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Wang Q, Yuan J, Shen H, Zhu Q, Chen B, Wang J, Zhu W, Yorek MA, Hall DD, Wang Z, Song LS. Calpain inhibition protects against atrial fibrillation by mitigating diabetes-associated atrial fibrosis and calcium handling dysfunction in type 2 diabetes mice. Heart Rhythm. 2024 Jul;21(7):1143-1151. doi: 10.1016/j.hrthm.2024.02.036. Epub 2024 Feb 21. PubMed PMID: 38395244.
Wang CL, Skeie JM, Allamargot C, Goldstein AS, Nishimura DY, Huffman JM, Aldrich BT, Schmidt GA, Teixeira LBC, Kuehn MH, Yorek M, Greiner MA. Rat Model of Type 2 Diabetes Mellitus Recapitulates Human Disease in the Anterior Segment of the Eye. Am J Pathol. 2024 Jun;194(6):1090-1105. doi: 10.1016/j.ajpath.2024.02.004. Epub 2024 Feb 24. PubMed PMID: 38403162.
Yorek M. Combination therapy is it in the future for successfully treating peripheral diabetic neuropathy?. Front Endocrinol (Lausanne). 2024;15:1357859. doi: 10.3389/fendo.2024.1357859. eCollection 2024. Review. PubMed PMID: 38812811; PubMed Central PMCID: PMC11133577.
Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, Talley JJ, Adams CM. Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. J Nutr. 2022 Apr 1;152(4):926-938. doi: 10.1093/jn/nxab440. Review. PubMed PMID: 34958390; PubMed Central PMCID: PMC8970988.
Yorek M. Treatment for Diabetic Peripheral Neuropathy: What have we Learned from Animal Models?. Curr Diabetes Rev. 2022;18(5):e040521193121. doi: 10.2174/1573399817666210504101609. Review. PubMed PMID: 33949936; PubMed Central PMCID: PMC8965779.
Obrosov A, Coppey LJ, Shevalye H, Yorek MA. COMPARATIVE EFFECT OF A HIGH FAT WITH OR WITHOUT HIGH LEVELS OF SUCROSE DIETS ON PERIPHERAL NEUROPATHY IN C57BL/6J MICE. J Diabet Complicat Ther. 2022;1(1). PubMed PMID: 37332358; PubMed Central PMCID: PMC10274354.
Rysted JE, Lin Z, Walters GC, Rauckhorst AJ, Noterman M, Liu G, Taylor EB, Strack S, Usachev YM. Distinct properties of Ca(2+) efflux from brain, heart and liver mitochondria: The effects of Na(+), Li(+) and the mitochondrial Na(+)/Ca(2+) exchange inhibitor CGP37157. Cell Calcium. 2021 Jun;96:102382. doi: 10.1016/j.ceca.2021.102382. Epub 2021 Feb 22. PubMed PMID: 33684833; PubMed Central PMCID: PMC8187304.
Keyes AL, Kim YC, Bosch PJ, Usachev YM, Aldridge GM. Stay or go? Neuronal activity in medial frontal cortex during a voluntary tactile preference task in head-fixed mice. Cell Calcium. 2021 Jun;96:102388. doi: 10.1016/j.ceca.2021.102388. Epub 2021 Mar 4. PubMed PMID: 33740531; PubMed Central PMCID: PMC8224542.
Obrosov A, Coppey LJ, Shevalye H, Yorek MA. COMPARATIVE EFFECT OF A HIGH FAT WITH OR WITHOUT HIGH LEVELS OF SUCROSE DIETS ON PERIPHERAL NEUROPATHY IN C57BL/6J MICE. Journal of Diabetic Complications & Therapy. 2021 April; 1(1).
Coppey L, Obrosov A, Shevalye H, Davidson E, Paradee W, Yorek MA. Characterization of Mice Ubiquitously Overexpressing Human 15-Lipoxygenase-1: Effect of Diabetes on Peripheral Neuropathy and Treatment with Menhaden Oil. J Diabetes Res. 2021;2021:5564477. doi: 10.1155/2021/5564477. eCollection 2021. PubMed PMID: 33816635; PubMed Central PMCID: PMC7987465.
Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI. Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect. 2021 Feb;9(1):e00701. doi: 10.1002/prp2.701. PubMed PMID: 33547885; PubMed Central PMCID: PMC7866483.
Strom A, Strassburger K, Schmuck M, Shevalye H, Davidson E, Zivehe F, Bönhof G, Reimer R, Belgardt BF, Fleming T, Biermann B, Burkart V, Müssig K, Szendroedi J, Yorek MA, Fritsche E, Nawroth PP, Roden M, Ziegler D. Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models. Mol Metab. 2021 Jan;43:101114. doi: 10.1016/j.molmet.2020.101114. Epub 2020 Nov 6. PubMed PMID: 33166742; PubMed Central PMCID: PMC7704399.
Andreasen LJ, Kirk RK, Fledelius C, Yorek MA, Lykkesfeldt J, Akerstrom T. Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes. J Diabetes Res. 2020;2020:9626398. doi: 10.1155/2020/9626398. eCollection 2020. PubMed PMID: 32832565; PubMed Central PMCID: PMC7424504.
Fink B, Coppey L, Davidson E, Shevalye H, Obrosov A, Chheda PR, Kerns R, Sivitz W, Yorek M. Effect of mitoquinone (Mito-Q) on neuropathic endpoints in an obese and type 2 diabetic rat model. Free Radic Res. 2020 May;54(5):311-318. doi: 10.1080/10715762.2020.1754409. Epub 2020 Apr 24. PubMed PMID: 32326763; PubMed Central PMCID: PMC7329571.
Coppey L, Davidson E, Shevalye H, Obrosov A, Torres M, Yorek MA. Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment. Diabetes Metab Syndr Obes. 2020;13:1367-1384. doi: 10.2147/DMSO.S247571. eCollection 2020. PubMed PMID: 32425569; PubMed Central PMCID: PMC7189026.
Flippo KH, Lin Z, Dickey AS, Zhou X, Dhanesha NA, Walters GC, Liu Y, Merrill RA, Meller R, Simon RP, Chauhan AK, Usachev YM, Strack S. Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. J Neurosci. 2020 Apr 8;40(15):3119-3129. doi: 10.1523/JNEUROSCI.1926-19.2020. Epub 2020 Mar 6. PubMed PMID: 32144179; PubMed Central PMCID: PMC7141887.
Coppey L, Davidson E, Shevalye H, Obrosov A, Yorek M. Effect of Early and Late Interventions with Dietary Oils on Vascular and Neural Complications in a Type 2 Diabetic Rat Model. J Diabetes Res. 2019;2019:5020465. doi: 10.1155/2019/5020465. eCollection 2019. PubMed PMID: 31485451; PubMed Central PMCID: PMC6702827.
Coppey LJ, Shevalye H, Obrosov A, Davidson EP, Yorek MA. Determination of peripheral neuropathy in high-fat diet fed low-dose streptozotocin-treated female C57Bl/6J mice and Sprague-Dawley rats. J Diabetes Investig. 2018 Sep;9(5):1033-1040. doi: 10.1111/jdi.12814. Epub 2018 Mar 25. PubMed PMID: 29412513; PubMed Central PMCID: PMC6123046.
Yorek MA. The Potential Role of Fatty Acids in Treating Diabetic Neuropathy. Curr Diab Rep. 2018 Aug 25;18(10):86. doi: 10.1007/s11892-018-1046-9. Review. PubMed PMID: 30145729; PubMed Central PMCID: PMC6816026.
Nuno DW, Coppey LJ, Yorek MA, Lamping KG. Dietary fats modify vascular fat composition, eNOS localization within lipid rafts and vascular function in obesity. Physiol Rep. 2018 Aug;6(15):e13820. doi: 10.14814/phy2.13820. PubMed PMID: 30105819; PubMed Central PMCID: PMC6090220.
Davidson EP, Coppey LJ, Shevalye H, Obrosov A, Yorek MA. Vascular and Neural Complications in Type 2 Diabetic Rats: Improvement by Sacubitril/Valsartan Greater Than Valsartan Alone. Diabetes. 2018 Aug;67(8):1616-1626. doi: 10.2337/db18-0062. Epub 2018 Jun 25. PubMed PMID: 29941448.
Davidson EP, Coppey LJ, Shevalye H, Obrosov A, Yorek MA. Effect of Dietary Content of Menhaden Oil with or without Salsalate on Neuropathic Endpoints in High-Fat-Fed/Low-Dose Streptozotocin-Treated Sprague Dawley Rats. J Diabetes Res. 2018;2018:2967127. doi: 10.1155/2018/2967127. eCollection 2018. PubMed PMID: 30057911; PubMed Central PMCID: PMC6051246.
Coppey L, Davidson E, Shevalye H, Torres ME, Yorek MA. Effect of dietary oils on peripheral neuropathy-related endpoints in dietary obese rats. Diabetes Metab Syndr Obes. 2018;11:117-127. doi: 10.2147/DMSO.S159071. eCollection 2018. PubMed PMID: 29674850; PubMed Central PMCID: PMC5898889.
Yorek MA. Is Fish Oil a Potential Treatment for Diabetic Peripheral Neuropathy?. Curr Diabetes Rev. 2018;14(4):339-349. doi: 10.2174/1573399813666170522155327. Review. PubMed PMID: 28530530.
Obrosov A, Coppey LJ, Shevalye H, Yorek MA. Effect of Fish Oil vs. Resolvin D1, E1, Methyl Esters of Resolvins D1 or D2 on Diabetic Peripheral Neuropathy. J Neurol Neurophysiol. 2017;8(6). doi: 10.4172/2155-9562.1000453. Epub 2017 Dec 24. PubMed PMID: 29423332; PubMed Central PMCID: PMC5800519.
Davidson EP, Coppey LJ, Shevalye H, Obrosov A, Kardon RH, Yorek MA. Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril. Cornea. 2017 Jun;36(6):725-731. doi: 10.1097/ICO.0000000000001182. PubMed PMID: 28476051; PubMed Central PMCID: PMC5421399.
Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH, Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang G, Burkart AM, Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat Med. 2017 Jun;23(6):753-762. doi: 10.1038/nm.4328. Epub 2017 Apr 24. PubMed PMID: 28436957; PubMed Central PMCID: PMC5575773.
Obrosov A, Shevalye H, Coppey LJ, Yorek MA. Effect of tempol on peripheral neuropathy in diet-induced obese and high-fat fed/low-dose streptozotocin-treated C57Bl6/J mice. Free Radic Res. 2017 Apr;51(4):360-367. doi: 10.1080/10715762.2017.1315767. Epub 2017 Apr 19. PubMed PMID: 28376643; PubMed Central PMCID: PMC5575770.
Yorek MS, Obrosov A, Shevalye H, Coppey LJ, Kardon RH, Yorek MA. Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints. Neuropharmacology. 2017 Apr;116:122-131. doi: 10.1016/j.neuropharm.2016.12.022. Epub 2016 Dec 23. PubMed PMID: 28025096; PubMed Central PMCID: PMC5385152.
Yorek MS, Obrosov A, Lu B, Gerard C, Kardon RH, Yorek MA. Effect of Inhibition or Deletion of Neutral Endopeptidase on Neuropathic Endpoints in High Fat Fed/Low Dose Streptozotocin-Treated Mice. J Neuropathol Exp Neurol. 2016 Nov 1;75(11):1072-1080. doi: 10.1093/jnen/nlw083. PubMed PMID: 27634964; PubMed Central PMCID: PMC7714044.
Yorek MS, Coppey LJ, Shevalye H, Obrosov A, Kardon RH, Yorek MA. Effect of Treatment with Salsalate, Menhaden Oil, Combination of Salsalate and Menhaden Oil, or Resolvin D1 of C57Bl/6J Type 1 Diabetic Mouse on Neuropathic Endpoints. J Nutr Metab. 2016;2016:5905891. doi: 10.1155/2016/5905891. Epub 2016 Sep 28. PubMed PMID: 27774316; PubMed Central PMCID: PMC5059581.
Yorek MS, Obrosov A, Lu B, Gerard C, Kardon RH, Yorek MA. Effect of Inhibition or Deletion of Neutral Endopeptidase on Neuropathic Endpoints in High Fat Fed/Low Dose Streptozotocin-Treated Mice. Journal Neuropathology Experimental Neurology. 2016 September; 75(11):1072. doi: 10.1093/jnen/nlw083.
Trammell SA, Weidemann BJ, Chadda A, Yorek MS, Holmes A, Coppey LJ, Obrosov A, Kardon RH, Yorek MA, Brenner C. Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice. Sci Rep. 2016 May 27;6:26933. doi: 10.1038/srep26933. PubMed PMID: 27230286; PubMed Central PMCID: PMC4882590.
Yorek MS, Davidson EP, Poolman P, Coppey LJ, Obrosov A, Holmes A, Kardon RH, Yorek MA. Corneal Sensitivity to Hyperosmolar Eye Drops: A Novel Behavioral Assay to Assess Diabetic Peripheral Neuropathy. Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2412-9. doi: 10.1167/iovs.16-19435. PubMed PMID: 27145474; PubMed Central PMCID: PMC5113984.
Yorek MA. Alternatives to the Streptozotocin-Diabetic Rodent. Int Rev Neurobiol. 2016;127:89-112. doi: 10.1016/bs.irn.2016.03.002. Epub 2016 Mar 28. Review. PubMed PMID: 27133146; PubMed Central PMCID: PMC5577923.
Davidson EP, Holmes A, Coppey LJ, Yorek MA. Effect of combination therapy consisting of enalapril, α-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat. Eur J Pharmacol. 2015 Oct 15;765:258-67. doi: 10.1016/j.ejphar.2015.08.015. Epub 2015 Aug 18. PubMed PMID: 26291662.
Yorek MA. Vascular Impairment of Epineurial Arterioles of the Sciatic Nerve: Implications for Diabetic Peripheral Neuropathy. Rev Diabet Stud. 2015 Spring-Summer;12(1-2):13-28. doi: 10.1900/RDS.2015.12.13. Epub 2015 Aug 10. Review. PubMed PMID: 26676659; PubMed Central PMCID: PMC5397981.
Holmes A, Coppey LJ, Davidson EP, Yorek MA. Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints. J Diabetes Res. 2015;2015:307285. doi: 10.1155/2015/307285. Epub 2015 Jul 2. PubMed PMID: 26229968; PubMed Central PMCID: PMC4503545.
Shevalye H, Yorek MS, Coppey LJ, Holmes A, Harper MM, Kardon RH, Yorek MA. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. J Neurophysiol. 2015 Jul;114(1):199-208. doi: 10.1152/jn.00224.2015. Epub 2015 Apr 29. PubMed PMID: 25925322; PubMed Central PMCID: PMC4507972.
Edwards JF, Casellini CM, Parson HK, Obrosova IG, Yorek M, Vinik AI. Role of Peroxynitrite in the Development of Diabetic Peripheral Neuropathy. Diabetes Care. 2015 Jul;38(7):e100-1. doi: 10.2337/dc14-2918. PubMed PMID: 26106228; PubMed Central PMCID: PMC5321249.
Yorek MS, Obrosov A, Shevalye H, Holmes A, Harper MM, Kardon RH, Yorek MA. Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice. J Peripher Nerv Syst. 2015 Mar;20(1):24-31. doi: 10.1111/jns.12111. PubMed PMID: 25858759; PubMed Central PMCID: PMC4470853.
Coppey LJ, Davidson EP, Obrosov A, Yorek MA. Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats. J Neurophysiol. 2015 Feb 1;113(3):701-8. doi: 10.1152/jn.00718.2014. Epub 2014 Nov 5. PubMed PMID: 25376787; PubMed Central PMCID: PMC4312862.
Dominguez JM 2nd, Yorek MA, Grant MB. Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats. Diabetes. 2015 Feb;64(2):643-53. doi: 10.2337/db14-0433. Epub 2014 Sep 9. PubMed PMID: 25204979; PubMed Central PMCID: PMC4876792.
Stavniichuk R, Shevalye H, Lupachyk S, Obrosov A, Groves JT, Obrosova IG, Yorek MA. Peroxynitrite and protein nitration in the pathogenesis of diabetic peripheral neuropathy. Diabetes Metab Res Rev. 2014 Nov;30(8):669-78. doi: 10.1002/dmrr.2549. PubMed PMID: 24687457; PubMed Central PMCID: PMC4177961.
Davidson EP, Coppey LJ, Holmes A, Lupachyk S, Dake BL, Oltman CL, Peterson RG, Yorek MA. Characterization of diabetic neuropathy in the Zucker diabetic Sprague-Dawley rat: a new animal model for type 2 diabetes. J Diabetes Res. 2014;2014:714273. doi: 10.1155/2014/714273. Epub 2014 Oct 13. PubMed PMID: 25371906; PubMed Central PMCID: PMC4211210.
Yorek MS, Obrosov A, Shevalye H, Lupachyk S, Harper MM, Kardon RH, Yorek MA. Effect of glycemic control on corneal nerves and peripheral neuropathy in streptozotocin-induced diabetic C57Bl/6J mice. J Peripher Nerv Syst. 2014 Sep;19(3):205-17. doi: 10.1111/jns.12086. PubMed PMID: 25403729; PubMed Central PMCID: PMC4986703.
Biessels GJ, Bril V, Calcutt NA, Cameron NE, Cotter MA, Dobrowsky R, Feldman EL, Fernyhough P, Jakobsen J, Malik RA, Mizisin AP, Oates PJ, Obrosova IG, Pop-Busui R, Russell JW, Sima AA, Stevens MJ, Schmidt RE, Tesfaye S, Veves A, Vinik AI, Wright DE, Yagihashi S, Yorek MA, Ziegler D, Zochodne DW. Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab). J Peripher Nerv Syst. 2014 Jun;19(2):77-87. doi: 10.1111/jns5.12072. Review. PubMed PMID: 24934510; PubMed Central PMCID: PMC4303044.
Davidson EP, Coppey LJ, Kardon RH, Yorek MA. Differences and similarities in development of corneal nerve damage and peripheral neuropathy and in diet-induced obesity and type 2 diabetic rats. Invest Ophthalmol Vis Sci. 2014 Mar 3;55(3):1222-30. doi: 10.1167/iovs.13-13794. PubMed PMID: 24519423; PubMed Central PMCID: PMC3941618.
Stavniichuk R, Obrosov AA, Drel VR, Nadler JL, Obrosova IG, Yorek MA. 12/15-Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy. J Diabetes Mellitus. 2013 Aug;3(3). doi: 10.4236/jdm.2013.33015. PubMed PMID: 24175152; PubMed Central PMCID: PMC3808974.
Lupachyk S, Watcho P, Shevalye H, Vareniuk I, Obrosov A, Obrosova IG, Yorek MA. Na+/H+ exchanger 1 inhibition reverses manifestation of peripheral diabetic neuropathy in type 1 diabetic rats. Am J Physiol Endocrinol Metab. 2013 Aug 1;305(3):E396-404. doi: 10.1152/ajpendo.00186.2013. Epub 2013 Jun 4. PubMed PMID: 23736542; PubMed Central PMCID: PMC3742852.
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