My Bibliography

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Orozco S, Aljobaily N, Reynolds HM, Oceguera GA, Lee T, Bettini M, Bettini ML. Flt3L-Derived Antigen-Presenting Cell Transfer in Neonatal NOD Mice Reduces the Incidence of Type 1 Diabetes. Diabetes. 2026 Jan 1;75(1):133-143. doi: 10.2337/db25-0055. PubMed PMID: 41196654; PubMed Central PMCID: PMC12716620.

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Majumdar S, Echelibe H, Bettini M, Bettini ML. The impact of CD3ζ ITAM multiplicity and sequence on CAR T-cell survival and function. Front Immunol. 2024;15:1509980. doi: 10.3389/fimmu.2024.1509980. eCollection 2024. PubMed PMID: 39885989; PubMed Central PMCID: PMC11779709.

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Aljobaily N, Allard D, Perkins B, Raugh A, Galland T, Jing Y, Stephens WZ, Bettini ML, Hale JS, Bettini M. Autoimmune CD4(+) T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes. Immunity. 2024 Nov 12;57(11):2583-2596.e6. doi: 10.1016/j.immuni.2024.09.016. Epub 2024 Oct 12. PubMed PMID: 39396521; PubMed Central PMCID: PMC11563894.

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Raugh A, Jing Y, Bettini ML, Bettini M. The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes. Sci Rep. 2023 Oct 30;13(1):18653. doi: 10.1038/s41598-023-45738-4. PubMed PMID: 37903947; PubMed Central PMCID: PMC10616065.

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Nguyen NX, Richens AW, Sircy LM, Allard DE, Kolawole EM, Evavold BD, Bettini M, Hale JS. Immunogen-Specific Strengths and Limitations of the Activation-Induced Marker Assay for Assessing Murine Antigen-Specific CD4+ T Cell Responses. J Immunol. 2023 Apr 1;210(7):916-925. doi: 10.4049/jimmunol.2200638. PubMed PMID: 36883856; PubMed Central PMCID: PMC10038905.

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Jing Y, Kong Y, Allard D, Liu B, Kolawole E, Sprouse M, Evavold B, Bettini M, Bettini M. Increased TCR signaling in regulatory T cells is disengaged from TCR affinity. bioRxiv. 2023 Jan 24;. doi: 10.1101/2023.01.17.523999. PubMed PMID: 36711832; PubMed Central PMCID: PMC9882247.

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Raugh A, Allard D, Bettini M. Nature vs. nurture: FOXP3, genetics, and tissue environment shape Treg function. Front Immunol. 2022;13:911151. doi: 10.3389/fimmu.2022.911151. eCollection 2022. Review. PubMed PMID: 36032083; PubMed Central PMCID: PMC9411801.

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Lin Y, Perovanovic J, Kong Y, Igyarto BZ, Zurawski S, Tantin D, Zurawski G, Bettini M, Bettini ML. Antibody-Mediated Targeting of a Hybrid Insulin Peptide Toward Neonatal Thymic Langerin-Positive Cells Enhances T-Cell Central Tolerance and Delays Autoimmune Diabetes. Diabetes. 2022 Aug 1;71(8):1735-1745. doi: 10.2337/db21-1069. PubMed PMID: 35622068; PubMed Central PMCID: PMC9490359.

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Jing Y, Kong Y, McGinty J, Blahnik-Fagan G, Lee T, Orozco-Figueroa S, Bettini ML, James EA, Bettini M. T-Cell Receptor/HLA Humanized Mice Reveal Reduced Tolerance and Increased Immunogenicity of Posttranslationally Modified GAD65 Epitope. Diabetes. 2022 May 1;71(5):1012-1022. doi: 10.2337/db21-0993. PubMed PMID: 35179565; PubMed Central PMCID: PMC9044133.

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Kong Y, Jing Y, Allard D, Scavuzzo MA, Sprouse ML, Borowiak M, Bettini ML, Bettini M. A dormant T-cell population with autoimmune potential exhibits low self-reactivity and infiltrates islets in type 1 diabetes. Eur J Immunol. 2022 Jul;52(7):1158-1170. doi: 10.1002/eji.202149690. Epub 2022 Apr 22. PubMed PMID: 35389516; PubMed Central PMCID: PMC9673076.

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Bettini M, Bettini ML. Function, Failure, and the Future Potential of Tregs in Type 1 Diabetes. Diabetes. 2021 Jun;70(6):1211-1219. doi: 10.2337/dbi18-0058. Epub 2021 May 20. Review. PubMed PMID: 34016597; PubMed Central PMCID: PMC8275894.

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Boddul SV, Sharma RK, Dubnovitsky A, Raposo B, Gerstner C, Shen Y, Iyer VS, Kasza Z, Kwok WW, Winkler AR, Klareskog L, Malmström V, Bettini M, Wermeling F. In vitro and ex vivo functional characterization of human HLA-DRB1∗04 restricted T cell receptors. J Transl Autoimmun. 2021;4:100087. doi: 10.1016/j.jtauto.2021.100087. eCollection 2021. PubMed PMID: 33768201; PubMed Central PMCID: PMC7980064.

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Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML. A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells. Diabetes. 2020 Mar;69(3):392-400. doi: 10.2337/db19-0821. Epub 2019 Dec 13. PubMed PMID: 31836691; PubMed Central PMCID: PMC7034183.

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Liu B, Hood JD, Kolawole EM, Woodruff DM, Vignali DA, Bettini M, Evavold BD. A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery. Diabetes. 2020 Mar;69(3):381-391. doi: 10.2337/db19-0399. Epub 2019 Dec 5. PubMed PMID: 31806623; PubMed Central PMCID: PMC7034185.

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Gu BH, Sprouse ML, Madison MC, Hong MJ, Yuan X, Tung HY, Landers CT, Song LZ, Corry DB, Bettini M, Kheradmand F. A Novel Animal Model of Emphysema Induced by Anti-Elastin Autoimmunity. J Immunol. 2019 Jul 15;203(2):349-359. doi: 10.4049/jimmunol.1900113. Epub 2019 Jun 10. PubMed PMID: 31182478; PubMed Central PMCID: PMC6688643.

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Kong Y, Jing Y, Bettini M. Generation of T Cell Receptor Retrogenic Mice. Curr Protoc Immunol. 2019 Jun;125(1):e76. doi: 10.1002/cpim.76. Epub 2019 May 15. PubMed PMID: 31090255; PubMed Central PMCID: PMC6570547.

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Zeng Q, Sun X, Xiao L, Xie Z, Bettini M, Deng T. A Unique Population: Adipose-Resident Regulatory T Cells. Front Immunol. 2018;9:2075. doi: 10.3389/fimmu.2018.02075. eCollection 2018. Review. PubMed PMID: 30323806; PubMed Central PMCID: PMC6172295.

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Scavuzzo MA, Hill MC, Chmielowiec J, Yang D, Teaw J, Sheng K, Kong Y, Bettini M, Zong C, Martin JF, Borowiak M. Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Nat Commun. 2018 Aug 22;9(1):3356. doi: 10.1038/s41467-018-05740-1. PubMed PMID: 30135482; PubMed Central PMCID: PMC6105717.

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Sprouse ML, Scavuzzo MA, Blum S, Shevchenko I, Lee T, Makedonas G, Borowiak M, Bettini ML, Bettini M. High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity. JCI Insight. 2018 Jan 25;3(2). doi: 10.1172/jci.insight.97322. eCollection 2018 Jan 25. PubMed PMID: 29367462; PubMed Central PMCID: PMC5821181.

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Sprouse ML, Shevchenko I, Scavuzzo MA, Joseph F, Lee T, Blum S, Borowiak M, Bettini ML, Bettini M. Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity. J Immunol. 2018 Feb 1;200(3):909-914. doi: 10.4049/jimmunol.1700156. Epub 2017 Dec 27. PubMed PMID: 29282307; PubMed Central PMCID: PMC5962277.

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Bettini ML, Bettini M. Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex. Front Endocrinol (Lausanne). 2017;8:351. doi: 10.3389/fendo.2017.00351. eCollection 2017. Review. PubMed PMID: 29312143; PubMed Central PMCID: PMC5735072.

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Sprouse ML, Blahnik G, Lee T, Tully N, Benarjee P, James EA, Redondo MJ, Bettini ML, Bettini M. Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs. J Vis Exp. 2017 Sep 10;(127). doi: 10.3791/55379. PubMed PMID: 28930975; PubMed Central PMCID: PMC5752194.

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Lee T, Sprouse ML, Banerjee P, Bettini M, Bettini ML. Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells. J Immunol. 2017 Oct 1;199(7):2270-2278. doi: 10.4049/jimmunol.1700207. Epub 2017 Aug 23. PubMed PMID: 28835461; PubMed Central PMCID: PMC5605461.

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Zhang Q, Chikina M, Szymczak-Workman AL, Horne W, Kolls JK, Vignali KM, Normolle D, Bettini M, Workman CJ, Vignali DAA. LAG3 limits regulatory T cell proliferation and function in autoimmune diabetes. Sci Immunol. 2017 Mar 31;2(9). doi: 10.1126/sciimmunol.aah4569. PubMed PMID: 28783703; PubMed Central PMCID: PMC5609824.

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Sprouse ML, Blahnik G, Lee T, Tully N, Banerjee P, James EA, Redondo MJ, Bettini ML, Bettini M. Rapid identification and expression of human TCRs in retrogenic mice. J Immunol Methods. 2016 Dec;439:29-36. doi: 10.1016/j.jim.2016.08.010. Epub 2016 Aug 31. PubMed PMID: 27589924; PubMed Central PMCID: PMC5439214.

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Lee T, Shevchenko I, Sprouse ML, Bettini M, Bettini ML. Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice. J Vis Exp. 2016 Jul 11;(113). doi: 10.3791/54196. PubMed PMID: 27500835; PubMed Central PMCID: PMC4993443.

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Bettini M, Blanchfield L, Castellaw A, Zhang Q, Nakayama M, Smeltzer MP, Zhang H, Hogquist KA, Evavold BD, Vignali DA. TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. J Immunol. 2014 Jul 15;193(2):571-9. doi: 10.4049/jimmunol.1400043. Epub 2014 Jun 18. PubMed PMID: 24943217; PubMed Central PMCID: PMC4082738.

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Bettini ML, Bettini M, Nakayama M, Guy CS, Vignali DA. Generation of T cell receptor-retrogenic mice: improved retroviral-mediated stem cell gene transfer. Nat Protoc. 2013 Oct;8(10):1837-40. doi: 10.1038/nprot.2013.111. Epub 2013 Sep 5. PubMed PMID: 24008379; PubMed Central PMCID: PMC3832243.

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Bettini ML, Bettini M, Vignali DA. T-cell receptor retrogenic mice: a rapid, flexible alternative to T-cell receptor transgenic mice. Immunology. 2012 Jul;136(3):265-72. doi: 10.1111/j.1365-2567.2012.03574.x. Review. PubMed PMID: 22348644; PubMed Central PMCID: PMC3385026.

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Bettini ML, Pan F, Bettini M, Finkelstein D, Rehg JE, Floess S, Bell BD, Ziegler SF, Huehn J, Pardoll DM, Vignali DA. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity. 2012 May 25;36(5):717-30. doi: 10.1016/j.immuni.2012.03.020. Epub 2012 May 10. PubMed PMID: 22579476; PubMed Central PMCID: PMC3361541.

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Bettini M, Castellaw AH, Lennon GP, Burton AR, Vignali DA. Prevention of autoimmune diabetes by ectopic pancreatic β-cell expression of interleukin-35. Diabetes. 2012 Jun;61(6):1519-26. doi: 10.2337/db11-0784. Epub 2012 Mar 16. PubMed PMID: 22427377; PubMed Central PMCID: PMC3357277.

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Workman CJ, Collison LW, Bettini M, Pillai MR, Rehg JE, Vignali DA. In vivo Treg suppression assays. Methods Mol Biol. 2011;707:119-56. doi: 10.1007/978-1-61737-979-6_9. PubMed PMID: 21287333; PubMed Central PMCID: PMC3049949.

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Bettini M, Vignali DA. T cell-driven initiation and propagation of autoimmune diabetes. Curr Opin Immunol. 2011 Dec;23(6):754-60. doi: 10.1016/j.coi.2011.10.002. Epub 2011 Nov 4. Review. PubMed PMID: 22056379; PubMed Central PMCID: PMC3232326.

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Bettini M, Szymczak-Workman AL, Forbes K, Castellaw AH, Selby M, Pan X, Drake CG, Korman AJ, Vignali DA. Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3. J Immunol. 2011 Oct 1;187(7):3493-8. doi: 10.4049/jimmunol.1100714. Epub 2011 Aug 26. PubMed PMID: 21873518; PubMed Central PMCID: PMC3178660.

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Bettini M, Vignali DA. Regulatory T cells and inhibitory cytokines in autoimmunity. Curr Opin Immunol. 2009 Dec;21(6):612-8. doi: 10.1016/j.coi.2009.09.011. Epub 2009 Oct 23. Review. PubMed PMID: 19854631; PubMed Central PMCID: PMC2787714.

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Lennon GP, Bettini M, Burton AR, Vincent E, Arnold PY, Santamaria P, Vignali DA. T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity. 2009 Oct 16;31(4):643-53. doi: 10.1016/j.immuni.2009.07.008. Epub 2009 Oct 8. PubMed PMID: 19818656; PubMed Central PMCID: PMC2763021.

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Bettini M, Rosenthal K, Evavold BD. Pathogenic MOG-reactive CD8+ T cells require MOG-reactive CD4+ T cells for sustained CNS inflammation during chronic EAE. J Neuroimmunol. 2009 Aug 18;213(1-2):60-8. doi: 10.1016/j.jneuroim.2009.05.017. Epub 2009 Jun 21. PubMed PMID: 19540601; PubMed Central PMCID: PMC2752735.

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Zakharova M, Ziegler HK. Paradoxical anti-inflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells. J Immunol. 2005 Oct 15;175(8):5024-33. doi: 10.4049/jimmunol.175.8.5024. PubMed PMID: 16210605.