Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd1provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1provided by MGI
Primary source: MGI:MGI:1917497
See related: Ensembl:ENSMUSG00000026229 AllianceGenome:MGI:1917497
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S1; P112; 2410026J11Rik
Summary: In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a self-compartmentalizing protease comprised of approximately 31 different subunits. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. Protein degradation by proteasomes is the source of most antigenic peptides presented on MHC class I molecules. This gene encodes a non-ATPase subunit of the 26S proteasome. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 41.0), placenta adult (RPKM 37.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.94 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (85992341..86067017)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (86064619..86139295)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Individual proteasome subunits are important for the regulation of age-related changes in both proteasome activity and protein oxidation.
Title: LMP2 knock-out mice have reduced proteasome activities and increased levels of oxidatively damaged proteins.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Htr2b (e-PCR), detects polymorphism
- UniSTS:143423

Htr2b (e-PCR), detects polymorphism
- UniSTS:495966

D11S3747 (e-PCR)
- UniSTS:152977

PSMD1 (e-PCR)
- UniSTS:512658

AJ012488 (e-PCR)
- UniSTS:163256

AV377389 (e-PCR)
- UniSTS:178426

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in proteasome storage granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 1

Names: 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027357.2 → NP_081633.1 26S proteasome non-ATPase regulatory subunit 1

See identical proteins and their annotated locations for NP_081633.1

Status: PROVISIONAL

Source sequence(s)

AK153386

Consensus CDS

CCDS15117.1

UniProtKB/Swiss-Prot

B2RRP8, Q3TXS7

UniProtKB/TrEMBL

Q8CGI9

Related

ENSMUSP00000027432.9, ENSMUST00000027432.9

Conserved Domains (3) summary

COG5116
Location:2 → 934

RPN2; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

pfam01851
Location:651 → 685

PC_rep; Proteasome/cyclosome repeat

sd00044
Location:601 → 624

HEAT; HEAT repeat [structural motif]