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27902939,24476525,29080382,28581691,25652913,27556350,25263390,23834599,27071044,26743168,15869585,25809477,16556896,18420845,18224415,23279671,29665207,25458735,11756340,28688221,28687225,25643920,23407795,20431856,10910914,16364233,25070582,33569603,25377187,24503678,33214340,23276530,28520207,16243775,26516704,28804836,31914974,22850052,11816711,1984679,2860124,12529747,22928875,22498982,29448295,21155966,26489782,22273510,29724819,22633530,30773828,7832189,16270634,8905624,33836790,8039759,29851904,16920044,19141159,19804366,28651441,24004348,27942785,22536427,17571589,30198311,20218626,34894081,34531230,24118344,34718987,24286209,28632435,21455864,19239406,23303819,11027461,15892856,12193980,32759568,16855365,7950289,36577625,12526104,33562624,21224475,24258426,16036868,16616323,30415489,16095459,22234520,24497117,24196490,19598071,27306330,24354581,35072429,22698903,12429174,2895608,18392324,28345289,7660361,32167951,27167905,7375813,10801785,22104068,28166607,35331308,16146462,23070535,15572253,29344582,8922891,23065324,22205503,25614284,9028951,2861869,11323018,22451421,27344554,33847063,29675848,37099358,30070418,30419598,28406553,33668986,34784091,19996413,31989767,31764516,28516512,21798378,2880615,12794066,10795765,26588447,35975501,9312126,15281516,1681898,36700504,24983320,35494504,17594539,36371257,28318109,27056150,11851434,36934722,26836269,31055797,35243202,28761875,11106327,32942343,32491399,7400341,11460485,10913112,24261582,11251655,33669007,32016928,2413926,29738861,27453290,7914444,26575494,29028293,3224139,33671748,25031548,514066,18673233,31159152,24331944,11755957,10446086,1989686,12558790,32560304,9776123,11588039,32678423,24408323,8130686,16026274,31766577,6661434,30888101,21276979,30446212,28432284,27540479,18564219,9187018,1000087,3471145,36372609,15502066,27622634,32311817,26654441,21471521,29027765,31493396,23960083,15692256,33498248,32513506,22019897,7323610,30489053,27648200,8362376,24958246,14675096,12181053,12053001,28728890,269298,9814641,18338137,3170575,32852328,597618,9920838,36094687,2866798,27363989,28707410,18955560,4629559,34154000,23761984,22477542,25663511,33806700,3066350,26588445,7705548,2815074,27069637,2358199,22245244,35563115,2857179,10805274,21613262,30784776,20402172,31383913,6853717,34286623,32332276,32710383,29578313,3189718,27214035,31578814,26453059,27215067,31989092,16353946,30489000,35045578,27207415,27519977,34607717,32023756,34506591,11826242,15924160,24871873,32335064,22923741,36609460,6801810,12130481,10919717,2763783,36706781,16244775,678674,32360976,36580025,36818773,26970715,31361371,3678279,29095761,26249653,33802692,2858990,2571199,30549977,4854289,36473493,36111375,2859670,33578732,11684129,26619833,9920840,23508224,12515735,35330024,31396426,30915671,34431201,31388547,1768763,35453539,34724570,21245142,27071047,6810448,26370866,30087086,23493770,910923,24142643,31695005,31697820,27074907,21189773,28734018,35997167,20163831,27483648,32060721,10674253,14604285,30506109,34065924,33603527,37059930,27917497,5279517,6484899,10943598,32751988,4002201,7265118,27522062,33583894,20375315,17310105,35186643,31189431,15060422,3607295,32168410,4571301,33851388,3187967,2433883,3196810,31469059,6429995,21640701,11118574,2714001,5750166,4718816,4565370,1162651,36876994,33208779,3768349,728710,9988331,9750687,32869231,1677916,3156225,33489380,33094094,30706822,32335063,3314976,4508929,2184890,28472132,19192107,4122681,2737926,4608005,31414482,863294,9663708,25739763,7583523,3623262,35873217,3201134,5059648,14165504,6982198,7929131,14209212,594661,28503124,10074908,7392532,163506,28664679,2325555,9259108,4966686,7918847,9651143,4629558,6142542,24575291,35278986,34976787,27346867,9017120,4214572,35456177,30867844,1092544,25909778,2339368,5290703,17078074,8652397,32805070,7341914,6054840,11369414,12900121,2765674,28894750,6731823,8474654,35585586,30228917,6135380,6482979,25778889,36670303,4428470,4164878,6105415,9253803,34380648,410213,28926188,28871658,35887938,4414691,2880614,4005184,14142505,29269148,30915205,4967475,5447956,6102074,11895779,3607290,26312861,36975624,629763,5625411,37006978,2349544,15136875,1239386,16641533,4425722,14177246,923953,425075,33589932,20284777,11460520,4977303,5970512,34484775,32731296,4978700,34736472,6573546,2620871,27781024,33927952,27635271,27749008,27748995,14330047,13502411,30884069,4508921,13979716,4812252,28421433,32839100,20396790,30855859,33603988,14863891,5804403,3778782,4129348,36082161,21000399,27642336,5941202,35049734,14384874,30564010,6114269,21991236,3779113,29416866,2611148,23543997,23495278,36454477[uid]

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Factor XIII deficiency enhances thrombin generation due to impaired fibrin polymerization - An effect corrected by Factor XIII replacement.

Pitkänen HH, Jouppila A, Lemponen M, Ilmakunnas M, Ahonen J, Lassila R. Pitkänen HH, et al. Thromb Res. 2017 Jan;149:56-61. doi: 10.1016/j.thromres.2016.11.012. Epub 2016 Nov 16. Thromb Res. 2017. PMID: 27902939

Factor XIII: congenital deficiency factor XIII, acquired deficiency, factor XIII A-subunit, and factor XIII B-subunit.

Tahlan A, Ahluwalia J. Tahlan A, et al. Arch Pathol Lab Med. 2014 Feb;138(2):278-81. doi: 10.5858/arpa.2012-0639-RS. Arch Pathol Lab Med. 2014. PMID: 24476525 Free article. Review.

Factor XIII cotreatment with hemostatic agents in hemophilia A increases fibrin α-chain crosslinking.

Beckman JD, Holle LA, Wolberg AS. Beckman JD, et al. J Thromb Haemost. 2018 Jan;16(1):131-141. doi: 10.1111/jth.13887. Epub 2017 Nov 20. J Thromb Haemost. 2018. PMID: 29080382 Free PMC article.

Recombinant factor XIII prophylaxis is safe and effective in young children with congenital factor XIII-A deficiency: international phase 3b trial results.

Kerlin BA, Inbal A, Will A, Williams M, Garly ML, Jacobsen L, Kearney SL. Kerlin BA, et al. J Thromb Haemost. 2017 Aug;15(8):1601-1606. doi: 10.1111/jth.13748. Epub 2017 Jul 10. J Thromb Haemost. 2017. PMID: 28581691 Free article. Clinical Trial.

Coagulation factor XIII: a multifunctional transglutaminase with clinical potential in a range of conditions.

Dickneite G, Herwald H, Korte W, Allanore Y, Denton CP, Matucci Cerinic M. Dickneite G, et al. Thromb Haemost. 2015 Apr;113(4):686-97. doi: 10.1160/TH14-07-0625. Epub 2015 Feb 5. Thromb Haemost. 2015. PMID: 25652913 Review.

Developing the First Recombinant Factor XIII for Congenital Factor XIII Deficiency: Clinical Challenges and Successes.

Carcao M, Fukutake K, Inbal A, Kerlin B, Lassila R, Oldenburg J, Garly ML, Nugent D. Carcao M, et al. Semin Thromb Hemost. 2017 Feb;43(1):59-68. doi: 10.1055/s-0036-1585076. Epub 2016 Aug 24. Semin Thromb Hemost. 2017. PMID: 27556350

Pharmacokinetics of recombinant factor XIII at steady state in patients with congenital factor XIII A-subunit deficiency.

Kerlin B, Brand B, Inbal A, Halimeh S, Nugent D, Lundblad M, Tehranchi R. Kerlin B, et al. J Thromb Haemost. 2014 Dec;12(12):2038-43. doi: 10.1111/jth.12739. Epub 2014 Oct 25. J Thromb Haemost. 2014. PMID: 25263390 Free article. Clinical Trial.

Pharmacokinetics of recombinant factor XIII in young children with congenital FXIII deficiency and comparison with older patients.

Williams M, Will A, Stenmo C, Rosholm A, Tehranchi R. Williams M, et al. Haemophilia. 2014 Jan;20(1):99-105. doi: 10.1111/hae.12224. Epub 2013 Jul 9. Haemophilia. 2014. PMID: 23834599 Clinical Trial.

Clinical Use of Factor XIII Concentrates.

Lassila R. Lassila R. Semin Thromb Hemost. 2016 Jun;42(4):440-4. doi: 10.1055/s-0036-1572324. Epub 2016 Apr 12. Semin Thromb Hemost. 2016. PMID: 27071044 Review.

Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis.

Duval C, Ali M, Chaudhry WW, Ridger VC, Ariëns RA, Philippou H. Duval C, et al. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):308-16. doi: 10.1161/ATVBAHA.115.306695. Epub 2016 Jan 7. Arterioscler Thromb Vasc Biol. 2016. PMID: 26743168 Free article.

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