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Welch DR, Hurst DR. Defining the Hallmarks of Metastasis. Cancer Res. 2019 Jun 15;79(12):3011-3027. doi: 10.1158/0008-5472.CAN-19-0458. Epub 2019 May 3. Review. PubMed PMID: 31053634; PubMed Central PMCID: PMC6571042.
Fingleton B, Lange K, Caldwell B, Bankaitis KV. Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an example. Clin Exp Metastasis. 2017 Dec;34(8):443-447. doi: 10.1007/s10585-017-9872-8. Epub 2018 Feb 26. PubMed PMID: 29484519.
Lewis MJ, Liu J, Libby EF, Lee M, Crawford NP, Hurst DR. SIN3A and SIN3B differentially regulate breast cancer metastasis. Oncotarget. 2016 Nov 29;7(48):78713-78725. doi: 10.18632/oncotarget.12805. PubMed PMID: 27780928; PubMed Central PMCID: PMC5340233.
Li YI, Libby EF, Lewis MJ, Liu J, Shacka JJ, Hurst DR. Increased autophagic response in a population of metastatic breast cancer cells. Oncol Lett. 2016 Jul;12(1):523-529. doi: 10.3892/ol.2016.4613. Epub 2016 May 24. PubMed PMID: 27347175; PubMed Central PMCID: PMC4906619.
Welch DR, Manton CA, Hurst DR. Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic Mechanism of Action. Adv Cancer Res. 2016;132:111-37. doi: 10.1016/bs.acr.2016.05.003. Epub 2016 Jun 17. Review. PubMed PMID: 27613131.
Falk Libby E, Liu J, Li YI, Lewis MJ, Demark-Wahnefried W, Hurst DR. Globular adiponectin enhances invasion in human breast cancer cells. Oncol Lett. 2016 Jan;11(1):633-641. doi: 10.3892/ol.2015.3965. Epub 2015 Nov 24. PubMed PMID: 26870258; PubMed Central PMCID: PMC4726973.
Yu H, Liu Y, McFarland BC, Deshane JS, Hurst DR, Ponnazhagan S, Benveniste EN, Qin H. SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells. Cancer Immunol Res. 2015 Jul;3(7):727-40. doi: 10.1158/2326-6066.CIR-15-0004. Epub 2015 Feb 3. PubMed PMID: 25649351; PubMed Central PMCID: PMC4570503.
Cody JJ, Hurst DR. Promising oncolytic agents for metastatic breast cancer treatment. Oncolytic Virother. 2015;4:63-73. doi: 10.2147/OV.S63045. eCollection 2015. Review. PubMed PMID: 27512671; PubMed Central PMCID: PMC4918380.
Khotskaya YB, Beck BH, Hurst DR, Han Z, Xia W, Hung MC, Welch DR. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Mol Carcinog. 2014 Dec;53(12):1011-26. doi: 10.1002/mc.22068. Epub 2013 Sep 2. PubMed PMID: 24000122; PubMed Central PMCID: PMC3939074.
Libby EF, Frost AR, Demark-Wahnefried W, Hurst DR. Linking adiponectin and autophagy in the regulation of breast cancer metastasis. J Mol Med (Berl). 2014 Oct;92(10):1015-23. doi: 10.1007/s00109-014-1179-5. Epub 2014 Jun 7. Review. PubMed PMID: 24903246; PubMed Central PMCID: PMC4197061.
Cody JJ, Markert JM, Hurst DR. Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells. PLoS One. 2014;9(3):e92919. doi: 10.1371/journal.pone.0092919. eCollection 2014. PubMed PMID: 24651853; PubMed Central PMCID: PMC3961437.
Diers AR, Vayalil PK, Oliva CR, Griguer CE, Darley-Usmar V, Hurst DR, Welch DR, Landar A. Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α. PLoS One. 2013;8(6):e68348. doi: 10.1371/journal.pone.0068348. Print 2013. PubMed PMID: 23840849; PubMed Central PMCID: PMC3696014.
Welch DR, Hurst DR. Unraveling the 'TGF-β paradox' one metastamir at a time. Breast Cancer Res. 2013 Feb 27;15(1):305. doi: 10.1186/bcr3383. PubMed PMID: 23448381; PubMed Central PMCID: PMC3672695.
Hurst DR, Xie Y, Thomas JW, Liu J, Edmonds MD, Stewart MD, Welch DR. The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression. PLoS One. 2013;8(2):e55966. doi: 10.1371/journal.pone.0055966. Epub 2013 Feb 4. PubMed PMID: 23390556; PubMed Central PMCID: PMC3563580.
Cody JJ, Hurst DR. Improving oncolytic herpes simplex virus for metastatic breast cancer. Journal of genetic syndromes & gene therapy. 2013; 4(1):126.
Hurst DR. Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes. Cancer Metastasis Rev. 2012 Dec;31(3-4):641-51. doi: 10.1007/s10555-012-9363-y. Review. PubMed PMID: 22678236.
Frost AR, Hurst DR, Shevde LA, Samant RS. The influence of the cancer microenvironment on the process of metastasis. Int J Breast Cancer. 2012;2012:756257. doi: 10.1155/2012/756257. Epub 2012 Apr 18. PubMed PMID: 22570792; PubMed Central PMCID: PMC3337591.
Ulasov IV, Kaverina NV, Pytel P, Thaci B, Liu F, Hurst DR, Welch DR, Sattar HA, Olopade OI, Baryshnikov AY, Kadagidze ZG, Lesniak MS. Clinical significance of KISS1 protein expression for brain invasion and metastasis. Cancer. 2012 Apr 15;118(8):2096-105. doi: 10.1002/cncr.26525. Epub 2011 Sep 16. PubMed PMID: 21928364; PubMed Central PMCID: PMC3674482.
Cook LM, Cao X, Dowell AE, Debies MT, Edmonds MD, Beck BH, Kesterson RA, Desmond RA, Frost AR, Hurst DR, Welch DR. Ubiquitous Brms1 expression is critical for mammary carcinoma metastasis suppression via promotion of apoptosis. Clin Exp Metastasis. 2012 Apr;29(4):315-25. doi: 10.1007/s10585-012-9452-x. Epub 2012 Jan 13. PubMed PMID: 22241150; PubMed Central PMCID: PMC3660968.
Hurst DR, Welch DR. Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression. FEBS Lett. 2011 Oct 20;585(20):3185-90. doi: 10.1016/j.febslet.2011.07.045. Epub 2011 Aug 5. Review. PubMed PMID: 21827753; PubMed Central PMCID: PMC3195837.
Purushothaman A, Hurst DR, Pisano C, Mizumoto S, Sugahara K, Sanderson RD. Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive tumor phenotype. J Biol Chem. 2011 Sep 2;286(35):30377-30383. doi: 10.1074/jbc.M111.254789. Epub 2011 Jul 11. PubMed PMID: 21757697; PubMed Central PMCID: PMC3162396.
Kwon YJ, Hurst DR, Steg AD, Yuan K, Vaidya KS, Welch DR, Frost AR. Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines. Clin Exp Metastasis. 2011 Jun;28(5):437-49. doi: 10.1007/s10585-011-9382-z. Epub 2011 Mar 27. PubMed PMID: 21442356; PubMed Central PMCID: PMC3081062.
Cook LM, Hurst DR, Welch DR. Metastasis suppressors and the tumor microenvironment. Semin Cancer Biol. 2011 Apr;21(2):113-22. doi: 10.1016/j.semcancer.2010.12.005. Epub 2010 Dec 17. Review. PubMed PMID: 21168504; PubMed Central PMCID: PMC3053584.
Lee S, Terry D, Hurst DR, Welch DR, Sang QX. Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA. J Cancer. 2011 Mar 16;2:165-76. doi: 10.7150/jca.2.165. PubMed PMID: 21475635; PubMed Central PMCID: PMC3069352.
Hurst DR, Welch DR. Metastasis suppressor genes at the interface between the environment and tumor cell growth. Int Rev Cell Mol Biol. 2011;286:107-80. doi: 10.1016/B978-0-12-385859-7.00003-3. Review. PubMed PMID: 21199781; PubMed Central PMCID: PMC3575029.
Edmonds MD, Hurst DR, Vaidya KS, Stafford LJ, Chen D, Welch DR. Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression. Int J Cancer. 2009 Oct 15;125(8):1778-85. doi: 10.1002/ijc.24616. PubMed PMID: 19585508; PubMed Central PMCID: PMC2749950.
Hurst DR, Edmonds MD, Welch DR. Metastamir: the field of metastasis-regulatory microRNA is spreading. Cancer Res. 2009 Oct 1;69(19):7495-8. doi: 10.1158/0008-5472.CAN-09-2111. Epub 2009 Sep 22. Review. PubMed PMID: 19773429; PubMed Central PMCID: PMC2756311.
Edmonds MD, Hurst DR, Welch DR. Linking metastasis suppression with metastamiR regulation. Cell Cycle. 2009 Sep 1;8(17):2673-5. doi: 10.4161/cc.8.17.9303. Epub 2009 Sep 23. PubMed PMID: 19690456; PubMed Central PMCID: PMC2758027.
Silveira AC, Hurst DR, Vaidya KS, Ayer DE, Welch DR. Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells. Cancer Lett. 2009 Apr 8;276(1):32-7. doi: 10.1016/j.canlet.2008.10.024. Epub 2008 Dec 13. PubMed PMID: 19070953; PubMed Central PMCID: PMC2692985.
Shin R, Welch DR, Mishra VK, Nash KT, Hurst DR, Rama Krishna N. Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution. Clin Exp Metastasis. 2009;26(6):527-33. doi: 10.1007/s10585-009-9252-0. Epub 2009 Mar 24. PubMed PMID: 19308666; PubMed Central PMCID: PMC2756240.
Richert MM, Vaidya KS, Mills CN, Wong D, Korz W, Hurst DR, Welch DR. Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone. Oncol Rep. 2009 Mar;21(3):761-7. PubMed PMID: 19212637.
Hurst DR, Edmonds MD, Scott GK, Benz CC, Vaidya KS, Welch DR. Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. Cancer Res. 2009 Feb 15;69(4):1279-83. doi: 10.1158/0008-5472.CAN-08-3559. Epub 2009 Feb 3. PubMed PMID: 19190326; PubMed Central PMCID: PMC2754225.
Hurst DR, Xie Y, Edmonds MD, Welch DR. Multiple forms of BRMS1 are differentially expressed in the MCF10 isogenic breast cancer progression model. Clin Exp Metastasis. 2009;26(2):89-96. doi: 10.1007/s10585-008-9216-9. Epub 2008 Oct 8. PubMed PMID: 18841483; PubMed Central PMCID: PMC2754230.
Welch DR, Cooper CR, Hurst DR, Lynch CC, Martin MD, Vaidya KS, VanSaun MN, Mastro AM. Metastasis Research Society-American Association For Cancer Research Joint Conference on Metastasis. Cancer Res. 2008 Dec 1;68(23):9578-82. doi: 10.1158/0008-5472.CAN-08-3360. PubMed PMID: 19047132; PubMed Central PMCID: PMC2741417.
Vaidya KS, Harihar S, Phadke PA, Stafford LJ, Hurst DR, Hicks DG, Casey G, DeWald DB, Welch DR. Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling. J Biol Chem. 2008 Oct 17;283(42):28354-60. doi: 10.1074/jbc.M710068200. Epub 2008 Jul 29. PubMed PMID: 18664570; PubMed Central PMCID: PMC2661398.
Hurst DR, Xie Y, Vaidya KS, Mehta A, Moore BP, Accavitti-Loper MA, Samant RS, Saxena R, Silveira AC, Welch DR. Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells. J Biol Chem. 2008 Mar 21;283(12):7438-44. doi: 10.1074/jbc.M709446200. Epub 2008 Jan 22. PubMed PMID: 18211900; PubMed Central PMCID: PMC2293288.
Phadke PA, Vaidya KS, Nash KT, Hurst DR, Welch DR. BRMS1 suppresses breast cancer experimental metastasis to multiple organs by inhibiting several steps of the metastatic process. Am J Pathol. 2008 Mar;172(3):809-17. doi: 10.2353/ajpath.2008.070772. Epub 2008 Feb 14. PubMed PMID: 18276787; PubMed Central PMCID: PMC2258257.
Hurst DR, Welch DR. A MSC-ing link in metastasis?. Nat Med. 2007 Nov;13(11):1289-91. doi: 10.1038/nm1107-1289. PubMed PMID: 17987025; PubMed Central PMCID: PMC2267025.
Nash KT, Phadke PA, Navenot JM, Hurst DR, Accavitti-Loper MA, Sztul E, Vaidya KS, Frost AR, Kappes JC, Peiper SC, Welch DR. Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy. J Natl Cancer Inst. 2007 Feb 21;99(4):309-21. doi: 10.1093/jnci/djk053. PubMed PMID: 17312308; PubMed Central PMCID: PMC1820615.
Hurst DR, Mehta A, Moore BP, Phadke PA, Meehan WJ, Accavitti MA, Shevde LA, Hopper JE, Xie Y, Welch DR, Samant RS. Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem Biophys Res Commun. 2006 Oct 6;348(4):1429-35. doi: 10.1016/j.bbrc.2006.08.005. Epub 2006 Aug 10. PubMed PMID: 16919237; PubMed Central PMCID: PMC1557677.
Samant RS, Debies MT, Hurst DR, Moore BP, Shevde LA, Welch DR. Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1). Cancer Lett. 2006 Apr 28;235(2):260-5. doi: 10.1016/j.canlet.2005.04.032. Epub 2005 Jun 22. PubMed PMID: 15978719.
Sang QX, Jin Y, Newcomer RG, Monroe SC, Fang X, Hurst DR, Lee S, Cao Q, Schwartz MA. Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases. Curr Top Med Chem. 2006;6(4):289-316. doi: 10.2174/156802606776287045. Review. PubMed PMID: 16611144.
Hurst DR, Schwartz MA, Jin Y, Ghaffari MA, Kozarekar P, Cao J, Sang QX. Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors. Biochem J. 2005 Dec 15;392(Pt 3):527-36. doi: 10.1042/BJ20050545. PubMed PMID: 16026329; PubMed Central PMCID: PMC1316292.
Hurst DR, Schwartz MA, Ghaffari MA, Jin Y, Tschesche H, Fields GB, Sang QX. Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities. Biochem J. 2004 Feb 1;377(Pt 3):775-9. doi: 10.1042/BJ20031067. PubMed PMID: 14533979; PubMed Central PMCID: PMC1223890.
Park HI, Jin Y, Hurst DR, Monroe CA, Lee S, Schwartz MA, Sang QX. The intermediate S1' pocket of the endometase/matrilysin-2 active site revealed by enzyme inhibition kinetic studies, protein sequence analyses, and homology modeling. J Biol Chem. 2003 Dec 19;278(51):51646-53. doi: 10.1074/jbc.M310109200. Epub 2003 Oct 7. PubMed PMID: 14532275.
Wei P, Zhao YG, Zhuang L, Hurst DR, Ruben S, Sang QX. Protein engineering and properties of human metalloproteinase and thrombospondin 1. Biochem Biophys Res Commun. 2002 Apr 26;293(1):478-88. doi: 10.1016/S0006-291X(02)00255-3. PubMed PMID: 12054626.
Hurst DR, Li H, Xu X, Badisa VL, Shi YE, Sang QX. Development and characterization of a new polyclonal antibody specifically against tissue inhibitor of metalloproteinases 4 in human breast cancer. Biochem Biophys Res Commun. 2001 Feb 16;281(1):166-71. doi: 10.1006/bbrc.2000.4319. PubMed PMID: 11178975.
Embree MC, Grant SP, Townsend JD, Downs JD, Hurst DR, Cordray TL, Beam CF. The Preparation of 5-(2-Phenyl-4-quinolinyl)-1H-pyrazoles from Dilithiated C(alpha),N-Phenylhydrazones and Methyl 2-Phenyl-4-quinolinecarboxylate. Organic preparations and procedures international. 2001; 33:91.
Angel AJ, Finefrock AE, French KL, Hurst DR, Williams AR, Rampay ME, Studor-Martinez SL, Beam CF. Preparation of 4-Oxo-N-Aryl-4H-1-Benzothiopyran-2-Acetamides from Trilithiated Acetoacetanilides and Lithiated Methyl Thiosalicylate. Canadian journal of chemistry. 1999; 77:94.
Studer-Martinez SL, Rampay ME, Halkyard CE, Williams AR, Angel AJ, Hurst DR, Townsend JD, Finefrock AF, Beam CF. Spectral Studies and Multiple Anion-Type Preparation of 2-(5-Aryl-1-carbomethoxy-1H-pyrazol-3-yl)phenols. Photochemistry and photobiology. 1999; 70:176.
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