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Vidovic D, Huynh T, Konda P, Dean C, Cruickshank B, Sultan M, Koyle K, Gujar S, Marcato P. Long non-coding RNA NRAD1 is a novel target for triple-negative breast tumors and cancer stem cells. Cell death and differentiation (Accepted). Forthcoming;
Giacomantonio M, Sterea A, Murphy P, Kim Y, Clements D, Boydun M, Kennedy B, Giacomantonio C, Waisman D, Gujar S. Quantitative Temporal Proteomics Captures Differential Anti-Reoviral Immune Responses in M1- and M2-like Macrophages (Under review; Original submission: 7th Feb. 2019). Journal of immunology (Baltimore, Md. : 1950). Forthcoming;
Kennedy BE, Murphy JP, Clements DR, Konda P, Holay N, Kim Y, Pathak GP, Giacomantonio MA, El Hiani Y, Gujar S. Inhibition of pyruvate dehydrogenase kinase enhances the antitumor efficacy of oncolytic reovirus. Cancer Res. 2019 May 14;. doi: 10.1158/0008-5472.CAN-18-2414. [Epub ahead of print] PubMed PMID: 31088833.
Sharif T, Martell E, Dai C, Singh SK, Gujar S. Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells. Autophagy. 2019 May;15(5):934-936. doi: 10.1080/15548627.2019.1586321. Epub 2019 Mar 8. PubMed PMID: 30849274; PubMed Central PMCID: PMC6526861.
Xu M, Almasi S, Yang Y, Yan C, Sterea AM, Rizvi Syeda AK, Shen B, Richard Derek C, Huang P, Gujar S, Wang J, Zong WX, Trebak M, El Hiani Y, Dong XP. The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways. Cell Calcium. 2019 May;79:80-88. doi: 10.1016/j.ceca.2019.02.010. Epub 2019 Mar 2. PubMed PMID: 30889511; PubMed Central PMCID: PMC6698368.
Murphy JP, Yu Q, Konda P, Paulo JA, Jedrychowski MP, Kowalewski DJ, Schuster H, Kim Y, Clements D, Jain A, Stevanovic S, Gygi SP, Mancias JD, Gujar S. Multiplexed Relative Quantitation with Isobaric Tagging Mass Spectrometry Reveals Class I Major Histocompatibility Complex Ligand Dynamics in Response to Doxorubicin. Anal Chem. 2019 Apr 16;91(8):5106-5115. doi: 10.1021/acs.analchem.8b05616. Epub 2019 Feb 22. PubMed PMID: 30779550.
Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Margam NN, Parmar HB, Giacomantonio CA, Duncan R, Lee PWK, Gujar S. HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. Autophagy. 2019 Apr;15(4):686-706. doi: 10.1080/15548627.2018.1548547. Epub 2018 Dec 4. PubMed PMID: 30444165; PubMed Central PMCID: PMC6526821.
Mohamed A, Clements D, Konda P, Gujar S, Lee P, Smiley J, Schmulevitz M. Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains. BioRiv. 2019 March; doi:
Sharif T, Dai C, Martell E, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Kennedy BE, Venugopal C, Subapanditha M, Giacomantonio CA, Marcato P, Singh SK, Gujar S. TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem-Like Cells in a Redox-Sensitive Manner. Clin Cancer Res. 2019 Mar 15;25(6):2001-2017. doi: 10.1158/1078-0432.CCR-17-3177. Epub 2018 Dec 28. PubMed PMID: 30593514.
Almasi S, Sterea AM, Fernando W, Clements DR, Marcato P, Hoskin DW, Gujar S, El Hiani Y. TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway. Sci Rep. 2019 Mar 12;9(1):4182. doi: 10.1038/s41598-019-40330-1. PubMed PMID: 30862883; PubMed Central PMCID: PMC6414629.
Konda P, Murphy JP, Gujar S. Improving MHC-I Ligand Identifications from LC-MS/MS Data by Incorporating Allelic Peptide Motifs. Proteomics. 2019 Mar;19(5):e1800458. doi: 10.1002/pmic.201800458. Epub 2019 Feb 19. PubMed PMID: 30710433.
Gujar S, Bell J, Diallo JS. SnapShot: Cancer Immunotherapy with Oncolytic Viruses. Cell. 2019 Feb 21;176(5):1240-1240.e1. doi: 10.1016/j.cell.2019.01.051. PubMed PMID: 30794777.
Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Kennedy BE, Lee PWK, Gujar S. Regulation of Cancer and Cancer-Related Genes via NAD. Antioxid Redox Signal. 2019 Feb 20;30(6):906-923. doi: 10.1089/ars.2017.7478. Epub 2018 Feb 22. PubMed PMID: 29334761.
Monro S, Colón KL, Yin H, Roque J 3rd, Konda P, Gujar S, Thummel RP, Lilge L, Cameron CG, McFarland SA. Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433. Chem Rev. 2019 Jan 23;119(2):797-828. doi: 10.1021/acs.chemrev.8b00211. Epub 2018 Oct 8. PubMed PMID: 30295467; PubMed Central PMCID: PMC6453754.
Murphy P, Kim Y, Konda P, Schuster H, Kowalewski D, Joao P, Stevanovich S, Gygi S, Gujar S. Newly induced MHC I ligands shape neo antitumor CD8 T cell responses during oncolytic reovirus-based cancer immunotherapy (Original submission date: January 3 2019; Under review). EMBO reports. 2019;
Sharif T, Martell E, Daii C, Murphy P, Singh S, Gujar S. NMNAT3 regulates the expression of glycolytic enzymes via an epigenetic intra-regulatory interplay involving three Sirtuins in cancer (Under review; Original submission on 28th Jan 2019). The EMBO journal. 2019;
Almasi S, Long CY, Sterea A, Clements DR, Gujar S, El Hiani Y. TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway. Cell Physiol Biochem. 2019;52(4):742-757. doi: 10.33594/000000052. PubMed PMID: 30933439.
Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Lee K, Singh SK, Weaver ICG, Gujar S. Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells. Cell Death Dis. 2018 Sep 24;9(10):990. doi: 10.1038/s41419-018-0997-8. PubMed PMID: 30250195; PubMed Central PMCID: PMC6155240.
Murphy JP, Giacomantonio MA, Paulo JA, Everley RA, Kennedy BE, Pathak GP, Clements DR, Kim Y, Dai C, Sharif T, Gygi SP, Gujar S. The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis. Cell Rep. 2018 Aug 28;24(9):2381-2391.e5. doi: 10.1016/j.celrep.2018.07.086. PubMed PMID: 30157431; PubMed Central PMCID: PMC6402325.
G Pol J, Lévesque S, Workenhe ST, Gujar S, Le Boeuf F, R Clements D, Fahrner JE, Fend L, C Bell J, L Mossman K, Fucikova J, Spisek R, Zitvogel L, Kroemer G, Galluzzi L. Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors. Oncoimmunology. 2018;7(12):e1503032. doi: 10.1080/2162402X.2018.1503032. eCollection 2018. Review. PubMed PMID: 30524901; PubMed Central PMCID: PMC6279343.
Pathak GP, Shah R, Kennedy BE, Murphy JP, Clements D, Konda P, Giacomantonio M, Xu Z, Schlaepfer IR, Gujar S. RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers. Mol Ther. 2018 Aug 1;26(8):2019-2033. doi: 10.1016/j.ymthe.2018.05.026. Epub 2018 Jun 30. PubMed PMID: 30078441; PubMed Central PMCID: PMC6094397.
Sultan M, Vidovic D, Paine AS, Huynh TT, Coyle KM, Thomas ML, Cruickshank BM, Dean CA, Clements DR, Kim Y, Lee K, Gujar SA, Weaver ICG, Marcato P. Epigenetic Silencing of TAP1 in Aldefluor+ Breast Cancer Stem Cells Contributes to Their Enhanced Immune Evasion. Stem Cells. 2018 May;36(5):641-654. doi: 10.1002/stem.2780. Epub 2018 Jan 30. PubMed PMID: 29341428.
Cruickshank B, Giacomantonio M, Marcato P, McFarland S, Pol J, Gujar S. Dying to Be Noticed: Epigenetic Regulation of Immunogenic Cell Death for Cancer Immunotherapy. Front Immunol. 2018;9:654. doi: 10.3389/fimmu.2018.00654. eCollection 2018. Review. PubMed PMID: 29666625; PubMed Central PMCID: PMC5891575.
Lee P, Gujar S. Potentiating prostate cancer immunotherapy with oncolytic viruses. Nat Rev Urol. 2018 Apr;15(4):235-250. doi: 10.1038/nrurol.2018.10. Epub 2018 Feb 13. Review. PubMed PMID: 29434366.
Gujar S, Pol JG, Kroemer G. Heating it up: Oncolytic viruses make tumors 'hot' and suitable for checkpoint blockade immunotherapies. Oncoimmunology. 2018;7(8):e1442169. doi: 10.1080/2162402X.2018.1442169. eCollection 2018. PubMed PMID: 30221036; PubMed Central PMCID: PMC6136862.
Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9;293(10):3637-3650. doi: 10.1074/jbc.M117.817635. Epub 2018 Jan 17. PubMed PMID: 29343514; PubMed Central PMCID: PMC5846146.
Gujar S, Pol JG, Kim Y, Lee PW, Kroemer G. Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies. Trends Immunol. 2018 Mar;39(3):209-221. doi: 10.1016/ Epub 2017 Dec 20. Review. PubMed PMID: 29275092.
Warford JR, Lamport AC, Clements DR, Malone A, Kennedy BE, Kim Y, Gujar SA, Hoskin DW, Easton AS. Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis. Acta Neuropathol Commun. 2018 Jan 4;6(1):4. doi: 10.1186/s40478-017-0506-9. PubMed PMID: 29301568; PubMed Central PMCID: PMC5755315.
Yoo BH, Khan IA, Koomson A, Gowda P, Sasazuki T, Shirasawa S, Gujar S, Rosen KV. Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells. Autophagy. 2018;14(1):134-151. doi: 10.1080/15548627.2017.1370171. Epub 2017 Dec 21. PubMed PMID: 28933585; PubMed Central PMCID: PMC5846558.
Clements DR, Murphy JP, Sterea A, Kennedy BE, Kim Y, Helson E, Almasi S, Holay N, Konda P, Paulo JA, Sharif T, Lee PW, Weekes MP, Gygi SP, Gujar S. Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages. J Proteome Res. 2017 Sep 1;16(9):3391-3406. doi: 10.1021/acs.jproteome.7b00425. Epub 2017 Aug 23. PubMed PMID: 28768414; PubMed Central PMCID: PMC5648240.
Holay N, Kim Y, Lee P, Gujar S. Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines. Front Immunol. 2017;8:800. doi: 10.3389/fimmu.2017.00800. eCollection 2017. Review. PubMed PMID: 28751892; PubMed Central PMCID: PMC5507961.
Murphy JP, Konda P, Kowalewski DJ, Schuster H, Clements D, Kim Y, Cohen AM, Sharif T, Nielsen M, Stevanovic S, Lee PW, Gujar S. MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies. J Proteome Res. 2017 Apr 7;16(4):1806-1816. doi: 10.1021/acs.jproteome.6b00971. Epub 2017 Mar 21. PubMed PMID: 28244318.
Sultan M, Coyle KM, Vidovic D, Thomas ML, Gujar S, Marcato P. Hide-and-seek: the interplay between cancer stem cells and the immune system. Carcinogenesis. 2017 Feb 1;38(2):107-118. doi: 10.1093/carcin/bgw115. Review. PubMed PMID: 27866156.
Sharif T, Martell E, Dai C, Kennedy BE, Murphy P, Clements DR, Kim Y, Lee PW, Gujar SA. Autophagic homeostasis is required for the pluripotency of cancer stem cells. Autophagy. 2017 Feb;13(2):264-284. doi: 10.1080/15548627.2016.1260808. Epub 2016 Dec 8. PubMed PMID: 27929731; PubMed Central PMCID: PMC5324853.
Kennedy BE, Sharif T, Martell E, Dai C, Kim Y, Lee PW, Gujar SA. NAD+ salvage pathway in cancer metabolism and therapy. Pharmacol Res. 2016 Dec;114:274-283. doi: 10.1016/j.phrs.2016.10.027. Epub 2016 Nov 2. Review. PubMed PMID: 27816507.
Smith N, Mitton C, Hiltz MA, Campbell M, Dowling L, Magee JF, Gujar SA. A Qualitative Evaluation of Program Budgeting and Marginal Analysis in a Canadian Pediatric Tertiary Care Institution. Appl Health Econ Health Policy. 2016 Oct;14(5):559-68. doi: 10.1007/s40258-016-0250-5. PubMed PMID: 27289589.
Coyle KM, Murphy JP, Vidovic D, Vaghar-Kashani A, Dean CA, Sultan M, Clements D, Wallace M, Thomas ML, Hundert A, Giacomantonio CA, Helyer L, Gujar SA, Lee PW, Weaver IC, Marcato P. Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1. Oncotarget. 2016 Jul 12;7(28):44096-44112. doi: 10.18632/oncotarget.9858. PubMed PMID: 27286452; PubMed Central PMCID: PMC5190082.
Sharif T, Ahn DG, Liu RZ, Pringle E, Martell E, Dai C, Nunokawa A, Kwak M, Clements D, Murphy JP, Dean C, Marcato P, McCormick C, Godbout R, Gujar SA, Lee PW. The NAD(+) salvage pathway modulates cancer cell viability via p73. Cell Death Differ. 2016 Apr;23(4):669-80. doi: 10.1038/cdd.2015.134. Epub 2015 Nov 20. PubMed PMID: 26586573; PubMed Central PMCID: PMC4986639.
Garant KA, Shmulevitz M, Pan L, Daigle RM, Ahn DG, Gujar SA, Lee PW. Oncolytic reovirus induces intracellular redistribution of Ras to promote apoptosis and progeny virus release. Oncogene. 2016 Feb 11;35(6):771-82. doi: 10.1038/onc.2015.136. Epub 2015 May 11. PubMed PMID: 25961930.
Clements DR, Kim Y, Gujar SA, Lee PW. All that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy. Oncoimmunology. 2016;5(1):e1057674. doi: 10.1080/2162402X.2015.1057674. eCollection 2016. PubMed PMID: 26942069; PubMed Central PMCID: PMC4760287.
Kim Y, Clements DR, Sterea AM, Jang HW, Gujar SA, Lee PW. Dendritic Cells in Oncolytic Virus-Based Anti-Cancer Therapy. Viruses. 2015 Dec 9;7(12):6506-25. doi: 10.3390/v7122953. Review. PubMed PMID: 26690204; PubMed Central PMCID: PMC4690876.
Smith N, Mitton C, Dowling L, Hiltz MA, Campbell M, Gujar SA. Introducing New Priority Setting and Resource Allocation Processes in a Canadian Healthcare Organization: A Case Study Analysis Informed by Multiple Streams Theory. Int J Health Policy Manag. 2015 Sep 24;5(1):23-31. doi: 10.15171/ijhpm.2015.169. PubMed PMID: 26673646; PubMed Central PMCID: PMC4676967.
Taylor B, Wilcox A, Morrison K, Hiltz M, Campbell M, Gujar S. Implementation of a Game-based Information System and e-Therapeutic Platform in a Pediatric Emergency Department Waiting Room: Preliminary Evidence of Benefit. Procedia computer science. 2015 September; doi: 10.1016/j.procs.2015.08.351.
Ahn DG, Sharif T, Chisholm K, Pinto DM, Gujar SA, Lee PW. Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response. Cell Cycle. 2015;14(14):2301-10. doi: 10.1080/15384101.2015.1044187. Epub 2015 May 6. PubMed PMID: 25946643; PubMed Central PMCID: PMC4614670.
Clements DR, Sterea AM, Kim Y, Helson E, Dean CA, Nunokawa A, Coyle KM, Sharif T, Marcato P, Gujar SA, Lee PW. Newly recruited CD11b+, GR-1+, Ly6C(high) myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus. J Immunol. 2015 May 1;194(9):4397-412. doi: 10.4049/jimmunol.1402132. Epub 2015 Mar 30. PubMed PMID: 25825443.
Hiltz MA, Mitton C, Smith N, Dowling L, Campbell M, Magee JF, Gibson JL, Gujar SA, Levy A. Olly Olly Oxen Free (or Ally Ally in Free): Playing Hide and Seek in Allocating Resources for Child and Youth Health. Healthc Q. 2015;18(2):36-9. doi: 10.12927/hcq.2015.24289. PubMed PMID: 26358999.
Marcato P, Dean CA, Liu RZ, Coyle KM, Bydoun M, Wallace M, Clements D, Turner C, Mathenge EG, Gujar SA, Giacomantonio CA, Mackey JR, Godbout R, Lee PW. Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling. Mol Oncol. 2015 Jan;9(1):17-31. doi: 10.1016/j.molonc.2014.07.010. Epub 2014 Jul 24. PubMed PMID: 25106087; PubMed Central PMCID: PMC5528683.
Mathenge EG, Dean CA, Clements D, Vaghar-Kashani A, Photopoulos S, Coyle KM, Giacomantonio M, Malueth B, Nunokawa A, Jordan J, Lewis JD, Gujar SA, Marcato P, Lee PW, Giacomantonio CA. Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model. Neoplasia. 2014 Nov;16(11):950-60. doi: 10.1016/j.neo.2014.09.004. eCollection 2014 Nov. PubMed PMID: 25425969; PubMed Central PMCID: PMC4240917.
Clements D, Helson E, Gujar SA, Lee PW. Reovirus in cancer therapy: an evidence-based review. Oncolytic Virother. 2014;3:69-82. doi: 10.2147/OV.S51321. eCollection 2014. Review. PubMed PMID: 27512664; PubMed Central PMCID: PMC4918368.
Gujar SA, Lee PW. Oncolytic virus-mediated reversal of impaired tumor antigen presentation. Front Oncol. 2014;4:77. doi: 10.3389/fonc.2014.00077. eCollection 2014. Review. PubMed PMID: 24782988; PubMed Central PMCID: PMC3989761.
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