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Roach JC, Funk CC, Glusman G, Merrill DA, Hodes JF, Rapozo MK, Edens L, Vaidyaraman A, Shankle WR, Hood L, Bramen JE, COCOA Consortium. Specific plasma proteins and metabolites convey the effects of lifestyle interventions that improve cognition and function in Alzheimer’s disease. Alzheimers Dement. 2025 January; 20(Suppl 7):e091942.
Roach JC, Freidin MB. Editorial: Insights in human and medical genomics: 2022. Front Genet. 2023;14:1287894. doi: 10.3389/fgene.2023.1287894. eCollection 2023. PubMed PMID: 37818104; PubMed Central PMCID: PMC10561311.
Fecho K, Bizon C, Issabekova T, Moxon S, Thessen AE, Abdollahi S, Baranzini SE, Belhu B, Byrd WE, Chung L, Crouse A, Duby MP, Ferguson S, Foksinska A, Forero L, Friedman J, Gardner V, Glusman G, Hadlock J, Hanspers K, Hinderer E, Hobbs C, Hyde G, Huang S, Koslicki D, Mease P, Muller S, Mungall CJ, Ramsey SA, Roach J, Rubin I, Schurman SH, Shalev A, Smith B, Soman K, Stemann S, Su AI, Ta C, Watkins PB, Williams MD, Wu C, Xu CH. An approach for collaborative development of a federated biomedical knowledge graph-based question-answering system: Question-of-the-Month challenges. J Clin Transl Sci. 2023;7(1):e214. doi: 10.1017/cts.2023.619. eCollection 2023. PubMed PMID: 37900350; PubMed Central PMCID: PMC10603356.
Kaye JA, Lima L, Pico A, Lam S, Traglia M, Deng M, Mahajan S, Shin M, Thomas R, Daub A, Kratter I, Zahed H, Dunlap M, May H, Jo L, Barbe L, Roby E, Nelson A, Holloway A, Gillis T, MacDonald M, Jackson J, Li H, Glusman G, Roach JC, Ross CA, Foroud T, Wyman S, Finkbeiner S. Family-Based Whole Genome Sequence Analysis Uncovers Age Onset Modifiers of Huntington's Disease. [preprint]. 2023 July. Available from: https://ssrn.com/abstract=4522050.
Watanabe K, Wilmanski T, Baloni P, Robinson M, Garcia GG, Hoopmann MR, Midha MK, Baxter DH, Maes M, Morrone SR, Crebs KM, Kapil C, Kusebauch U, Wiedrick J, Lapidus J, Pflieger L, Lausted C, Roach JC, Glusman G, Cummings SR, Schork NJ, Price ND, Hood L, Miller RA, Moritz RL, Rappaport N. Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers. Commun Biol. 2023 Jul 22;6(1):768. doi: 10.1038/s42003-023-05128-y. PubMed PMID: 37481675; PubMed Central PMCID: PMC10363145.
Merrill DA, Bramen JE, Hodes JF, Rapozo MK, Glatt RM, Ganapathi AS, Wong CL, Porter VR, Kim M, Tongson YM, Bookheimer TH, Popa ES, Meysami S, Nomura N, Choden P, Dye RV, Togashi T, Loong S, Kress G, Panos SE, Miller KJ, Siddarth P, Roach JC. Precision Recommendations to Optimize Neurocognition [PREVENTION] Trial: Preliminary Results. AAIC; 2023 July 16; Amsterdam, Netherlands. Alzheimer's Association; c2023.
Glen AK, Ma C, Mendoza L, Womack F, Wood EC, Sinha M, Acevedo L, Kvarfordt LG, Peene RC, Liu S, Hoffman AS, Roach JC, Deutsch EW, Ramsey SA, Koslicki D. ARAX: a graph-based modular reasoning tool for translational biomedicine. Bioinformatics. 2023 Mar 1;39(3). doi: 10.1093/bioinformatics/btad082. PubMed PMID: 36752514; PubMed Central PMCID: PMC10027432.
Roach JC, Rapozo MK, Hara J, Glusman G, Lovejoy J, Shankle WR, Hood L. A Remotely Coached Multimodal Lifestyle Intervention for Alzheimer's Disease Ameliorates Functional and Cognitive Outcomes. J Alzheimers Dis. 2023;96(2):591-607. doi: 10.3233/JAD-230403. PubMed PMID: 37840487.
Bramen JE, Siddarth P, Popa ES, Kress GT, Rapozo MK, Hodes JF, Ganapathi AS, Slyapich CB, Glatt RM, Pierce K, Porter VR, Wong C, Kim M, Dye RV, Panos S, Bookheimer T, Togashi T, Loong S, Raji CA, Bookheimer SY, Roach JC, Merrill DA. Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer's Disease: A Small Sample Study. J Alzheimers Dis. 2023;96(1):329-342. doi: 10.3233/JAD-230458. PubMed PMID: 37742646; PubMed Central PMCID: PMC10657694.
Goldman JD, Wang K, Röltgen K, Nielsen SCA, Roach JC, Naccache SN, Yang F, Wirz OF, Yost KE, Lee JY, Chun K, Wrin T, Petropoulos CJ, Lee I, Fallen S, Manner PM, Wallick JA, Algren HA, Murray KM, Hadlock J, Chen D, Dai CL, Yuan D, Su Y, Jeharajah J, Berrington WR, Pappas GP, Nyatsatsang ST, Greninger AL, Satpathy AT, Pauk JS, Boyd SD, Heath JR. Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report. Vaccines (Basel). 2022 Dec 20;11(1). doi: 10.3390/vaccines11010005. PubMed PMID: 36679852; PubMed Central PMCID: PMC9861578.
Roach JC, Edens LE, Rajbhandari S, Hara J, Bramen J, Rapozo MK, Funk CC, Shankle WR, Hood L. A multimodal clinical and lifestyle intervention induces multiomic systemic effects and improves cognitive outcomes in Alzheimer’s disease. CTAD; 2022 December; San Francisco, CA, USA. c2022.
Wood EC, Glen AK, Kvarfordt LG, Womack F, Acevedo L, Yoon TS, Ma C, Flores V, Sinha M, Chodpathumwan Y, Termehchy A, Roach JC, Mendoza L, Hoffman AS, Deutsch EW, Koslicki D, Ramsey SA. RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine. BMC Bioinformatics. 2022 Sep 29;23(1):400. doi: 10.1186/s12859-022-04932-3. PubMed PMID: 36175836; PubMed Central PMCID: PMC9520835.
Roach JC, Edens L, Markewych DR, Rapozo MK, Hara J, Glusman G, Funk CC, Bramen J, Baloni P, Shankle WR, Hood L. A multimodal intervention for Alzheimer’s disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes. [preprint]. 2022 September. Available from: https://www.medrxiv.org/content/10.1101/2022.09.27.22280385v1. doi: 10.1101/2022.09.27.22280385.
Hasin N, Riggs LM, Shekhtman T, Ashworth J, Lease R, Oshone RT, Humphries EM, Badner JA, Thomson PA, Glahn DC, Craig DW, Edenberg HJ, Gershon ES, McMahon FJ, Nurnberger JI, Zandi PP, Kelsoe JR, Roach JC, Gould TD, Ament SA. Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Mol Psychiatry. 2022 Sep;27(9):3842-3856. doi: 10.1038/s41380-022-01609-4. Epub 2022 May 11. PubMed PMID: 35546635.
Unni DR, Moxon SAT, Bada M, Brush M, Bruskiewich R, Caufield JH, Clemons PA, Dancik V, Dumontier M, Fecho K, Glusman G, Hadlock JJ, Harris NL, Joshi A, Putman T, Qin G, Ramsey SA, Shefchek KA, Solbrig H, Soman K, Thessen AE, Haendel MA, Bizon C, Mungall CJ. Biolink Model: A universal schema for knowledge graphs in clinical, biomedical, and translational science. Clin Transl Sci. 2022 Aug;15(8):1848-1855. doi: 10.1111/cts.13302. Epub 2022 Jun 6. Review. PubMed PMID: 36125173; PubMed Central PMCID: PMC9372416.
Fecho K, Thessen AE, Baranzini SE, Bizon C, Hadlock JJ, Huang S, Roper RT, Southall N, Ta C, Watkins PB, Williams MD, Xu H, Byrd W, Dančík V, Duby MP, Dumontier M, Glusman G, Harris NL, Hinderer EW, Hyde G, Johs A, Su AI, Qin G, Zhu Q. Progress toward a universal biomedical data translator. Clin Transl Sci. 2022 Aug;15(8):1838-1847. doi: 10.1111/cts.13301. Epub 2022 Jun 6. Review. PubMed PMID: 35611543; PubMed Central PMCID: PMC9372428.
Roach JC, Hara J, Edens L, Rajbhandari S, Dill L, Romansik R, Rapozo MK, Funk CC, Jade K, Merrill DA, Bramen JE, Panos SE, Porter VR, Dye RV, Ganapathi AS, Hodes JS, Slyapich CB, Glatt RM, Wong CL, Fortier D, Shankle WR. Frequent Cognitive Tests Increase Power for Alzheimer’s Disease Clinical Trials. AAIC; 2022 August; San Diego, CA, USA. Alzheimer's Association; c2022.
Roach JC, Hara J, Fridman D, Lovejoy JC, Jade K, Heim L, Romansik R, Swietlikowski A, Phillips S, Rapozo MK, Shay MA, Fischer D, Funk C, Dill L, Brant-Zawadzki M, Hood L, Shankle WR. The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design. Alzheimers Dement (N Y). 2022;8(1):e12318. doi: 10.1002/trc2.12318. eCollection 2022. PubMed PMID: 35910672; PubMed Central PMCID: PMC9322829.
Watanabe K, Wilmanski T, Baloni P, Robinson M, Garcia GG, Hoopman MR, Midha MK, Baxter DH, Maes M, Morrone SR, Crebs KM, Kapil C, Kusebauch U, Wiedrick J, Lapidus J, Lovejoy JC, Magis AT, Lausted C, Roach JC, Glusman G, Schork NJ, Orwoll ES, Price ND, Hood L, Miller RA, Moritz RL, Rappaport N. Systems-level patterns in biological processes are changed under prolongevity interventions and across biological age. Version: 2. [preprint]. 2022 July. Available from: https://www.medrxiv.org/content/10.1101/2022.07.11.22277435v2. doi: 10.1101/2022.07.11.22277435.
Roach JC, Hodes JF, Funk CC, Shankle WR, Merrill DA, Hood L, Bramen J. Dense data enables 21st century clinical trials. Alzheimers Dement (N Y). 2022;8(1):e12297. doi: 10.1002/trc2.12297. eCollection 2022. PubMed PMID: 35733645; PubMed Central PMCID: PMC9191823.
Roach JC. Empirical Model of Spring 2020 Decrease in Daily Confirmed COVID-19 Cases in King County, Washington. medRxiv. 2022 Feb 7;. doi: 10.1101/2020.05.11.20098798. PubMed PMID: 35734092; PubMed Central PMCID: PMC9216716.
Bramen J, Popa E, Rapozo M, Siddarth P, Hodes J, Ganapathi A, Slyapich C, Glatt R, Porter V, Wong C, Bookheimer S, Roach J, Merrill D. Net Carbohydrate Consumption is Associated with Cortical Thickness in Cognitively Impaired Older Adults with Confirmed Amyloid Burden. Alzheimer's & Dementia. 2022; 18(S11):e062649.
Roach J, Hara J, Edens L, Rajbhandari S, Dill L, Romansik R, Rapozo M, Funk C, Jade K, Merrill D, Bramen J, Panos S, Porter V, Dye R, Ganapathi A, Hodes J, Slyapich C, Glatt R, Wong C, Fortier D, Shankle W. Frequent Cognitive Tests Increase Power for Alzheimer’s Disease Clinical Trials. Alzheimer's & Dementia. 2022; 18(S10):e063995.
Meysami S, Raji C, Chwa W, Popa E, Ganapathi A, Bookheimer T, Slyapich C, Pierce K, Richards C, Gill J, Lampa M, Rapozo M, Hodes J, Glatt R, Tongson Y, Wong C, Kim M, Porter V, Kaiser S, Panos S, Dye R, Miller K, Bookheimer S, Martin N, Kesari S, Kelly D, Siddarth P, Roach J, Bramen J, Merrill D. Preliminary Evaluation of Longitudinal Brain MRI Volumetric Quantification in Persons with Cognitive Decline and Confirmed Amyloid Burden Undergoing Multi-Modal Interventions at an Outpatient Memory Clinic. Alzheimer's & Dementia. 2022; 18(S5):e063695.
Ross MK, Raji C, Lokken KL, Bredesen DE, Roach JC, Funk CC, Price N, Rappaport N, Hood L, Heath JR. Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer's Disease. J Alzheimers Dis Parkinsonism. 2021;11(Suppl 5). Epub 2021 Aug 25. PubMed PMID: 35237464; PubMed Central PMCID: PMC8887953.
McEwen SC, Merrill DA, Bramen J, Porter V, Panos S, Kaiser S, Hodes J, Ganapathi A, Bell L, Bookheimer T, Glatt R, Rapozo M, Ross MK, Price ND, Kelly D, Funk CC, Hood L, Roach JC. A systems-biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease. Alzheimers Dement (N Y). 2021;7(1):e12191. doi: 10.1002/trc2.12191. eCollection 2021. PubMed PMID: 34295960; PubMed Central PMCID: PMC8290633.
Goldman JD, Wang K, Röltgen K, Nielsen SCA, Roach JC, Naccache SN, Yang F, Wirz OF, Yost KE, Lee JY, Chun K, Wrin T, Petropoulos CJ, Lee I, Fallen S, Manner PM, Wallick JA, Algren HA, Murray KM, Su Y, Hadlock J, Jeharajah J, Berrington WR, Pappas GP, Nyatsatsang ST, Greninger AL, Satpathy AT, Pauk JS, Boyd SD, Heath JR. Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report. medRxiv. 2020 Sep 25;. doi: 10.1101/2020.09.22.20192443. PubMed PMID: 32995830; PubMed Central PMCID: PMC7523175.
Roach JC. Empirical Model of Spring 2020 Decrease in Daily Confirmed COVID-19 Cases in King County, Washington. MedRxiv. 2020 May. doi: 10.1101/2020.05.11.20098798v4.
McEwen S, Roach J, et al. A Precision Medicine Multimodal Lifestyle Intervention for Treating Cognitive Impairment: Conceptual Framework of the PREVENTION Trial. Clinical Trials on Alzheimer's Disease Annual Conference (CTAD); 2019 December; San Diego, CA, USA. c2019.
Fecho K, Ahalt SC, Arunachalam S, Champion J, Chute CG, Davis S, Gersing K, Glusman G, Hadlock J, Lee J, Pfaff E, Robinson M, Sid E, Ta C, Xu H, Zhu R, Zhu Q, Peden DB. Sex, obesity, diabetes, and exposure to particulate matter among patients with severe asthma: Scientific insights from a comparative analysis of open clinical data sources during a five-day hackathon. J Biomed Inform. 2019 Dec;100:103325. doi: 10.1016/j.jbi.2019.103325. Epub 2019 Oct 30. PubMed PMID: 31676459; PubMed Central PMCID: PMC6953386.
Hasin N, Roach J, Ament S, et al. Characterization of a novel rare missense variant of the D-amino acid oxidase gene as a penetrant cause of psychosis. Neuroscience 2019 (SfN); 2019 October 23; Chicago, IL, USA. c2019.
Ahalt SC, Chute CG, Fecho K, Glusman G, Hadlock J, Taylor CO, Pfaff ER, Robinson PN, Solbrig H, Ta C, Tatonetti N, Weng C. Clinical Data: Sources and Types, Regulatory Constraints, Applications. Clin Transl Sci. 2019 Jul;12(4):329-333. doi: 10.1111/cts.12638. Epub 2019 May 9. PubMed PMID: 31074176; PubMed Central PMCID: PMC6617834.
Knijnenburg TA, Vockley JG, Chambwe N, Gibbs DL, Humphries C, Huddleston KC, Klein E, Kothiyal P, Tasseff R, Dhankani V, Bodian DL, Wong WSW, Glusman G, Mauldin DE, Miller M, Slagel J, Elasady S, Roach JC, Kramer R, Leinonen K, Linthorst J, Baveja R, Baker R, Solomon BD, Eley G, Iyer RK, Maxwell GL, Bernard B, Shmulevich I, Hood L, Niederhuber JE. Genomic and molecular characterization of preterm birth. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5819-5827. doi: 10.1073/pnas.1716314116. Epub 2019 Mar 4. PubMed PMID: 30833390; PubMed Central PMCID: PMC6431191.
The Biomedical Data Translator Program: Conception, Culture, and Community. Clin Transl Sci. 2019 Mar;12(2):91-94. doi: 10.1111/cts.12592. Epub 2018 Nov 9. PubMed PMID: 30412340; PubMed Central PMCID: PMC6440573.
Toward A Universal Biomedical Data Translator. Clin Transl Sci. 2019 Mar;12(2):86-90. doi: 10.1111/cts.12591. Epub 2018 Nov 9. PubMed PMID: 30412337; PubMed Central PMCID: PMC6440568.
Budde M, Friedrichs S, Alliey-Rodriguez N, Ament S, Badner JA, Berrettini WH, Bloss CS, Byerley W, Cichon S, Comes AL, Coryell W, Craig DW, Degenhardt F, Edenberg HJ, Foroud T, Forstner AJ, Frank J, Gershon ES, Goes FS, Greenwood TA, Guo Y, Hipolito M, Hood L, Keating BJ, Koller DL, Lawson WB, Liu C, Mahon PB, McInnis MG, McMahon FJ, Meier SM, Mühleisen TW, Murray SS, Nievergelt CM, Nurnberger JI Jr, Nwulia EA, Potash JB, Quarless D, Rice J, Roach JC, Scheftner WA, Schork NJ, Shekhtman T, Shilling PD, Smith EN, Streit F, Strohmaier J, Szelinger S, Treutlein J, Witt SH, Zandi PP, Zhang P, Zöllner S, Bickeböller H, Falkai PG, Kelsoe JR, Nöthen MM, Rietschel M, Schulze TG, Malzahn D. Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder. Eur Neuropsychopharmacol. 2019 Jan;29(1):156-170. doi: 10.1016/j.euroneuro.2018.10.005. Epub 2018 Nov 29. PubMed PMID: 30503783.
Roach J, et al. The Coaching for Cognition in Alzheimer's (COCOA) Trial. AAIC; 2019; c2019.
Roach J, et al. Dense Longitudinal Molecular Data for Turbocharging Clinical Trials. Clinical Trials on Alzheimer's Disease Annual Conference (CTAD); 2019; San Diego, CA. c2019.
Miller N, Ament SA, Shekhtman T, Roach JC, Kelsoe JR. Variants in the Promoter of Trkb are Associated with a Good Response to Lithium in Bipolar Disorder. European Neuropsychopharmacology. 2019 January; 29(3):S965. doi: https://doi.org/10.1016/j.euroneuro.2017.08.328.
Roach J, Hara J, Lovejoy J, Fridman D, Funk C, Heath L, Price N, Hood L, Heim L, Brant-Zawadski M, Shankle W. P4-017: COACHING FOR COGNITION IN ALZHEIMER'S (COCOA) TRIAL. Alzheimer's & Dementia. 2019; 15(7S_Part_24):P1279-P1280.
Roach JC. Complex Medical Therapies for Treating Complex Diseases. Translational Medicine Symposium: Creating Solutions for Clinical Problems. 2018 October; WSU Health Sciences Spokane, WA.
Chao MJ, Kim KH, Shin JW, Lucente D, Wheeler VC, Li H, Roach JC, Hood L, Wexler NS, Jardim LB, Holmans P, Jones L, Orth M, Kwak S, MacDonald ME, Gusella JF, Lee JM. Population-specific genetic modification of Huntington's disease in Venezuela. PLoS Genet. 2018 May;14(5):e1007274. doi: 10.1371/journal.pgen.1007274. eCollection 2018 May. PubMed PMID: 29750799; PubMed Central PMCID: PMC5965898.
Hou L, Kember RL, Roach JC, O'Connell JR, Craig DW, Bucan M, Scott WK, Pericak-Vance M, Haines JL, Crawford MH, Shuldiner AR, McMahon FJ. A population-specific reference panel empowers genetic studies of Anabaptist populations. Sci Rep. 2017 Jul 20;7(1):6079. doi: 10.1038/s41598-017-05445-3. PubMed PMID: 28729679; PubMed Central PMCID: PMC5519631.
Miller N, Ament SA, Shekhtman T, Roach JC, Bipolar Genome Study, Kelsoe JR. Search for Risk Variants in TrkB and BDNF that Predispose to Lithium Responsiveness in Bipolar Disorder. Biological Psychiatry. 2017 May; 81(10):S96.
Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD. Evolutionary history of Tibetans inferred from whole-genome sequencing. PLoS Genet. 2017 Apr;13(4):e1006675. doi: 10.1371/journal.pgen.1006675. eCollection 2017 Apr. PubMed PMID: 28448578; PubMed Central PMCID: PMC5407610.
Goldmann JM, Wong WS, Pinelli M, Farrah T, Bodian D, Stittrich AB, Glusman G, Vissers LE, Hoischen A, Roach JC, Vockley JG, Veltman JA, Solomon BD, Gilissen C, Niederhuber JE. Parent-of-origin-specific signatures of de novo mutations. Nat Genet. 2016 Aug;48(8):935-9. doi: 10.1038/ng.3597. Epub 2016 Jun 20. PubMed PMID: 27322544.
Stittrich AB, Ashworth J, Shi M, Robinson M, Mauldin D, Brunkow ME, Biswas S, Kim JM, Kwon KS, Jung JU, Galas D, Serikawa K, Duerr RH, Guthery SL, Peschon J, Hood L, Roach JC, Glusman G. Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals. Hum Genome Var. 2016;3:15060. doi: 10.1038/hgv.2015.60. eCollection 2016. PubMed PMID: 27081563; PubMed Central PMCID: PMC4785573.
Kaye J, Dunlap M, May H, Li H, Holloway A, Wyman S, Roach JC, Finkbeiner S. Investigation of a Genetic Modifier Identified by Whole Genome Sequencing of Huntington’s Disease patients in Induced Pluripotent Stem Cells. International Society for Stem Cell Research. 2016.
Ameziane N, May P, Haitjema A, van de Vrugt HJ, van Rossum-Fikkert SE, Ristic D, Williams GJ, Balk J, Rockx D, Li H, Rooimans MA, Oostra AB, Velleuer E, Dietrich R, Bleijerveld OB, Maarten Altelaar AF, Meijers-Heijboer H, Joenje H, Glusman G, Roach J, Hood L, Galas D, Wyman C, Balling R, den Dunnen J, de Winter JP, Kanaar R, Gelinas R, Dorsman JC. A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51. Nat Commun. 2015 Dec 18;6:8829. doi: 10.1038/ncomms9829. PubMed PMID: 26681308; PubMed Central PMCID: PMC4703882.
Lalli MA, Bettcher BM, Arcila ML, Garcia G, Guzman C, Madrigal L, Ramirez L, Acosta-Uribe J, Baena A, Wojta KJ, Coppola G, Fitch R, de Both MD, Huentelman MJ, Reiman EM, Brunkow ME, Glusman G, Roach JC, Kao AW, Lopera F, Kosik KS. Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease. Mol Psychiatry. 2015 Nov;20(11):1294-300. doi: 10.1038/mp.2015.131. Epub 2015 Sep 1. PubMed PMID: 26324103; PubMed Central PMCID: PMC4759097.
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