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Twigg HL 3rd, Lipscomb MF, Yoffe B, Barbaro DJ, Weissler JC. Enhanced accessory cell function by alveolar macrophages from patients infected with the human immunodeficiency virus: potential role for depletion of CD4+ cells in the lung. Am J Respir Cell Mol Biol. 1989 Nov;1(5):391-400. doi: 10.1165/ajrcmb/1.5.391. PubMed PMID: 2576909.
Twigg HL 3rd, Weissler JC, Yoffe B, Ball EJ, Lipscomb MF. Monocyte accessory cell function in patients infected with the human immunodeficiency virus. Clin Immunol Immunopathol. 1991 Jun;59(3):436-48. doi: 10.1016/0090-1229(91)90039-d. PubMed PMID: 1827620.
Twigg HL 3rd, Iwamoto GK, Soliman DM. Role of cytokines in alveolar macrophage accessory cell function in HIV-infected individuals. J Immunol. 1992 Aug 15;149(4):1462-9. PubMed PMID: 1500725.
Soliman DM, Twigg HL 3rd. Cigarette smoking decreases bioactive interleukin-6 secretion by alveolar macrophages. Am J Physiol. 1992 Oct;263(4 Pt 1):L471-8. doi: 10.1152/ajplung.1992.263.4.L471. PubMed PMID: 1415725.
Twigg HL 3rd. Bronchoalveolar lavage fluid in HIV-infected patients. "Cytokine soup". Chest. 1993 Sep;104(3):659-61. doi: 10.1378/chest.104.3.659. PubMed PMID: 8365268.
Twigg HL 3rd, Soliman DM, Spain BA. Impaired alveolar macrophage accessory cell function and reduced incidence of lymphocytic alveolitis in HIV-infected patients who smoke. AIDS. 1994 May;8(5):611-8. doi: 10.1097/00002030-199405000-00006. PubMed PMID: 8060541.
Iwamoto GK, Konicek SA, Twigg HL 3rd. Modulation of accessory cell function and interleukin-6 production by the HIV-1 tat gene. Am J Respir Cell Mol Biol. 1994 May;10(5):580-5. doi: 10.1165/ajrcmb.10.5.8179923. PubMed PMID: 8179923.
Twigg HL 3rd, Wilkes DS, Soliman DM. Measurement of IL-6 inhibitory activity in cultured cell supernatants and lysates. J Lab Clin Med. 1994 Aug;124(2):283-92. PubMed PMID: 8051493.
Twigg HL 3rd, Soliman DM. Role of alveolar macrophage-T cell adherence in accessory cell function in human immunodeficiency virus-infected individuals. Am J Respir Cell Mol Biol. 1994 Aug;11(2):138-46. doi: 10.1165/ajrcmb.11.2.7519433. PubMed PMID: 7519433.
Downing JF, Pasula R, Wright JR, Twigg HL 3rd, Martin WJ 2nd. Surfactant protein a promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4848-52. doi: 10.1073/pnas.92.11.4848. PubMed PMID: 7761411; PubMed Central PMCID: PMC41804.
Spain BA, Soliman DM, Sidner RA, Twigg HL. Enhanced proliferation and IL-2 secretion by lung lymphocytes from HIV-infected subjects. Am J Physiol. 1995 Oct;269(4 Pt 1):L498-506. doi: 10.1152/ajplung.1995.269.4.L498. PubMed PMID: 7485522.
Martin WJ 2nd, Downing JF, Williams MD, Pasula R, Twigg HL 3rd, Wright JR. Role of surfactant protein A in the pathogenesis of tuberculosis in subjects with human immunodeficiency virus infection. Proc Assoc Am Physicians. 1995 Oct;107(3):340-5. PubMed PMID: 8608420.
Wilkes DS, Neimeier M, Mathur PN, Soliman DM, Twigg HL 3rd, Bowen LK, Heidler KM. Effect of human lung allograft alveolar macrophages on IgG production: immunoregulatory role of interleukin-10, transforming growth factor-beta, and interleukin-6. Am J Respir Cell Mol Biol. 1995 Nov;13(5):621-8. doi: 10.1165/ajrcmb.13.5.7576699. PubMed PMID: 7576699.
Twigg HL 3rd, Spain BA, Soliman DM, Bowen LK, Heidler KM, Wilkes DS. Impaired IgG production in the lungs of HIV-infected individuals. Cell Immunol. 1996 May 25;170(1):127-33. doi: 10.1006/cimm.1996.0142. PubMed PMID: 8660808.
Twigg HL 3rd. Pulmonary host defenses. J Thorac Imaging. 1998 Oct;13(4):221-33. doi: 10.1097/00005382-199810000-00003. Review. PubMed PMID: 9799131.
Twigg HL 3rd, Spain BA, Soliman DM, Knox K, Sidner RA, Schnizlein-Bick C, Wilkes DS, Iwamoto GK. Production of interferon-gamma by lung lymphocytes in HIV-infected individuals. Am J Physiol. 1999 Feb;276(2):L256-62. doi: 10.1152/ajplung.1999.276.2.L256. PubMed PMID: 9950887.
Twigg HL, Soliman DM, Day RB, Knox KS, Anderson RJ, Wilkes DS, Schnizlein-Bick CT. Lymphocytic alveolitis, bronchoalveolar lavage viral load, and outcome in human immunodeficiency virus infection. Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1439-44. doi: 10.1164/ajrccm.159.5.9808031. PubMed PMID: 10228108.
Wilkes DS, Twigg HL 3rd. B-lymphocytes in the lung: a topic to be revisited. Sarcoidosis Vasc Diffuse Lung Dis. 2001 Mar;18(1):34-49. Review. PubMed PMID: 11354546.
Wood KL, Hage CA, Knox KS, Kleiman MB, Sannuti A, Day RB, Wheat LJ, Twigg HL 3rd. Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy. Am J Respir Crit Care Med. 2003 May 1;167(9):1279-82. doi: 10.1164/rccm.200206-563OC. Epub 2003 Feb 13. PubMed PMID: 12615627.
Wood KL, Chaiyarit P, Day RB, Wang Y, Schnizlein-Bick CT, Gregory RL, Twigg HL 3rd. Measurements of HIV viral loads from different levels of the respiratory tract. Chest. 2003 Aug;124(2):536-42. doi: 10.1378/chest.124.2.536. PubMed PMID: 12907539.
Gordon SB, Miller DE, Day RB, Ferry T, Wilkes DS, Schnizlein-Bick CT, Zijlstra EE, Read RC, Molyneux ME, Twigg HL 3rd. Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults. J Infect Dis. 2003 Sep 1;188(5):666-70. doi: 10.1086/377480. Epub 2003 Aug 20. PubMed PMID: 12934182.
Twigg HL 3rd. Macrophages in innate and acquired immunity. Semin Respir Crit Care Med. 2004 Feb;25(1):21-31. doi: 10.1055/s-2004-822302. PubMed PMID: 16088446.
Day RB, Wang Y, Knox KS, Pasula R, Martin WJ 2nd, Twigg HL 3rd. Alveolar macrophages from HIV-infected subjects are resistant to Mycobacterium tuberculosis in vitro. Am J Respir Cell Mol Biol. 2004 Mar;30(3):403-10. doi: 10.1165/rcmb.2003-0059OC. Epub 2003 Sep 11. PubMed PMID: 12972398.
Knox KS, Day RB, Wood KL, Kohli LL, Hage CA, Foresman BH, Schnizlein-Bick CT, Twigg HL 3rd. Macrophages exposed to lymphotropic and monocytotropic HIV induce similar CTL responses despite differences in productive infection. Cell Immunol. 2004 Jun;229(2):130-8. doi: 10.1016/j.cellimm.2004.07.004. PubMed PMID: 15474527.
Twigg HL 3rd. Humoral immune defense (antibodies): recent advances. Proc Am Thorac Soc. 2005;2(5):417-21. doi: 10.1513/pats.200508-089JS. Review. PubMed PMID: 16322592.
Hage CA, Kohli LL, Cho S, Brutkiewicz RR, Twigg HL 3rd, Knox KS. Human immunodeficiency virus gp120 downregulates CD1d cell surface expression. Immunol Lett. 2005 Apr 15;98(1):131-5. doi: 10.1016/j.imlet.2004.10.025. Epub 2004 Nov 24. PubMed PMID: 15790518.
Summers KH, Zillich AJ, Nyhuis AW, Twigg HL 3rd. Outcomes of American Lung Association-Indiana Lung Centers asthma program. Dis Manag. 2005 Oct;8(5):311-8. doi: 10.1089/dis.2005.8.311. PubMed PMID: 16212516.
Hage CA, Wheat LJ, Twigg HL, Knox KS. Infliximab does not affect dendritic cells' mediated lymphoproliferative response to Histoplasma capsulatum. Clin Infect Dis. 2005 Dec 1;41(11):1685-7; author reply 1687. doi: 10.1086/498032. PubMed PMID: 16267748.
Wood KL, Knox KS, Wang Y, Day RB, Schnizlein-Bick C, Twigg HL 3rd. Apoptosis of CD57+ and CD57- lymphocytes in the lung and blood of HIV-infected subjects. Clin Immunol. 2005 Dec;117(3):294-301. doi: 10.1016/j.clim.2005.09.009. Epub 2005 Nov 11. PubMed PMID: 16290071.
Smith PA, Kohli LM, Wood KL, Hage CA, Twigg HL 3rd, Knox KS. Cytometric analysis of BAL T cells labeled with a standardized antibody cocktail correlates with immunohistochemical staining. Cytometry B Clin Cytom. 2006 May;70(3):170-8. doi: 10.1002/cyto.b.20101. PubMed PMID: 16568476.
Knox KS, Day RB, Kohli LM, Hage CA, Twigg HL 3rd. Functional impairment of CD4 T cells despite normalization of T cell number in HIV. Cell Immunol. 2006 Jul;242(1):46-51. doi: 10.1016/j.cellimm.2006.09.003. Epub 2006 Oct 30. PubMed PMID: 17070790; PubMed Central PMCID: PMC1821122.
Twigg HL 3rd, Knox KS. HIV-Related Lung Disorders. Drug Discov Today Dis Mech. 2007;4(2):95-101. doi: 10.1016/j.ddmec.2007.11.001. PubMed PMID: 18709181; PubMed Central PMCID: PMC2516945.
Thornburg A, Abonour R, Smith P, Knox K, Twigg HL 3rd. Hypersensitivity pneumonitis-like syndrome associated with the use of lenalidomide. Chest. 2007 May;131(5):1572-4. doi: 10.1378/chest.06-1734. PubMed PMID: 17494808.
Eagan R, Twigg HL 3rd, French N, Musaya J, Day RB, Zijlstra EE, Tolmie H, Wyler D, Molyneux ME, Gordon SB. Lung fluid immunoglobulin from HIV-infected subjects has impaired opsonic function against pneumococci. Clin Infect Dis. 2007 Jun 15;44(12):1632-8. doi: 10.1086/518133. Epub 2007 May 10. PubMed PMID: 17516409.
Twigg Iii HL, Weiden M, Valentine F, Schnizlein-Bick CT, Bassett R, Zheng L, Wheat J, Day RB, Rominger H, Collman RG, Fox L, Brizz B, Dragavon J, Coombs RW, Bucy RP. Effect of highly active antiretroviral therapy on viral burden in the lungs of HIV-infected subjects. J Infect Dis. 2008 Jan 1;197(1):109-16. doi: 10.1086/523766. PubMed PMID: 18171293.
Brenchley JM, Knox KS, Asher AI, Price DA, Kohli LM, Gostick E, Hill BJ, Hage CA, Brahmi Z, Khoruts A, Twigg HL 3rd, Schacker TW, Douek DC. High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage. Mucosal Immunol. 2008 Jan;1(1):49-58. doi: 10.1038/mi.2007.5. PubMed PMID: 19079160; PubMed Central PMCID: PMC2777611.
Petrache I, Diab K, Knox KS, Twigg HL 3rd, Stephens RS, Flores S, Tuder RM. HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism. Thorax. 2008 May;63(5):463-9. doi: 10.1136/thx.2007.079111. Review. PubMed PMID: 18443163.
Wood KL, Twigg HL 3rd, Doseff AI. Dysregulation of CD8+ lymphocyte apoptosis, chronic disease, and immune regulation. Front Biosci (Landmark Ed). 2009 Jan 1;14(10):3771-81. doi: 10.2741/3487. Review. PubMed PMID: 19273309; PubMed Central PMCID: PMC2740383.
Heath L, Fox A, McClure J, Diem K, van 't Wout AB, Zhao H, Park DR, Schouten JT, Twigg HL, Corey L, Mullins JI, Mittler JE. Evidence for limited genetic compartmentalization of HIV-1 between lung and blood. PLoS One. 2009 Sep 14;4(9):e6949. doi: 10.1371/journal.pone.0006949. PubMed PMID: 19759830; PubMed Central PMCID: PMC2736399.
Twigg HL, Schnizlein-Bick CT, Weiden M, Valentine F, Wheat J, Day RB, Rominger H, Zheng L, Collman RG, Coombs RW, Bucy RP, Rezk NL, Kashuba AD. Measurement of antiretroviral drugs in the lungs of HIV-infected patients. HIV Ther. 2010 Mar 1;4(2):247-251. doi: 10.2217/hiv.10.5. PubMed PMID: 20436781; PubMed Central PMCID: PMC2861507.
Knox KS, Vinton C, Hage CA, Kohli LM, Twigg HL 3rd, Klatt NR, Zwickl B, Waltz J, Goldman M, Douek DC, Brenchley JM. Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy. J Virol. 2010 Sep;84(18):9010-8. doi: 10.1128/JVI.01138-10. Epub 2010 Jul 7. PubMed PMID: 20610726; PubMed Central PMCID: PMC2937631.
Petrusca DN, Gu Y, Adamowicz JJ, Rush NI, Hubbard WC, Smith PA, Berdyshev EV, Birukov KG, Lee CH, Tuder RM, Twigg HL 3rd, Vandivier RW, Petrache I. Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages. J Biol Chem. 2010 Dec 17;285(51):40322-32. doi: 10.1074/jbc.M110.137604. Epub 2010 Oct 18. PubMed PMID: 20956540; PubMed Central PMCID: PMC3001012.
Morris A, Crothers K, Beck JM, Huang L. An official ATS workshop report: Emerging issues and current controversies in HIV-associated pulmonary diseases. Proc Am Thorac Soc. 2011 Mar;8(1):17-26. doi: 10.1513/pats.2009-047WS. Review. PubMed PMID: 21364216; PubMed Central PMCID: PMC5830656.
Clauss M, Voswinckel R, Rajashekhar G, Sigua NL, Fehrenbach H, Rush NI, Schweitzer KS, Yildirim AÖ, Kamocki K, Fisher AJ, Gu Y, Safadi B, Nikam S, Hubbard WC, Tuder RM, Twigg HL 3rd, Presson RG, Sethi S, Petrache I. Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice. J Clin Invest. 2011 Jun;121(6):2470-9. doi: 10.1172/JCI43881. Epub 2011 May 16. PubMed PMID: 21576822; PubMed Central PMCID: PMC3104742.
Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med. 2013 May 15;187(10):1067-75. doi: 10.1164/rccm.201210-1913OC. PubMed PMID: 23491408; PubMed Central PMCID: PMC3734620.
Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med. 2013 May 15;187(10):1110-7. doi: 10.1164/rccm.201211-2145OC. PubMed PMID: 23392441; PubMed Central PMCID: PMC3734615.
Twigg HL 3rd, Knox KS. Impact of antiretroviral therapy on lung immunology and inflammation. Clin Chest Med. 2013 Jun;34(2):155-64. doi: 10.1016/j.ccm.2013.01.004. Epub 2013 Apr 8. Review. PubMed PMID: 23702167; PubMed Central PMCID: PMC3664015.
Twigg HL 3rd, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G. Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. Lancet Respir Med. 2013 Jul;1(5):354-6. doi: 10.1016/S2213-2600(13)70117-6. Epub 2013 Jul 8. PubMed PMID: 24429191.
Twigg 3rd HL, Nelson DE, Day RB, Gregory R, Dong Q, Rong R, Knox K, Crothers K, Sodergren E, Weinstock GW. Comparison of Whole and Acellular Bronchoalveolar Lavage to Oral Wash Microbiomes. Should Acellular Bronchoalveolar Lavage be the Standard?. Annals of the American Thoracic Society. 2014; 11:S72-S73.
Gupta S, Smith P, Twigg Iii HL, Hage CA. Bronchoalveolar lavage cellular patterns in monoclonal antibody-induced lung disease. Respiration. 2014;88(3):185-9. doi: 10.1159/000362521. Epub 2014 Jun 13. PubMed PMID: 24942974.
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