My Bibliography

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McKinney-Aguirre CA, Stewart AS, Freund JM, Singh A, Hojnacki JI, Tomblyn S, Berger MB, Washburn SA, Gonzalez LM. Human Placental Extract Enhances Neonatal Intestinal Epithelial Reparative Capacity in Porcine Models. Cell Mol Gastroenterol Hepatol. 2026;20(1):101619. doi: 10.1016/j.jcmgh.2025.101619. Epub 2025 Sep 2. PubMed PMID: 40907660; PubMed Central PMCID: PMC12596962.

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Stewart AS, Kopper JJ, McKinney-Aguirre C, Veerasamy B, Sahoo DK, Freund JM, Gonzalez LM. Assessment of equine intestinal epithelial junctional complexes and barrier permeability using a monolayer culture system. Front Vet Sci. 2024;11:1455262. doi: 10.3389/fvets.2024.1455262. eCollection 2024. PubMed PMID: 39502947; PubMed Central PMCID: PMC11536341.

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McKinney-Aguirre CA, Schaaf CR, Goya-Jorge E, Freund JM, Gonzalez LM. Large animal models enhance the study of crypt-mediated epithelial recovery from prolonged intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2024 Dec 1;327(6):G783-G788. doi: 10.1152/ajpgi.00236.2024. Epub 2024 Oct 15. PubMed PMID: 39404771; PubMed Central PMCID: PMC11684884.

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Hellstrom E, McKinney-Aguirre C, Gonzalez L, Ziegler A, Blikslager A. Equine Enteric Glial Culture and Application to the Study of a Neural Inflammatory Mechanism in Equine Colic. J Vis Exp. 2024 Oct 4;(212). doi: 10.3791/67244. PubMed PMID: 39431775; NIHMSID:NIHMS2161855.

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Ludwig EK, Abraham N, Schaaf CR, McKinney CA, Freund J, Stewart AS, Veerasammy BA, Thomas M, Cardona DM, Garman K, Barbas AS, Sudan DL, Gonzalez LM. Comparison of the effects of normothermic machine perfusion and cold storage preservation on porcine intestinal allograft regenerative potential and viability. Am J Transplant. 2024 Apr;24(4):564-576. doi: 10.1016/j.ajt.2023.10.026. Epub 2023 Oct 31. PubMed PMID: 37918482; PubMed Central PMCID: PMC11082874.

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Schaaf CR, Polkoff KM, Carter A, Stewart AS, Sheahan B, Freund J, Ginzel J, Snyder JC, Roper J, Piedrahita JA, Gonzalez LM. A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease. FASEB J. 2023 Jun;37(6):e22975. doi: 10.1096/fj.202300223R. PubMed PMID: 37159340; PubMed Central PMCID: PMC10446885.

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Veerasammy B, Gonzalez G, Báez-Ramos P, Schaaf CR, Stewart AS, Ludwig EK, McKinney-Aguirre C, Freund J, Robertson J, Gonzalez LM. Changes in equine intestinal stem/progenitor cell number at resection margins in cases of small intestinal strangulation. Equine Vet J. 2023 Nov;55(6):995-1002. doi: 10.1111/evj.13927. Epub 2023 Feb 9. PubMed PMID: 36716291; PubMed Central PMCID: PMC10387127.

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Ludwig EK, Hobbs KJ, McKinney-Aguirre CA, Gonzalez LM. Biomarkers of Intestinal Injury in Colic. Animals (Basel). 2023 Jan 7;13(2). doi: 10.3390/ani13020227. Review. PubMed PMID: 36670767; PubMed Central PMCID: PMC9854801.

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Abraham N, Ludwig EK, Schaaf CR, Veerasammy B, Stewart AS, McKinney C, Freund J, Brassil J, Samy KP, Gao Q, Kahan R, Niedzwiecki D, Cardona DM, Garman KS, Barbas AS, Sudan DL, Gonzalez LM. Orthotopic Transplantation of the Full-length Porcine Intestine After Normothermic Machine Perfusion. Transplant Direct. 2022 Nov;8(11):e1390. doi: 10.1097/TXD.0000000000001390. eCollection 2022 Nov. PubMed PMID: 36299444; PubMed Central PMCID: PMC9592306.

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Schaaf CR, Gonzalez LM. Use of Translational, Genetically Modified Porcine Models to Ultimately Improve Intestinal Disease Treatment. Front Vet Sci. 2022;9:878952. doi: 10.3389/fvets.2022.878952. eCollection 2022. Review. PubMed PMID: 35669174; PubMed Central PMCID: PMC9164269.

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Tse LV, Meganck RM, Araba KC, Yount BL, Shaffer KM, Hou YJ, Munt JE, Adams LE, Wykoff JA, Morowitz JM, Dong S, Magness ST, Marzluff WF, Gonzalez LM, Ehre C, Baric RS. Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2118126119. doi: 10.1073/pnas.2118126119. Epub 2022 Apr 27. PubMed PMID: 35476513; PubMed Central PMCID: PMC9170153.

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Stewart AS, Schaaf CR, Luff JA, Freund JM, Becker TC, Tufts SR, Robertson JB, Gonzalez LM. HOPX(+) injury-resistant intestinal stem cells drive epithelial recovery after severe intestinal ischemia. Am J Physiol Gastrointest Liver Physiol. 2021 Nov 1;321(5):G588-G602. doi: 10.1152/ajpgi.00165.2021. Epub 2021 Sep 22. PubMed PMID: 34549599; PubMed Central PMCID: PMC8616590.

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Vermeire B, Gonzalez LM, Jansens RJJ, Cox E, Devriendt B. Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut. Vet Res. 2021 Jun 26;52(1):94. doi: 10.1186/s13567-021-00961-7. PubMed PMID: 34174960; PubMed Central PMCID: PMC8235647.

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Gonzalez LM, Baker WT, Hughes FE, Blikslager AT, Fogle CA. Comparison of histomorphometric characteristics of dorsal colon and pelvic flexure biopsy specimens obtained from horses with large colon volvulus that underwent resection. Am J Vet Res. 2020 Nov;81(11):899-903. doi: 10.2460/ajvr.81.11.899. PubMed PMID: 33107753; PubMed Central PMCID: PMC8972794.

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Orr KE, Baker WT, Lynch TM, Hughes FE, Clark CK, Slone DE Jr, Fogle CA, Gonzalez LM. Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus. Vet Surg. 2020 Apr;49(3):472-479. doi: 10.1111/vsu.13361. Epub 2020 Jan 9. PubMed PMID: 31916608; PubMed Central PMCID: PMC8984623.

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Singh AP, Hung YH, Shanahan MT, Kanke M, Bonfini A, Dame MK, Biraud M, Peck BCE, Oyesola OO, Freund JM, Cubitt RL, Curry EG, Gonzalez LM, Bewick GA, Tait-Wojno ED, Kurpios NA, Ding S, Spence JR, Dekaney CM, Buchon N, Sethupathy P. Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner. Cell Mol Gastroenterol Hepatol. 2020;9(3):447-464. doi: 10.1016/j.jcmgh.2019.11.001. Epub 2019 Nov 19. PubMed PMID: 31756561; PubMed Central PMCID: PMC7021555.

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Gonzalez LM, Stewart AS, Freund J, Kucera CR, Dekaney CM, Magness ST, Blikslager AT. Preservation of reserve intestinal epithelial stem cells following severe ischemic injury. Am J Physiol Gastrointest Liver Physiol. 2019 Apr 1;316(4):G482-G494. doi: 10.1152/ajpgi.00262.2018. Epub 2019 Feb 4. PubMed PMID: 30714814; PubMed Central PMCID: PMC6483022.

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Ziegler AL, Pridgen TA, Mills JK, Gonzalez LM, Van Landeghem L, Odle J, Blikslager AT. Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair. PLoS One. 2018;13(8):e0200674. doi: 10.1371/journal.pone.0200674. eCollection 2018. PubMed PMID: 30138372; PubMed Central PMCID: PMC6107120.

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Fletcher OJ, Mansell R, Martin MP, Borst LB, Barnes HJ, Gonzalez LM. Gross Morphometry, Histomorphometry, and Immunohistochemistry Confirm Early and Persistent Jejunal Crypt Hyperplasia in Poults with Enteritis and Depressed Growth. Avian Dis. 2018 Jun;62(2):163-170. doi: 10.1637/11759-101717-Reg.1. PubMed PMID: 29944394; PubMed Central PMCID: PMC6176685.

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Stieler Stewart A, Freund JM, Blikslager AT, Gonzalez LM. Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia. J Vis Exp. 2018 May 18;(135). doi: 10.3791/57647. PubMed PMID: 29863654; PubMed Central PMCID: PMC6101266.

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Royal KD, Hunt SA, Gonzalez LM, Lewbart GA, Bailey KM. Veterinary Medical Students' Motivations for Exercise. J Vet Med Educ. 2018 Fall;45(3):367-373. doi: 10.3138/jvme.0117-004r. Epub 2018 Jan 18. PubMed PMID: 30106662.

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Kucera CR, Stranahan LW, Hughes F, Blikslager AT, Gonzalez LM. Protein biomarker of cell proliferation determines survival to discharge in cases of equine large colon volvulus. Equine Vet J. 2018 Jul;50(4):452-456. doi: 10.1111/evj.12767. Epub 2017 Nov 27. PubMed PMID: 29032573; PubMed Central PMCID: PMC5899956.

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Blikslager A, Gonzalez L. Equine Intestinal Mucosal Pathobiology. Annu Rev Anim Biosci. 2018 Feb 15;6:157-175. doi: 10.1146/annurev-animal-030117-014748. Epub 2017 Nov 16. Review. PubMed PMID: 29144770; PubMed Central PMCID: PMC7769316.

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Stewart AS, Freund JM, Gonzalez LM. Advanced three-dimensional culture of equine intestinal epithelial stem cells. Equine Vet J. 2018 Mar;50(2):241-248. doi: 10.1111/evj.12734. Epub 2017 Sep 6. PubMed PMID: 28792626; PubMed Central PMCID: PMC5796842.

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von Furstenberg RJ, Li J, Stolarchuk C, Feder R, Campbell A, Kruger L, Gonzalez LM, Blikslager AT, Cardona DM, McCall SJ, Henning SJ, Garman KS. Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation. Cell Mol Gastroenterol Hepatol. 2017 Nov;4(3):385-404. doi: 10.1016/j.jcmgh.2017.07.005. eCollection 2017 Nov. PubMed PMID: 28936470; PubMed Central PMCID: PMC5602779.

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Krüger L, Gonzalez LM, Pridgen TA, McCall SJ, von Furstenberg RJ, Harnden I, Carnighan GE, Cox AM, Blikslager AT, Garman KS. Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair. Am J Physiol Gastrointest Liver Physiol. 2017 Sep 1;313(3):G180-G191. doi: 10.1152/ajpgi.00036.2017. Epub 2017 Jun 1. PubMed PMID: 28572084; PubMed Central PMCID: PMC5625137.

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Stewart AS, Pratt-Phillips S, Gonzalez LM. Alterations in Intestinal Permeability: The Role of the "Leaky Gut" in Health and Disease. J Equine Vet Sci. 2017 May;52:10-22. doi: 10.1016/j.jevs.2017.02.009. Epub 2017 Mar 7. PubMed PMID: 31000910; PubMed Central PMCID: PMC6467570.

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Gonzalez LM, Kinnin LA, Blikslager AT. Characterization of discrete equine intestinal epithelial cell lineages. Am J Vet Res. 2015 Apr;76(4):358-66. doi: 10.2460/ajvr.76.4.358. PubMed PMID: 25815577; PubMed Central PMCID: PMC4517574.

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Gonzalez LM, Moeser AJ, Blikslager AT. Porcine models of digestive disease: the future of large animal translational research. Transl Res. 2015 Jul;166(1):12-27. doi: 10.1016/j.trsl.2015.01.004. Epub 2015 Jan 13. Review. PubMed PMID: 25655839; PubMed Central PMCID: PMC4458388.

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Gonzalez LM, Moeser AJ, Blikslager AT. Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G63-75. doi: 10.1152/ajpgi.00112.2013. Epub 2014 Nov 20. Review. PubMed PMID: 25414098; PubMed Central PMCID: PMC4297854.

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Gonzalez LM, Fogle CA, Baker WT, Hughes FE, Law JM, Motsinger-Reif AA, Blikslager AT. Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013. Equine Vet J. 2015 May;47(3):279-84. doi: 10.1111/evj.12273. Epub 2014 May 29. PubMed PMID: 24735170; PubMed Central PMCID: PMC4198525.

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Gonzalez LM, Williamson I, Piedrahita JA, Blikslager AT, Magness ST. Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration. PLoS One. 2013;8(6):e66465. doi: 10.1371/journal.pone.0066465. Print 2013. PubMed PMID: 23840480; PubMed Central PMCID: PMC3696067.

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Gonzalez LM, Schramme MC, Robertson ID, Thrall DE, Redding RW. MRI features of metacarpo(tarso)phalangeal region lameness in 40 horses. Vet Radiol Ultrasound. 2010 Jul-Aug;51(4):404-14. doi: 10.1111/j.1740-8261.2010.01676.x. PubMed PMID: 20806872.