Similar articles for PMID: 28339198

Year	Number of Results
1968	1
2006	3
2009	3
2010	2
2011	1
2012	3
2013	9
2014	22
2015	14
2016	15
2017	11
2018	4
2019	3
2021	2
2024	0

1

Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development.

Aguilar A, Lu J, Liu L, Du D, Bernard D, McEachern D, Przybranowski S, Li X, Luo R, Wen B, Sun D, Wang H, Wen J, Wang G, Zhai Y, Guo M, Yang D, Wang S. Aguilar A, et al. J Med Chem. 2017 Apr 13;60(7):2819-2839. doi: 10.1021/acs.jmedchem.6b01665. Epub 2017 Mar 24. J Med Chem. 2017. PMID: 28339198 Free PMC article.

2

Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors.

Zhao Y, Liu L, Sun W, Lu J, McEachern D, Li X, Yu S, Bernard D, Ochsenbein P, Ferey V, Carry JC, Deschamps JR, Sun D, Wang S. Zhao Y, et al. J Am Chem Soc. 2013 May 15;135(19):7223-34. doi: 10.1021/ja3125417. Epub 2013 May 3. J Am Chem Soc. 2013. PMID: 23641733 Free PMC article.

3

A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53^wt osteosarcoma cells.

Skalniak L, Twarda-Clapa A, Neochoritis CG, Surmiak E, Machula M, Wisniewska A, Labuzek B, Ali AM, Krzanik S, Dubin G, Groves M, Dömling A, Holak TA. Skalniak L, et al. FEBS J. 2019 Apr;286(7):1360-1374. doi: 10.1111/febs.14774. Epub 2019 Feb 16. FEBS J. 2019. PMID: 30715803 Free PMC article.

4

Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction.

Yu S, Qin D, Shangary S, Chen J, Wang G, Ding K, McEachern D, Qiu S, Nikolovska-Coleska Z, Miller R, Kang S, Yang D, Wang S. Yu S, et al. J Med Chem. 2009 Dec 24;52(24):7970-3. doi: 10.1021/jm901400z. J Med Chem. 2009. PMID: 19928922 Free PMC article.

5

Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.

Aguilar A, Sun W, Liu L, Lu J, McEachern D, Bernard D, Deschamps JR, Wang S. Aguilar A, et al. J Med Chem. 2014 Dec 26;57(24):10486-98. doi: 10.1021/jm501541j. Epub 2014 Dec 12. J Med Chem. 2014. PMID: 25496041 Free PMC article.

6

Small-molecule MDM2-p53 inhibitors: recent advances.

Zhang B, Golding BT, Hardcastle IR. Zhang B, et al. Future Med Chem. 2015;7(5):631-45. doi: 10.4155/fmc.15.13. Future Med Chem. 2015. PMID: 25921402 Review.

7

Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor.

Miyazaki M, Uoto K, Sugimoto Y, Naito H, Yoshida K, Okayama T, Kawato H, Miyazaki M, Kitagawa M, Seki T, Fukutake S, Aonuma M, Soga T. Miyazaki M, et al. Bioorg Med Chem. 2015 May 15;23(10):2360-7. doi: 10.1016/j.bmc.2015.03.069. Epub 2015 Mar 31. Bioorg Med Chem. 2015. PMID: 25882531

8

A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.

Zhao Y, Yu S, Sun W, Liu L, Lu J, McEachern D, Shargary S, Bernard D, Li X, Zhao T, Zou P, Sun D, Wang S. Zhao Y, et al. J Med Chem. 2013 Jul 11;56(13):5553-61. doi: 10.1021/jm4005708. Epub 2013 Jun 20. J Med Chem. 2013. PMID: 23786219 Free PMC article.

9

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.

Tisato V, Voltan R, Gonelli A, Secchiero P, Zauli G. Tisato V, et al. J Hematol Oncol. 2017 Jul 3;10(1):133. doi: 10.1186/s13045-017-0500-5. J Hematol Oncol. 2017. PMID: 28673313 Free PMC article. Review.

10

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

Gonzalez AZ, Li Z, Beck HP, Canon J, Chen A, Chow D, Duquette J, Eksterowicz J, Fox BM, Fu J, Huang X, Houze J, Jin L, Li Y, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Sun D, Medina JC. Gonzalez AZ, et al. J Med Chem. 2014 Apr 10;57(7):2963-88. doi: 10.1021/jm401911v. Epub 2014 Mar 27. J Med Chem. 2014. PMID: 24601644

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