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Verma M, Michalec L, Sripada A, McKay J, Sirohi K, Verma D, Sheth D, Martin R, Dyjack N, Seibold MA, Knapp JR, Tu TH, O'Connor BP, Gorska MM, Alam R. The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma. J Exp Med. 2021 Jul 5;218(7). doi: 10.1084/jem.20201354. Epub 2021 Jun 2. PubMed PMID: 34076685; PubMed Central PMCID: PMC8176441.
Sripada A, Sirohi K, Michalec L, Guo L, McKay JT, Yadav S, Verma M, Good J, Rollins D, Gorska MM, Alam R. Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases. PLoS Biol. 2021 Mar;19(3):e3001063. doi: 10.1371/journal.pbio.3001063. eCollection 2021 Mar. PubMed PMID: 33684096; PubMed Central PMCID: PMC7971865.
Qian Q, Chowdhury BP, Sun Z, Lenberg J, Alam R, Vivier E, Gorska MM. Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B. J Clin Invest. 2020 Aug 3;130(8):4133-4151. doi: 10.1172/JCI130324. PubMed PMID: 32407293; PubMed Central PMCID: PMC7410053.
Liu S, Sirohi K, Verma M, McKay J, Michalec L, Sripada A, Danhorn T, Rollins D, Good J, Gorska MM, Martin RJ, Alam R. Optimal identification of human conventional and nonconventional (CRTH2-IL7Rα-) ILC2s using additional surface markers. J Allergy Clin Immunol. 2020 Aug;146(2):390-405. doi: 10.1016/j.jaci.2020.01.038. Epub 2020 Feb 4. PubMed PMID: 32032632; PubMed Central PMCID: PMC7398840.
Verma M, Liu S, Michalec L, Sripada A, Gorska MM, Alam R. Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9+ and IL-13+ type 2 innate lymphoid cell subpopulations. J Allergy Clin Immunol. 2018 Sep;142(3):793-803.e8. doi: 10.1016/j.jaci.2017.10.020. Epub 2017 Nov 10. PubMed PMID: 29132961; PubMed Central PMCID: PMC5945345.
Lenberg J, Qian Q, Sun Z, Alam R, Gorska MM. Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1β and IL-17A. J Allergy Clin Immunol. 2018 Mar;141(3):1118-1122.e3. doi: 10.1016/j.jaci.2017.09.002. Epub 2017 Sep 21. PubMed PMID: 28943469; PubMed Central PMCID: PMC5844783.
Gorska MM. Mouse Models of Asthma. Methods Mol Biol. 2018;1809:351-362. doi: 10.1007/978-1-4939-8570-8_23. PubMed PMID: 29987800.
Liu S, Verma M, Michalec L, Liu W, Sripada A, Rollins D, Good J, Ito Y, Chu H, Gorska MM, Martin RJ, Alam R. Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin. J Allergy Clin Immunol. 2018 Jan;141(1):257-268.e6. doi: 10.1016/j.jaci.2017.03.032. Epub 2017 Apr 20. PubMed PMID: 28433687; PubMed Central PMCID: PMC5650571.
Liu W, Liu S, Verma M, Zafar I, Good JT, Rollins D, Groshong S, Gorska MM, Martin RJ, Alam R. Mechanism of TH2/TH17-predominant and neutrophilic TH2/TH17-low subtypes of asthma. J Allergy Clin Immunol. 2017 May;139(5):1548-1558.e4. doi: 10.1016/j.jaci.2016.08.032. Epub 2016 Oct 1. PubMed PMID: 27702673; PubMed Central PMCID: PMC5376378.
Gorska MM. Natural killer cells in asthma. Curr Opin Allergy Clin Immunol. 2017 Feb;17(1):50-54. doi: 10.1097/ACI.0000000000000327. Review. PubMed PMID: 27841766; PubMed Central PMCID: PMC5495007.
Christianson CA, Goplen NP, Zafar I, Irvin C, Good JT Jr, Rollins DR, Gorentla B, Liu W, Gorska MM, Chu H, Martin RJ, Alam R. Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33. J Allergy Clin Immunol. 2015 Jul;136(1):59-68.e14. doi: 10.1016/j.jaci.2014.11.037. Epub 2015 Jan 21. PubMed PMID: 25617223; PubMed Central PMCID: PMC4494983.
Irvin C, Zafar I, Good J, Rollins D, Christianson C, Gorska MM, Martin RJ, Alam R. Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J Allergy Clin Immunol. 2014 Nov;134(5):1175-1186.e7. doi: 10.1016/j.jaci.2014.05.038. Epub 2014 Jul 18. PubMed PMID: 25042748; PubMed Central PMCID: PMC4254017.
Manners S, Alam R, Schwartz DA, Gorska MM. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J Allergy Clin Immunol. 2014 Jul;134(1):63-72. doi: 10.1016/j.jaci.2013.10.047. Epub 2013 Dec 22. PubMed PMID: 24365139; PubMed Central PMCID: PMC4065237.
Guo L, Chen C, Liang Q, Karim MZ, Gorska MM, Alam R. Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor. J Immunol. 2013 Jan 1;190(1):159-67. doi: 10.4049/jimmunol.1201657. Epub 2012 Dec 5. PubMed PMID: 23225884; PubMed Central PMCID: PMC3530839.
Gorska MM, Alam R. Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia. Curr Allergy Asthma Rep. 2012 Oct;12(5):396-401. doi: 10.1007/s11882-012-0281-4. Review. PubMed PMID: 22729960.
Goplen N, Karim Z, Guo L, Zhuang Y, Huang H, Gorska MM, Gelfand E, Pagés G, Pouysségur J, Alam R. ERK1 is important for Th2 differentiation and development of experimental asthma. FASEB J. 2012 May;26(5):1934-45. doi: 10.1096/fj.11-196477. Epub 2012 Jan 18. PubMed PMID: 22262639; PubMed Central PMCID: PMC3336776.
Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012 Feb 9;119(6):1399-406. doi: 10.1182/blood-2011-04-350686. Epub 2011 Dec 19. PubMed PMID: 22184408; PubMed Central PMCID: PMC3286207.
Alam R, Gorska MM. Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma. Clin Exp Allergy. 2011 Feb;41(2):149-59. doi: 10.1111/j.1365-2222.2010.03658.x. Epub 2010 Dec 1. Review. PubMed PMID: 21121982; PubMed Central PMCID: PMC3115726.
Liang Q, Guo L, Gogate S, Karim Z, Hanifi A, Leung DY, Gorska MM, Alam R. IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. J Immunol. 2010 Nov 15;185(10):5704-13. doi: 10.4049/jimmunol.1000690. Epub 2010 Oct 6. PubMed PMID: 20926789; PubMed Central PMCID: PMC3367768.
Gorska MM, Goplen N, Liang Q, Alam R. Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma. J Immunol. 2010 Apr 15;184(8):4488-96. doi: 10.4049/jimmunol.0903115. Epub 2010 Mar 10. PubMed PMID: 20220094.
Liu W, Tundwal K, Liang Q, Goplen N, Rozario S, Quayum N, Gorska M, Wenzel S, Balzar S, Alam R. Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function. Mol Cell Biol. 2010 Apr;30(7):1783-99. doi: 10.1128/MCB.01003-09. Epub 2010 Feb 1. PubMed PMID: 20123980; PubMed Central PMCID: PMC2838067.
Karim Z, Vepachedu R, Gorska M, Alam R. UNC119 inhibits dynamin and dynamin-dependent endocytic processes. Cell Signal. 2010 Jan;22(1):128-37. doi: 10.1016/j.cellsig.2009.09.022. Epub 2009 Sep 23. PubMed PMID: 19781630.
Gorska MM, Liang Q, Karim Z, Alam R. Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation. J Immunol. 2009 Aug 1;183(3):1675-84. doi: 10.4049/jimmunol.0900792. Epub 2009 Jul 10. PubMed PMID: 19592652.
Goplen N, Karim MZ, Liang Q, Gorska MM, Rozario S, Guo L, Alam R. Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma. J Allergy Clin Immunol. 2009 Apr;123(4):925-32.e11. doi: 10.1016/j.jaci.2009.02.009. PubMed PMID: 19348928; PubMed Central PMCID: PMC2683988.
Liu W, Liang Q, Balzar S, Wenzel S, Gorska M, Alam R. Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways. J Allergy Clin Immunol. 2008 Apr;121(4):893-902.e2. doi: 10.1016/j.jaci.2008.02.004. PubMed PMID: 18395552.
Goplen N, Gorska MM, Stafford SJ, Rozario S, Guo L, Liang Q, Alam R. A phosphosite screen identifies autocrine TGF-beta-driven activation of protein kinase R as a survival-limiting factor for eosinophils. J Immunol. 2008 Mar 15;180(6):4256-64. doi: 10.4049/jimmunol.180.6.4256. PubMed PMID: 18322238.
Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R. MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med. 2007 Jul 9;204(7):1637-52. doi: 10.1084/jem.20062621. Epub 2007 Jun 25. PubMed PMID: 17576778; PubMed Central PMCID: PMC2118652.
Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R. Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. J Immunol. 2007 Jul 1;179(1):682-90. doi: 10.4049/jimmunol.179.1.682. PubMed PMID: 17579091.
Gorska-Ciebiada M, Ciebiada M, Gorska MM, Gorski P, Grzelewska-Rzymowska I. Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity. Ann Allergy Asthma Immunol. 2006 Jul;97(1):66-72. doi: 10.1016/S1081-1206(10)61372-5. PubMed PMID: 16892784.
Gorska MM, Cen O, Liang Q, Stafford SJ, Alam R. Differential regulation of interleukin 5-stimulated signaling pathways by dynamin. J Biol Chem. 2006 May 19;281(20):14429-39. doi: 10.1074/jbc.M512718200. Epub 2006 Mar 23. PubMed PMID: 16556602.
Gorska MM, Alam R. The signaling mechanism of eosinophil activation. Expert Rev Clin Immunol. 2005 Jul;1(2):247-56. doi: 10.1586/1744666X.1.2.247. PubMed PMID: 20476938.
Gorska MM, Stafford SJ, Cen O, Sur S, Alam R. Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J Exp Med. 2004 Feb 2;199(3):369-79. doi: 10.1084/jem.20030589. Epub 2004 Jan 23. PubMed PMID: 14757743; PubMed Central PMCID: PMC2211793.
Gorska MM, Alam R. Signaling molecules as therapeutic targets in allergic diseases. J Allergy Clin Immunol. 2003 Aug;112(2):241-50; quiz 251. doi: 10.1067/mai.2003.1667. Review. PubMed PMID: 12897726.
Cen O, Gorska MM, Stafford SJ, Sur S, Alam R. Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. J Biol Chem. 2003 Mar 7;278(10):8837-45. doi: 10.1074/jbc.M208261200. Epub 2002 Dec 19. PubMed PMID: 12496276.
Alam R, Gorska M. 3. Lymphocytes. J Allergy Clin Immunol. 2003 Feb;111(2 Suppl):S476-85. doi: 10.1067/mai.2003.121. Review. PubMed PMID: 12592294.
Alam R, Gorska M. Genomic microarrays: arraying order in biological chaos?. Am J Respir Cell Mol Biol. 2001 Oct;25(4):405-8. doi: 10.1165/ajrcmb.25.4.f217. Review. PubMed PMID: 11694444.
Gorska MM, Kowalski ML. Gene knock-out technology - application in experimental medical research. Allergy, Asthma, Immunology-Clinical Review. 1997; 2:162-169.
Woszczek G, Borowiec M, Miś M, Górska M, Kowalski ML. Comparison of serological and molecular (PCR-SSP) techniques of HLA-DR typing in clinical laboratory routine. Ann Transplant. 1997;2(1):39-42. PubMed PMID: 9869840.
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