[The role of blood S100B and lactate levels in minor head traumas in children and adults and correlation with brain computerized tomography]

Ulus Travma Acil Cerrahi Derg. 2012 Sep;18(5):411-6. doi: 10.5505/tjtes.2012.76736.
[Article in Turkish]

Abstract

Background: In this study, we aimed to set levels of blood S100B and lactate and to determine any correlation with brain computerized tomography in minor head traumas in children and adults.

Methods: This clinical trial is a prospective study including 100 head trauma patients who applied to Ankara Training and Research Hospital emergency service.

Results: In this study, cut-off ranges of 0.0-0.15 ug/ml and 0.9-1.7 mmol/L for blood S100B and lactate levels, respectively, were used. S100B level was higher than the cut-off range in 42% of patients and lactate level was higher in 56% of patients. No significant differences were determined between age groups. When the relation between S100B and lactate levels with brain CT was evaluated, no statistically significant relation was determined.

Conclusion: According to our results, in minor head traumas, the determination of elevated serum S100B and lactate levels cannot take the place of clinical examination and the use of cranial CT. Although the patients in our study group had minor head trauma, we do not consider S100B and lactate to be reliable markers for estimating progression.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Brain / diagnostic imaging*
  • Child
  • Child, Preschool
  • Craniocerebral Trauma / blood
  • Craniocerebral Trauma / diagnosis*
  • Craniocerebral Trauma / diagnostic imaging
  • Female
  • Humans
  • Lactic Acid / blood*
  • Male
  • Middle Aged
  • Prospective Studies
  • Reference Values
  • S100 Calcium Binding Protein beta Subunit / blood*
  • Tomography, X-Ray Computed*
  • Young Adult

Substances

  • S100 Calcium Binding Protein beta Subunit
  • S100B protein, human
  • Lactic Acid