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Bartels S, Faisal M, Büsche G, Schlue J, Hasemeier B, Schipper E, Vogtmann J, Westphal L, Lehmann U, Kreipe H. Mutations associated with age-related clonal hematopoiesis in PMF patients with rapid progression to myelofibrosis. Leukemia. 2019 Nov 27;. doi: 10.1038/s41375-019-0668-5. [Epub ahead of print] PubMed PMID: 31776465.
Pfarr N, Kirchner M, Lehmann U, Leichsenring J, Merkelbach-Bruse S, Glade J, Hummel M, Stögbauer F, Lehmann A, Trautmann M, Kumbrink J, Jung A, Dietmaier W, Endris V, Kazdal D, Evert M, Horst D, Kreipe H, Kirchner T, Wardelmann E, Lassen U, Büttner R, Weichert W, Dietel M, Schirmacher P, Stenzinger A. Testing NTRK testing: Wet-lab and in silico comparison of RNA-based targeted sequencing assays. Genes Chromosomes Cancer. 2019 Oct 25;. doi: 10.1002/gcc.22819. [Epub ahead of print] PubMed PMID: 31652375.
Christians A, Adel-Horowski A, Banan R, Lehmann U, Bartels S, Behling F, Barrantes-Freer A, Stadelmann C, Rohde V, Stockhammer F, Hartmann C. The prognostic role of IDH mutations in homogeneously treated patients with anaplastic astrocytomas and glioblastomas. Acta Neuropathol Commun. 2019 Oct 17;7(1):156. doi: 10.1186/s40478-019-0817-0. PubMed PMID: 31623667; PubMed Central PMCID: PMC6798425.
Anwar SL, Hasemeier B, Schipper E, Vogel A, Kreipe H, Lehmann U. LINE-1 hypomethylation in human hepatocellular carcinomas correlates with shorter overall survival and CIMP phenotype. PLoS One. 2019;14(5):e0216374. doi: 10.1371/journal.pone.0216374. eCollection 2019. PubMed PMID: 31059558; PubMed Central PMCID: PMC6502450.
Lehmann U, Bartels S. [Liquid biopsy in tumor diagnostics : Applications, perspectives, and limitations of the "cancer liquidome"]. Pathologe. 2019 May 2;. doi: 10.1007/s00292-019-0604-5. [Epub ahead of print] Review. PubMed PMID: 31049676.
Faisal M, Büsche G, Schlue J, Kreipe H, Lehmann U, Bartels S. RNA-binding protein (RBFOX1) inherited polymorphism rs8051518 is not associated with splice factor mutations in myelodysplastic syndromes and myeloproliferative neoplasms. Ann Hematol. 2019 May;98(5):1297-1299. doi: 10.1007/s00277-018-3478-3. Epub 2018 Aug 29. PubMed PMID: 30159600.
Feist H, Brüschke C, Lehmann U, Blöcker T, Gbur K, Peters J, Müller AM. Discordancy for a Villous Maturation Defect in a Dizygotic Twin Placenta. Fetal Pediatr Pathol. 2019 Apr 26;:1-5. doi: 10.1080/15513815.2019.1604924. [Epub ahead of print] PubMed PMID: 31025579.
Leichsenring J, Horak P, Kreutzfeldt S, Heining C, Christopoulos P, Volckmar AL, Neumann O, Kirchner M, Ploeger C, Budczies J, Heilig CE, Hutter B, Fröhlich M, Uhrig S, Kazdal D, Allgäuer M, Harms A, Rempel E, Lehmann U, Thomas M, Pfarr N, Azoitei N, Bonzheim I, Marienfeld R, Möller P, Werner M, Fend F, Boerries M, von Bubnoff N, Lassmann S, Longerich T, Bitzer M, Seufferlein T, Malek N, Weichert W, Schirmacher P, Penzel R, Endris V, Brors B, Klauschen F, Glimm H, Fröhling S, Stenzinger A. Variant classification in precision oncology. Int J Cancer. 2019 Apr 22;. doi: 10.1002/ijc.32358. [Epub ahead of print] PubMed PMID: 31008532.
Korth J, Anastasiou OE, Bräsen JH, Brinkhoff A, Lehmann U, Kribben A, Dittmer U, Verheyen J, Wilde B, Ciesek S, Witzke O, Widera M. The detection of BKPyV genotypes II and IV after renal transplantation as a simple tool for risk assessment for PyVAN and transplant outcome already at early stages of BKPyV reactivation. J Clin Virol. 2019 Apr;113:14-19. doi: 10.1016/j.jcv.2019.02.002. Epub 2019 Feb 10. PubMed PMID: 30771597.
Christgen M, Bartels S, Radner M, Raap M, Rieger L, Christgen H, Gluz O, Nitz U, Harbeck N, Lehmann U, Kreipe H. ERBB2 mutation frequency in lobular breast cancer with pleomorphic histology or high-risk characteristics by molecular expression profiling. Genes Chromosomes Cancer. 2019 Mar;58(3):175-185. doi: 10.1002/gcc.22716. Epub 2019 Jan 7. PubMed PMID: 30520184.
Faisal M, Stark H, Büsche G, Schlue J, Teiken K, Kreipe HH, Lehmann U, Bartels S. Comprehensive mutation profiling and mRNA expression analysis in atypical chronic myeloid leukemia in comparison with chronic myelomonocytic leukemia. Cancer Med. 2019 Feb;8(2):742-750. doi: 10.1002/cam4.1946. Epub 2019 Jan 11. PubMed PMID: 30635983; PubMed Central PMCID: PMC6382710.
Dugge R, Kreipe H, Rosenwald A, Lehmann U, Möller P, Barth TFE, Erlemann R. Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis. Ann Hematol. 2019 Feb;98(2):515-517. doi: 10.1007/s00277-018-3434-2. Epub 2018 Jul 7. PubMed PMID: 29982850.
Christgen M, Bartels S, Luft A, Persing S, Henkel D, Lehmann U, Kreipe H. Activating human epidermal growth factor receptor 2 (HER2) gene mutation in bone metastases from breast cancer. Virchows Arch. 2018 Nov;473(5):577-582. doi: 10.1007/s00428-018-2414-1. Epub 2018 Aug 9. PubMed PMID: 30094493.
Hong B, Banan R, Christians A, Nakamura M, Lalk M, Lehmann U, Hartmann C, Krauss JK. Cerebellar glioblastoma: a clinical series with contemporary molecular analysis. Acta Neurochir (Wien). 2018 Nov;160(11):2237-2248. doi: 10.1007/s00701-018-3673-y. Epub 2018 Sep 10. PubMed PMID: 30203362.
Granit RZ, Masury H, Condiotti R, Fixler Y, Gabai Y, Glikman T, Dalin S, Winter E, Nevo Y, Carmon E, Sella T, Sonnenblick A, Peretz T, Lehmann U, Paz K, Piccioni F, Regev A, Root DE, Ben-Porath I. Regulation of Cellular Heterogeneity and Rates of Symmetric and Asymmetric Divisions in Triple-Negative Breast Cancer. Cell Rep. 2018 Sep 18;24(12):3237-3250. doi: 10.1016/j.celrep.2018.08.053. PubMed PMID: 30232005.
Bartels S, Schipper E, Hasemeier B, Kreipe H, Lehmann U. Hotspot mutations in cancer genes may be missed in routine diagnostics due to neighbouring sequence variants. Exp Mol Pathol. 2018 Aug;105(1):37-40. doi: 10.1016/j.yexmp.2018.05.010. Epub 2018 May 27. PubMed PMID: 29847769.
Schacht V, Lehmann U, Reineke-Plaass T, Länger F, Auber B, Morlot S, Kreipe HH. [Possibilities and limitations of molecular pathology in dermatohistology]. Hautarzt. 2018 Jul;69(7):563-569. doi: 10.1007/s00105-018-4206-6. Review. PubMed PMID: 29876610.
Scholz C, Golas MM, Weber RG, Hartmann C, Lehmann U, Sahm F, Schmidt G, Auber B, Sturm M, Schlegelberger B, Illig T, Steinemann D, Hofmann W. Rare compound heterozygous variants in PNKP identified by whole exome sequencing in a German patient with ataxia-oculomotor apraxia 4 and pilocytic astrocytoma. Clin Genet. 2018 Jul;94(1):185-186. doi: 10.1111/cge.13216. Epub 2018 Mar 2. PubMed PMID: 29498415.
Bartels S, van Luttikhuizen JL, Christgen M, Mägel L, Luft A, Hänzelmann S, Lehmann U, Schlegelberger B, Leo F, Steinemann D, Kreipe H. CDKN2A loss and PIK3CA mutation in myoepithelial-like metaplastic breast cancer. J Pathol. 2018 Jul;245(3):373-383. doi: 10.1002/path.5091. Epub 2018 May 28. PubMed PMID: 29708279.
Bartels S, Adisa A, Aladelusi T, Lemound J, Stucki-Koch A, Hussein S, Kreipe H, Hartmann C, Lehmann U, Hussein K. Molecular defects in BRAF wild-type ameloblastomas and craniopharyngiomas-differences in mutation profiles in epithelial-derived oropharyngeal neoplasms. Virchows Arch. 2018 Jun;472(6):1055-1059. doi: 10.1007/s00428-018-2323-3. Epub 2018 Mar 15. PubMed PMID: 29546640.
Bartels S, Faisal M, Büsche G, Schlue J, Kreipe H, Lehmann U. Fibrotic progression in Polycythemia vera is associated with early concomitant driver-mutations besides JAK2. Leukemia. 2018 Feb;32(2):556-558. doi: 10.1038/leu.2017.298. Epub 2017 Sep 22. PubMed PMID: 28935989.
Anwar SL, Lehmann U. Detection of Aberrant DNA Methylation Patterns in the RB1 Gene. Methods Mol Biol. 2018;1726:35-47. doi: 10.1007/978-1-4939-7565-5_5. PubMed PMID: 29468542.
Mägel L, Bartels S, Lehmann U. Next-Generation Sequencing Analysis of Laser-Microdissected Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Specimens. Methods Mol Biol. 2018;1723:111-118. doi: 10.1007/978-1-4939-7558-7_5. PubMed PMID: 29344856.
Raap M, Gronewold M, Christgen H, Glage S, Bentires-Alj M, Koren S, Derksen PW, Boelens M, Jonkers J, Lehmann U, Feuerhake F, Kuehnle E, Gluz O, Kates R, Nitz U, Harbeck N, Kreipe HH, Christgen M. Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2β. Lab Invest. 2018 Jan;98(1):117-129. doi: 10.1038/labinvest.2017.106. Epub 2017 Oct 16. PubMed PMID: 29035379.
Bartels S, Christgen M, Luft A, Persing S, Jödecke K, Lehmann U, Kreipe H. Estrogen receptor (ESR1) mutation in bone metastases from breast cancer. Mod Pathol. 2018 Jan;31(1):56-61. doi: 10.1038/modpathol.2017.95. Epub 2017 Aug 11. PubMed PMID: 28799536.
Banan R, Christians A, Bartels S, Lehmann U, Hartmann C. Absence of MGMT promoter methylation in diffuse midline glioma, H3 K27M-mutant. Acta Neuropathol Commun. 2017 Dec 15;5(1):98. doi: 10.1186/s40478-017-0500-2. PubMed PMID: 29246238; PubMed Central PMCID: PMC5732448.
Fassunke J, Ihle MA, Lenze D, Lehmann A, Hummel M, Vollbrecht C, Penzel R, Volckmar AL, Stenzinger A, Endris V, Jung A, Lehmann U, Zeugner S, Baretton G, Kreipe H, Schirmacher P, Kirchner T, Dietel M, Büttner R, Merkelbach-Bruse S. EGFR T790M mutation testing of non-small cell lung cancer tissue and blood samples artificially spiked with circulating cell-free tumor DNA: results of a round robin trial. Virchows Arch. 2017 Oct;471(4):509-520. doi: 10.1007/s00428-017-2226-8. Epub 2017 Sep 8. PubMed PMID: 28884371.
Bartels S, Persing S, Hasemeier B, Schipper E, Kreipe H, Lehmann U. Molecular Analysis of Circulating Cell-Free DNA from Lung Cancer Patients in Routine Laboratory Practice: A Cross-Platform Comparison of Three Different Molecular Methods for Mutation Detection. J Mol Diagn. 2017 Sep;19(5):722-732. doi: 10.1016/j.jmoldx.2017.05.008. Epub 2017 Jul 16. PubMed PMID: 28723342.
Christgen M, Bartels S, van Luttikhuizen JL, Schieck M, Pertschy S, Kundu S, Lehmann U, Sander B, Pelz E, Länger F, Schlegelberger B, Steinemann D, Kreipe H. Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid-papillary carcinoma. J Pathol Clin Res. 2017 Jul;3(3):191-202. doi: 10.1002/cjp2.76. eCollection 2017 Jul. PubMed PMID: 28770103; PubMed Central PMCID: PMC5527319.
Kröger N, Panagiota V, Badbaran A, Zabelina T, Triviai I, Araujo Cruz MM, Shahswar R, Ayuk F, Gehlhaar M, Wolschke C, Bollin R, Walter C, Dugas M, Wiehlmann L, Lehmann U, Koenecke C, Chaturvedi A, Alchalby H, Stadler M, Eder M, Christopeit M, Göhring G, Koenigsmann M, Schlegelberger B, Kreipe HH, Ganser A, Stocking C, Fehse B, Thol F, Heuser M. Impact of Molecular Genetics on Outcome in Myelofibrosis Patients after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2017 Jul;23(7):1095-1101. doi: 10.1016/j.bbmt.2017.03.034. Epub 2017 Apr 4. PubMed PMID: 28389256.
Anwar SL, Wulaningsih W, Lehmann U. Transposable Elements in Human Cancer: Causes and Consequences of Deregulation. Int J Mol Sci. 2017 May 4;18(5). doi: 10.3390/ijms18050974. Review. PubMed PMID: 28471386; PubMed Central PMCID: PMC5454887.
Anwar SL, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A, Kreipe H, Buurman R, Skawran B, Lehmann U. hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma. World J Gastroenterol. 2017 Mar 7;23(9):1568-1575. doi: 10.3748/wjg.v23.i9.1568. PubMed PMID: 28321157; PubMed Central PMCID: PMC5340808.
Wimmer K, Beilken A, Nustede R, Ripperger T, Lamottke B, Ure B, Steinmann D, Reineke-Plaass T, Lehmann U, Zschocke J, Valle L, Fauth C, Kratz CP. A novel germline POLE mutation causes an early onset cancer prone syndrome mimicking constitutional mismatch repair deficiency. Fam Cancer. 2017 Jan;16(1):67-71. doi: 10.1007/s10689-016-9925-1. PubMed PMID: 27573199; PubMed Central PMCID: PMC5243902.
Loosen SH, Schmeding M, Roderburg C, Binnebösel M, Temizel I, Mottaghy FM, Tischendorf JJ, Tacke F, Gaisa NT, Hussein K, Lehmann U, Trautwein C, Neumann UP, Luedde T. A liver nodule in a patient transplanted for primary sclerosing cholangitis: an interdisciplinary diagnostic approach. Z Gastroenterol. 2017 Jan;55(1):56-62. doi: 10.1055/s-0042-111048. Epub 2016 Oct 5. PubMed PMID: 27706546.
Christgen M, van Luttikhuizen JL, Raap M, Braubach P, Schmidt L, Jonigk D, Feuerhake F, Lehmann U, Schlegelberger B, Kreipe HH, Steinemann D. Precise ERBB2 copy number assessment in breast cancer by means of molecular inversion probe array analysis. Oncotarget. 2016 Dec 13;7(50):82733-82740. doi: 10.18632/oncotarget.12421. PubMed PMID: 27716627; PubMed Central PMCID: PMC5347728.
Dietmaier W, Merkelbach-Bruse S, Jung A, Lehmann U. [Report on sessions and the general meeting of the working group Molecular Pathology]. Pathologe. 2016 Nov;37(Suppl 2):249-252. doi: 10.1007/s00292-016-0191-7. PubMed PMID: 27638533.
Leo F, Bartels S, Mägel L, Framke T, Büsche G, Jonigk D, Christgen M, Lehmann U, Kreipe H. Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer. Virchows Arch. 2016 Aug;469(2):191-201. doi: 10.1007/s00428-016-1950-9. Epub 2016 May 25. PubMed PMID: 27220763; PubMed Central PMCID: PMC4978764.
Bartels S, Lehmann U, Büsche G, Schlue J, Kreipe H. Evolution of chronic myelomonocytic leukemia to myeloproliferative neoplasm. Ann Hematol. 2016 Aug;95(8):1377-80. doi: 10.1007/s00277-016-2699-6. Epub 2016 May 25. PubMed PMID: 27220638.
Endris V, Stenzinger A, Pfarr N, Penzel R, Möbs M, Lenze D, Darb-Esfahani S, Hummel M, Sabine-Merkelbach-Bruse, Jung A, Lehmann U, Kreipe H, Kirchner T, Büttner R, Jochum W, Höfler G, Dietel M, Weichert W, Schirmacher P. NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial. Virchows Arch. 2016 Jun;468(6):697-705. doi: 10.1007/s00428-016-1919-8. Epub 2016 Mar 22. PubMed PMID: 27003155.
Bartels S, Schipper E, Hasemeier B, Kreipe H, Lehmann U. Routine clinical mutation profiling using next generation sequencing and a customized gene panel improves diagnostic precision in myeloid neoplasms. Oncotarget. 2016 May 24;7(21):30084-93. doi: 10.18632/oncotarget.8310. Review. PubMed PMID: 27029036; PubMed Central PMCID: PMC5058665.
Dietmaier W, Weichert W, Wickenhauser C, Lehmann U. [Report of the meeting and the general assembly of the working group on molecular pathology]. Pathologe. 2015 Nov;36 Suppl 2:234-6. doi: 10.1007/s00292-015-0067-2. PubMed PMID: 26391243.
Anwar SL, Krech T, Hasemeier B, Schipper E, Schweitzer N, Vogel A, Kreipe H, Lehmann U. Loss of DNA methylation at imprinted loci is a frequent event in hepatocellular carcinoma and identifies patients with shortened survival. Clin Epigenetics. 2015;7:110. doi: 10.1186/s13148-015-0145-6. eCollection 2015. PubMed PMID: 26473022; PubMed Central PMCID: PMC4606497.
van Agthoven T, Dorssers LC, Lehmann U, Kreipe H, Looijenga LH, Christgen M. Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives Proliferation of IPH-926 lobular Carcinoma Cells. PLoS One. 2015;10(8):e0136845. doi: 10.1371/journal.pone.0136845. eCollection 2015. PubMed PMID: 26317614; PubMed Central PMCID: PMC4552740.
Anwar SL, Lehmann U. MicroRNAs: Emerging Novel Clinical Biomarkers for Hepatocellular Carcinomas. J Clin Med. 2015 Aug 18;4(8):1631-50. doi: 10.3390/jcm4081631. Review. PubMed PMID: 26295264; PubMed Central PMCID: PMC4555081.
Schlegelberger B, Kreipe H, Lehmann U, Steinemann D, Ripperger T, Göhring G, Thomay K, Rump A, Di Donato N, Suttorp M. A child with Li-Fraumeni syndrome: Modes to inactivate the second allele of TP53 in three different malignancies. Pediatr Blood Cancer. 2015 Aug;62(8):1481-4. doi: 10.1002/pbc.25486. Epub 2015 Mar 18. PubMed PMID: 25787918.
Bartels S, Schipper E, Kreipe HH, Lehmann U. Comprehensive Molecular Profiling of Archival Bone Marrow Trephines Using a Commercially Available Leukemia Panel and Semiconductor-Based Targeted Resequencing. PLoS One. 2015;10(7):e0133930. doi: 10.1371/journal.pone.0133930. eCollection 2015. PubMed PMID: 26222071; PubMed Central PMCID: PMC4519100.
Lehmann U. Lobular breast cancer--the most common special subtype or a most special common subtype?. Breast Cancer Res. 2015 Jul 28;17:99. doi: 10.1186/s13058-015-0606-z. PubMed PMID: 26215581; PubMed Central PMCID: PMC4531830.
Bartels S, Lehmann U, Büsche G, Schlue J, Hussein K, Debatin D, Karcher A, Andrulis M, Schirmacher P, Kreipe H. De novo CSF3R mutation associated with transformation of myeloproliferative neoplasm to atypical CML. Ann Hematol. 2015 Jul;94(7):1255-6. doi: 10.1007/s00277-015-2366-3. Epub 2015 Apr 14. PubMed PMID: 25865944.
Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grässer F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM. Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma. Clin Sci (Lond). 2015 Jun;128(11):761-74. doi: 10.1042/CS20140606. PubMed PMID: 25602745.
Solbach P, Potthoff A, Raatschen HJ, Soudah B, Lehmann U, Schneider A, Gebel MJ, Manns MP, Vogel A. Testosterone-receptor positive hepatocellular carcinoma in a 29-year old bodybuilder with a history of anabolic androgenic steroid abuse: a case report. BMC Gastroenterol. 2015 May 20;15:60. doi: 10.1186/s12876-015-0288-0. PubMed PMID: 25986067; PubMed Central PMCID: PMC4461943.
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