My Bibliography

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Haines R, Wan D, Zhong G, Fan H. Comparative transcriptomics reveals genes commonly induced by distinct stressors in Chlamydia. Infect Immun. 2026 Mar 10;94(3):e0075825. doi: 10.1128/iai.00758-25. Epub 2026 Feb 20. PubMed PMID: 41718471; PubMed Central PMCID: PMC12974147.

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Wu Y, Abdelsalam AM, Fan H, Baxter VK, Sun X, Zhong G. Identification of collaborative cross mouse strains susceptible to chlamydial induction of hydrosalpinx. Infect Immun. 2026 Mar 10;94(3):e0074425. doi: 10.1128/iai.00744-25. Epub 2026 Feb 17. PubMed PMID: 41700879; PubMed Central PMCID: PMC12974144.

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Wang Y, Pan M, Coker TV, Wang J, Wang L, Zhong G, Fan H. Chlamydial Histones Control Developmental Fitness in the Next Infection Cycle. bioRxiv. 2026 Feb 11;. doi: 10.64898/2026.02.10.705219. PubMed PMID: 41694620; PubMed Central PMCID: PMC12903203.

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Haines R, Wan D, Zhong G, Fan H. Comparative Transcriptomics Reveals Genes Commonly Induced by Distinct Stressors in Chlamydia. bioRxiv. 2025 Dec 30;. doi: 10.64898/2025.12.30.696969. PubMed PMID: 41509351; PubMed Central PMCID: PMC12776308.

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Huang Y, Wang Y, Pan M, Wan D, Wang L, Fondell JD, Wu X, Zhong G, Fan H. A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress. bioRxiv. 2025 May 30;. doi: 10.1101/2025.05.30.657042. PubMed PMID: 40501649; PubMed Central PMCID: PMC12154930.

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Wan D, Pan M, Zhong G, Fan H. Chlamydia plasmid-encoded protein Pgp2 is a replication initiator with a unique β-hairpin necessary for iteron-binding and plasmid replication. Infect Immun. 2025 Mar 11;93(3):e0060224. doi: 10.1128/iai.00602-24. Epub 2025 Feb 7. PubMed PMID: 39918305; PubMed Central PMCID: PMC11895440.

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Wan D, Pan M, Zhong G, Fan H. Chlamydia plasmid-encoded protein Pgp2 is a replication initiator with a unique β-hairpin necessary for iteron-binding and plasmid replication. bioRxiv. 2024 Nov 15;. doi: 10.1101/2024.11.14.623704. PubMed PMID: 39569140; PubMed Central PMCID: PMC11577247.

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Wan D, Cheng A, Wang Y, Zhong G, Li WV, Fan H. Analyzing RNA-Seq data from Chlamydia with super broad transcriptomic activation: challenges, solutions, and implications for other systems. BMC Genomics. 2024 Aug 25;25(1):801. doi: 10.1186/s12864-024-10714-3. PubMed PMID: 39182031; PubMed Central PMCID: PMC11344909.

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Wang Y, Fondell JD, Zhong G, Fan H. rRNA expression kinetics during the chlamydial developmental cycle. Microbiol Spectr. 2024 Aug 6;12(8):e0013224. doi: 10.1128/spectrum.00132-24. Epub 2024 Jun 25. PubMed PMID: 38916351; PubMed Central PMCID: PMC11302117.

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Wan D, Cheng A, Wang Y, Zhong G, Li WV, Fan H. Analyzing RNA-Seq Data from Chlamydia with Super Broad Transcriptomic Activation: Challenges, Solutions, and Implications for Other Systems. bioRxiv. 2024 May 21;. doi: 10.1101/2024.05.16.594566. PubMed PMID: 38826265; PubMed Central PMCID: PMC11142123.

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Wurihan W, Wang Y, Yeung S, Zou Y, Lai Z, Fondell JD, Li WV, Zhong G, Fan H. Expression activation of over 70% of Chlamydia trachomatis genes during the first hour of infection. Infect Immun. 2024 Mar 12;92(3):e0053923. doi: 10.1128/iai.00539-23. Epub 2024 Feb 1. PubMed PMID: 38299827; PubMed Central PMCID: PMC10929459.

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Lu B, Wang Y, Wurihan W, Cheng A, Yeung S, Fondell JD, Lai Z, Wan D, Wu X, Li WV, Fan H. Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance. mBio. 2024 Jan 16;15(1):e0203623. doi: 10.1128/mbio.02036-23. Epub 2023 Dec 19. PubMed PMID: 38112466; PubMed Central PMCID: PMC10790707.

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Lu B, Wang Y, Wurihan W, Cheng A, Yeung S, Fondell JD, Lai Z, Wan D, Wu X, Li WV, Fan H. Requirement of GrgA for Chlamydia infectious progeny production, optimal growth, and efficient plasmid maintenance. bioRxiv. 2023 Aug 2;. doi: 10.1101/2023.08.02.551707. PubMed PMID: 37577610; PubMed Central PMCID: PMC10418237.

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Lu B, Qiao Q, Park ER, Wang Y, Gilleran JA, Pan M, Pilch DS, Wu X, Roberge JY, Fan H. Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency. ACS Omega. 2023 Feb 21;8(7):6597-6607. doi: 10.1021/acsomega.2c06992. eCollection 2023 Feb 21. PubMed PMID: 36844602; PubMed Central PMCID: PMC9947980.

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Cheng A, Wan D, Ghatak A, Wang C, Feng D, Fondell JD, Ebright RH, Fan H. Identification and Structural Modeling of the RNA Polymerase Omega Subunits in Chlamydiae and Other Obligate Intracellular Bacteria. mBio. 2023 Feb 28;14(1):e0349922. doi: 10.1128/mbio.03499-22. Epub 2023 Jan 31. PubMed PMID: 36719197; PubMed Central PMCID: PMC9973325.

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Huang Y, Wurihan W, Lu B, Zou Y, Wang Y, Weldon K, Fondell JD, Lai Z, Wu X, Fan H. Robust Heat Shock Response in Chlamydia Lacking a Typical Heat Shock Sigma Factor. Front Microbiol. 2021;12:812448. doi: 10.3389/fmicb.2021.812448. eCollection 2021. PubMed PMID: 35046926; PubMed Central PMCID: PMC8762339.

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Wurihan W, Zou Y, Weber AM, Weldon K, Huang Y, Bao X, Zhu C, Wu X, Wang Y, Lai Z, Fan H. Identification of a GrgA-Euo-HrcA Transcriptional Regulatory Network in Chlamydia. mSystems. 2021 Aug 31;6(4):e0073821. doi: 10.1128/mSystems.00738-21. Epub 2021 Aug 3. PubMed PMID: 34342542; PubMed Central PMCID: PMC8409740.

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Wurihan W, Weber AM, Gong Z, Lou Z, Sun S, Zhou J, Fan H. GrgA overexpression inhibits Chlamydia trachomatis growth through sigma(66)- and sigma(28)-dependent mechanisms. Microb Pathog. 2021 Jul;156:104917. doi: 10.1016/j.micpath.2021.104917. Epub 2021 May 1. PubMed PMID: 33940135; PubMed Central PMCID: PMC8187326.

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Desai M, Zhang H, Fan H. Optimal cultivation of Chlamydia requires testing of serum on individual species. BMC Res Notes. 2020 Jan 13;13(1):28. doi: 10.1186/s13104-020-4893-9. PubMed PMID: 31931876; PubMed Central PMCID: PMC6958709.

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Wurihan W, Huang Y, Weber AM, Wu X, Fan H. Nonspecific toxicities of Streptococcus pyogenes and Staphylococcus aureus dCas9 in Chlamydia trachomatis. Pathog Dis. 2019 Dec 1;77(9). doi: 10.1093/femspd/ftaa005. PubMed PMID: 32011704; PubMed Central PMCID: PMC7040368.

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Desai M, Di R, Fan H. Application of Biolayer Interferometry (BLI) for Studying Protein-Protein Interactions in Transcription. J Vis Exp. 2019 Jul 26;(149). doi: 10.3791/59687. PubMed PMID: 31403627; PubMed Central PMCID: PMC6693641.

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Zhang H, Vellappan S, Tang MM, Bao X, Fan H. GrgA as a potential target of selective antichlamydials. PLoS One. 2019;14(3):e0212874. doi: 10.1371/journal.pone.0212874. eCollection 2019. PubMed PMID: 30822328; PubMed Central PMCID: PMC6396966.

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Desai M, Wurihan W, Di R, Fondell JD, Nickels BE, Bao X, Fan H. Role for GrgA in Regulation of σ(28)-Dependent Transcription in the Obligate Intracellular Bacterial Pathogen Chlamydia trachomatis. J Bacteriol. 2018 Oct 15;200(20). doi: 10.1128/JB.00298-18. Print 2018 Oct 15. PubMed PMID: 30061357; PubMed Central PMCID: PMC6153665.

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Li JL, Yang N, Huang L, Chen D, Zhao Y, Tang MM, Fan H, Bao X. Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth. Antimicrob Agents Chemother. 2018 Jun;62(6). doi: 10.1128/AAC.02260-17. Print 2018 Jun. PubMed PMID: 29610203; PubMed Central PMCID: PMC5971585.

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Fan H, Zhong G. 2017: beginning of a new era for Chlamydia research in China and the rest of the world. Microbes Infect. 2018 Jan;20(1):5-8. doi: 10.1016/j.micinf.2017.09.009. Epub 2017 Oct 6. PubMed PMID: 28988996; PubMed Central PMCID: PMC5819738.

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Zhang H, Kunadia A, Lin Y, Fondell JD, Seidel D, Fan H. Identification of a strong and specific antichlamydial N-acylhydrazone. PLoS One. 2017;12(10):e0185783. doi: 10.1371/journal.pone.0185783. eCollection 2017. PubMed PMID: 28973037; PubMed Central PMCID: PMC5626472.

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Li JL, Chen D, Huang L, Ni M, Zhao Y, Fan H, Bao X. Antichlamydial Dimeric Indole Derivatives from Marine Actinomycete Rubrobacter radiotolerans. Planta Med. 2017 Jun;83(9):805-811. doi: 10.1055/s-0043-100382. Epub 2017 Jan 17. PubMed PMID: 28095586; PubMed Central PMCID: PMC6660345.

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Gong Z, Tang MM, Wu X, Phillips N, Galkowski D, Jarvis GA, Fan H. Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae. PLoS One. 2016;11(1):e0147637. doi: 10.1371/journal.pone.0147637. eCollection 2016. PubMed PMID: 26808268; PubMed Central PMCID: PMC4726613.

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Gong Z, Luna Y, Yu P, Fan H. Lactobacilli inactivate Chlamydia trachomatis through lactic acid but not H2O2. PLoS One. 2014;9(9):e107758. doi: 10.1371/journal.pone.0107758. eCollection 2014. PubMed PMID: 25215504; PubMed Central PMCID: PMC4162611.

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Bao X, Gylfe A, Sturdevant GL, Gong Z, Xu S, Caldwell HD, Elofsson M, Fan H. Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner. J Bacteriol. 2014 Aug 15;196(16):2989-3001. doi: 10.1128/JB.01677-14. Epub 2014 Jun 9. PubMed PMID: 24914180; PubMed Central PMCID: PMC4135636.

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Xu S, Battaglia L, Bao X, Fan H. Chloramphenicol acetyltransferase as a selection marker for chlamydial transformation. BMC Res Notes. 2013 Sep 23;6:377. doi: 10.1186/1756-0500-6-377. PubMed PMID: 24060200; PubMed Central PMCID: PMC3849861.

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Bao X, Beatty WL, Fan H. Exploration of chlamydial type III secretion system reconstitution in Escherichia coli. PLoS One. 2012;7(12):e50833. doi: 10.1371/journal.pone.0050833. Epub 2012 Dec 11. PubMed PMID: 23239989; PubMed Central PMCID: PMC3519817.

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Bao X, Nickels BE, Fan H. Chlamydia trachomatis protein GrgA activates transcription by contacting the nonconserved region of σ66. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16870-5. doi: 10.1073/pnas.1207300109. Epub 2012 Oct 1. PubMed PMID: 23027952; PubMed Central PMCID: PMC3479454.

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Fan H. Blindness-causing trachomatous trichiasis biomarkers sighted. Invest Ophthalmol Vis Sci. 2012 May 14;53(6):2560. doi: 10.1167/iovs.12-9835. PubMed PMID: 22586179.

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Fan H. Blindness-causing trachomatous trichiasis biomarkers sighted. Invest Ophthalmol Vis Sci. 2012 May 1;53(6). doi: 10.1167/iovs.12-9835. PubMed PMID: 23065646.

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Li X, Pérez L, Fan H. Inhibitory role of TACE/ADAM17 cytotail in protein ectodomain shedding. World J Biol Chem. 2011 Nov 26;2(11):246-51. doi: 10.4331/wjbc.v2.i11.246. PubMed PMID: 22125668; PubMed Central PMCID: PMC3224872.

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Yasir M, Pachikara ND, Bao X, Pan Z, Fan H. Regulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles. Infect Immun. 2011 Oct;79(10):4019-28. doi: 10.1128/IAI.05308-11. Epub 2011 Aug 1. PubMed PMID: 21807906; PubMed Central PMCID: PMC3187247.

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Bao X, Pachikara ND, Oey CB, Balakrishnan A, Westblade LF, Tan M, Chase T, Nickels BE, Fan H. Non-coding nucleotides and amino acids near the active site regulate peptide deformylase expression and inhibitor susceptibility in Chlamydia trachomatis. Microbiology (Reading). 2011 Sep;157(Pt 9):2569-2581. doi: 10.1099/mic.0.049668-0. Epub 2011 Jun 30. PubMed PMID: 21719536; PubMed Central PMCID: PMC3352175.

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Oey CB, Bao X, Lewis C, Kerrigan JE, Fan H. High tolerance to mutations in a Chlamydia trachomatis peptide deformylase loop. World J Biol Chem. 2011 May 26;2(5):90-7. doi: 10.4331/wjbc.v2.i5.90. PubMed PMID: 21666811; PubMed Central PMCID: PMC3110899.

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Mo X, Nguyen NX, Mu FT, Yang W, Luo SZ, Fan H, Andrews RK, Berndt MC, Li R. Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha. J Biol Chem. 2010 Oct 15;285(42):32096-104. doi: 10.1074/jbc.M110.111864. Epub 2010 Aug 17. PubMed PMID: 20716526; PubMed Central PMCID: PMC2952211.

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Pachikara N, Zhang H, Pan Z, Jin S, Fan H. Productive Chlamydia trachomatis lymphogranuloma venereum 434 infection in cells with augmented or inactivated autophagic activities. FEMS Microbiol Lett. 2009 Mar;292(2):240-9. doi: 10.1111/j.1574-6968.2009.01494.x. Epub 2009 Jan 28. PubMed PMID: 19187200; PubMed Central PMCID: PMC2671565.

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Li X, Pérez L, Pan Z, Fan H. The transmembrane domain of TACE regulates protein ectodomain shedding. Cell Res. 2007 Dec;17(12):985-98. doi: 10.1038/cr.2007.98. PubMed PMID: 18040288.

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Balakrishnan A, Wang L, Li X, Ohman-Strickland P, Malatesta P, Fan H. Inhibition of chlamydial infection in the genital tract of female mice by topical application of a peptide deformylase inhibitor. Microbiol Res. 2009;164(3):338-46. doi: 10.1016/j.micres.2007.05.002. Epub 2007 Oct 23. PubMed PMID: 17936604; PubMed Central PMCID: PMC2735082.

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Pérez L, Kerrigan JE, Li X, Fan H. Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity. Biochem Cell Biol. 2007 Feb;85(1):141-9. doi: 10.1139/o06-179. PubMed PMID: 17464354.

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Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6901-6. doi: 10.1073/pnas.0509719103. Epub 2006 Apr 25. PubMed PMID: 16641105; PubMed Central PMCID: PMC1458991.

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Balakrishnan A, Patel B, Sieber SA, Chen D, Pachikara N, Zhong G, Cravatt BF, Fan H. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J Biol Chem. 2006 Jun 16;281(24):16691-9. doi: 10.1074/jbc.M513648200. Epub 2006 Mar 24. PubMed PMID: 16565079.

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Li X, Fan H. Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE). J Biol Chem. 2004 Jun 25;279(26):27365-75. doi: 10.1074/jbc.M401690200. Epub 2004 Apr 9. PubMed PMID: 15075334.

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Fan H, Turck CW, Derynck R. Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem. 2003 May 16;278(20):18617-27. doi: 10.1074/jbc.M300331200. Epub 2003 Mar 5. PubMed PMID: 12621058.

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Fan H, Derynck R. Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J. 1999 Dec 15;18(24):6962-72. doi: 10.1093/emboj/18.24.6962. PubMed PMID: 10601018; PubMed Central PMCID: PMC1171759.

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Fan H, Villegas C, Chan AK, Wright JA. Myc-epitope tagged proteins detected with the 9E10 antibody in immunofluorescence and immunoprecipitation assays but not in western blot analysis. Biochem Cell Biol. 1998;76(1):125-8. PubMed PMID: 9666314.