Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
  • Page of 1
Korswagen HC, van der Linden AM, Plasterk RH. G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration. EMBO J. 1998 Sep 1;17(17):5059-65. doi: 10.1093/emboj/17.17.5059. PubMed PMID: 9724641; PubMed Central PMCID: PMC1170833.
van der Linden AM, Simmer F, Cuppen E, Plasterk RH. The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16. Genetics. 2001 May;158(1):221-35. doi: 10.1093/genetics/158.1.221. PubMed PMID: 11333232; PubMed Central PMCID: PMC1461628.
Cuppen E, van der Linden AM, Jansen G, Plasterk RH. Proteins interacting with Caenorhabditis elegans Galpha subunits. Comp Funct Genomics. 2003;4(5):479-91. doi: 10.1002/cfg.318. PubMed PMID: 18629017; PubMed Central PMCID: PMC2447299.
van der Linden AM, Moorman C, Cuppen E, Korswagen HC, Plasterk RH. Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr Biol. 2003 Mar 18;13(6):516-21. doi: 10.1016/s0960-9822(03)00164-7. PubMed PMID: 12646136.
Simmer F, Moorman C, van der Linden AM, Kuijk E, van den Berghe PV, Kamath RS, Fraser AG, Ahringer J, Plasterk RH. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol. 2003 Oct;1(1):E12. doi: 10.1371/journal.pbio.0000012. Epub 2003 Oct 13. PubMed PMID: 14551910; PubMed Central PMCID: PMC212692.
van der Linden AM, Plasterk RH. Shotgun cloning of transposon insertions in the genome of Caenorhabditis elegans. Comp Funct Genomics. 2004;5(3):225-9. doi: 10.1002/cfg.392. PubMed PMID: 18629154; PubMed Central PMCID: PMC2447444.
Fitzgerald K, Tertyshnikova S, Moore L, Bjerke L, Burley B, Cao J, Carroll P, Choy R, Doberstein S, Dubaquie Y, Franke Y, Kopczynski J, Korswagen H, Krystek SR, Lodge NJ, Plasterk R, Starrett J, Stouch T, Thalody G, Wayne H, van der Linden A, Zhang Y, Walker SG, Cockett M, Wardwell-Swanson J, Ross-Macdonald P, Kindt RM. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57. doi: 10.1371/journal.pgen.0020057. Epub 2006 Apr 21. PubMed PMID: 16683034; PubMed Central PMCID: PMC1440875.
van der Linden AM, Nolan KM, Sengupta P. KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. EMBO J. 2007 Jan 24;26(2):358-70. doi: 10.1038/sj.emboj.7601479. Epub 2006 Dec 14. PubMed PMID: 17170704; PubMed Central PMCID: PMC1783467.
Bauer Huang SL, Saheki Y, VanHoven MK, Torayama I, Ishihara T, Katsura I, van der Linden A, Sengupta P, Bargmann CI. Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. Neural Dev. 2007 Nov 6;2:24. doi: 10.1186/1749-8104-2-24. PubMed PMID: 17986337; PubMed Central PMCID: PMC2213652.
van der Linden AM, Wiener S, You YJ, Kim K, Avery L, Sengupta P. The EGL-4 PKG acts with KIN-29 salt-inducible kinase and protein kinase A to regulate chemoreceptor gene expression and sensory behaviors in Caenorhabditis elegans. Genetics. 2008 Nov;180(3):1475-91. doi: 10.1534/genetics.108.094771. Epub 2008 Oct 1. PubMed PMID: 18832350; PubMed Central PMCID: PMC2581950.
Nokes EB, Van Der Linden AM, Winslow C, Mukhopadhyay S, Ma K, Sengupta P. Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans. Dev Dyn. 2009 Dec;238(12):3080-92. doi: 10.1002/dvdy.22147. PubMed PMID: 19924784; PubMed Central PMCID: PMC4078920.
van der Linden AM, Beverly M, Kadener S, Rodriguez J, Wasserman S, Rosbash M, Sengupta P. Genome-wide analysis of light- and temperature-entrained circadian transcripts in Caenorhabditis elegans. PLoS Biol. 2010 Oct 12;8(10):e1000503. doi: 10.1371/journal.pbio.1000503. PubMed PMID: 20967231; PubMed Central PMCID: PMC2953524.
Pravosudov VV, Roth TC 2nd, Forister ML, Ladage LD, Kramer R, Schilkey F, van der Linden AM. Differential hippocampal gene expression is associated with climate-related natural variation in memory and the hippocampus in food-caching chickadees. Mol Ecol. 2013 Jan;22(2):397-408. doi: 10.1111/mec.12146. Epub 2012 Dec 3. PubMed PMID: 23205699; PubMed Central PMCID: PMC4120876.
Gruner M, Nelson D, Winbush A, Hintz R, Ryu L, Chung SH, Kim K, Gabel CV, van der Linden AM. Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs. PLoS Genet. 2014 Oct;10(10):e1004707. doi: 10.1371/journal.pgen.1004707. eCollection 2014 Oct. PubMed PMID: 25357003; PubMed Central PMCID: PMC4214617.
Gruner M, van der Linden AM. Plasticity of chemoreceptor gene expression: Sensory and circuit inputs modulate state-dependent chemoreceptors. Worm. 2015 Apr-Jun;4(2):e1023497. doi: 10.1080/21624054.2015.1023497. eCollection 2015 Apr-Jun. PubMed PMID: 26430563; PubMed Central PMCID: PMC4588537.
Winbush A, Gruner M, Hennig GW, van der Linden AM. Long-term imaging of circadian locomotor rhythms of a freely crawling C. elegans population. J Neurosci Methods. 2015 Jul 15;249:66-74. doi: 10.1016/j.jneumeth.2015.04.009. Epub 2015 Apr 22. PubMed PMID: 25911068; PubMed Central PMCID: PMC4821420.
Gruner M, Grubbs J, McDonagh A, Valdes D, Winbush A, van der Linden AM. Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors. PLoS Genet. 2016 Aug;12(8):e1006237. doi: 10.1371/journal.pgen.1006237. eCollection 2016 Aug. PubMed PMID: 27487365; PubMed Central PMCID: PMC4972359.
Regalado JM, Cortez MB, Grubbs J, Link JA, van der Linden A, Zhang Y. Increased food intake after starvation enhances sleep in Drosophila melanogaster. J Genet Genomics. 2017 Jun 20;44(6):319-326. doi: 10.1016/j.jgg.2017.05.006. Epub 2017 Jun 13. PubMed PMID: 28645777; PubMed Central PMCID: PMC5536855.
Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. Global accumulation of circRNAs during aging in Caenorhabditis elegans. BMC Genomics. 2018 Jan 3;19(1):8. doi: 10.1186/s12864-017-4386-y. PubMed PMID: 29298683; PubMed Central PMCID: PMC5753478.
Grubbs JJ, Lopes LE, van der Linden AM, Raizen DM. A salt-induced kinase is required for the metabolic regulation of sleep. PLoS Biol. 2020 Apr;18(4):e3000220. doi: 10.1371/journal.pbio.3000220. eCollection 2020 Apr. PubMed PMID: 32315298; PubMed Central PMCID: PMC7173979.
Grubbs JJ, van der Linden AM, Raizen DM. Regulation of sleep by KIN-29 is not developmental. MicroPubl Biol. 2020 May 7;2020. doi: 10.17912/micropub.biology.000247. PubMed PMID: 32550493; PubMed Central PMCID: PMC7252321.
Sparacio AP, Trojanowski NF, Snetselaar K, Nelson MD, Raizen DM. Teething during sleep: Ultrastructural analysis of pharyngeal muscle and cuticular grinder during the molt in Caenorhabditis elegans. PLoS One. 2020;15(5):e0233059. doi: 10.1371/journal.pone.0233059. eCollection 2020. PubMed PMID: 32433687; PubMed Central PMCID: PMC7239488.
Nikooei T, McDonagh A, M van der Linden A. The salt-inducible kinase KIN-29 regulates lifespan via the class II histone-deacetylase HDA-4. MicroPubl Biol. 2020 Aug 9;2020. doi: 10.17912/micropub.biology.000289. PubMed PMID: 33111058; PubMed Central PMCID: PMC7581299.
Raizen D. Worms sleep: a perspective. J Neurogenet. 2020 Sep-Dec;34(3-4):427-429. doi: 10.1080/01677063.2020.1833007. Review. PubMed PMID: 33446018; PubMed Central PMCID: PMC7875286.
Knupp D, Jorgensen BG, Alshareef HZ, Bhat JM, Grubbs JJ, Miura P, van der Linden AM. Loss of circRNAs from the crh-1 gene extends the mean lifespan in Caenorhabditis elegans. Aging Cell. 2022 Feb;21(2):e13560. doi: 10.1111/acel.13560. Epub 2022 Jan 31. PubMed PMID: 35102684; PubMed Central PMCID: PMC8844124.
McDonagh A, Crew J, van der Linden AM. Dietary vitamin B12 regulates chemosensory receptor gene expression via the MEF2 transcription factor in Caenorhabditis elegans. G3 (Bethesda). 2022 May 30;12(6). doi: 10.1093/g3journal/jkac107. PubMed PMID: 35512190; PubMed Central PMCID: PMC9157118.
What would you like to do?
  • Page of 1