My Bibliography

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Packard RR, Shi GP. Atherosclerosis progression and monocyte emigration from plaque. Future Cardiol. 2006 Jul;2(4):415-8. doi: 10.2217/14796678.2.4.415. PubMed PMID: 19804177.

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Packard RR, Schlegel S, Senouf D, Burger F, Sigaud P, Perneger T, Siegrist CA, Mach F. Atorvastatin treatment and vaccination efficacy. J Clin Pharmacol. 2007 Aug;47(8):1022-7. doi: 10.1177/0091270007302169. Epub 2007 Jun 4. PubMed PMID: 17548534.

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Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008 Jan;54(1):24-38. doi: 10.1373/clinchem.2007.097360. Review. PubMed PMID: 18160725.

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Packard RR, Maganto-García E, Gotsman I, Tabas I, Libby P, Lichtman AH. CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res. 2008 Oct 24;103(9):965-73. doi: 10.1161/CIRCRESAHA.108.185793. Epub 2008 Oct 2. PubMed PMID: 18832748; PubMed Central PMCID: PMC2668806.

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Smadja DM, Godier A, Susen S, Packard RR, Fabiani JN, Aiach M, Gaussem P. Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery. Thromb Haemost. 2009 May;101(5):983-5. PubMed PMID: 19404556.

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Packard RR, Lichtman AH, Libby P. Innate and adaptive immunity in atherosclerosis. Semin Immunopathol. 2009 Jun;31(1):5-22. doi: 10.1007/s00281-009-0153-8. Epub 2009 May 16. Review. PubMed PMID: 19449008; PubMed Central PMCID: PMC2823132.

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Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI. Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation. 2009 Aug 4;120(5):427-36. doi: 10.1161/CIRCULATIONAHA.108.814582. Epub 2009 Jul 20. PubMed PMID: 19620505; PubMed Central PMCID: PMC3070397.

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Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW. Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. J Biol Chem. 2009 Sep 11;284(37):24914-24. doi: 10.1074/jbc.M109.000059. Epub 2009 Jul 14. PubMed PMID: 19602726; PubMed Central PMCID: PMC2757194.

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Bhutani S, Tobis J, Gevorgyan R, Sinha A, Suh W, Honda HM, Vorobiof G, Packard RR, Steadman R, Wray C, Busuttil R, Tseng CH. Accuracy of stress myocardial perfusion imaging to diagnose coronary artery disease in end stage liver disease patients. Am J Cardiol. 2013 Apr 1;111(7):1057-61. doi: 10.1016/j.amjcard.2012.12.023. Epub 2013 Jan 18. PubMed PMID: 23337839.

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Packard RR, Huang SC, Dahlbom M, Czernin J, Maddahi J. Absolute quantitation of myocardial blood flow in human subjects with or without myocardial ischemia using dynamic flurpiridaz F 18 PET. J Nucl Med. 2014 Sep;55(9):1438-44. doi: 10.2967/jnumed.114.141093. Epub 2014 Jul 28. PubMed PMID: 25071096; PubMed Central PMCID: PMC4315668.

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Maddahi J, Packard RR. Cardiac PET perfusion tracers: current status and future directions. Semin Nucl Med. 2014 Sep;44(5):333-43. doi: 10.1053/j.semnuclmed.2014.06.011. Review. PubMed PMID: 25234078; PubMed Central PMCID: PMC4333146.

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Lee J, Packard RR, Hsiai TK. Blood flow modulation of vascular dynamics. Curr Opin Lipidol. 2015 Oct;26(5):376-83. doi: 10.1097/MOL.0000000000000218. Review. PubMed PMID: 26218416; PubMed Central PMCID: PMC4626080.

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Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2015 Dec;11(12):e1005711. doi: 10.1371/journal.pgen.1005711. eCollection 2015 Dec. PubMed PMID: 26694027; PubMed Central PMCID: PMC4687930.

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Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Sevag Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2016 Mar;12(3):e1005913. doi: 10.1371/journal.pgen.1005913. eCollection 2016 Mar. PubMed PMID: 26934746; PubMed Central PMCID: PMC4775237.

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Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Sci Rep. 2016 Mar 3;6:22489. doi: 10.1038/srep22489. PubMed PMID: 26935567; PubMed Central PMCID: PMC4776137.

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Lee J, Fei P, Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016 May 2;126(5):1679-90. doi: 10.1172/JCI83496. Epub 2016 Mar 28. PubMed PMID: 27018592; PubMed Central PMCID: PMC4855946.

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Sevag Packard RR, Karlsberg RP. Integrating FFRCT Into Routine Clinical Practice: A Solid PLATFORM or Slippery Slope?. J Am Coll Cardiol. 2016 Aug 2;68(5):446-449. doi: 10.1016/j.jacc.2016.05.056. PubMed PMID: 27470450; PubMed Central PMCID: PMC5378152.

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Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 Sep;44(9):2695-706. doi: 10.1007/s10439-016-1559-9. Epub 2016 Feb 8. PubMed PMID: 26857007; PubMed Central PMCID: PMC5403741.

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Ma J, Luo Y, Sevag Packard RR, Ma T, Ding Y, Abiri P, Tai YC, Zhou Q, Shung KK, Li R, Hsiai T. Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques. Sens Actuators B Chem. 2016 Nov 1;235:154-161. doi: 10.1016/j.snb.2016.04.179. Epub 2016 May 7. PubMed PMID: 27773967; PubMed Central PMCID: PMC5068578.

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Packard RR, Li D, Budoff MJ, Karlsberg RP. Fractional flow reserve by computerized tomography and subsequent coronary revascularization. Eur Heart J Cardiovasc Imaging. 2017 Feb;18(2):145-152. doi: 10.1093/ehjci/jew148. Epub 2016 Jul 28. PubMed PMID: 27469588; PubMed Central PMCID: PMC5837723.

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Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions. Theranostics. 2017;7(9):2431-2442. doi: 10.7150/thno.19184. eCollection 2017. PubMed PMID: 28744325; PubMed Central PMCID: PMC5525747.

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Abiri P, Abiri A, Packard RRS, Ding Y, Yousefi A, Ma J, Bersohn M, Nguyen KL, Markovic D, Moloudi S, Hsiai TK. Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system. Sci Rep. 2017 Jul 21;7(1):6180. doi: 10.1038/s41598-017-06493-5. PubMed PMID: 28733677; PubMed Central PMCID: PMC5522478.

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Packard RRS, Maddahi J. Regadenoson-induced hyperemia for absolute myocardial blood flow quantitation by ¹³N-ammonia PET and detection of cardiac allograft vasculopathy. J Nucl Cardiol. 2017 Aug;24(4):1145-1148. doi: 10.1007/s12350-016-0763-1. Epub 2017 Jan 30. PubMed PMID: 28138814.

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Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017 Aug 17;7(1):8603. doi: 10.1038/s41598-017-09152-x. PubMed PMID: 28819303; PubMed Central PMCID: PMC5561066.

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Ding Y, Abiri A, Abiri P, Li S, Chang CC, Baek KI, Hsu JJ, Sideris E, Li Y, Lee J, Segura T, Nguyen TP, Bui A, Sevag Packard RR, Fei P, Hsiai TK. Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics. JCI Insight. 2017 Nov 16;2(22). doi: 10.1172/jci.insight.97180. eCollection 2017 Nov 16. PubMed PMID: 29202458; PubMed Central PMCID: PMC5752380.

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Maddahi J, Packard RRS. PET should replace SPECT in cardiac imaging for diagnosis and risk assessment of patients with known or suspected CAD: Pro. J Nucl Cardiol. 2017 Dec;24(6):1955-1959. doi: 10.1007/s12350-015-0300-7. Epub 2017 Apr 10. PubMed PMID: 28397181.

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Luo Y, Abiri P, Zhang S, Chang CC, Kaboodrangi AH, Li R, Sahib AK, Bui A, Kumar R, Woo M, Li Z, Packard RRS, Tai YC, Hsiai TK. Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content. Theranostics. 2018;8(6):1636-1647. doi: 10.7150/thno.22233. eCollection 2018. PubMed PMID: 29556346; PubMed Central PMCID: PMC5858172.

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Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair. Curr Cardiol Rep. 2018 Mar 24;20(5):35. doi: 10.1007/s11886-018-0979-6. Review. PubMed PMID: 29574550; PubMed Central PMCID: PMC5987244.

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Votaw JR, Packard RRS. Technical aspects of acquiring and measuring myocardial blood flow: Method, technique, and QA. J Nucl Cardiol. 2018 Apr;25(2):665-670. doi: 10.1007/s12350-017-1049-y. Epub 2017 Sep 1. PubMed PMID: 28864981; PubMed Central PMCID: PMC6443413.

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Baek KI, Packard RRS, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particle Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxid Redox Signal. 2018 May 1;28(13):1209-1223. doi: 10.1089/ars.2017.7166. Epub 2017 Nov 17. PubMed PMID: 29037123; PubMed Central PMCID: PMC5912723.

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Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 Jul 12;3(13). doi: 10.1172/jci.insight.96672. PubMed PMID: 29997298; PubMed Central PMCID: PMC6124527.

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Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 Aug 23;3(16). doi: 10.1172/jci.insight.121396. eCollection 2018 Aug 23. Review. PubMed PMID: 30135307; PubMed Central PMCID: PMC6141183.

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Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2016-2027. doi: 10.1161/ATVBAHA.118.311266. PubMed PMID: 30026271; PubMed Central PMCID: PMC6202168.

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Baek KI, Ding Y, Chang CC, Chang M, Sevag Packard RR, Hsu JJ, Fei P, Hsiai TK. Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging. Prog Biophys Mol Biol. 2018 Oct;138:105-115. doi: 10.1016/j.pbiomolbio.2018.05.003. Epub 2018 May 9. Review. PubMed PMID: 29752956; PubMed Central PMCID: PMC6226366.

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Abiri A, Ding Y, Abiri P, Packard RRS, Vedula V, Marsden A, Kuo CJ, Hsiai TK. Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach. Ann Biomed Eng. 2018 Dec;46(12):2177-2188. doi: 10.1007/s10439-018-02113-z. Epub 2018 Aug 15. PubMed PMID: 30112710; PubMed Central PMCID: PMC6249076.

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Chen J, Ding Y, Chen M, Gau J, Jen N, Nahal C, Tu S, Chen C, Zhou S, Chang CC, Lyu J, Xu X, Hsiai TK, Packard RRS. Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration. JCI Insight. 2019 Apr 18;4(8). doi: 10.1172/jci.insight.125362. eCollection 2019 Apr 18. PubMed PMID: 30996130; PubMed Central PMCID: PMC6538350.

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Packard RRS, Maddahi J. Assessment of left ventricular mass by SPECT MPI. J Nucl Cardiol. 2019 Jun;26(3):906-908. doi: 10.1007/s12350-017-1146-y. Epub 2017 Dec 14. PubMed PMID: 29243071.

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Tuzovic M, Yang EH, Sevag Packard RR, Ganz PA, Fonarow GC, Ziaeian B. National Outcomes in Hospitalized Patients With Cancer and Comorbid Heart Failure. J Card Fail. 2019 Jul;25(7):516-521. doi: 10.1016/j.cardfail.2019.02.007. Epub 2019 Feb 12. PubMed PMID: 30769035; PubMed Central PMCID: PMC7659987.

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Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Dis Model Mech. 2019 Oct 1;12(10). doi: 10.1242/dmm.040154. PubMed PMID: 31492659; PubMed Central PMCID: PMC6826022.

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Chen J, Packard RRS. Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish. J Vis Exp. 2020 Feb 6;(156). doi: 10.3791/60547. PubMed PMID: 32090990.

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Votaw JR, Packard RRS. Motion correction to enhance absolute myocardial blood flow quantitation by PET. J Nucl Cardiol. 2020 Aug;27(4):1114-1117. doi: 10.1007/s12350-019-01912-8. Epub 2019 Oct 24. PubMed PMID: 31650493.

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Packard RRS. Dipyridamole infusion protocols for absolute myocardial blood flow quantitation by PET. J Nucl Cardiol. 2020 Oct;27(5):1829-1831. doi: 10.1007/s12350-018-01554-2. Epub 2018 Dec 4. PubMed PMID: 30515747.

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Ding Y, Gudapati V, Lin R, Fei Y, Packard RRS, Song S, Chang CC, Baek KI, Wang Z, Roustaei M, Kuang D, Kuo CJ, Hsiai TK. Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation. IEEE Trans Biomed Eng. 2021 Jan;68(1):225-235. doi: 10.1109/TBME.2020.2991754. Epub 2020 Dec 21. PubMed PMID: 32365015; PubMed Central PMCID: PMC7606319.

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Packard RRS, Lazewatsky JL, Orlandi C, Maddahi J. Diagnostic Performance of PET Versus SPECT Myocardial Perfusion Imaging in Patients with Smaller Left Ventricles: A Substudy of the ¹⁸F-Flurpiridaz Phase III Clinical Trial. J Nucl Med. 2021 Jun 1;62(6):849-854. doi: 10.2967/jnumed.120.252007. Epub 2020 Nov 27. PubMed PMID: 33246979; PubMed Central PMCID: PMC8729859.

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Khan MO, Tran JS, Zhu H, Boyd J, Packard RRS, Karlsberg RP, Kahn AM, Marsden AL. Low Wall Shear Stress Is Associated with Saphenous Vein Graft Stenosis in Patients with Coronary Artery Bypass Grafting. J Cardiovasc Transl Res. 2021 Aug;14(4):770-781. doi: 10.1007/s12265-020-09982-7. Epub 2020 Apr 2. PubMed PMID: 32240496; PubMed Central PMCID: PMC7529767.

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Jong J, Packard RRS. ¹⁸F-FDG PET imaging of myocardial inflammation and viability following experimental infarction and anti-inflammatory treatment with compound MCC950. J Nucl Cardiol. 2021 Oct;28(5):2358-2360. doi: 10.1007/s12350-020-02104-5. Epub 2020 Apr 24. PubMed PMID: 32333277.

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Packard RRS, Votaw JR, Cooke CD, Van Train KF, Garcia EV, Maddahi J. 18F-flurpiridaz positron emission tomography segmental and territory myocardial blood flow metrics: incremental value beyond perfusion for coronary artery disease categorization. Eur Heart J Cardiovasc Imaging. 2021 Dec 20;. doi: 10.1093/ehjci/jeab267. [Epub ahead of print] PubMed PMID: 34928321.

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Packard RRS, Cooke CD, Van Train KF, Votaw JR, Sayre JW, Lazewatsky JL, Champagne KM, Orlandi C, Garcia EV, Maddahi J. Development, diagnostic performance, and interobserver agreement of a ¹⁸F-flurpiridaz PET automated perfusion quantitation system. J Nucl Cardiol. 2022 Apr;29(2):698-708. doi: 10.1007/s12350-020-02335-6. Epub 2020 Sep 7. PubMed PMID: 32895856; PubMed Central PMCID: PMC7936994.