Uses and Abuses of Big Data in Ophthalmology Research.
Ophthalmology. 2026 July; 133(7):825-828. doi: 10.1016/j.ophtha.2026.02.018.
Traumatic brain injury and late-life Alzheimer's disease neuropathology: Quantitative investigation in the Adult Changes in Thought study.
J Alzheimers Dis.
2026 Aug;112(3):1194-1205. doi: 10.1177/13872877261457138. Epub 2026 Jun 16. PubMed PMID:
42300698; PubMed Central PMCID:
PMC13309140.
Semaglutide and Neovascular Age-Related Macular Degeneration among Adults with Type 2 Diabetes: An Observational Health Data Sciences and Informatics Network Study.
Ophthalmology.
2026 Oct;133(10):1221-1229. doi: 10.1016/j.ophtha.2026.05.034. Epub 2026 Jun 2. PubMed PMID:
42229813; PubMed Central PMCID:
PMC13318194.
Glucagon-Like Peptide 1 Receptor Agonists and Age-Related Macular Degeneration Incidence.
Ophthalmol Retina.
2026 Oct;10(10):1017-1026. doi: 10.1016/j.oret.2026.05.016. Epub 2026 Jun 1. PubMed PMID:
42229850; PubMed Central PMCID:
PMC13629172.
A three-dimensional multi-modal foundation model for optical coherence tomography.
Nature Biomedical Engineering. 2026 April; :-. doi: 10.1038/s41551-026-01662-2.
Multimodal prediction of visual improvement in diabetic macular edema using real-world electronic health records and optical coherence tomography images. [Preprint]. 2026 April. doi: 10.64898/2026.04.23.26351616.
A Manual of Procedures for the Generation of the AI-Ready and Exploratory Atlas for Diabetes Insights (AI-READI) Database.
medRxiv.
2026 Apr 4;. doi: 10.64898/2026.03.30.26349552. PubMed PMID:
41959775; PubMed Central PMCID:
PMC13060450.
Age-related macular degeneration severity and risk of Alzheimer's disease in older adults in a prospective, community-based cohort study.
Alzheimers Dement (Amst).
2026 Apr-Jun;18(2):e70368. doi: 10.1002/dad2.70368. eCollection 2026 Apr-Jun. PubMed PMID:
42255955; PubMed Central PMCID:
PMC13239676.
Ground Truth Reliability and Clinical Generalisability in Deep Learning for Reticular Pseudodrusen-Response.
Clin Exp Ophthalmol.
2026 Jul;54(5):736-737. doi: 10.1111/ceo.70108. Epub 2026 Mar 16. PubMed PMID:
41839708.
Racial Disparities Associated with Non-Infectious Anterior Uveitis and Concurrent Ocular Conditions: Results from a Large Multi-Institutional Research Network.
Ocul Immunol Inflamm.
2026 Mar 12;:1-7. doi: 10.1080/09273948.2026.2637781. [Epub ahead of print] PubMed PMID:
41817272.
An LLM-assisted framework for accelerated and verifiable clinical hypothesis testing from electronic health records. [Preprint]. 2026 February. doi: 10.64898/2026.02.10.26346008.
Evolution of Oculomics: From Naked Eye Observations to Artificial Intelligence over 100 Years.
Ophthalmol Sci.
2026 Apr;6(4):101079. doi: 10.1016/j.xops.2026.101079. eCollection 2026 Apr. PubMed PMID:
41808910; PubMed Central PMCID:
PMC12969096.
Research Code Sharing in Support of Gold Standard Science.
J Diabetes Sci Technol.
2026 May;20(3):609-619. doi: 10.1177/19322968251391819. Epub 2026 Jan 14. PubMed PMID:
41532590; PubMed Central PMCID:
PMC12804059.
Beyond convolutions and supervised learning with transformers and representation learning for retinal image analysis.
Prog Retin Eye Res.
2026 Jan;110:101419. doi: 10.1016/j.preteyeres.2025.101419. Epub 2025 Dec 4. Review. PubMed PMID:
41352580; PubMed Central PMCID:
PMC12753162.
Enhancing diagnostic accuracy in rare and common fundus diseases with a knowledge-rich vision-language model.
Nat Commun.
2025 Jul 1;16(1):5528. doi: 10.1038/s41467-025-60577-9. PubMed PMID:
40592857; PubMed Central PMCID:
PMC12214743.
Using Machine Learning to Identify Ophthalmology Subspecialty Care and Advance Workforce Research with the IRIS® Registry (Intelligent Research in Sight).
Ophthalmol Sci.
2025 Nov-Dec;5(6):100855. doi: 10.1016/j.xops.2025.100855. eCollection 2025 Nov-Dec. PubMed PMID:
40727325; PubMed Central PMCID:
PMC12302636.
Elevated Intraocular Pressure Immediately after Cataract Surgery and Future Risk of Primary Open-Angle Glaucoma in the IRIS® Registry (Intelligent Research in Sight).
Ophthalmol Sci.
2025 Nov-Dec;5(6):100851. doi: 10.1016/j.xops.2025.100851. eCollection 2025 Nov-Dec. PubMed PMID:
40727324; PubMed Central PMCID:
PMC12302645.
Incidence of Endophthalmitis after Cataract Surgery in the Setting of Uveitis and Immunosuppressive Therapy within the IRIS® Registry.
Ophthalmology.
2025 Nov;132(11):1253-1259. doi: 10.1016/j.ophtha.2025.06.005. Epub 2025 Jun 9. PubMed PMID:
40499788; PubMed Central PMCID:
PMC12283248.
Improving Residency Matching Through Computational Optimization.
JAMA Netw Open.
2025 Jun 2;8(6):e2517077. doi: 10.1001/jamanetworkopen.2025.17077. PubMed PMID:
40549382; PubMed Central PMCID:
PMC12186513.
Burden of Noninfectious Ocular Inflammatory Disease in United States Ophthalmology Practice.
Ophthalmology.
2025 Oct;132(10):1182-1184. doi: 10.1016/j.ophtha.2025.05.018. Epub 2025 May 23. PubMed PMID:
40414429; PubMed Central PMCID:
PMC12358172.
The march to harmonized imaging standards for retinal imaging.
Prog Retin Eye Res.
2025 Jul;107:101363. doi: 10.1016/j.preteyeres.2025.101363. Epub 2025 May 11. Review. PubMed PMID:
40360070; PubMed Central PMCID:
PMC12240699.
A Data-driven Age-related Macular Degeneration Severity Scoring System Leveraging the AREDS Studies and Clinical Electronic Medical Records.
Ophthalmology.
2025 Oct;132(10):1076-1087. doi: 10.1016/j.ophtha.2025.04.026. Epub 2025 Apr 30. PubMed PMID:
40311699; PubMed Central PMCID:
PMC12353429.
Gap Analysis of Standard Automated Perimetry Concept Representation in Medical Terminologies.
J Glaucoma.
2025 Aug 1;34(8):644-649. doi: 10.1097/IJG.0000000000002575. Epub 2025 Apr 8. PubMed PMID:
40193233; PubMed Central PMCID:
PMC13452578.
Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy.
JAMA Ophthalmol.
2025 Apr 1;143(4):304-314. doi: 10.1001/jamaophthalmol.2024.6555. PubMed PMID:
39976940; PubMed Central PMCID:
PMC11843465.
What will the future role for large language models (LLMs) be in managing patients with glaucoma?.
Expert Rev Ophthalmol.
2025 Jun;20(3):123-126. doi: 10.1080/17469899.2025.2487532. Epub 2025 Apr 1. PubMed PMID:
40800545; PubMed Central PMCID:
PMC12338126.
Retinal imaging in an era of open science and privacy protection.
Exp Eye Res.
2025 Jun;255:110341. doi: 10.1016/j.exer.2025.110341. Epub 2025 Mar 14. Review. PubMed PMID:
40090567; PubMed Central PMCID:
PMC12059805.
Publicly available imaging datasets for age-related macular degeneration: Evaluation according to the Findable, Accessible, Interoperable, Reusable (FAIR) principles.
Exp Eye Res.
2025 Jun;255:110342. doi: 10.1016/j.exer.2025.110342. Epub 2025 Mar 13. Review. PubMed PMID:
40089134; PubMed Central PMCID:
PMC12058379.
Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI).
BMJ Open.
2025 Feb 6;15(2):e097449. doi: 10.1136/bmjopen-2024-097449. PubMed PMID:
39915016; PubMed Central PMCID:
PMC11800295.
INCIDENCE AND PROGRESSION OF AGE-RELATED MACULAR DEGENERATION AMONG PATIENTS WITH AND WITHOUT OBSTRUCTIVE SLEEP APNEA: A National Cohort Study.
Retina.
2025 Feb 1;45(2):198-206. doi: 10.1097/IAE.0000000000004293. PubMed PMID:
39454055; PubMed Central PMCID:
PMC12211732.
Associations between dementia and exposure to topical glaucoma medications.
J Alzheimers Dis.
2025 Feb;103(3):679-686. doi: 10.1177/13872877241305745. Epub 2025 Jan 21. PubMed PMID:
39834248; PubMed Central PMCID:
PMC12036566.
Predictors of Health Care Disparities in Fuchs Dystrophy Treatment Using the IRIS Registry.
Cornea.
2026 Jan 1;45(1):3-12. doi: 10.1097/ICO.0000000000003789. Epub 2025 Jan 8. PubMed PMID:
39778162; PubMed Central PMCID:
PMC12234801.
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology.
Nat Commun.
2025 Jan 2;16(1):60. doi: 10.1038/s41467-024-55198-7. PubMed PMID:
39746957; PubMed Central PMCID:
PMC11696055.
How Generalizable Are Findings from a Community-Based Prospective Cohort Study? Extending Estimates from the Adult Changes in Thought Study to Its Source Population.
J Alzheimers Dis.
2024;100(1):163-174. doi: 10.3233/JAD-240247. PubMed PMID:
38848188; PubMed Central PMCID:
PMC11423796.
Eye Adult Changes in Thought (Eye ACT) Study: Design and Report on the Inaugural Cohort.
J Alzheimers Dis.
2024;100(1):309-320. doi: 10.3233/JAD-240203. PubMed PMID:
38875039; PubMed Central PMCID:
PMC11556780.
AI-READI: rethinking AI data collection, preparation and sharing in diabetes research and beyond.
Nat Metab.
2024 Dec;6(12):2210-2212. doi: 10.1038/s42255-024-01165-x. PubMed PMID:
39516364; PubMed Central PMCID:
PMC12126850.
Treatment Patterns of Childhood Glaucoma in the United States: Analysis of IRIS(Ⓡ) Registry (Intelligent Research in Sight).
Am J Ophthalmol.
2025 Mar;271:210-221. doi: 10.1016/j.ajo.2024.11.020. Epub 2024 Nov 30. PubMed PMID:
39617117.
Comparison Between Optical Coherence Tomography B-scan and En Face Imaging for the Diagnosis of Early Macular Atrophy in Age-Related Macular Degeneration.
Am J Ophthalmol.
2025 Feb;270:252-260. doi: 10.1016/j.ajo.2024.10.002. Epub 2024 Oct 9. PubMed PMID:
39389406; PubMed Central PMCID:
PMC11735321.
Outer Retinal Thinning is Associated With Brain Atrophy in Early Age-Related Macular Degeneration.
Am J Ophthalmol.
2025 Jan;269:457-465. doi: 10.1016/j.ajo.2024.09.033. Epub 2024 Oct 5. PubMed PMID:
39369929; PubMed Central PMCID:
PMC11634662.
Comparing generative and retrieval-based chatbots in answering patient questions regarding age-related macular degeneration and diabetic retinopathy.
Br J Ophthalmol.
2024 Sep 20;108(10):1443-1449. doi: 10.1136/bjo-2023-324533. PubMed PMID:
38749531; PubMed Central PMCID:
PMC11716104.
Association Between Glucagon-Like Peptide-1 Receptor Agonists Exposure and Intraocular Pressure Change: GLP-1 Receptor Agonists and Intraocular Pressure Change.
Am J Ophthalmol.
2025 Jan;269:255-265. doi: 10.1016/j.ajo.2024.08.030. Epub 2024 Sep 3. PubMed PMID:
39237049; PubMed Central PMCID:
PMC11634659.
Ethical considerations for large language models in ophthalmology.
Curr Opin Ophthalmol.
2024 Nov 1;35(6):438-446. doi: 10.1097/ICU.0000000000001083. Epub 2024 Aug 26. Review. PubMed PMID:
39259616; PubMed Central PMCID:
PMC11427135.
Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends.
Prog Retin Eye Res.
2024 Nov;103:101290. doi: 10.1016/j.preteyeres.2024.101290. Epub 2024 Aug 22. Review. PubMed PMID:
39173942; PubMed Central PMCID:
PMC11767958.
Exploring associations between blue light filtering intraocular lenses and dementia risk.
Indian J Ophthalmol.
2024 Aug 1;72(8):1214-1215. doi: 10.4103/IJO.IJO_2578_23. Epub 2024 Jul 29. PubMed PMID:
39078968; PubMed Central PMCID:
PMC11451782.
Estimating Uncertainty of Geographic Atrophy Segmentations with Bayesian Deep Learning.
Ophthalmol Sci.
2025 Jan-Feb;5(1):100587. doi: 10.1016/j.xops.2024.100587. eCollection 2025 Jan-Feb. PubMed PMID:
39380882; PubMed Central PMCID:
PMC11459066.
Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop.
Nat Rev Cardiol.
2025 Jan;22(1):47-63. doi: 10.1038/s41569-024-01060-8. Epub 2024 Jul 22. Review. PubMed PMID:
39039178.
Beyond Pathology- Exploring Salutogenesis as a Novel Approach to Eye Inflammatory Disease Prevention and Management: A Perspective.
Ocul Immunol Inflamm.
2024 Dec;32(10):2506-2514. doi: 10.1080/09273948.2024.2359621. Epub 2024 Jun 6. Review. PubMed PMID:
38842198.
A Clinician's Guide to Sharing Data for AI in Ophthalmology.
Invest Ophthalmol Vis Sci.
2024 Jun 3;65(6):21. doi: 10.1167/iovs.65.6.21. Review. PubMed PMID:
38864811; PubMed Central PMCID:
PMC11174091.
Sociodemographic and Visual Outcomes of Juvenile Idiopathic Arthritis Uveitis: IRIS(®) Registry Study.
Clin Ophthalmol.
2024;18:1257-1266. doi: 10.2147/OPTH.S456252. eCollection 2024. PubMed PMID:
38741584; PubMed Central PMCID:
PMC11089303.
Outer Retinal Thickness Is Associated With Cognitive Function in Normal Aging to Intermediate Age-Related Macular Degeneration.
Invest Ophthalmol Vis Sci.
2024 May 1;65(5):16. doi: 10.1167/iovs.65.5.16. PubMed PMID:
38717425; PubMed Central PMCID:
PMC11090140.
Variations in Using Diagnosis Codes for Defining Age-Related Macular Degeneration Cohorts.
Informatics (MDPI).
2024 Jun;11(2). doi: 10.3390/informatics11020028. Epub 2024 May 1. PubMed PMID:
40012991; PubMed Central PMCID:
PMC11864795.
What would you like to do?