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Wong A, Kean L, Maurer R. Sequence of the dnaB gene of Salmonella typhimurium. J Bacteriol. 1988 Jun;170(6):2668-75. doi: 10.1128/jb.170.6.2668-2675.1988. PubMed PMID: 2836367; PubMed Central PMCID: PMC211186.
Kean LS, Fuller RS, Nichols JW. Retrograde lipid traffic in yeast: identification of two distinct pathways for internalization of fluorescent-labeled phosphatidylcholine from the plasma membrane. J Cell Biol. 1993 Dec;123(6 Pt 1):1403-19. doi: 10.1083/jcb.123.6.1403. PubMed PMID: 8253840; PubMed Central PMCID: PMC2290883.
Kean LS, Grant AM, Angeletti C, Mahé Y, Kuchler K, Fuller RS, Nichols JW. Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. J Cell Biol. 1997 Jul 28;138(2):255-70. doi: 10.1083/jcb.138.2.255. PubMed PMID: 9230069; PubMed Central PMCID: PMC2138184.
Olney PN, Kean LS, Graham D, Elsas LJ, May KM. Campomelic syndrome and deletion of SOX9. Am J Med Genet. 1999 May 7;84(1):20-4. PubMed PMID: 10213041.
Adams AB, Durham MM, Kean L, Shirasugi N, Ha J, Williams MA, Rees PA, Cheung MC, Mittelstaedt S, Bingaman AW, Archer DR, Pearson TC, Waller EK, Larsen CP. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression. J Immunol. 2001 Jul 15;167(2):1103-11. doi: 10.4049/jimmunol.167.2.1103. PubMed PMID: 11441122.
Kean LS, Durham MM, Adams AB, Hsu LL, Perry JR, Dillehay D, Pearson TC, Waller EK, Larsen CP, Archer DR. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood. 2002 Mar 1;99(5):1840-9. doi: 10.1182/blood.v99.5.1840. PubMed PMID: 11861303.
Kean LS, Brown LE, Nichols JW, Mohandas N, Archer DR, Hsu LL. Comparison of mechanisms of anemia in mice with sickle cell disease and beta-thalassemia: peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure. Exp Hematol. 2002 May;30(5):394-402. doi: 10.1016/s0301-472x(02)00780-4. PubMed PMID: 12031645.
Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003 Dec 15;102(13):4582-93. doi: 10.1182/blood-2003-03-0712. Epub 2003 Aug 21. PubMed PMID: 12933586.
Roberts C, Kean L, Archer D, Balkan C, Hsu LL. Murine and math models for the level of stable mixed chimerism to cure beta-thalassemia by nonmyeloablative bone marrow transplantation. Ann N Y Acad Sci. 2005;1054:423-8. doi: 10.1196/annals.1345.061. PubMed PMID: 16339691.
Kean LS, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams AB, Heiss E, Pearson TC, Larsen CP. NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation. Am J Transplant. 2006 Feb;6(2):292-304. doi: 10.1111/j.1600-6143.2005.01172.x. PubMed PMID: 16426313.
Kean LS, Gangappa S, Pearson TC, Larsen CP. Transplant tolerance in non-human primates: progress, current challenges and unmet needs. Am J Transplant. 2006 May;6(5 Pt 1):884-93. doi: 10.1111/j.1600-6143.2006.01260.x. Review. PubMed PMID: 16611324.
Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP. Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression. Am J Transplant. 2007 Feb;7(2):320-35. doi: 10.1111/j.1600-6143.2006.01622.x. PubMed PMID: 17241112.
Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW. Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation. 2007 Jul 27;84(2):196-206. doi: 10.1097/ PubMed PMID: 17667811.
Hamby K, Trexler A, Pearson TC, Larsen CP, Rigby MR, Kean LS. NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism. Am J Transplant. 2007 Aug;7(8):1884-96. doi: 10.1111/j.1600-6143.2007.01864.x. PubMed PMID: 17617852.
Stapler D, Lee ED, Selvaraj SA, Evans AG, Kean LS, Speck SH, Larsen CP, Gangappa S. Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance. J Immunol. 2008 Mar 1;180(5):3190-200. doi: 10.4049/jimmunol.180.5.3190. PubMed PMID: 18292543.
Anderson A, Martens CL, Hendrix R, Stempora LL, Miller WP, Hamby K, Russell M, Strobert E, Blazar BR, Pearson TC, Larsen CP, Kean LS. Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses. Am J Transplant. 2008 Nov;8(11):2252-64. doi: 10.1111/j.1600-6143.2008.02376.x. Epub 2008 Sep 17. PubMed PMID: 18801023; PubMed Central PMCID: PMC2874242.
Ferguson B, Capitanio J, Folks T, Hotchkiss C, Johnson Z, Kean L, Kubisch HM, Lank S, Lyons L, Miller GM, Nylander J, O'Connor D, Vallender EJ, Wiseman R. Resource brief: the National Non-Human Primate DNA Bank. Methods. 2009 Sep;49(1):3-4. doi: 10.1016/j.ymeth.2009.07.011. PubMed PMID: 19706346; PubMed Central PMCID: PMC3172814.
Kanthaswamy S, Capitanio JP, Dubay CJ, Ferguson B, Folks T, Ha JC, Hotchkiss CE, Johnson ZP, Katze MG, Kean LS, Kubisch HM, Lank S, Lyons LA, Miller GM, Nylander J, O'Connor DH, Palermo RE, Smith DG, Vallender EJ, Wiseman RW, Rogers J. Resources for genetic management and genomics research on non-human primates at the National Primate Research Centers (NPRCs). J Med Primatol. 2009 Oct;38 Suppl 1:17-23. doi: 10.1111/j.1600-0684.2009.00371.x. PubMed PMID: 19863674.
Larsen CP, Page A, Linzie KH, Russell M, Deane T, Stempora L, Strobert E, Penedo MC, Ward T, Wiseman R, O'Connor D, Miller W, Sen S, Singh K, Kean LS. An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching. Am J Transplant. 2010 Nov;10(11):2396-409. doi: 10.1111/j.1600-6143.2010.03272.x. Epub 2010 Sep 17. PubMed PMID: 20849552; PubMed Central PMCID: PMC2980834.
Miller WP, Srinivasan S, Panoskaltsis-Mortari A, Singh K, Sen S, Hamby K, Deane T, Stempora L, Beus J, Turner A, Wheeler C, Anderson DC, Sharma P, Garcia A, Strobert E, Elder E, Crocker I, Crenshaw T, Penedo MC, Ward T, Song M, Horan J, Larsen CP, Blazar BR, Kean LS. GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression. Blood. 2010 Dec 9;116(24):5403-18. doi: 10.1182/blood-2010-06-289272. Epub 2010 Sep 10. PubMed PMID: 20833977; PubMed Central PMCID: PMC3012549.
Kean LS, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, Bonifacino AC, Metzger ME, Promislow DE, Mattapallil JJ, Donahue RE. Significant mobilization of both conventional and regulatory T cells with AMD3100. Blood. 2011 Dec 15;118(25):6580-90. doi: 10.1182/blood-2011-06-359331. Epub 2011 Oct 11. PubMed PMID: 21989987; PubMed Central PMCID: PMC3242720.
Page A, Srinivasan S, Singh K, Russell M, Hamby K, Deane T, Sen S, Stempora L, Leopardi F, Price AA, Strobert E, Reimann KA, Kirk AD, Larsen CP, Kean LS. CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model. Am J Transplant. 2012 Jan;12(1):115-25. doi: 10.1111/j.1600-6143.2011.03737.x. Epub 2011 Sep 19. PubMed PMID: 21929643; PubMed Central PMCID: PMC3259212.
Hendrickson JE, Hod EA, Perry JR, Ghosh S, Chappa P, Adisa O, Kean LS, Ofori-Acquah SF, Archer DR, Spitalnik SL, Zimring JC. Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease. Transfusion. 2012 Feb;52(2):231-40. doi: 10.1111/j.1537-2995.2011.03255.x. Epub 2011 Jul 25. PubMed PMID: 21790627; PubMed Central PMCID: PMC3218203.
Kean LS, Singh K, Blazar BR, Larsen CP. Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old. Am J Transplant. 2012 Apr;12(4):812-9. doi: 10.1111/j.1600-6143.2011.03873.x. Epub 2011 Dec 17. Review. PubMed PMID: 22177005; PubMed Central PMCID: PMC3482466.
Johnson ZP, Eady RD, Ahmad SF, Agravat S, Morris T, Else J, Lank SM, Wiseman RW, O'Connor DH, Penedo MC, Larsen CP, Kean LS. Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets. Immunogenetics. 2012 Apr;64(4):329-36. doi: 10.1007/s00251-011-0587-8. Epub 2011 Nov 15. PubMed PMID: 22080300; PubMed Central PMCID: PMC3514553.
Singh K, Kozyr N, Stempora L, Kirk AD, Larsen CP, Blazar BR, Kean LS. Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus. Am J Transplant. 2012 Jun;12(6):1441-57. doi: 10.1111/j.1600-6143.2011.03963.x. Epub 2012 Feb 2. PubMed PMID: 22300641; PubMed Central PMCID: PMC3471086.
Ramakrishnan SK, Page A, Farris AB 3rd, Singh K, Leopardi F, Hamby K, Sen S, Polnett A, Deane T, Song M, Stempora L, Strobert E, Kirk AD, Larsen CP, Kean LS. Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. Am J Transplant. 2012 Jul;12(7):1755-64. doi: 10.1111/j.1600-6143.2012.04045.x. Epub 2012 May 29. PubMed PMID: 22642491; PubMed Central PMCID: PMC3387328.
Kean LS, Blazar BR. Cooking up tolerance: has a new recipe been created?. Am J Transplant. 2012 Jul;12(7):1667-9. doi: 10.1111/j.1600-6143.2012.04154.x. Epub 2012 Jun 15. PubMed PMID: 22702487; PubMed Central PMCID: PMC3482492.
Pearl JI, Kean LS, Davis MM, Wu JC. Pluripotent stem cells: immune to the immune system?. Sci Transl Med. 2012 Dec 12;4(164):164ps25. doi: 10.1126/scitranslmed.3005090. Review. PubMed PMID: 23241742; PubMed Central PMCID: PMC3638038.
Huang AY, Haining WN, Barkauskas DS, Myers JT, Petrosiute A, Garrett AP, Singh K, Cooke KR, Kean LS. Viewing transplantation immunology through today's lens: new models, new imaging, and new insights. Biol Blood Marrow Transplant. 2013 Jan;19(1 Suppl):S44-51. doi: 10.1016/j.bbmt.2012.10.020. Epub 2012 Oct 22. Review. PubMed PMID: 23092813; PubMed Central PMCID: PMC4437564.
Beus JM, Hashmi SS, Selvaraj SA, Duan D, Stempora LL, Monday SA, Cheeseman JA, Hamby KM, Speck SH, Larsen CP, Kirk AD, Kean LS. Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. PLoS One. 2013;8(8):e71221. doi: 10.1371/journal.pone.0071221. Print 2013. PubMed PMID: 23940724; PubMed Central PMCID: PMC3733932.
Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS. In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial. Biol Blood Marrow Transplant. 2013 Nov;19(11):1638-49. doi: 10.1016/j.bbmt.2013.09.003. Epub 2013 Sep 15. PubMed PMID: 24047754.
Kaliyaperumal S, Watkins B, Sharma P, Furlan S, Ramakrishnan S, Giver C, Garcia A, Courtney C, Knight H, Strobert E, Elder E, Crenshaw T, Blazar BR, Waller EK, Westmoreland S, Kean LS. CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis. Blood. 2014 Mar 20;123(12):1967-9. doi: 10.1182/blood-2014-01-547612. PubMed PMID: 24652969; PubMed Central PMCID: PMC3962171.
Kirk AD, Guasch A, Xu H, Cheeseman J, Mead SI, Ghali A, Mehta AK, Wu D, Gebel H, Bray R, Horan J, Kean LS, Larsen CP, Pearson TC. Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors. Am J Transplant. 2014 May;14(5):1142-51. doi: 10.1111/ajt.12712. Epub 2014 Mar 31. PubMed PMID: 24684552; PubMed Central PMCID: PMC4642731.
Mavigner M, Watkins B, Lawson B, Lee ST, Chahroudi A, Kean L, Silvestri G. Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant. PLoS Pathog. 2014 Sep;10(9):e1004406. doi: 10.1371/journal.ppat.1004406. eCollection 2014 Sep. PubMed PMID: 25254512; PubMed Central PMCID: PMC4177994.
Singh K, Stempora L, Harvey RD, Kirk AD, Larsen CP, Blazar BR, Kean LS. Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer. Am J Transplant. 2014 Dec;14(12):2691-703. doi: 10.1111/ajt.12934. Epub 2014 Oct 30. PubMed PMID: 25359003; PubMed Central PMCID: PMC4236286.
Nickel RS, Osunkwo I, Garrett A, Robertson J, Archer DR, Promislow DE, Horan JT, Hendrickson JE, Kean LS. Immune parameter analysis of children with sickle cell disease on hydroxycarbamide or chronic transfusion therapy. Br J Haematol. 2015 May;169(4):574-83. doi: 10.1111/bjh.13326. Epub 2015 Mar 5. PubMed PMID: 25753210; PubMed Central PMCID: PMC4668585.
Suessmuth Y, Mukherjee R, Watkins B, Koura DT, Finstermeier K, Desmarais C, Stempora L, Horan JT, Langston A, Qayed M, Khoury HJ, Grizzle A, Cheeseman JA, Conger JA, Robertson J, Garrett A, Kirk AD, Waller EK, Blazar BR, Mehta AK, Robins HS, Kean LS. CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire. Blood. 2015 Jun 18;125(25):3835-50. doi: 10.1182/blood-2015-03-631853. Epub 2015 Apr 7. PubMed PMID: 25852054; PubMed Central PMCID: PMC4473113.
Nickel RS, Hendrickson JE, Yee MM, Bray RA, Gebel HM, Kean LS, Miklos DB, Horan JT. Red blood cell transfusions are associated with HLA class I but not H-Y alloantibodies in children with sickle cell disease. Br J Haematol. 2015 Jul;170(2):247-56. doi: 10.1111/bjh.13424. Epub 2015 Apr 19. PubMed PMID: 25891976; PubMed Central PMCID: PMC4490004.
Furlan SN, Watkins B, Tkachev V, Flynn R, Cooley S, Ramakrishnan S, Singh K, Giver C, Hamby K, Stempora L, Garrett A, Chen J, Betz KM, Ziegler CG, Tharp GK, Bosinger SE, Promislow DE, Miller JS, Waller EK, Blazar BR, Kean LS. Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention. Sci Transl Med. 2015 Nov 25;7(315):315ra191. doi: 10.1126/scitranslmed.aad3231. PubMed PMID: 26606970; PubMed Central PMCID: PMC4876606.
Nickel RS, Horan JT, Fasano RM, Meyer E, Josephson CD, Winkler AM, Yee ME, Kean LS, Hendrickson JE. Immunophenotypic parameters and RBC alloimmunization in children with sickle cell disease on chronic transfusion. Am J Hematol. 2015 Dec;90(12):1135-41. doi: 10.1002/ajh.24188. Epub 2015 Oct 6. PubMed PMID: 26361243.
Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016 Jul 1;126(7):2642-60. doi: 10.1172/JCI85796. Epub 2016 Jun 13. PubMed PMID: 27294527; PubMed Central PMCID: PMC4922691.
Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, Brown M, Hunt DJ, Schell JB, Zeleski K, Yu A, Giver CR, Waller EK, Miller JS, Blazar BR, Kean LS. Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells. Blood. 2016 Nov 24;128(21):2568-2579. doi: 10.1182/blood-2016-07-726547. Epub 2016 Oct 6. PubMed PMID: 27758873; PubMed Central PMCID: PMC5123196.
Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR. Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease. Transplantation. 2016 Dec;100(12):2630-2639. doi: 10.1097/TP.0000000000001465. PubMed PMID: 27861291; PubMed Central PMCID: PMC5175408.
Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS. The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques. Am J Transplant. 2017 Mar;17(3):657-670. doi: 10.1111/ajt.14006. Epub 2016 Sep 19. PubMed PMID: 27500470; PubMed Central PMCID: PMC5338742.
Kean LS, Turka LA, Blazar BR. Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunol Rev. 2017 Mar;276(1):192-212. doi: 10.1111/imr.12523. Review. PubMed PMID: 28258702; PubMed Central PMCID: PMC5338458.
Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS. Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant. Sci Transl Med. 2017 Sep 20;9(408). doi: 10.1126/scitranslmed.aan3085. PubMed PMID: 28931653; PubMed Central PMCID: PMC5681253.
Hippen KL, O'Connor RS, Lemire AM, Saha A, Hanse EA, Tennis NC, Merkel SC, Kelekar A, Riley JL, Levine BL, June CH, Turka LA, Kean LS, MacMillan ML, Miller JS, Wagner JE, Munn DH, Blazar BR. In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines. Am J Transplant. 2017 Dec;17(12):3098-3113. doi: 10.1111/ajt.14338. Epub 2017 Jun 14. PubMed PMID: 28470889; PubMed Central PMCID: PMC5671378.
Perales MA, Kebriaei P, Kean LS, Sadelain M. Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR. Biol Blood Marrow Transplant. 2018 Jan;24(1):27-31. doi: 10.1016/j.bbmt.2017.10.017. Epub 2017 Oct 13. Review. PubMed PMID: 29032264; PubMed Central PMCID: PMC5901894.
Perales MA, Kebriaei P, Kean LS, Sadelain M. Reprint of: Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR. Biol Blood Marrow Transplant. 2018 Mar;24(3S):S15-S19. doi: 10.1016/j.bbmt.2017.12.789. Review. PubMed PMID: 29425516.
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