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Myung S, Lee YJ, Moon MH, Taraszka J, Sowell R, Koeniger S, Hilderbrand AE, Valentine SJ, Cherbas L, Cherbas P, Kaufmann TC, Miller DF, Mechref Y, Novotny MV, Ewing MA, Sporleder CR, Clemmer DE. Development of high-sensitivity ion trap ion mobility spectrometry time-of-flight techniques: a high-throughput nano-LC-IMS-TOF separation of peptides arising from a Drosophila protein extract. Anal Chem. 2003 Oct 1;75(19):5137-45. doi: 10.1021/ac030107f. PubMed PMID: 14708788.
Sowell RA, Koeniger SL, Valentine SJ, Moon MH, Clemmer DE. Nanoflow LC/IMS-MS and LC/IMS-CID/MS of protein mixtures. J Am Soc Mass Spectrom. 2004 Sep;15(9):1341-53. doi: 10.1016/j.jasms.2004.06.014. PubMed PMID: 15337515.
Taraszka JA, Kurulugama R, Sowell RA, Valentine SJ, Koeniger SL, Arnold RJ, Miller DF, Kaufman TC, Clemmer DE. Mapping the proteome of Drosophila melanogaster: analysis of embryos and adult heads by LC-IMS-MS methods. J Proteome Res. 2005 Jul-Aug;4(4):1223-37. doi: 10.1021/pr050038g. PubMed PMID: 16083272.
Taraszka JA, Gao X, Valentine SJ, Sowell RA, Koeniger SL, Miller DF, Kaufman TC, Clemmer DE. Proteome profiling for assessing diversity: analysis of individual heads of Drosophila melanogaster using LC-ion mobility-MS. J Proteome Res. 2005 Jul-Aug;4(4):1238-47. doi: 10.1021/pr050037o. PubMed PMID: 16083273.
Xun Z, Sowell RA, Kaufman TC, Clemmer DE. Protein expression in a Drosophila model of Parkinson's disease. J Proteome Res. 2007 Jan;6(1):348-57. doi: 10.1021/pr060488o. PubMed PMID: 17203978; PubMed Central PMCID: PMC2597372.
Sowell RA, Hersberger KE, Kaufman TC, Clemmer DE. Examining the proteome of Drosophila across organism lifespan. J Proteome Res. 2007 Sep;6(9):3637-47. doi: 10.1021/pr070224h. Epub 2007 Aug 16. PubMed PMID: 17696518.
Xun Z, Sowell RA, Kaufman TC, Clemmer DE. Lifetime proteomic profiling of an A30P alpha-synuclein Drosophila model of Parkinson's disease. J Proteome Res. 2007 Sep;6(9):3729-38. doi: 10.1021/pr0700504. Epub 2007 Aug 7. PubMed PMID: 17683129.
Xun Z, Sowell RA, Kaufman TC, Clemmer DE. Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease. Mol Cell Proteomics. 2008 Jul;7(7):1191-203. doi: 10.1074/mcp.M700467-MCP200. Epub 2008 Mar 18. PubMed PMID: 18353766; PubMed Central PMCID: PMC2493378.
Kurulugama RT, Valentine SJ, Sowell RA, Clemmer DE. Development of a high-throughput IMS-IMS-MS approach for analyzing mixtures of biomolecules. J Proteomics. 2008 Aug 21;71(3):318-31. doi: 10.1016/j.jprot.2008.06.010. Epub 2008 Jun 25. PubMed PMID: 18590839; PubMed Central PMCID: PMC2626180.
Aluise CD, Sowell RA, Butterfield DA. Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease. Biochim Biophys Acta. 2008 Oct;1782(10):549-58. doi: 10.1016/j.bbadis.2008.07.008. Epub 2008 Aug 7. Review. PubMed PMID: 18760351; PubMed Central PMCID: PMC2629398.
Sowell RA, Owen JB, Butterfield DA. Proteomics in animal models of Alzheimer's and Parkinson's diseases. Ageing Res Rev. 2009 Jan;8(1):1-17. doi: 10.1016/j.arr.2008.07.003. Epub 2008 Jul 18. Review. PubMed PMID: 18703168; PubMed Central PMCID: PMC2630427.
Sultana R, Sowell RA, Butterfield DA. Nitrated Proteins in the Progression of Alzheimer’s Disease: A Proteomics Comparison of Mild Cognitive Impairment and Alzheimer’s Disease Brain. In: Veasey SC, editor. Oxidative Neural Injury [Internet] Totowa, NJ: Humana Press; 2009. p.137-157. Available from:
Valentine SJ, Kurulugama RT, Bohrer BC, Merenbloom SI, Sowell RA, Mechref Y, Clemmer DE. Developing IMS–IMS–MS for rapid characterization of abundant proteins in human plasma. International Journal of Mass Spectrometry. 2009 June; 283(1):149-160. NIHMSID: NIHMS1798973.doi:
Butterfield DA, Galvan V, Lange MB, Tang H, Sowell RA, Spilman P, Fombonne J, Gorostiza O, Zhang J, Sultana R, Bredesen DE. In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP. Free Radic Biol Med. 2010 Jan 1;48(1):136-44. doi: 10.1016/j.freeradbiomed.2009.10.035. Epub 2009 Oct 23. PubMed PMID: 19854267; PubMed Central PMCID: PMC2818480.
Sowell RA, Aluise CD, Butterfield DA. Acetyl-l-carnitine and ferulic acid action in aging and neurodegenerative diseases. Micronutrients and Brain Health Packer, Lester.; Sies, Helmut; Eggersdorfer, Manfred; Cadenas, Enrique Eds. CRC Press: Florida. 2010; 26:341-353. doi: 10.1201/9781420073522.ch23.
Aluise CD, Robinson RA, Beckett TL, Murphy MP, Cai J, Pierce WM, Markesbery WR, Butterfield DA. Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics. Neurobiol Dis. 2010 Aug;39(2):221-8. doi: 10.1016/j.nbd.2010.04.011. Epub 2010 Apr 23. PubMed PMID: 20399861; PubMed Central PMCID: PMC2885559.
Robinson RA, Kellie JF, Kaufman TC, Clemmer DE. Insights into aging through measurements of the Drosophila proteome as a function of temperature. Mech Ageing Dev. 2010 Sep;131(9):584-90. doi: 10.1016/j.mad.2010.08.004. Epub 2010 Aug 21. PubMed PMID: 20732347; PubMed Central PMCID: PMC2949476.
Di Domenico F, Owen JB, Sultana R, Sowell RA, Perluigi M, Cini C, Cai J, Pierce WM, Butterfield DA. The wheat germ agglutinin-fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression. J Neurosci Res. 2010 Dec;88(16):3566-77. doi: 10.1002/jnr.22528. Epub 2010 Oct 8. PubMed PMID: 20936705.
Aluise CD, Robinson RA, Cai J, Pierce WM, Markesbery WR, Butterfield DA. Redox proteomics analysis of brains from subjects with amnestic mild cognitive impairment compared to brains from subjects with preclinical Alzheimer's disease: insights into memory loss in MCI. J Alzheimers Dis. 2011;23(2):257-69. doi: 10.3233/JAD-2010-101083. PubMed PMID: 20930294.
Sowell RA, Butterfield DA. Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively Bred Strains (SAM Strains). In: De Deyn PP, Van Dam D, editors. Animal Models of Dementia [Internet] Totowa, NJ: Humana Press; 2011. p.271-293. 271-293p. Available from:
Robinson RA, Lange MB, Sultana R, Galvan V, Fombonne J, Gorostiza O, Zhang J, Warrier G, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Differential expression and redox proteomics analyses of an Alzheimer disease transgenic mouse model: effects of the amyloid-β peptide of amyloid precursor protein. Neuroscience. 2011 Mar 17;177:207-22. doi: 10.1016/j.neuroscience.2011.01.005. Epub 2011 Jan 9. PubMed PMID: 21223993; PubMed Central PMCID: PMC3058851.
Sultana R, Robinson RA, Di Domenico F, Abdul HM, St Clair DK, Markesbery WR, Cai J, Pierce WM, Butterfield DA. Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. J Proteomics. 2011 Oct 19;74(11):2430-40. doi: 10.1016/j.jprot.2011.06.015. Epub 2011 Jun 25. PubMed PMID: 21726674; PubMed Central PMCID: PMC3199338.
Robinson RA, Joshi G, Huang Q, Sultana R, Baker AS, Cai J, Pierce W, St Clair DK, Markesbery WR, Butterfield DA. Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease. Proteomics. 2011 Nov;11(21):4243-56. doi: 10.1002/pmic.201000523. Epub 2011 Sep 22. PubMed PMID: 21954051; PubMed Central PMCID: PMC3517055.
Evans AR, Miriyala S, St Clair DK, Butterfield DA, Robinson RA. Global effects of adriamycin treatment on mouse splenic protein levels. J Proteome Res. 2012 Feb 3;11(2):1054-64. doi: 10.1021/pr200798g. Epub 2012 Jan 4. PubMed PMID: 22112237.
Robinson RA, Evans AR. Enhanced sample multiplexing for nitrotyrosine-modified proteins using combined precursor isotopic labeling and isobaric tagging. Anal Chem. 2012 Jun 5;84(11):4677-86. doi: 10.1021/ac202000v. Epub 2012 May 7. PubMed PMID: 22509719.
Sultana R, Robinson RA, Lange MB, Fiorini A, Galvan V, Fombonne J, Baker A, Gorostiza O, Zhang J, Cai J, Pierce WM, Bredesen DE, Butterfield DA. Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis?. Antioxid Redox Signal. 2012 Dec 1;17(11):1507-14. doi: 10.1089/ars.2011.4470. Epub 2012 Jun 6. PubMed PMID: 22500616; PubMed Central PMCID: PMC3448937.
Butterfield DA, Perluigi M, Reed T, Muharib T, Hughes CP, Robinson RA, Sultana R. Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications. Antioxid Redox Signal. 2012 Dec 1;17(11):1610-55. doi: 10.1089/ars.2011.4109. Epub 2012 Jan 18. Review. PubMed PMID: 22115501; PubMed Central PMCID: PMC3448942.
Robinson RA, Cao Z, Williams C. Oxidative stress in CD90+ T-cells of AβPP/PS-1 transgenic mice. J Alzheimers Dis. 2013;37(4):661-6. doi: 10.3233/JAD-130665. PubMed PMID: 23948908.
Evans AR, Robinson RA. Proteomics quantification of protein nitration. Reviews in Analytical Chemistry. 2013; 32(3). doi:
Robinson RA, Butterfield DA. Insights from Proteomics into Mild Cognitive Impairment, Likely the Earliest Stage of Alzheimer’s Disease. In: Sun M, editor. Alzheimer's Disease Research Compendium [Internet] Online: Nova Science Publishers Inc., ISBN: 978-1-62257-510-7.; 2013. Chapter 7; p.97-116. 97-116p. Available from:
Shi H, Gu L, Clemmer DE, Robinson RA. Effects of Fe(II)/H2O2 oxidation on ubiquitin conformers measured by ion mobility-mass spectrometry. J Phys Chem B. 2013 Jan 10;117(1):164-73. doi: 10.1021/jp3099544. Epub 2012 Dec 19. PubMed PMID: 23211023; PubMed Central PMCID: PMC3552375.
Cao Z, Yende S, Kellum JA, Robinson RA. Additions to the Human Plasma Proteome via a Tandem MARS Depletion iTRAQ-Based Workflow. Int J Proteomics. 2013;2013:654356. doi: 10.1155/2013/654356. Epub 2013 Feb 19. PubMed PMID: 23509626; PubMed Central PMCID: PMC3590782.
Jiang W. Ion Mobility-Mass Spectrometry. Encyclopedia of Analytical Chemistry. 2013 March. doi:
Evans AR, Robinson RA. Global combined precursor isotopic labeling and isobaric tagging (cPILOT) approach with selective MS(3) acquisition. Proteomics. 2013 Nov;13(22):3267-72. doi: 10.1002/pmic.201300198. Epub 2013 Oct 20. PubMed PMID: 24124127.
Cao Z, Robinson RA. Proteome characterization of splenocytes from an Aβpp/ps-1 Alzheimer's disease model. Proteomics. 2014 Feb;14(2-3):291-7. doi: 10.1002/pmic.201300130. Epub 2014 Jan 6. PubMed PMID: 24293237.
Cao Z, Robinson RA. The role of proteomics in understanding biological mechanisms of sepsis. Proteomics Clin Appl. 2014 Feb;8(1-2):35-52. doi: 10.1002/prca.201300101. Review. PubMed PMID: 24339042.
Cao Z, Yende S, Kellum JA, Angus DC, Robinson RA. Proteomics reveals age-related differences in the host immune response to sepsis. J Proteome Res. 2014 Feb 7;13(2):422-32. doi: 10.1021/pr400814s. Epub 2013 Dec 4. PubMed PMID: 24266763; PubMed Central PMCID: PMC3976438.
Bai H, Jiang W, Kotchey GP, Saidi WA, Bythell BJ, Jarvis JM, Marshall AG, Robinson RA, Star A. Insight into the Mechanism of Graphene Oxide Degradation via the Photo-Fenton Reaction. J Phys Chem C Nanomater Interfaces. 2014 May 15;118(19):10519-10529. doi: 10.1021/jp503413s. Epub 2014 Apr 15. PubMed PMID: 24860637; PubMed Central PMCID: PMC4025574.
Butterfield DA, Gu L, Di Domenico F, Robinson RA. Mass spectrometry and redox proteomics: applications in disease. Mass Spectrom Rev. 2014 Jul-Aug;33(4):277-301. doi: 10.1002/mas.21374. Epub 2013 Sep 30. Review. PubMed PMID: 24930952.
Gu L, Robinson RA. Multiple proteases to localize oxidation sites. PLoS One. 2015;10(3):e0116606. doi: 10.1371/journal.pone.0116606. eCollection 2015. PubMed PMID: 25775238; PubMed Central PMCID: PMC4361631.
Gu L, Evans AR, Robinson RA. Sample multiplexing with cysteine-selective approaches: cysDML and cPILOT. J Am Soc Mass Spectrom. 2015 Apr;26(4):615-30. doi: 10.1007/s13361-014-1059-9. Epub 2015 Jan 15. PubMed PMID: 25588721.
Cao Z, Evans AR, Robinson RA. MS(3)-based quantitative proteomics using pulsed-Q dissociation. Rapid Commun Mass Spectrom. 2015 Jun 15;29(11):1025-30. doi: 10.1002/rcm.7192. PubMed PMID: 26044269.
Evans AR, Gu L, Guerrero R Jr, Robinson RA. Global cPILOT analysis of the APP/PS-1 mouse liver proteome. Proteomics Clin Appl. 2015 Oct;9(9-10):872-84. doi: 10.1002/prca.201400149. Epub 2015 May 12. PubMed PMID: 25620666.
Gu L, Robinson RA. A simple isotopic labeling method to study cysteine oxidation in Alzheimer's disease: oxidized cysteine-selective dimethylation (OxcysDML). Anal Bioanal Chem. 2016 Apr;408(11):2993-3004. doi: 10.1007/s00216-016-9307-4. Epub 2016 Jan 22. PubMed PMID: 26800981.
Gu L, Robinson RA. High-throughput endogenous measurement of S-nitrosylation in Alzheimer's disease using oxidized cysteine-selective cPILOT. Analyst. 2016 Jun 21;141(12):3904-15. doi: 10.1039/c6an00417b. Epub 2016 May 6. PubMed PMID: 27152368; PubMed Central PMCID: PMC4904844.
Gu L, Robinson RA. Proteomic approaches to quantify cysteine reversible modifications in aging and neurodegenerative diseases. Proteomics Clin Appl. 2016 Dec;10(12):1159-1177. doi: 10.1002/prca.201600015. Epub 2016 Nov 11. Review. PubMed PMID: 27666938; PubMed Central PMCID: PMC5157156.
Henderson M, Rice B, Sebastian A, Sullivan PG, King C, Robinson RA, Reed TT. Neuroproteomic study of nitrated proteins in moderate traumatic brain injured rats treated with gamma glutamyl cysteine ethyl ester administration post injury: Insight into the role of glutathione elevation in nitrosative stress. Proteomics Clin Appl. 2016 Dec;10(12):1218-1224. doi: 10.1002/prca.201600004. Epub 2016 Nov 11. PubMed PMID: 27739215; PubMed Central PMCID: PMC5698013.
Dyer RR, Robinson RA. S-nitrosylation in Alzheimer’s Disease using Oxidized Cysteine-Selective cPILOT. In: Santamaría E, Fernández-Irigoyen J, Walz W, editors. Current Proteomic Approaches Applied to Brain Function [Internet] Pamplona, Spain: Humana Press; 2017. p.225-241. Available from:
Robinson RA, Amin B, Guest PC. Multiplexing Biomarker Methods, Proteomics and Considerations for Alzheimer's Disease. Adv Exp Med Biol. 2017;974:21-48. doi: 10.1007/978-3-319-52479-5_2. Review. PubMed PMID: 28353223.
King CD, Singh D, Holden K, Govan AB, Keith S, Ghazi A, Robinson RA. Dataset of proteomics analysis of aging C. elegans exposed to Pseudomonas aeruginosa strain PA01. Data Brief. 2017 Apr;11:245-251. doi: 10.1016/j.dib.2017.02.001. eCollection 2017 Apr. PubMed PMID: 28243620; PubMed Central PMCID: PMC5320047.
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