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28294313,31812347,24018532,14624311,31531696,24913977,21297009,30520029,27351282,19376606,22028323,27198610,16011514,16409838,29520760,20221597,30368725,26450924,17979847,29795370,28947140,30009488,34049930,10987295,21098225,10406192,28096300,17462500,26363382,10725753,17342333,28633645,27203391,28556970,29559473,32973811,29752021,23658368,21493160,22230748,11956095,22122798,17187419,16934422,23182710,34971473,9886380,27410037,18507097,29997124,31653827,12874260,28564605,10452972,30881361,17484804,10530496,16246626,16895556,19545862,18207027,18537185,29973666,28675711,28549432,24030703,18793383,33483371,15083197,20516727,23998316,23121668,25753156,27901642,20142835,28664991,23276721,16792867,18760855,23650543,23980793,19079985,10374486,16367909,25936433,7543022,15577330,16525645,28634588,29485973,29403496,23994885,15153469,17760876,17490538,32245319,32229377,12639482,24990079,33910591,21042762,20817010,31053598,34715491,19200815,26971685,27181332,31666238,21483862,17058712,19369232,26829099,28743554,22880059,20539017,20015094,28410529,34309966,11859111,29372378,32536918,31409352,33526609,15147038,17923500,31195061,19238011,26786094,11120766,30421497,27377534,25012502,29576533,27306834,30622538,26162501,21818755,28548102,29408569,21910729,21361909,18787130,26452628,28445973,11761440,34016722,32275969,31396936,30864713,20581468,21847125,16197336,23374145,19211791,29740200,18684934,20190758,34800368,22245894,30710528,11739514,30336981,15769894,27803187,33193386,11429607,29699516,35292875,19903740,15534487,15004140,22535664,30619378,27390910,26669617,16772085,29625896,12806278,33340930,34673334,27166856,27910927,29867097,12492111,22219594,24344806,18818389,27793569,16834573,32686113,15599405,24412610,18606689,23063584,31185213,31278476,33383126,12067758,23295983,26034288,11527700,18508655,30610059,28504276,18354184,31849934,22066016,29054890,31413529,27297778,28701757,1315167,31462506,22649570,19929456,31161238,16237753,28077213,29298343,10880536,20720209,27639182,21491085,29048671,33658783,30057419,9142127,29115974,10026886,31776459,28512265,12393687,29593736,24406364,34025657,28754680,25316312,24023916,30968254,22723958,31981231,15031535,19454494,31913856,18057935,25625609,18322209,19817769,19234171,12822512,28008905,8668922,28412740,31228946,20195476,32788651,28369855,18253127,33613517,19381017,31904453,27471636,21258206,29508025,23935988,28818640,17709554,15163400,9376269,8032539,34524671,35155685,9490200,30742405,28436481,31608722,17395611,24569142,30619259,19190335,8305969,30233577,21860662,31943150,31047849,20020049,28330473,22426862,27520877,18272486,33955746,9803675,34815265,29907693,33505397,18270329,33068606,31974378,22190974,17947674,33046212,9034595,30019620,8633023,27722909,25070035,34536555,28714465,24816916,31878993,7585045,31019508,31036082,31445190,22534863,26639061,27622331,21804019,31160756,31387604,7896454,36512635,32829008,29482062,28932640,20053774,16455969,33262196,23717436,28423736,20308597,31178863,21930769,24947606,1678733,22592322,28128200,32475338,35367532,31031760,10746543,28096089,29465830,34638944,30403212,27485135,16438651,28364502,31075434,35070229,10947067,34478917,27718206,34255901,29267866,32144446,19689735,32587587,31454248,30103789,20300136,35008335,32301504,33807943,32810392,36357313,18497879,2955069,20963618,36361783,29706956,12070293,34210970,31037142,29345636,34112200,7981054,34493268,31796596,30469401,15832426,28595519,15934833,32061376,6611523,27301196,32733447,22081022,21139241,19008445,33207188,34012451,26181041,17709989,22379024,31988324,35074498,20664933,36990268,28844702,30626493,34124275,28073775,15004492,23077535,29602780,11531937,32332013,31289564,23675964,18362171,33193401,36333297,20067541,12006212,28295265,19293186,28622514,24683188,30563320,10589036,19968878,26075613,27343466,29115604,26608912,32973325,33453147,10618425,33815694,28234914,30558663,25314062,25282504,19997099,20442876,29163518,32767586,33649389,17935669,11895473,20379390,31619293,30718505,27819292,30409872,8932341,29680372,22855148,31998326,7775156,24812664,12193222,35665592,34376537,32269339,10780529,9095181,15069718,21283989,34224797,21336773,15611285,2104938,15251043,36792123,8032538,28595516,30502288,21311755,22042251,17339421,28987386,30017792,22105838,28276165,29743559,29331106,32293057,34193879,32557835,30619288,30321818,30385729,28331179,9575338,24445938,8526097,28751311,15929187,9028961,20427765,23364915,20885961,30002659,8944838,33613696,21108702,19302243,32076273,29686284,31844672,24294600,32547743,32286296,35712122,34283809,34461859,36893559,20160037,24693200,35371019,31847937,23112154,34511903,31713611,35017152,32209667,36631633,33051343,18544278,27893426,23264897,9482910,20508728,36470303,34140678,23359264,34141869,9286390,35682578,32486257,15553666,27133068,27141339,23272178,8602462,28931654,17114423,35616683,17584150,12114371,33809369,23009638,35106759,35981886,30018042,29144460,1582736,33391470,24723452,22808277,11762753,29526974,25866635,7824889,24957461,18213574,15757379,3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Suppression of murine tumour growth through CD8⁺ cytotoxic T lymphocytes via activated DEC-205⁺ dendritic cells by sequential administration of α-galactosylceramide in vivo.

Kogo H, Shimizu M, Negishi Y, Uchida E, Takahashi H. Kogo H, et al. Immunology. 2017 Jul;151(3):324-339. doi: 10.1111/imm.12733. Epub 2017 Apr 18. Immunology. 2017. PMID: 28294313 Free PMC article.

A combination of check-point blockade and α-galactosylceramide elicits long-lasting suppressive effects on murine hepatoma cell growth in vivo.

Ishii K, Shimizu M, Kogo H, Negishi Y, Tamura H, Morita R, Takahashi H. Ishii K, et al. Immunobiology. 2020 Jan;225(1):151860. doi: 10.1016/j.imbio.2019.10.009. Epub 2019 Nov 4. Immunobiology. 2020. PMID: 31812347 Free article.

Inactivation of tumor-specific CD8⁺ CTLs by tumor-infiltrating tolerogenic dendritic cells.

Harimoto H, Shimizu M, Nakagawa Y, Nakatsuka K, Wakabayashi A, Sakamoto C, Takahashi H. Harimoto H, et al. Immunol Cell Biol. 2013 Oct;91(9):545-55. doi: 10.1038/icb.2013.38. Epub 2013 Sep 10. Immunol Cell Biol. 2013. PMID: 24018532 Free PMC article.

In vivo priming of natural killer T cells by dendritic cells pulsed with hepatoma-derived acid-eluted substances.

Ishii R, Shimizu M, Nakagawa Y, Shimizu K, Tanaka S, Takahashi H. Ishii R, et al. Cancer Immunol Immunother. 2004 May;53(5):383-90. doi: 10.1007/s00262-003-0453-0. Epub 2003 Nov 18. Cancer Immunol Immunother. 2004. PMID: 14624311

Induction of tumor-specific CD8⁺ cytotoxic T lymphocytes from naïve human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells.

Tomita Y, Watanabe E, Shimizu M, Negishi Y, Kondo Y, Takahashi H. Tomita Y, et al. Cancer Immunol Immunother. 2019 Oct;68(10):1605-1619. doi: 10.1007/s00262-019-02396-8. Epub 2019 Sep 17. Cancer Immunol Immunother. 2019. PMID: 31531696 Free PMC article.

Targeted delivery of α-galactosylceramide to CD8α+ dendritic cells optimizes type I NKT cell-based antitumor responses.

Macho-Fernandez E, Cruz LJ, Ghinnagow R, Fontaine J, Bialecki E, Frisch B, Trottein F, Faveeuw C. Macho-Fernandez E, et al. J Immunol. 2014 Jul 15;193(2):961-9. doi: 10.4049/jimmunol.1303029. Epub 2014 Jun 9. J Immunol. 2014. PMID: 24913977

Administration of alpha-galactosylceramide impairs the survival of dendritic cell subpopulations in vivo.

Simkins HM, Hyde E, Farrand KJ, Ong ML, Degli-Esposti MA, Hermans IF, Ronchese F. Simkins HM, et al. J Leukoc Biol. 2011 May;89(5):753-62. doi: 10.1189/jlb.0910480. Epub 2011 Feb 4. J Leukoc Biol. 2011. PMID: 21297009

CD8⁺ cytotoxic T lymphocytes in cancer immunotherapy: A review.

Farhood B, Najafi M, Mortezaee K. Farhood B, et al. J Cell Physiol. 2019 Jun;234(6):8509-8521. doi: 10.1002/jcp.27782. Epub 2018 Nov 22. J Cell Physiol. 2019. PMID: 30520029 Review.

Immunotherapy based on dendritic cells pulsed with CTPFoxM1 fusion protein protects against the development of hepatocellular carcinoma.

Su H, Li B, Zheng L, Wang H, Zhang L. Su H, et al. Oncotarget. 2016 Jul 26;7(30):48401-48411. doi: 10.18632/oncotarget.10269. Oncotarget. 2016. PMID: 27351282 Free PMC article.

Activated liver dendritic cells generate strong acquired immunity in alpha-galactosylceramide treatment.

Sasakawa A, Tatsumi T, Takehara T, Yamaguchi S, Yamamoto M, Ohkawa K, Miyagi T, Hayashi N. Sasakawa A, et al. J Hepatol. 2009 Jun;50(6):1155-62. doi: 10.1016/j.jhep.2008.12.027. Epub 2009 Feb 26. J Hepatol. 2009. PMID: 19376606

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