My Bibliography

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Ocampo A, Barrientos A. From the bakery to the brain business: developing inducible yeast models of human neurodegenerative disorders. Biotechniques. 2008 Oct;45(4):vii-xiv. doi: 10.2144/000112746. PubMed PMID: 18855765.

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Fozo EM, Kawano M, Fontaine F, Kaya Y, Mendieta KS, Jones KL, Ocampo A, Rudd KE, Storz G. Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. Mol Microbiol. 2008 Dec;70(5):1076-93. doi: 10.1111/j.1365-2958.2008.06394.x. Epub 2008 Aug 14. PubMed PMID: 18710431; PubMed Central PMCID: PMC2597788.

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Ocampo A, Zambrano A, Barrientos A. Suppression of polyglutamine-induced cytotoxicity in Saccharomyces cerevisiae by enhancement of mitochondrial biogenesis. FASEB J. 2010 May;24(5):1431-41. doi: 10.1096/fj.09-148601. Epub 2009 Dec 14. PubMed PMID: 20008543.

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Ocampo A, Barrientos A. Developing yeast models of human neurodegenerative disorders. Methods Mol Biol. 2011;793:113-27. doi: 10.1007/978-1-61779-328-8_8. PubMed PMID: 21913097.

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Pan Y, Schroeder EA, Ocampo A, Barrientos A, Shadel GS. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab. 2011 Jun 8;13(6):668-78. doi: 10.1016/j.cmet.2011.03.018. PubMed PMID: 21641548; PubMed Central PMCID: PMC3110654.

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Ocampo A, Barrientos A. Quick and reliable assessment of chronological life span in yeast cell populations by flow cytometry. Mech Ageing Dev. 2011 Jun-Jul;132(6-7):315-23. doi: 10.1016/j.mad.2011.06.007. Epub 2011 Jun 28. PubMed PMID: 21736893.

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Ocampo A, Liu J, Schroeder EA, Shadel GS, Barrientos A. Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab. 2012 Jul 3;16(1):55-67. doi: 10.1016/j.cmet.2012.05.013. PubMed PMID: 22768839; PubMed Central PMCID: PMC3397320.

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Ocampo A, Liu J, Barrientos A. NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins. Hum Mol Genet. 2013 May 1;22(9):1699-708. doi: 10.1093/hmg/ddt016. Epub 2013 Jan 18. PubMed PMID: 23335597; PubMed Central PMCID: PMC3657478.

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Xu X, Duan S, Yi F, Ocampo A, Liu GH, Izpisua Belmonte JC. Mitochondrial regulation in pluripotent stem cells. Cell Metab. 2013 Sep 3;18(3):325-32. doi: 10.1016/j.cmet.2013.06.005. Epub 2013 Jul 11. Review. PubMed PMID: 23850316.

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Zhu X, Fu L, Yi F, Liu GH, Ocampo A, Qu J, Izpisua Belmonte JC. Regeneration: making muscle from hPSCs. Cell Res. 2014 Oct;24(10):1159-61. doi: 10.1038/cr.2014.91. Epub 2014 Jul 8. PubMed PMID: 25001388; PubMed Central PMCID: PMC4185353.

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Sancho-Martinez I, Ocampo A, Izpisua Belmonte JC. Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation. Curr Opin Genet Dev. 2014 Oct;28:57-63. doi: 10.1016/j.gde.2014.09.009. Epub 2014 Oct 14. Review. PubMed PMID: 25461451; PubMed Central PMCID: PMC4262641.

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Aguirre A, Montserrat N, Zacchigna S, Nivet E, Hishida T, Krause MN, Kurian L, Ocampo A, Vazquez-Ferrer E, Rodriguez-Esteban C, Kumar S, Moresco JJ, Yates JR 3rd, Campistol JM, Sancho-Martinez I, Giacca M, Izpisua Belmonte JC. In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell. 2014 Nov 6;15(5):589-604. doi: 10.1016/j.stem.2014.10.003. Epub 2014 Nov 6. PubMed PMID: 25517466; PubMed Central PMCID: PMC4270016.

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Ocampo A, Izpisua Belmonte JC. Stem cells. Holding your breath for longevity. Science. 2015 Mar 20;347(6228):1319-20. doi: 10.1126/science.aaa9608. PubMed PMID: 25792319; PubMed Central PMCID: PMC4494667.

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Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell. 2015 Apr 23;161(3):459-469. doi: 10.1016/j.cell.2015.03.051. PubMed PMID: 25910206; PubMed Central PMCID: PMC4505837.

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Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356. Epub 2015 Apr 30. PubMed PMID: 25931448; PubMed Central PMCID: PMC4494668.

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Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature. 2015 Aug 13;524(7564):234-8. doi: 10.1038/nature14546. Epub 2015 Jul 15. PubMed PMID: 26176921.

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Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte JC. Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. Nat Commun. 2016 Feb 22;7:10743. doi: 10.1038/ncomms10743. PubMed PMID: 26899176; PubMed Central PMCID: PMC4764898.

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Ruetenik AL, Ocampo A, Ruan K, Zhu Y, Li C, Zhai RG, Barrientos A. Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging. Microb Cell. 2016 Jul 26;3(8):338-351. doi: 10.15698/mic2016.08.518. PubMed PMID: 28357370; PubMed Central PMCID: PMC5349013.

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Ocampo A, Reddy P, Belmonte JCI. Anti-Aging Strategies Based on Cellular Reprogramming. Trends Mol Med. 2016 Aug;22(8):725-738. doi: 10.1016/j.molmed.2016.06.005. Epub 2016 Jul 14. Review. PubMed PMID: 27426043.

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Wu J, Ocampo A, Belmonte JCI. Cellular Metabolism and Induced Pluripotency. Cell. 2016 Sep 8;166(6):1371-1385. doi: 10.1016/j.cell.2016.08.008. Review. PubMed PMID: 27610564.

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Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Rodriguez Esteban C, Nuñez G, Nuñez Delicado E, Campistol JM, Guillen I, Guillen P, Izpisua Belmonte JC. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell. 2016 Dec 15;167(7):1719-1733.e12. doi: 10.1016/j.cell.2016.11.052. PubMed PMID: 27984723; PubMed Central PMCID: PMC5679279.

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Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilariño M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sánchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nuñez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC. Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036. PubMed PMID: 28129541; PubMed Central PMCID: PMC5679265.

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Hatanaka F, Ocampo A, Izpisua Belmonte JC. Keeping the Rhythm while Changing the Lyrics: Circadian Biology in Aging. Cell. 2017 Aug 10;170(4):599-600. doi: 10.1016/j.cell.2017.07.039. PubMed PMID: 28802034.

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Ren R, Ocampo A, Liu GH, Izpisua Belmonte JC. Regulation of Stem Cell Aging by Metabolism and Epigenetics. Cell Metab. 2017 Sep 5;26(3):460-474. doi: 10.1016/j.cmet.2017.07.019. Epub 2017 Aug 17. Review. PubMed PMID: 28826795.

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Kurita M, Araoka T, Hishida T, O'Keefe DD, Takahashi Y, Sakamoto A, Sakurai M, Suzuki K, Wu J, Yamamoto M, Hernandez-Benitez R, Ocampo A, Reddy P, Shokhirev MN, Magistretti P, Núñez Delicado E, Eto H, Harii K, Izpisua Belmonte JC. In vivo reprogramming of wound-resident cells generates skin epithelial tissue. Nature. 2018 Sep;561(7722):243-247. doi: 10.1038/s41586-018-0477-4. Epub 2018 Sep 5. PubMed PMID: 30185909; PubMed Central PMCID: PMC9651909.

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Hishida T, Vazquez-Ferrer E, Hishida-Nozaki Y, Sancho-Martinez I, Takahashi Y, Hatanaka F, Wu J, Ocampo A, Reddy P, Wu MZ, Gerken L, Shaw RJ, Rodriguez Esteban C, Benner C, Nakagawa H, Guillen Garcia P, Nuñez Delicado E, Castells A, Campistol JM, Liu GH, Izpisua Belmonte JC. Mutations in foregut SOX2(+) cells induce efficient proliferation via CXCR2 pathway. Protein Cell. 2019 Jul;10(7):485-495. doi: 10.1007/s13238-019-0630-3. Epub 2019 Apr 30. PubMed PMID: 31041783; PubMed Central PMCID: PMC6588654.

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Suzuki K, Yamamoto M, Hernandez-Benitez R, Li Z, Wei C, Soligalla RD, Aizawa E, Hatanaka F, Kurita M, Reddy P, Ocampo A, Hishida T, Sakurai M, Nemeth AN, Nuñez Delicado E, Campistol JM, Magistretti P, Guillen P, Rodriguez Esteban C, Gong J, Yuan Y, Gu Y, Liu GH, López-Otín C, Wu J, Zhang K, Izpisua Belmonte JC. Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. Cell Res. 2019 Oct;29(10):804-819. doi: 10.1038/s41422-019-0213-0. Epub 2019 Aug 23. PubMed PMID: 31444470; PubMed Central PMCID: PMC6796851.

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Parras A, de Diego-Garcia L, Alves M, Beamer E, Conte G, Jimenez-Mateos EM, Morgan J, Ollà I, Hernandez-Santana Y, Delanty N, Farrell MA, O'Brien DF, Ocampo A, Henshall DC, Méndez R, Lucas JJ, Engel T. Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy. Brain. 2020 Jul 1;143(7):2139-2153. doi: 10.1093/brain/awaa168. PubMed PMID: 32594159.

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Conte G, Parras A, Alves M, Ollà I, De Diego-Garcia L, Beamer E, Alalqam R, Ocampo A, Mendez R, Henshall DC, Lucas JJ, Engel T. High concordance between hippocampal transcriptome of the mouse intra-amygdala kainic acid model and human temporal lobe epilepsy. Epilepsia. 2020 Dec;61(12):2795-2810. doi: 10.1111/epi.16714. Epub 2020 Oct 18. PubMed PMID: 33070315.

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de Magalhães JP, Ocampo A. Cellular reprogramming and the rise of rejuvenation biotech. Trends Biotechnol. 2022 Jun;40(6):639-642. doi: 10.1016/j.tibtech.2022.01.011. Epub 2022 Feb 18. PubMed PMID: 35190201.

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Della Valle F, Reddy P, Yamamoto M, Liu P, Saera-Vila A, Bensaddek D, Zhang H, Prieto Martinez J, Abassi L, Celii M, Ocampo A, Nuñez Delicado E, Mangiavacchi A, Aiese Cigliano R, Rodriguez Esteban C, Horvath S, Izpisua Belmonte JC, Orlando V. LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes. Sci Transl Med. 2022 Aug 10;14(657):eabl6057. doi: 10.1126/scitranslmed.abl6057. Epub 2022 Aug 10. PubMed PMID: 35947677.

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Vílchez-Acosta A, Desdín-Micó G, Ocampo A. Vitamin B(12) emerges as key player during cellular reprogramming. Nat Metab. 2023 Nov;5(11):1844-1845. doi: 10.1038/s42255-023-00917-5. PubMed PMID: 37973898.

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Parras A, Vílchez-Acosta A, Desdín-Micó G, Picó S, Mrabti C, Montenegro-Borbolla E, Maroun CY, Haghani A, Brooke R, Del Carmen Maza M, Rechsteiner C, Battiston F, Branchina C, Perez K, Horvath S, Bertelli C, Sempoux C, Ocampo A. In vivo reprogramming leads to premature death linked to hepatic and intestinal failure. Nat Aging. 2023 Dec;3(12):1509-1520. doi: 10.1038/s43587-023-00528-5. Epub 2023 Nov 27. PubMed PMID: 38012287.

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Paine PT, Rechsteiner C, Morandini F, Desdín-Micó G, Mrabti C, Parras A, Haghani A, Brooke R, Horvath S, Seluanov A, Gorbunova V, Ocampo A. Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging. Front Aging. 2023;4:1323194. doi: 10.3389/fragi.2023.1323194. eCollection 2023. PubMed PMID: 38322248; PubMed Central PMCID: PMC10844398.

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Paine PT, Nguyen A, Ocampo A. Partial cellular reprogramming: A deep dive into an emerging rejuvenation technology. Aging Cell. 2024 Feb;23(2):e14039. doi: 10.1111/acel.14039. Epub 2023 Dec 1. Review. PubMed PMID: 38040663; PubMed Central PMCID: PMC10861195.

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Perez K, Parras A, Picó S, Rechsteiner C, Haghani A, Brooke R, Mrabti C, Schoenfeldt L, Horvath S, Ocampo A. DNA repair-deficient premature aging models display accelerated epigenetic age. Aging Cell. 2024 Feb;23(2):e14058. doi: 10.1111/acel.14058. Epub 2023 Dec 22. PubMed PMID: 38140713; PubMed Central PMCID: PMC10861193.

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Agius T, Emsley R, Lyon A, MacArthur MR, Kiesworo K, Faivre A, Stavart L, Lambelet M, Legouis D, de Seigneux S, Golshayan D, Lazeyras F, Yeh H, Markmann JF, Uygun K, Ocampo A, Mitchell SJ, Allagnat F, Déglise S, Longchamp A. Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21. Nat Commun. 2024 Feb 5;15(1):1073. doi: 10.1038/s41467-024-44866-3. PubMed PMID: 38316771; PubMed Central PMCID: PMC10844297.

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Morandini F, Rechsteiner C, Perez K, Praz V, Lopez Garcia G, Hinte LC, von Meyenn F, Ocampo A. ATAC-clock: An aging clock based on chromatin accessibility. Geroscience. 2024 Apr;46(2):1789-1806. doi: 10.1007/s11357-023-00986-0. Epub 2023 Nov 4. PubMed PMID: 37924441; PubMed Central PMCID: PMC10828344.