed Central PMCID: PMC4444023.
Dickens AM, Anthony DC, Deutsch R, Mielke MM, Claridge TD, Grant I, Franklin D, Rosario D, Marcotte T, Letendre S, McArthur JC, Haughey NJ. Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients. AIDS. 2015 Mar 13;29(5):559-69. doi: 10.1097/QAD.0000000000000580. PubMed PMID: 25611149; PubMed Central PMCID: PMC4340743.
Sauerbeck AD, Laws JL, Bandaru VV, Popovich PG, Haughey NJ, McTigue DM. Spinal cord injury causes chronic liver pathology in rats. J Neurotrauma. 2015 Feb 1;32(3):159-69. doi: 10.1089/neu.2014.3497. Epub 2014 Oct 21. PubMed PMID: 25036371; PubMed Central PMCID: PMC4298754.
Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ. Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging. Aging Cell. 2015 Feb;14(1):112-21. doi: 10.1111/acel.12275. Epub 2014 Oct 24. PubMed PMID: 25345489; PubMed Central PMCID: PMC4310757.
Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. Neurotherapeutics. 2015 Jan;12(1):200-16. doi: 10.1007/s13311-014-0315-9. PubMed PMID: 25404050; PubMed Central PMCID: PMC4322069.
McFadden JW, Aja S, Li Q, Bandaru VV, Kim EK, Haughey NJ, Kuhajda FP, Ronnett GV. Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation. PLoS One. 2014;9(12):e115642. doi: 10.1371/journal.pone.0115642. eCollection 2014. PubMed PMID: 25541737; PubMed Central PMCID: PMC4277346.
Bandaru VV, Haughey NJ. Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. BMC Neurosci. 2014 Dec 24;15:137. doi: 10.1186/s12868-014-0137-z. PubMed PMID: 25539717; PubMed Central PMCID: PMC4304132.
Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D. Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol. 2014 Dec;20(6):620-6. doi: 10.1007/s13365-014-0292-0. Epub 2014 Nov 7. PubMed PMID: 25377444; PubMed Central PMCID: PMC4268406.
Bae M, Bandaru VV, Patel N, Haughey NJ. Ceramide metabolism analysis in a model of binge drinking reveals both neuroprotective and toxic effects of ethanol. J Neurochem. 2014 Dec;131(5):645-54. doi: 10.1111/jnc.12834. Epub 2014 Aug 21. PubMed PMID: 25060779; PubMed Central PMCID: PMC4405906.
Mielke MM, Haughey NJ, Bandaru VVR, Zetterberg H, Blennow K, Andreasson U, Johnson SC, Gleason CE, Blazel HM, Puglielli L, Sager MA, Asthana S, Carlsson CM. Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiol Aging. 2014 Nov;35(11):2486-2494. doi: 10.1016/j.neurobiolaging.2014.05.019. Epub 2014 May 27. PubMed PMID: 24952994; PubMed Central PMCID: PMC4170854.
Sacktor N, Robertson K. Evolving clinical phenotypes in HIV-associated neurocognitive disorders. Curr Opin HIV AIDS. 2014 Nov;9(6):517-20. doi: 10.1097/COH.0000000000000102. Review. PubMed PMID: 25203640; PubMed Central PMCID: PMC4212639.
Bora A, Ubaida Mohien C, Chaerkady R, Chang L, Moxley R 4th, Sacktor N, Haughey N, McArthur JC, Cotter R, Nath A, Graham DR. Identification of putative biomarkers for HIV-associated neurocognitive impairment in the CSF of HIV-infected patients under cART therapy determined by mass spectrometry. J Neurovirol. 2014 Oct;20(5):457-65. doi: 10.1007/s13365-014-0263-5. Epub 2014 Jul 24. PubMed PMID: 25056907; PubMed Central PMCID: PMC4493746.
Bae M, Patel N, Xu H, Lee M, Tominaga-Yamanaka K, Nath A, Geiger J, Gorospe M, Mattson MP, Haughey NJ. Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection. J Neurosci. 2014 Aug 20;34(34):11485-503. doi: 10.1523/JNEUROSCI.0210-14.2014. PubMed PMID: 25143627; PubMed Central PMCID: PMC4138351.
Vidaurre OG, Haines JD, Katz Sand I, Adula KP, Huynh JL, McGraw CA, Zhang F, Varghese M, Sotirchos E, Bhargava P, Bandaru VV, Pasinetti G, Zhang W, Inglese M, Calabresi PA, Wu G, Miller AE, Haughey NJ, Lublin FD, Casaccia P. Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics. Brain. 2014 Aug;137(Pt 8):2271-86. doi: 10.1093/brain/awu139. Epub 2014 Jun 3. PubMed PMID: 24893707; PubMed Central PMCID: PMC4164163.
Hulgan T, Levinson RT, Gerschenson M, Phanuphak N, Ananworanich J, Teeratakulpisarm N, Jadwattanakul T, LiButti DE, Fink H, McArthur JC, Ebenezer GJ, Hauer P, Murdock D, Shikuma CM, Samuels DC. Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy. AIDS. 2014 Jul 17;28(11):1625-33. doi: 10.1097/QAD.0000000000000297. PubMed PMID: 24785954; PubMed Central PMCID: PMC4427899.
Sacktor N, Nakasujja N, Redd AD, Manucci J, Laeyendecker O, Wendel SK, Porcella SF, Martens C, Bruno D, Skolasky RL, Okonkwo OC, Robertson K, Musisi S, Katabira E, Quinn TC. HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda. Metab Brain Dis. 2014 Jun;29(2):261-8. doi: 10.1007/s11011-014-9498-3. Epub 2014 Feb 12. PubMed PMID: 24515303; PubMed Central PMCID: PMC4024330.
Merali S, Barrero CA, Sacktor NC, Haughey NJ, Datta PK, Langford D, Khalili K. Polyamines: Predictive Biomarker for HIV-Associated Neurocognitive Disorders. J AIDS Clin Res. 2014;5(6):1000312. doi: 10.4172/2155-6113.1000312. PubMed PMID: 25893137; PubMed Central PMCID: PMC4397651.
Saleem M, Bandaru VV, Herrmann N, Swardfager W, Mielke MM, Oh PI, Shammi P, Kiss A, Haughey NJ, Rovinski R, Lanctôt KL. Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot study. BMC Geriatr. 2013 Dec 12;13:135. doi: 10.1186/1471-2318-13-135. PubMed PMID: 24330446; PubMed Central PMCID: PMC3924163.
Haughey NJ, Zhu X, Bandaru VV. A biological perspective of CSF lipids as surrogate markers for cognitive status in HIV. J Neuroimmune Pharmacol. 2013 Dec;8(5):1136-46. doi: 10.1007/s11481-013-9506-0. Epub 2013 Nov 8. Review. PubMed PMID: 24203462; PubMed Central PMCID: PMC3909934.
Tan IL, Smith BR, Hammond E, Vornbrock-Roosa H, Creighton J, Selnes O, McArthur JC, Sacktor N. Older individuals with HIV infection have greater memory deficits than younger individuals. J Neurovirol. 2013 Dec;19(6):531-6. doi: 10.1007/s13365-013-0209-3. PubMed PMID: 24078559; PubMed Central PMCID: PMC3946697.
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