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Manzoor S, Kane MS, Grenett M, Oh JY, Pat B, Lewis C, Davies JE, Steele C, Patel RP, Dell'Italia LJ. Elevated cardiac hemoglobin expression is associated with a pro-oxidative and inflammatory environment in primary mitral regurgitation. Free Radic Biol Med. 2023 Nov 1;208:126-133. doi: 10.1016/j.freeradbiomed.2023.08.007. Epub 2023 Aug 3. PubMed PMID: 37543167.
Grosicki GJ, Flatt AA, Cross BL, Vondrasek JD, Blumenburg WT, Lincoln ZR, Chall A, Bryan A, Patel RP, Ricart K, Linder BA, Sanchez SO, Watso JC, Robinson AT. Acute beetroot juice reduces blood pressure in young Black and White males but not females. Redox Biol. 2023 Jul;63:102718. doi: 10.1016/j.redox.2023.102718. Epub 2023 Apr 25. PubMed PMID: 37120928; PubMed Central PMCID: PMC10172749.
Oh JY, Marques MB, Xu X, Li J, Genschmer KR, Phillips E, Chimento MF, Mobley J, Gaggar A, Patel RP. Different-sized extracellular vesicles derived from stored red blood cells package diverse cargoes and cause distinct cellular effects. Transfusion. 2023 Mar;63(3):586-600. doi: 10.1111/trf.17271. Epub 2023 Feb 8. PubMed PMID: 36752125; PubMed Central PMCID: PMC10033430.
Shakya S, Pyles KD, Albert CJ, Patel RP, McCommis KS, Ford DA. Myeloperoxidase-derived hypochlorous acid targets human airway epithelial plasmalogens liberating protein modifying electrophilic 2-chlorofatty aldehydes. Redox Biol. 2023 Feb;59:102557. doi: 10.1016/j.redox.2022.102557. Epub 2022 Dec 7. PubMed PMID: 36508858; PubMed Central PMCID: PMC9763693.
Pat B, Oh JY, Masjoan Juncos JX, Powell PC, Collawn JF, Patel RP, Dell'Italia LJ. Red blood cell exosome hemoglobin content increases after cardiopulmonary bypass and mediates acute kidney injury in an animal model. J Thorac Cardiovasc Surg. 2022 Dec;164(6):e289-e308. doi: 10.1016/j.jtcvs.2020.11.102. Epub 2020 Dec 3. PubMed PMID: 33451850.
Morou-Bermúdez E, Torres-Colón JE, Bermúdez NS, Patel RP, Joshipura KJ. Pathways Linking Oral Bacteria, Nitric Oxide Metabolism, and Health. J Dent Res. 2022 Jun;101(6):623-631. doi: 10.1177/00220345211064571. Epub 2022 Jan 26. PubMed PMID: 35081826; PubMed Central PMCID: PMC9124908.
Oh JY, Bae CY, Kasztan M, Pollock DM, Russell RT, Lebensburger J, Patel RP. Peroxiredoxin-2 recycling is slower in denser and pediatric sickle cell red cells. FASEB J. 2022 Apr;36(4):e22267. doi: 10.1096/fj.202200052R. PubMed PMID: 35306694; PubMed Central PMCID: PMC10155932.
Basu S, Ricart K, Gladwin MT, Patel RP, Kim-Shapiro DB. Tri-iodide and vanadium chloride based chemiluminescent methods for quantification of nitrogen oxides. Nitric Oxide. 2022 Apr 1;121:11-19. doi: 10.1016/j.niox.2022.01.006. Epub 2022 Feb 4. PubMed PMID: 35124204; PubMed Central PMCID: PMC8860884.
Qi X, Ricart K, Ahmed KA, Patel RP, Boulton ME. Supplemental nitrite increases choroidal neovascularization in mice. Nitric Oxide. 2021 Dec 1;117:7-15. doi: 10.1016/j.niox.2021.09.005. Epub 2021 Sep 16. PubMed PMID: 34537345; PubMed Central PMCID: PMC8647281.
Miller L, Hébert CD, Grimes SD, Toomey JS, Oh JY, Rose JJ, Patel RP. Safety and toxicology assessment of sodium nitrite administered by intramuscular injection. Toxicol Appl Pharmacol. 2021 Oct 15;429:115702. doi: 10.1016/j.taap.2021.115702. Epub 2021 Aug 28. PubMed PMID: 34464673; PubMed Central PMCID: PMC8459319.
Lewis SE, Rosencrance CB, De Vallance E, Giromini A, Williams XM, Oh JY, Schmidt H, Straub AC, Chantler PD, Patel RP, Kelley EE. Human and rodent red blood cells do not demonstrate xanthine oxidase activity or XO-catalyzed nitrite reduction to NO. Free Radic Biol Med. 2021 Oct;174:84-88. doi: 10.1016/j.freeradbiomed.2021.07.012. Epub 2021 Jul 15. PubMed PMID: 34273539; PubMed Central PMCID: PMC9257433.
Ahmed KA, Kim K, Ricart K, Van Der Pol W, Qi X, Bamman MM, Behrens C, Fisher G, Boulton ME, Morrow C, O'Neal PV, Patel RP. Corrigendum to "Potential role for age as a modulator of oral nitrate reductase activity". [Nitric oxide J, (2021 Mar 1). 108. 1-7]. Nitric Oxide. 2021 Sep 1;113-114:78-79. doi: 10.1016/j.niox.2021.06.005. Epub 2021 Jul 9. PubMed PMID: 34253426.
Margaroli C, Benson P, Sharma NS, Madison MC, Robison SW, Arora N, Ton K, Liang Y, Zhang L, Patel RP, Gaggar A. Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures. Cell Rep Med. 2021 Apr 20;2(4):100242. doi: 10.1016/j.xcrm.2021.100242. Epub 2021 Mar 23. PubMed PMID: 33778787; PubMed Central PMCID: PMC7985929.
Robison SW, Li J, Viera L, Blackburn JP, Patel RP, Blalock JE, Gaggar A, Xu X. A mechanism for matrikine regulation in acute inflammatory lung injury. JCI Insight. 2021 Apr 8;6(7). doi: 10.1172/jci.insight.140750. PubMed PMID: 33830084; PubMed Central PMCID: PMC8119180.
Ahmed KA, Kim K, Ricart K, Van Der Pol W, Qi X, Bamman MM, Behrens C, Fisher G, Boulton ME, Morrow C, O'Neal PV, Patel RP. Potential role for age as a modulator of oral nitrate reductase activity. Nitric Oxide. 2021 Mar 1;108:1-7. doi: 10.1016/j.niox.2020.12.001. Epub 2020 Dec 13. PubMed PMID: 33321206; PubMed Central PMCID: PMC8085911.
Schmidt HM, Wood KC, Lewis SE, Hahn SA, Williams XM, McMahon B, Baust JJ, Yuan S, Bachman TN, Wang Y, Oh JY, Ghosh S, Ofori-Acquah SF, Lebensburger JD, Patel RP, Du J, Vitturi DA, Kelley EE, Straub AC. Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):769-782. doi: 10.1161/ATVBAHA.120.315081. Epub 2020 Dec 3. PubMed PMID: 33267657; PubMed Central PMCID: PMC8185582.
Gentle SJ, Ahmed KA, Yi N, Morrow CD, Ambalavanan N, Lal CV, Patel RP. Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants. Redox Biol. 2021 Jan;38:101782. doi: 10.1016/j.redox.2020.101782. Epub 2020 Nov 3. PubMed PMID: 33166868; PubMed Central PMCID: PMC7658701.
Harper SA, Bassler JR, Peramsetty S, Yang Y, Roberts LM, Drummer D, Mankowski RT, Leeuwenburgh C, Ricart K, Patel RP, Bamman MM, Anton SD, Jaeger BC, Buford TW. Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial. Exp Gerontol. 2021 Jan;143:111111. doi: 10.1016/j.exger.2020.111111. Epub 2020 Oct 15. PubMed PMID: 33068691; PubMed Central PMCID: PMC7855904.
Behrens CE Jr, Ahmed K, Ricart K, Linder B, Fernández J, Bertrand B, Patel RP, Fisher G. Acute beetroot juice supplementation improves exercise tolerance and cycling efficiency in adults with obesity. Physiol Rep. 2020 Oct;8(19):e14574. doi: 10.14814/phy2.14574. PubMed PMID: 33063953; PubMed Central PMCID: PMC7556310.
Gentle SJ, Freeman A, Patel RP, Ambalavanan N, Lal CV. Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia. Respir Res. 2020 Sep 21;21(1):244. doi: 10.1186/s12931-020-01508-8. PubMed PMID: 32957939; PubMed Central PMCID: PMC7504869.
Oh JY, Marques MB, Xu X, Li J, Genschmer K, Gaggar A, Jansen JO, Holcomb JB, Pittet JF, Patel RP. Damage to red blood cells during whole blood storage. J Trauma Acute Care Surg. 2020 Aug;89(2):344-350. doi: 10.1097/TA.0000000000002730. PubMed PMID: 32301878.
McDonald KR, Hernandez-Nichols AL, Barnes JW, Patel RP. Hydrogen peroxide regulates endothelial surface N-glycoforms to control inflammatory monocyte rolling and adhesion. Redox Biol. 2020 Jul;34:101498. doi: 10.1016/j.redox.2020.101498. Epub 2020 Mar 6. PubMed PMID: 32171755; PubMed Central PMCID: PMC7327964.
Regal-McDonald K, Patel RP. Selective Recruitment of Monocyte Subsets by Endothelial N-Glycans. Am J Pathol. 2020 May;190(5):947-957. doi: 10.1016/j.ajpath.2020.01.006. Epub 2020 Feb 18. Review. PubMed PMID: 32084367; PubMed Central PMCID: PMC7221295.
Ottolini M, Hong K, Cope EL, Daneva Z, DeLalio LJ, Sokolowski JD, Marziano C, Nguyen NY, Altschmied J, Haendeler J, Johnstone SR, Kalani MY, Park MS, Patel RP, Liedtke W, Isakson BE, Sonkusare SK. Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. Circulation. 2020 Apr 21;141(16):1318-1333. doi: 10.1161/CIRCULATIONAHA.119.043385. Epub 2020 Feb 3. PubMed PMID: 32008372; PubMed Central PMCID: PMC7195859.
Joshipura K, Muñoz-Torres F, Fernández-Santiago J, Patel RP, Lopez-Candales A. Over-the-counter mouthwash use, nitric oxide and hypertension risk. Blood Press. 2020 Apr;29(2):103-112. doi: 10.1080/08037051.2019.1680270. Epub 2019 Nov 11. PubMed PMID: 31709856; PubMed Central PMCID: PMC7125030.
Regal-McDonald K, Somarathna M, Lee T, Litovsky SH, Barnes J, Peretik JM, Traylor JG Jr, Orr AW, Patel RP. Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction. PLoS One. 2020;15(3):e0230358. doi: 10.1371/journal.pone.0230358. eCollection 2020. PubMed PMID: 32208424; PubMed Central PMCID: PMC7092995.
Hjelmeland AB, Patel RP. SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23376-23378. doi: 10.1073/pnas.1916214116. Epub 2019 Nov 6. PubMed PMID: 31694886; PubMed Central PMCID: PMC6876248.
Wagener BM, Hu PJ, Oh JY, Evans CA, Richter JR, Honavar J, Brandon AP, Creighton J, Stephens SW, Morgan C, Dull RO, Marques MB, Kerby JD, Pittet JF, Patel RP. Correction: Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study. PLoS Med. 2019 Nov;16(11):e1002991. doi: 10.1371/journal.pmed.1002991. eCollection 2019 Nov. PubMed PMID: 31721762; PubMed Central PMCID: PMC6853293.
Lundberg JO, Cabrales P, Tsai AG, Patel RP, Kim-Shapiro DB. Response by Lundberg et al to Letter Regarding Article, "Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell". Circulation. 2019 Nov 5;140(19):e760-e761. doi: 10.1161/CIRCULATIONAHA.119.043151. Epub 2019 Nov 4. PubMed PMID: 31682526; PubMed Central PMCID: PMC6834230.
Regal-McDonald K, Xu B, Barnes JW, Patel RP. High-mannose intercellular adhesion molecule-1 enhances CD16(+) monocyte adhesion to the endothelium. Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1028-H1038. doi: 10.1152/ajpheart.00306.2019. Epub 2019 Aug 9. PubMed PMID: 31398058; PubMed Central PMCID: PMC6879925.
Aggarwal S, Jilling T, Doran S, Ahmad I, Eagen JE, Gu S, Gillespie M, Albert CJ, Ford D, Oh JY, Patel RP, Matalon S. Phosgene inhalation causes hemolysis and acute lung injury. Toxicol Lett. 2019 Sep 15;312:204-213. doi: 10.1016/j.toxlet.2019.04.019. Epub 2019 Apr 30. PubMed PMID: 31047999; PubMed Central PMCID: PMC6653688.
Detterich JA, Liu H, Suriany S, Kato RM, Chalacheva P, Tedla B, Shah PM, Khoo MC, Wood JC, Coates TD, Milne GL, Oh JY, Patel RP, Forman HJ. Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents. Free Radic Biol Med. 2019 Sep;141:408-415. doi: 10.1016/j.freeradbiomed.2019.07.004. Epub 2019 Jul 3. PubMed PMID: 31279092; PubMed Central PMCID: PMC6750280.
MohanKumar K, Namachivayam K, Song T, Jake Cha B, Slate A, Hendrickson JE, Pan H, Wickline SA, Oh JY, Patel RP, He L, Torres BA, Maheshwari A. A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions. Nat Commun. 2019 Aug 2;10(1):3494. doi: 10.1038/s41467-019-11199-5. PubMed PMID: 31375667; PubMed Central PMCID: PMC6677753.
DeSantis SM, Brown DW, Jones AR, Yamal JM, Pittet JF, Patel RP, Wade CE, Holcomb JB, Wang H. Characterizing red blood cell age exposure in massive transfusion therapy: the scalar age of blood index (SBI). Transfusion. 2019 Aug;59(8):2699-2708. doi: 10.1111/trf.15334. Epub 2019 May 3. PubMed PMID: 31050809; PubMed Central PMCID: PMC6679795.
Sun CW, Yang J, Kleschyov AL, Zhuge Z, Carlström M, Pernow J, Wajih N, Isbell TS, Oh JY, Cabrales P, Tsai AG, Townes T, Kim-Shapiro DB, Patel RP, Lundberg JO. Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell. Circulation. 2019 Jun 4;139(23):2654-2663. doi: 10.1161/CIRCULATIONAHA.118.039284. Epub 2019 Mar 25. PubMed PMID: 30905171; PubMed Central PMCID: PMC6546526.
Jones AR, Patel RP, Marques MB, Donnelly JP, Griffin RL, Pittet JF, Kerby JD, Stephens SW, DeSantis SM, Hess JR, Wang HE. Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial. Ann Emerg Med. 2019 Jun;73(6):650-661. doi: 10.1016/j.annemergmed.2018.09.033. Epub 2018 Nov 15. PubMed PMID: 30447946; PubMed Central PMCID: PMC6517091.
Oh JY, Williams A, Patel RP. The role of redox-dependent mechanisms in heme release from hemoglobin and erythrocyte hemolysates. Arch Biochem Biophys. 2019 Feb 15;662:111-120. doi: 10.1016/j.abb.2018.12.005. Epub 2018 Dec 5. PubMed PMID: 30529102.
DeMartino AW, Kim-Shapiro DB, Patel RP, Gladwin MT. Nitrite and nitrate chemical biology and signalling. Br J Pharmacol. 2019 Jan;176(2):228-245. doi: 10.1111/bph.14484. Epub 2018 Oct 3. Review. PubMed PMID: 30152056; PubMed Central PMCID: PMC6295445.
Gautam R, Oh JY, Patel RP, Dluhy RA. Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy. Analyst. 2018 Dec 3;143(24):5950-5958. doi: 10.1039/c8an01135d. PubMed PMID: 30035796; PubMed Central PMCID: PMC6279605.
Gautam R, Oh JY, Marques MB, Dluhy RA, Patel RP. Characterization of Storage-Induced Red Blood Cell Hemolysis Using Raman Spectroscopy. Lab Med. 2018 Oct 11;49(4):298-310. doi: 10.1093/labmed/lmy018. PubMed PMID: 29893945; PubMed Central PMCID: PMC6180846.
Reeder KM, Mackel JJ, Godwin MS, Dunaway CW, Blackburn JP, Patel RP, Steele C. Role of Common γ-Chain Cytokines in Lung Interleukin-22 Regulation after Acute Exposure to Aspergillus fumigatus. Infect Immun. 2018 Oct;86(10). doi: 10.1128/IAI.00157-18. Print 2018 Oct. PubMed PMID: 30104211; PubMed Central PMCID: PMC6204727.
Hare GMT, Han K, Leshchyshyn Y, Mistry N, Kei T, Dai SY, Tsui AKY, Pirani RA, Honavar J, Patel RP, Yagnik S, Welker SL, Tam T, Romaschin A, Connelly PW, Beattie WS, Mazer CD. Potential biomarkers of tissue hypoxia during acute hemodilutional anemia in cardiac surgery: A prospective study to assess tissue hypoxia as a mechanism of organ injury. Can J Anaesth. 2018 Aug;65(8):901-913. doi: 10.1007/s12630-018-1140-0. Epub 2018 Apr 25. PubMed PMID: 29696581.
Barnes JW, Patel RP. Things We "kNOw" and Do Not "kNOw" about Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 Jul 15;198(2):151-152. doi: 10.1164/rccm.201803-0424ED. PubMed PMID: 29590535; PubMed Central PMCID: PMC6058978.
Oakley J, Zahr R, Aban I, Kulkarni V, Patel RP, Hurwitz J, Askenazi D, Hankins J, Lebensburger J. Acute Kidney Injury during Parvovirus B19-Induced Transient Aplastic Crisis in Sickle Cell Disease. Am J Hematol. 2018 May 14;. doi: 10.1002/ajh.25140. [Epub ahead of print] PubMed PMID: 29756409; PubMed Central PMCID: PMC6235726.
Duerr MA, Palladino END, Hartman CL, Lambert JA, Franke JD, Albert CJ, Matalon S, Patel RP, Slungaard A, Ford DA. Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and protein. J Lipid Res. 2018 Apr;59(4):696-705. doi: 10.1194/jlr.M083279. Epub 2018 Feb 14. PubMed PMID: 29444934; PubMed Central PMCID: PMC5880502.
Wagener BM, Hu PJ, Oh JY, Evans CA, Richter JR, Honavar J, Brandon AP, Creighton J, Stephens SW, Morgan C, Dull RO, Marques MB, Kerby JD, Pittet JF, Patel RP. Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study. PLoS Med. 2018 Mar;15(3):e1002522. doi: 10.1371/journal.pmed.1002522. eCollection 2018 Mar. PubMed PMID: 29522519; PubMed Central PMCID: PMC5844517.
Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan;58(1):255-266. doi: 10.1111/trf.14435. Epub 2017 Dec 15. PubMed PMID: 29243830; PubMed Central PMCID: PMC6258195.
Joshipura KJ, Muñoz-Torres FJ, Morou-Bermudez E, Patel RP. Over-the-counter mouthwash use and risk of pre-diabetes/diabetes. Nitric Oxide. 2017 Dec 1;71:14-20. doi: 10.1016/j.niox.2017.09.004. Epub 2017 Sep 20. PubMed PMID: 28939409; PubMed Central PMCID: PMC6628144.
Payne GA, Li J, Xu X, Jackson P, Qin H, Pollock DM, Wells JM, Oparil S, Leesar M, Patel RP, Blalock JE, Gaggar A. The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection. Sci Rep. 2017 Aug 8;7(1):7563. doi: 10.1038/s41598-017-07610-0. PubMed PMID: 28790330; PubMed Central PMCID: PMC5548740.
Lambert JA, Carlisle MA, Lam A, Aggarwal S, Doran S, Ren C, Bradley WE, Dell'Italia L, Ambalavanan N, Ford DA, Patel RP, Jilling T, Matalon S. Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice. Hypertension. 2017 Aug;70(2):390-400. doi: 10.1161/HYPERTENSIONAHA.117.09466. Epub 2017 Jun 12. PubMed PMID: 28607126; PubMed Central PMCID: PMC5518712.
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