VARP binds SNX27 to promote endosomal supercomplex formation on membranes.
Sci Adv.
2025 Feb 14;11(7):eadr9340. doi: 10.1126/sciadv.adr9340. Epub 2025 Feb 12. PubMed PMID:
39937906; PubMed Central PMCID:
PMC11817943.
Tepsin binds LC3B to promote ATG9A trafficking and delivery.
Mol Biol Cell.
2024 Apr 1;35(4):ar56. doi: 10.1091/mbc.E23-09-0359-T. Epub 2024 Feb 21. PubMed PMID:
38381558; PubMed Central PMCID:
PMC11064669.
An interaction between β'-COP and the ArfGAP, Glo3, maintains post-Golgi cargo recycling.
J Cell Biol.
2023 Apr 3;222(4). doi: 10.1083/jcb.202008061. Epub 2023 Feb 22. PubMed PMID:
36811888; PubMed Central PMCID:
PMC9960064.
AP-4 loss in CRISPR-edited zebrafish affects early embryo development.
Adv Biol Regul.
2023 Jan;87:100945. doi: 10.1016/j.jbior.2022.100945. Epub 2022 Dec 22. PubMed PMID:
36642642; PubMed Central PMCID:
PMC9992121.
Improved mammalian retromer cryo-EM structures reveal a new assembly interface.
J Biol Chem.
2022 Nov;298(11):102523. doi: 10.1016/j.jbc.2022.102523. Epub 2022 Sep 26. PubMed PMID:
36174678; PubMed Central PMCID:
PMC9636581.
Ubiquitination drives COPI priming and Golgi SNARE localization.
Elife.
2022 Jul 29;11. doi: 10.7554/eLife.80911. PubMed PMID:
35904239; PubMed Central PMCID:
PMC9374436.
Biochemical basis for an interaction between SNX27 and the flexible SNX1 N-terminus.
Adv Biol Regul.
2022 Jan;83:100842. doi: 10.1016/j.jbior.2021.100842. Epub 2021 Nov 27. PubMed PMID:
34866035; PubMed Central PMCID:
PMC8858909.
De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex.
Sci Adv.
2021 Dec 3;7(49):eabg4007. doi: 10.1126/sciadv.abg4007. Epub 2021 Dec 1. PubMed PMID:
34851660; PubMed Central PMCID:
PMC8635440.
Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease.
Front Cell Dev Biol.
2021;9:642378. doi: 10.3389/fcell.2021.642378. eCollection 2021. Review. PubMed PMID:
33937239; PubMed Central PMCID:
PMC8083963.
The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
Adv Biol Regul.
2021 Jan;79:100781. doi: 10.1016/j.jbior.2020.100781. Epub 2021 Jan 5. PubMed PMID:
33436318; PubMed Central PMCID:
PMC7920988.
Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis.
Cell Rep.
2020 Dec 22;33(12):108526. doi: 10.1016/j.celrep.2020.108526. PubMed PMID:
33357436; PubMed Central PMCID:
PMC7775634.
Unveiling the cryo-EM structure of retromer.
Biochem Soc Trans.
2020 Oct 30;48(5):2261-2272. doi: 10.1042/BST20200552. Review. PubMed PMID:
33125482; PubMed Central PMCID:
PMC8759072.
Integrating structural and evolutionary data to interpret variation and pathogenicity in adapter protein complex 4.
Protein Sci.
2020 Jun;29(6):1535-1549. doi: 10.1002/pro.3870. Epub 2020 Apr 25. PubMed PMID:
32285480; PubMed Central PMCID:
PMC7255511.
Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.
Front Pharmacol.
2020;11:550. doi: 10.3389/fphar.2020.00550. eCollection 2020. Review. PubMed PMID:
32431610; PubMed Central PMCID:
PMC7212895.
Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.
Structure.
2020 Apr 7;28(4):393-405.e4. doi: 10.1016/j.str.2020.01.009. Epub 2020 Feb 5. PubMed PMID:
32027819; PubMed Central PMCID:
PMC7145723.
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Nat Commun.
2018 Sep 27;9(1):3958. doi: 10.1038/s41467-018-06172-7. PubMed PMID:
30262884; PubMed Central PMCID:
PMC6160451.
COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal.
Elife.
2017 Oct 23;6. doi: 10.7554/eLife.28342. PubMed PMID:
29058666; PubMed Central PMCID:
PMC5663479.
Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin.
Traffic.
2017 Sep;18(9):590-603. doi: 10.1111/tra.12499. PubMed PMID:
28691777; PubMed Central PMCID:
PMC5567745.
Watching real-time endocytosis in living cells.
J Cell Biol.
2017 Jan 2;216(1):9-11. doi: 10.1083/jcb.201611115. Epub 2016 Dec 22. PubMed PMID:
28007916; PubMed Central PMCID:
PMC5223616.
Molecular Basis for the Interaction Between AP4 β4 and its Accessory Protein, Tepsin.
Traffic.
2016 Apr;17(4):400-15. doi: 10.1111/tra.12375. Epub 2016 Mar 4. PubMed PMID:
26756312; PubMed Central PMCID:
PMC4805503.
Structure and mechanism of COPI vesicle biogenesis.
Curr Opin Cell Biol.
2014 Aug;29:67-73. doi: 10.1016/j.ceb.2014.04.009. Epub 2014 May 17. Review. PubMed PMID:
24840894.
VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface.
Dev Cell.
2014 Jun 9;29(5):591-606. doi: 10.1016/j.devcel.2014.04.010. Epub 2014 May 22. PubMed PMID:
24856514; PubMed Central PMCID:
PMC4059916.
Molecular basis for recognition of dilysine trafficking motifs by COPI.
Dev Cell.
2012 Dec 11;23(6):1255-62. doi: 10.1016/j.devcel.2012.10.017. Epub 2012 Nov 21. PubMed PMID:
23177648; PubMed Central PMCID:
PMC3521961.
Structures and mechanisms of vesicle coat components and multisubunit tethering complexes.
Curr Opin Cell Biol.
2012 Aug;24(4):475-83. doi: 10.1016/j.ceb.2012.05.013. Epub 2012 Jun 22. Review. PubMed PMID:
22728063; PubMed Central PMCID:
PMC3425711.
Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles.
J Cell Biol.
2012 Apr 2;197(1):141-60. doi: 10.1083/jcb.201111049. PubMed PMID:
22472443; PubMed Central PMCID:
PMC3317806.
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex.
Cell.
2010 Jun 25;141(7):1220-9. doi: 10.1016/j.cell.2010.05.006. PubMed PMID:
20603002; PubMed Central PMCID:
PMC3655264.
Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.
Cell.
2008 Sep 5;134(5):817-27. doi: 10.1016/j.cell.2008.07.023. PubMed PMID:
18775314; PubMed Central PMCID:
PMC2648964.
Wheat streak mosaic virus--structural parameters for a Potyvirus.
Virology.
2005 Sep 15;340(1):64-9. doi: 10.1016/j.virol.2005.06.022. PubMed PMID:
16026812.
Flexible filamentous virus structures from fiber diffraction.
Fiber Diffraction Review. 2005; 13:38-42.
Surface features of potato virus X from fiber diffraction.
Virology.
2002 Sep 1;300(2):291-5. doi: 10.1006/viro.2002.1483. PubMed PMID:
12350359.
Improved mammalian retromer cryo-EM structures reveal a new assembly interface.
The Journal of biological chemistry. . NIHMSID: NIHMS1841879.
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